Zu "K08525" wurden 29 Artikel gefunden!
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LG100268
Artikelnummer: TGM-T19703-2mg
Description: LG100268 is an effective and selective rexinoid and retinoid-X receptor agonist. LG100268 binds to the alpha, beta, and gamma RXR receptors (IC50 = 3-4 nM). Target: Others. Smiles: CC1=C(C2(CC2)C3=CC=C(C(O)=O)C=N3)C=C4C(=C1)C(C)(C)CCC4(C)C. References: Cao M, Royce DB, Risingsong R, Williams CR, Sporn...
| Schlagworte: | LG 100268, LG-100268 |
| Anwendung: | RXR agonist |
| CAS | 153559-76-3 |
| MW: | 363.49 D |
59,00 €
HX 531
Artikelnummer: Cay20762-1
HX 531 is an antagonist of the retinoid X receptor (RXR) with an IC50 value of 18 nM that inhibits 9-cis retinoic acid (Cay-14587)-induced transactivation of RXR. It has been shown to reduce triglyceride content in white adipose tissue, skeletal muscle, and the liver of mice on a high fat diet.Formal Name:...
| Schlagworte: | 4-(7,8,9,10-tetrahydro-5,7,7,10,10-pentamethyl-2-nitro-5H-benzo[b]naphtho[2,3-e][1,4]diazepin-12-yl)-benzoic acid |
| Anwendung: | RXR antagonist |
| CAS | 188844-34-0 |
| MW: | 483.6 D |
ab 43,00 €
RXRbeta (human) Reporter Assay Kit
Artikelnummer: IB-IB00811
This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the human retinoid X receptor beta (NR2B2), a ligand-dependent transcription factor commonly referred to as RXRB or RXRbeta. INDIGO's reporter cells include the luciferase reporter...
| Schlagworte: | RXRB, NR2B2, Retinoid X receptor beta, Retinoic acid receptor RXR-beta, Nuclear receptor subfamily 2 group B member 2 |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
ab 1.448,00 €
UVI3003
Artikelnummer: Cay16026-5
UVI3003 is a full antagonist of RXR that demonstrates potent, nanomolar binding affinity. At 1 µM, UVI3003 does not affect the corepressor interaction capacity of the RARalpha subunit in the RAR-RXR heterodimer configuration. This compound can be used to isolate the contribution of RXR to the function of RXR...
| Schlagworte: | 3-[4-hydroxy-3-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-(pentyloxy)-2-naphthalenyl]phenyl]-2-propenoic acid |
| Anwendung: | RXR antagonist |
| CAS | 847239-17-2 |
| MW: | 436.6 D |
ab 130,00 €
LG 100754
Artikelnummer: Cay19647-1
LG 100754 is a ligand of retinoid X receptor (RXR) that modulates the activity of RXR dimers. It acts as an antagonist towards RXR homodimers but as an agonist of heterodimers consisting of RXR and retinoic acid receptor (RAR) or PPARs. LG 100754, at 1 µM, is a weak agonist of RXR-PPARgamma but strongly enhances...
| Schlagworte: | CD3159, LGD 100754, UVI2112,... |
| Anwendung: | RXR homodimer antagonist, RXR:PPAR alpha/gamma heterodimer agonist |
| CAS | 180713-37-5 |
| MW: | 396.6 D |
ab 43,00 €
LG 100268
Artikelnummer: Cay21606-1
LG 100268 is an agonist of retinoid X receptors (RXRs, Kd = 3 nM). It is selective for RXRs over retinoic acid receptors (RARs, Kd = >10,000 nM). In vitro, LG 100268 (1 µM) induces apoptosis in HL-60 human leukemia cells when used in combination with TTNPB (Cay-16144). LG 100268 (100, 300, and 1,000 nM)...
| Schlagworte: | AGN 192620, CD3127, 6-[1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)cyclopropyl]-3-pyridinecarboxylic acid |
| Anwendung: | RXR agonist |
| CAS | 153559-76-3 |
| MW: | 363.5 D |
ab 60,00 €
9-cis-Retinoic acid
Artikelnummer: LKT-R1777.25
A vitamin A analog that inhibits cell proliferation and induces cell differentiation.
| Schlagworte: | Alitretinoin |
| Anwendung: | Chemopreventive agent, Retinoid receptor agonist |
| CAS | 5300-03-8 |
| MW: | 300,44 D |
ab 102,00 €
Tazarotene
Artikelnummer: Cay23559-5
Tazarotene is a retinoid prodrug of tazarotenic acid (Cay-21367). It is metabolized by esterases in vivo to its active free acid form. Tazarotene (1 µM) inhibits proliferation of and collagen synthesis by human dermal fibroblasts in vitro. It also downregulates markers of keratinocyte differentiation, keratinocyte...
| Schlagworte: | AGN 190168, 6-[2-(3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl]-3-pyridinecarboxylic acid, ethyl ester |
| Anwendung: | Retinoic acid receptor (RAR) agonist |
| CAS | 118292-40-3 |
| MW: | 351.5 D |
ab 43,00 €
-30 %
Rabattaktion
Anti-Retinoid X Receptor beta, Internal
Artikelnummer: ARG63652.100
Protein function: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response...
| Schlagworte: | Anti-RXRB, Anti-NR2B2, Anti-Retinoid X receptor beta, Anti-Retinoic acid receptor RXR-beta, Anti-Nuclear receptor... |
| Anwendung: | ELISA, WB |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
784,00 €
548,80 €
Human Retinoic acid receptor RXR-beta / RXRB ELISA Kit
Artikelnummer: G-HUFI00938.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
641,00 €
Mouse Retinoic acid receptor RXR-beta / RXRB ELISA Kit
Artikelnummer: G-MOFI00331.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | mouse |
694,00 €
RXRbeta (human) Reporter Assay Kit
Artikelnummer: IB-IB00812
This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the human retinoid X receptor beta (NR2B2), a ligand-dependent transcription factor commonly referred to as RXRB or RXRbeta. INDIGO's reporter cells include the luciferase reporter...
| Schlagworte: | RXRB, NR2B2, Retinoid X receptor beta, Retinoic acid receptor RXR-beta, Nuclear receptor subfamily 2 group B member 2 |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
3.802,00 €