Zu "K08424" wurden 27 Artikel gefunden!
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AS1269574
Artikelnummer: TGM-T21623-100mg
Description: AS1269574 (AS 1269574) is a potent, orally available GPR119 agonist with potential for type 2 diabetes research. Target: TRP/TRPV Channel, GPR. Smiles: Cc1cc(NCCO)nc(n1)-c1ccc(Br)cc1. References: Yoshida S, et al. Identification of a novel GPR119 agonist, AS1269574, with in vitro and in vivo...
| Schlagworte: | AS 1269574 |
| Anwendung: | GPR119 agonist |
| CAS | 330981-72-1 |
| MW: | 308.17 D |
ab 42,00 €
APD668
Artikelnummer: TGM-T2088-1mg
Description: APD668 is a potent GPR119 agonist with EC50 of 2.7 nM and 33 nM for hGPR119 and ratGPR119, respectively. Target: GPR, Potassium Channel, P450. Smiles: CC(C)OC(=O)N1CCC(CC1)Oc1ncnc2n(ncc12)-c1ccc(cc1F)S(C)(=O)=O. References: Semple G, et al. Bioorg Med Chem Lett. 2011 May 15,21(10):3134-41.
| Schlagworte: | APD 668 |
| Anwendung: | GPR119 agonist |
| CAS | 832714-46-2 |
| MW: | 477.51 D |
ab 45,00 €
APD597
Artikelnummer: TGM-T3176-100mg
Description: APD597 (JNJ-38431055) is a GPR119 agonist, used in the treatment of type 2 diabetes. Target: GPR. Smiles: COc1c(Nc2ccc(nc2C)S(C)(=O)=O)ncnc1OC1CCN(CC1)C(=O)OC(C)C. References: Buzard DJ, et al. Bioorg Med Chem Lett. 2014 Sep 1,24(17):4332-5.
| Schlagworte: | JNJ-38431055 |
| Anwendung: | GPR119 agonist |
| CAS | 897732-93-3 |
| MW: | 479.55 D |
ab 63,00 €
2-Oleoylglycerol
Artikelnummer: TGM-T37526-1mg
Description: 2-Oleoylglycerol is a lipid found in palm kernel, sunflower seed and rice bran.2-Oleoylglycerol acts as a GPR119 agonist with neuroprotective effects and induces secretion of glucagon-like peptide 1 (GLP-1).2-Oleoylglycerol is used in the modelling of non-alcoholic steatohepatitis. Target: GPR. Smiles:...
| Schlagworte: | 2-Oleoyl Glycerol, 2-OG, 2-Monoolein |
| Anwendung: | GPR119 agonist |
| CAS | 3443-84-3 |
| MW: | 356.54 D |
ab 94,00 €
AR 231453
Artikelnummer: TGM-T8329-100mg
Description: AR 231453 is a selective and orally available GPR119 agonist,can stimulate beta-cell replication and improve islet graft function. Target: GPR. Smiles: N(=O)(=O)C=1C(=NC=NC1NC2=C(F)C=C(S(C)(=O)=O)C=C2)N3CCC(CC3)C4=NC(C(C)C)=NO4. References: Chu ZL, et al. A role for intestinal endocrine cell-expressed g...
| Anwendung: | GPR119 agonist |
| CAS | 733750-99-7 |
| MW: | 505.52 D |
ab 31,00 €
MBX-2982
Artikelnummer: TGM-T1793-100mg
Description: MBX-2982 is a selective, orally available GPR119 agonist used in the treatment of diabetes. Target: GPR. Smiles: CCc1cnc(nc1)N1CCC(CC1)c1ncc(COc2ccc(cc2)-n2cnnn2)s1. References: Hothersall JD, et al. Sustained wash-resistant receptor activation responses of GPR119 agonists. Eur J Pharmacol. 2015 Sep...
| Anwendung: | GPR119 agonist |
| CAS | 1037792-44-1 |
| MW: | 448.54 D |
ab 46,00 €
2-Oleoyl Glycerol
Artikelnummer: Cay16537-5
2-Oleoyl glycerol (2-OG) is a natural monoacylglycerol with an 18:1 oleoyl group at the sn-2 position of glycerol. 2-OG, like 2-arachidonoyl glycerol (2-AG, Cay-62160), is metabolized by monoacylglycerol lipase, but, unlike 2-AG, it is not metabolized by cyclooxygenases or lipoxygenases. 2-OG is an agonist of GPR119...
| Schlagworte: | 2-Monoolein, 2-OG, 2-hydroxy-1-(hydroxymethyl)ethyl ester-9Z-octadecenoic acid |
| Anwendung: | GPR119 agonist |
| CAS | 3443-84-3 |
| MW: | 356.5 D |
ab 44,00 €
Anti-GPR119
Artikelnummer: CSB-PA007283.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-GPR119, Anti-G-protein coupled receptor 119, Anti-Glucose-dependent insulinotropic receptor, G protein coupled... |
| Anwendung: | ELISA, WB, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 126,00 €
MBX-2982
Artikelnummer: Cay22206-5
MBX-2982 is an agonist of GPR119. It reduces nuclear and total protein levels of sterol regulatory element binding protein 1 (SREBP-1) in HepG2 cells and rat primary hepatocytes under high-glucose and -insulin conditions and increases phosphorylation of the inhibitory form, SREBP-1c. MBX-2982 (10 mg/kg) inhibits...
| Schlagworte: | 5-ethyl-2-[4-[4-[[4-(1H-tetrazol-1-yl)phenoxy]methyl]-2-thiazolyl]-1-piperidinyl]-pyrimidine |
| Anwendung: | GPR119 agonist |
| CAS | 1037792-44-1 |
| MW: | 448.5 D |
ab 209,00 €
PSN632408
Artikelnummer: Cay10008594-1
GPR119 (previously designated SNORF25) is an orphan G protein-coupled receptor expressed predominantly in the pancreas and gastrointestinal tract in humans and in the brain, pancreas, and gastrointestinal tract in rodents. It mediates a reduction in food intake and body weight gain in rats upon treatment with oleoyl...
| Schlagworte: | 4-[[3-(4-pyridinyl)-1,2,4-oxadiazol-5-yl]methoxy]-1-piperidinecarboxylic acid, 1,1-dimethylethyl ester |
| Anwendung: | GPR119 receptor agonist |
| CAS | 857652-30-3 |
| MW: | 360.4 D |
ab 39,00 €
Oleoyl Serinol
Artikelnummer: Cay13637-10
Oleoyl serinol is an analog of ceramide and an agonist of the cannabinoid receptor GPR119 that has an EC50 value of 12 µM for stimulating secretion of GLP-1 in mouse endocrine GLUTag cells. It has been found in E. coli that express human microbiota N-acyl synthase (hmNAS) genes. It induces cell death of F-11 murine...
| Schlagworte: | N-Oleoyl Serinol, S-18, N-[2-hydroxy-1-(hydroxymethyl)ethyl]-9Z-octadecenamide |
| Anwendung: | GPR119 agonist |
| CAS | 72809-08-6 |
| MW: | 355.6 D |
ab 57,00 €
APD668
Artikelnummer: Cay17642-5
GPR119, a glucose-dependent insulinotropic receptor, is a G protein-coupled receptor that is expressed in pancreatic beta-cells and intestinal L-cells. Activation of GPR119 by the endogenous ligands lyso-phosphatidylcholine (Cay-10172) and oleoyl ethanolamide (Cay-90265) increases intracellular cAMP levels and...
| Schlagworte: | JNJ-28630368, 4-[[1-[2-fluoro-4-(methylsulfonyl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy]-1-piperidinecarboxylic acid,... |
| Anwendung: | GPR119 agonist |
| CAS | 832714-46-2 |
| MW: | 477.5 D |
ab 61,00 €