Zu "K07827" wurden 255 Artikel gefunden!
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NEU
BI-2865
Artikelnummer: BPS-82711-1
BI-2865 is a non-covalent pan-KRAS Inhibitor. BI-2865 binds to WT, G12C, G12D, G12V and G13D mutant KRAS with KDs of 6.9, 4.5, 32, 26, 4.3 nM respectively. BI-2865 inhibits the proliferation of G12C, G12D or G12V mutant KRAS expressing BaF3 cells (mean IC50: roughly 140 nM).1
| Schlagworte: | BI-2865, pan-KRAS inhibitor, KRAS inhibitor, |
| Anwendung: | Non-covalent pan-KRAS inhibitor |
| CAS | 2937327-93-8 |
| MW: | 465,57 D |
ab 763,00 €
NEU
KRAS Isoform B Nucleotide Exchange Assay Kit
Artikelnummer: BPS-82846-1
The KRAS Isoform B Nucleotide Exchange Assay Kit is a fluorogenic homogeneous assay designed for the screening and profiling of KRAS Isoform B antagonists/inhibitors by using BODIPY(R)-GDP to monitor the KRAS Isoform B GDP or GTP binding status. The KRAS Isoform B Nucleotide Exchange Assay Kit comes in a convenient...
| Schlagworte: | KRAS, KRAS2, |
| Anwendung: | Enzyme kinetics, small molecular inhibitor screening, drug discovery, HTS |
| Spezies-Reaktivität: | human |
ab 2.985,00 €
Anti-KRAS
Artikelnummer: ABS-KC-128.100
Protein function: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:20949621). Plays an important role in the regulation of cell proliferation (PubMed:23698361, PubMed:22711838). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in...
| Schlagworte: | Anti-GTPase KRas, Anti-K-Ras 2, Anti-Ki-Ras, Anti-c-K-ras, Anti-c-Ki-ras) [Cleaved into: GTPase KRas, Anti-N-terminally... |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 232,00 €
Anti-KRAS
Artikelnummer: ABS-KC-141.100
Protein function: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:20949621). Plays an important role in the regulation of cell proliferation (PubMed:23698361, PubMed:22711838). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in...
| Schlagworte: | Anti-GTPase KRas, Anti-K-Ras 2, Anti-Ki-Ras, Anti-c-K-ras, Anti-c-Ki-ras) [Cleaved into: GTPase KRas, Anti-N-terminally... |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 232,00 €
Anti-KRAS
Artikelnummer: ATA-HPA072761.100
Polyclonal Antibody against Human KRAS, Gene description: KRAS proto-oncogene, GTPase, Alternative Gene Names: K-Ras4B, KRAS1, KRAS2, Validated applications: ICC, WB, Uniprot ID: P01116, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C. Protein function: Ras proteins bind...
| Schlagworte: | Anti-KRAS, Anti-KRAS2 |
| Anwendung: | WB, ICC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
382,00 €
RMC-6236
Artikelnummer: Cay41982-1
RMC-6236 is a non-covalent inhibitor of GTP-bound RAS. It binds to peptidyl-prolyl cis-trans isomerase A (PPIase A), also known as cyclophilin A (CypA, Kd = 55.3 nM) to form a binary complex that then binds to wild-type K-Ras, K-Ras(G12V), and K-Ras(G12D) (Kds = 131, 364, and 154 nM, respectively). RMC-6236 forms a...
| Schlagworte: | (1S,2S)-N-[(2R,14S,18S)-1-ethyl-18,19,20,21-tetrahydro-2-[2-[(1S)-1-methoxyethyl]-5-(4-methyl-1-piperazinyl)-3-pyridinyl]-... |
| Anwendung: | Non-covalent GTP-bound Ras inhibitor |
| CAS | 2765081-21-6 |
| MW: | 811.1 D |
ab 108,00 €
Erastin
Artikelnummer: Cay17754-10
Erastin, named for eradicator of RAS and small T (ST) antigen-expressing cells, is a ferroptosis inducer. It induces ferroptotic cell death in vitro, an effect that can be blocked by the ferroptosis inhibitors ciclopirox olamine, Trolox (Cay-10011659), ferrostatin-1 (Cay-17729), U-0126 (Cay-70970), cycloheximide...
| Schlagworte: | 2-[1-[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-quinazolinone |
| Anwendung: | Antitumor agent |
| CAS | 571203-78-6 |
| MW: | 547.1 D |
ab 61,00 €
Anti-Active Ras, monoclonal
Artikelnummer: NB-26909
Concentration: 1 mg/ml. Formulation: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol. Small GTPases are a super-family of cellular signaling regulators. Ras belongs to the Ras sub-family of GTPases that regulate cell proliferation, cell motility, and gene transcription. GTP binding increases the...
| Schlagworte: | Anti-KRAS, Anti-KRAS2 |
| Anwendung: | IP, IHC |
| Wirt: | Mouse |
| Spezies-Reaktivität: | vertebrates |
731,00 €
Divarasib
Artikelnummer: TGM-T9972-1mg
Description: Divarasib (GDC-6036) (GDC-6036) is an investigational, oral, high-potency and selective KRAS G12C inhibitor with an IC50 of < 0.01 µM. Divarasib irreversibly locks KRAS G12C oncoprotein in an inactive state and inhibits tumor cell growth. It is being investigated for use in solid tumors, including...
| Schlagworte: | GDC-6036 |
| Anwendung: | Targets GTPase KRas (KRAS, KRAS2) |
| CAS | 2417987-45-0 |
| MW: | 622.06 D |
ab 243,00 €
KRAS inhibitor-11
Artikelnummer: TGM-T72599-100mg
Description: KRAS inhibitor-11 is a KRAS inhibitor . Target: Others. Smiles: CC[C@H](C)[C@H]1C(=O)N[C@@H](CCN2C=C(CCCC(=O)NCC(=O)N3CCC[C@H]3C(=O)N1)N=N2)C(=O)N[C@@H](CC(C)C)C(=O)N
| MW: | 617.74 D |
ab 2.121,00 €
KRAS inhibitor-3
Artikelnummer: TGM-T72659-100mg
Description: KRAS inhibitor-3, an efficacious inhibitor of both wild-type (WT) and oncogenic KRAS mutations, exhibits high-affinity binding (K D: 0.28 µM for KRAS WT, 0.63 µM for KRAS G12C, 0.37 µM for KRAS G12D, and 0.74 µM for KRAS Q61H). Additionally, it impedes the interaction between KRAS and Raf, highlighting...
| Anwendung: | KRAS inhibitor |
| CAS | 900897-56-5 |
| MW: | 413.51 D |
ab 970,00 €
KRAS G12C inhibitor 28
Artikelnummer: TGM-T72334-100mg
Description: KRAS G12C Inhibitor 28 is a compound that effectively inhibits the KRAS G12C mutation, exhibiting potent antitumor effects with an inhibitory concentration (IC50) of 57 nanomoles (nM). Target: Others. Smiles:...
| Anwendung: | KRAS G12C inhibitor |
| CAS | 2649004-88-4 |
| MW: | 635.64 D |
ab 2.121,00 €