Zu "K07827" wurden 241 Artikel gefunden!
Für die Filterung wurden keine Ergebnisse gefunden!
NEU
GDC-6036
Artikelnummer: Cay41852-1
GDC-6036 is a covalent inhibitor of K-Ras containing a glycine-to-cysteine substitution at position 12 (K-RasG12C). It decreases tumor volume in a PaCa-2 pancreatic cancer mouse xenograft model when administered at doses ranging from 1 to 100 mg/kg per day.Formal Name:...
| Schlagworte: | Divarasib, RG-6330,... |
| Anwendung: | Covalent K-RasG12C inhibitor |
| CAS | 2417987-45-0 |
| MW: | 622.1 D |
ab 136,00 €
NEU
RMC-6236
Artikelnummer: Cay41982-1
RMC-6236 is a non-covalent inhibitor of GTP-bound RAS. It binds to peptidyl-prolyl cis-trans isomerase A (PPIase A), also known as cyclophilin A (CypA, Kd = 55.3 nM) to form a binary complex that then binds to wild-type K-Ras, K-Ras(G12V), and K-Ras(G12D) (Kds = 131, 364, and 154 nM, respectively). RMC-6236 forms a...
| Schlagworte: | (1S,2S)-N-[(2R,14S,18S)-1-ethyl-18,19,20,21-tetrahydro-2-[2-[(1S)-1-methoxyethyl]-5-(4-methyl-1-piperazinyl)-3-pyridinyl]-... |
| Anwendung: | Non-covalent GTP-bound Ras inhibitor |
| CAS | 2765081-21-6 |
| MW: | 811.1 D |
ab 108,00 €
BI-3406
Artikelnummer: TGM-T12979-100mg
Description: BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity. Target: Ras, p38 MAPK, MAPK. Smiles: COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(c3)C(F)(F)F)c2cc1O[C@H]1CCOC1. References: Marco H Hofmann, et al....
| Anwendung: | The K-Ras-SOS1 protein-protein interaction inhibitor |
| CAS | 2230836-55-0 |
| MW: | 462.46 D |
ab 66,00 €
MRTX-1257
Artikelnummer: TGM-T16143-100mg
Description: MRTX-1257 is a selective, irreversible, and covalent inhibitor of KRAS G12C with an IC50 of 900 pM for KRAS-dependent ERK phosphorylation in H358 cells. MRTX-1257 demonstrated 31% bioavailability in the mouse, with free fraction exposures well above cellular potency, and 77% target engagement in a PK/PD...
| Anwendung: | K-RasG12C covalent inhibitor |
| CAS | 2206736-04-9 |
| MW: | 565.71 D |
ab 57,00 €
Spiro-Oxanthromicin A
Artikelnummer: TGM-T36391-1mg
Description: Spiro-oxanthromicin A is a polyketide that has been found inStreptomyces.1It induces mislocalization of K-RAS in MDCK cells (IC50= 26.7 µM). Target: Others. Smiles: Cc1ccc2c(C(=O)c3c(C)c(C(O)=O)c(O)cc3C22CC=C3c4cc(O)c(C(O)=O)c(C)c4C(=O)c4c(O)c(C)cc2c34)c1O , t:23, . References: Salim, A.A., Xiao, X.,...
| Anwendung: | Bioactive polyketide |
| CAS | 1616622-10-6 |
| MW: | 618.594 D |
1.538,00 €
KRAS4b-PDEdelta stabilizer C19
Artikelnummer: TGM-T32419-100mg
Description: KRAS4b-PDEdelta stabilizer C19 is a stabilizer of the KRAS4b-PDEdelta complex which decreases the proliferation of colorectal cancer cells, and increases apoptosis via decreased activation of oncogenic KRAS4b signaling. Target: Others. Smiles: N(C(C(NCC1=CC(OC)=C(OC)C=C1)C)=O)C2=C(Cl)C=CC(Cl)=C2
| CAS | 1049727-35-6 |
| MW: | 383.27 D |
ab 1.491,00 €
KRAS G13D peptide, 25 mer
Artikelnummer: TGM-T38936-100mg
Description: KRAS G13D peptide, a 25-mer sequence, is derived from the KRAS activating oncogene mutation and serves as an immune potentiator. This peptide possesses immunogenic properties and can be utilized for the development of a KRAS vaccine. Smiles:...
| Schlagworte: | KRAS G13D peptide, 25 mer |
| CAS | 145019-94-9 |
| MW: | 2634.13 D |
Bitte fragen Sie den aktuellen Preis für diesen Artikel an.
K-Ras(G12C) Inhibitor 6
Artikelnummer: TGM-T3725-100mg
Description: K-Ras(G12C) inhibitor 6 is an irreversible, allosteric inhibitor of the K-Ras(G12C) mutant, achieving 100% protein modification at 10 µM after 24 hours in vitro. Target: Raf. Smiles: SCCCC(=O)NC1CCN(CC1)C(=O)COc1ccc(Cl)cc1Cl. References: Hunter JC, Gurbani D, Ficarro SB, Carrasco MA, Lim SM, Choi HG,...
| Anwendung: | K-Ras(G12C) inhibitor |
| CAS | 2060530-16-5 |
| MW: | 405.33 D |
ab 56,00 €
KRAS inhibitor-10
Artikelnummer: TGM-T36761-100mg
Description: KRAS inhibitor-10 (WO2021005165 A1, compound 11) is a potent and selective inhibitor of RAS proteins, with a specific focus on KRAS proteins. This orally active anti-cancer agent demonstrates strong efficacy in cancer research, specifically in pancreatic cancer, breast cancer, multiple myeloma,...
| Anwendung: | KRAS inhibitor |
| CAS | 2578876-75-0 |
| MW: | 519.63 D |
ab 1.491,00 €
KRAS G12D inhibitor 5
Artikelnummer: TGM-T40246-5mg
Description: KRAS G12D inhibitor 5 is a potential treatment for pancreatic cancer that targets the KRAS G12D mutation. Target: Others. Smiles: Oc1cc(-c2ncc3c(nc(OC[C@@]45CCCN4C[C@H](F)C5)nc3c2F)N2CC3CCC(C2)N3)c2c(Cl)cccc2c1 , TLB:8:26:33:29.30, . References: Kargbo RB. Targeting KRAS G12D Mutant for the Potential...
| Anwendung: | KRAS G12D inhibitor |
| CAS | 2621928-53-6 |
| MW: | 593.08 D |
951,00 €
KRAS mutant protein inhibitor 1
Artikelnummer: TGM-T40272-5mg
Description: KRAS mutant protein inhibitor 1 is a KRAS mutant protein inhibitor [for potential treatment in cancer]. Target: Others. Smiles: CC(C)c1nccc(C)c1-n1c2nc(c(Cl)cc2c(N2CCN(CC2)C(=O)C=C)c(C#N)c1=O)-c1c(N)c(Cl)cc(Cl)c1F. References: Kargbo RB. Targeting KRAS Mutant Protein Inhibitor for Potential Treatment in...
| Anwendung: | KRAS mutant protein inhibitor |
| CAS | 2642305-16-4 |
| MW: | 654.95 D |
951,00 €
KRAS G12D inhibitor 6
Artikelnummer: TGM-T40281-5mg
Description: KRAS G12D inhibitor 6 is an efficacious compound that effectively inhibits KRAS G12D. Target: Others. Smiles: CN1CCC[C@H]1COc1nc2CN(CCc2c(n1)N1CCN([C@@H](CC#N)C1)C(=O)[C@H]1CN1)c1cccc2cccc(Cl)c12. References: PITZEN, Jennifer, et al. COVALENT RAS INHIBITORS AND USES THEREOF. Patent WO2021108683A1.
| Anwendung: | KRAS G12D inhibitor |
| CAS | 2648552-32-1 |
| MW: | 601.15 D |
951,00 €