Zu "K07374" wurden 246 Artikel gefunden!
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Paclitaxel
Artikelnummer: AG-CN2-0045-M025
Anticancer compound. Chemotherapeutic used in patients with cancer and advanced forms of Kaposi's sarcoma. Microtubule assembly stabilizer. Reversibly binds to polymerized tubulin. Anti-mitotic. Mitotic spindle assembly, chromosome segregation and cell division inhibitor. Induces cell cycle arrest at the G2/M phase....
| Schlagworte: | Taxol, BMS 181339-01, NSC 125973 |
| Anwendung: | Apoptosis Inducer |
| Wirt: | Taxus brevifolia |
| CAS | 33069-62-4 |
| MW: | 853,9 D |
ab 22,00 €
Myoseverin
Artikelnummer: TGM-T21632-100mg
Description: Myoseverin, an inducer of the reversible fission of multinucleated myotubes into mononucleated fragments, affecting the expression of a variety of growth factor, immunomodulatory, extracellular matrix-remodeling, and stress response genes, consistent with the activation of pathways involved in wound...
| Anwendung: | Cell cycle arrest |
| CAS | 267402-71-1 |
| MW: | 432.52 D |
ab 31,00 €
Mertansine
Artikelnummer: TGM-T1992-1mg
Description: Mertansine (DM1) refers to the thiol-containing maytansinoid, DM1 (N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) attached to a monoclonal antibody through reaction of the thiol group with the SPP (N-succinimidyl 4-(2-pyridyldithio)) linker to create an antibody-drug conjugate or ADC. Experimental...
| Schlagworte: | DM1, Maytansinoid DM1 |
| Anwendung: | Maytansinoid tubulin inhibitor |
| CAS | 139504-50-0 |
| MW: | 738.29 D |
ab 31,00 €
7-Xylosyltaxol
Artikelnummer: TGM-T2S2378-1mL
Description: 7-xylosyltaxol is a taxol (Paclitaxel) derivative, has antineoplastic activity. Target: Others. Smiles: CC(=O)O[C@@H]1C2=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)c3ccccc3)[C@@H]3[C@@]4(CO[C@@H]4C[C@H](OC4OC[C@@H](O)[C@H](O)[C@H]4O)[C@@]3(C)C1=O)OC(C)=O)C2(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)c1ccccc1)c1ccccc1
| Anwendung: | Microtubule disruptor, anticancer agent, taxan |
| CAS | 90332-66-4 |
| MW: | 986.033 D |
ab 1.430,00 €
CAY10701
Artikelnummer: TGM-T36458-100mg
Description: CAY10701 is a 7-deazahypoxanthine analog that prevents microtubule formation, blocking the proliferation of HeLa and MCF-7 cells (GI50s = 22 and 38 nM, respectively). It also inhibits the growth of several different colorectal cancer cell lines (GI50 values range from 9 to 17 nM), while being at least...
| Schlagworte: | CAY10701 |
| Anwendung: | Microtubule formation inhibitor |
| CAS | 1616967-52-2 |
| MW: | 381.43 D |
ab 1.491,00 €
Cucurbitacin B
Artikelnummer: TGM-T3404-100mg
Description: Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-regulation of PTEN. Cucurbitacin B is an effective inhibitor of HIF-1 and provide new perspectives into the mechanism of its anticancer...
| Schlagworte: | DATISCACIN, Cuc B, Amarine |
| Anwendung: | Microtubule polymerization inhibitor |
| CAS | 6199-67-3 |
| MW: | 558.7 D |
ab 44,00 €
Curvulin
Artikelnummer: TGM-T36850-100mg
Description: Curvulin is the active metabolite isolated from Paraphoma sp. VIZR 1.46. Curvularin inhibits iNOS expression and microtubule assembly. Target: Microtubule Associated. Smiles: CCOC(=O)Cc1cc(O)cc(O)c1C(C)=O. References: Ekaterina Poluektova, et al. Curvulin and Phaeosphaeride A From Paraphoma Sp. VIZR...
| Anwendung: | Phytotoxin, Microtubule assembly inhibitor |
| CAS | 19054-27-4 |
| MW: | 238.24 D |
ab 145,00 €
Microtubule inhibitor 6
Artikelnummer: TGM-T62448-100mg
Description: Microtubule inhibitor 6 (compound 17o) is a potent microtubule inhibitor exhibiting cytotoxicity against NCI-H460, BxPC-3, and HT-29 cells, with IC50 values of 14.0, 6.6, and 7.0 nM, respectively. It effectively inhibits microtubule polymerization. Target: Others. Smiles:...
| Anwendung: | Microtubule inhibitor |
| CAS | 2416338-64-0 |
| MW: | 434.42 D |
ab 2.100,00 €
Fosbretabulin Disodium
Artikelnummer: TGM-T6272-100mg
Description: Fosbretabulin Disodium (CA 4P), a water-soluble prodrug of Combretastatin A4 (CA4), is a microtubule-targeting agent that binds beta-tubulin (Kd: 0.4 µM). Fosbretabulin Disodium(Combretastatin A4 disodium phosphate) inhibits the polymerization of tubulin (IC50: 2.4 µM), and also disrupts tumor...
| Schlagworte: | CA 4DP, Combretastatin A4 Phosphate, Combretastatin A4 disodium phosphate, CA 4P, Fosbretabulin (Combretastatin A4... |
| Anwendung: | Tubulin polymerization inhibitor, prodrug |
| CAS | 168555-66-6 |
| MW: | 440.29 D |
ab 33,00 €
Microtubule inhibitor 5
Artikelnummer: TGM-T61765-100mg
Description: Microtubule inhibitor 5 (compound 17f) is a highly potent cytotoxic agent that inhibits microtubule function, exhibiting a substantial cytotoxic effect on NCI-H460 cells with an IC50 value of 154.5 nM. Additionally, this compound demonstrates excellent cell permeability [1]. Target: Others. Smiles:...
| Anwendung: | Microtubule inhibitor |
| CAS | 2416338-55-9 |
| MW: | 390.36 D |
ab 1.491,00 €
10-Deacetyl-7-xylosyl paclitaxel
Artikelnummer: TGM-T5749-1mL
Description: 10-Deacetyl-7-xylosyl paclitaxel (7-Xylosyl-10-deacetyltaxol) is a Paclitaxel derivative with improved pharmacological features and higher water solubility,used in Chinese clinics to treat cancer. Target: Others, ADC Cytotoxin, Microtubule Associated. Smiles:...
| Schlagworte: | 10-Deacetyl-7-xylosyltaxol, 10-Deacetyltaxol 7-Xyloside, 7-Xylosyl-10-deacetyltaxol, 10-Deacetylpaclitaxel 7-Xyloside |
| Anwendung: | Microtubule disruptor |
| CAS | 90332-63-1 |
| MW: | 943.98 D |
ab 50,00 €
Microtubule inhibitor 7
Artikelnummer: TGM-T62639-100mg
Description: Compounds 17o (IC50= 14.0 nM, NCI-H460) and 17p (IC50= 2.9 nM, NCI-H460) with furan moieties show potent nanomolar levels of cytotoxic activity against various human cancer cell lines. Target: Others. Smiles: C(\C1=CC(C(=O)C2=CC=C(F)C=C2)=CC=C1)=C\3/C(=O)N/C(=C\C=4OC(COC)=CC4)/C(=O)N3
| Anwendung: | Microtubule inhibitor |
| CAS | 2416338-65-1 |
| MW: | 446.43 D |
ab 2.100,00 €