Zu "K07370" wurden 140 Artikel gefunden!
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Anti-BTK
Artikelnummer: ABS-KC-6102.100
Protein function: Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates...
| Schlagworte: | Anti-Tyrosine-protein kinase BTK, Anti-Agammaglobulinemia tyrosine kinase, Anti-ATK, Anti-B-cell progenitor kinase,... |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 232,00 €
Ibrutinib
Artikelnummer: TGM-T1835-100mg
Description: Ibrutinib (PCI-32765) is an irreversible inhibitor of BTK (IC50: 0.5 nM) that selectively blocks B cell activation. Target: Tyrosine Kinases, Src, BTK, Ligands for Target Protein for PROTAC. Smiles: NC1=C2C(N(N=C2C3=CC=C(OC4=CC=CC=C4)C=C3)[C@H]5CN(C(C=C)=O)CCC5)=NC=N1. References: Honigberg LA, et...
| Schlagworte: | PCI-32765 |
| Anwendung: | Targets Bruton agammaglobulinemia tyrosine kinase [EC:2.7.10.2] (BTK) |
| CAS | 936563-96-1 |
| MW: | 440.5 D |
ab 37,00 €
RN486
Artikelnummer: TGM-T1976-100mg
Description: RN486 is an effective and specific BTK inhibitor (IC50: 4 nM). Target: BTK. Smiles: CN1CCN(CC1)c1ccc(Nc2cc(cn(C)c2=O)-c2cccc(c2CO)-n2ccc3cc(cc(F)c3c2=O)C2CC2)nc1. References: Xu D, et al. J Pharmacol Exp Ther, 2012, 341(1), 90-103.
| Anwendung: | BTK inhibitor |
| CAS | 1242156-23-5 |
| MW: | 606.69 D |
ab 77,00 €
Edralbrutinib
Artikelnummer: TGM-T63272-100mg
Description: Edralbrutinib (TG-1701) is a potent BTK inhibitor with anticancer activity used in treating tumors, immune system disorders, and blood and lymphatic system disorders. Additionally, Edralbrutinib is studied for its efficacy in membranous glomerulonephritis and optic neuromyelitis optica. Target: BTK....
| Schlagworte: | TG-1701 |
| Anwendung: | Targets Bruton agammaglobulinemia tyrosine kinase [EC:2.7.10.2] (BTK) |
| CAS | 1858206-58-2 |
| MW: | 489.47 D |
ab 195,00 €
Ibrutinib
Artikelnummer: Cay16274-1
Bruton's tyrosine kinase (BTK) is a member of the BTK/Tec family of protein tyrosine kinases involved in signal transduction pathways regulating proliferation, survival, migration, and tissue homing of B-cells. Ibrutinib is an irreversible inhibitor of BTK (IC50 = 0.5 nM) that selectively blocks B cell activation,...
| Schlagworte: | Imbruvica, PCI 32765, 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one |
| Anwendung: | BTK inhibitor |
| CAS | 936563-96-1 |
| MW: | 440.5 D |
ab 52,00 €
BTK inhibitor 10
Artikelnummer: TGM-T10627-100mg
Description: BTK inhibitor 10 is a potent and orally active compound with potential applications in rheumatoid arthritis treatment. Target: Others. Smiles: C=CC(=O)Nc1cccc(Oc2ncnc3[nH]c(cc23)-c2ccc(cc2)N2CCOCC2)c1. References: HuiJun Yin, et al. Pyrrolo-aromatic heterocyclic compound, preparation method therefor,...
| Anwendung: | BTK inhibitor |
| CAS | 2241732-30-7 |
| MW: | 441.48 D |
ab 1.520,00 €
BTK inhibitor 13
Artikelnummer: TGM-T10628-100mg
Description: BTK inhibitor 13 (compound 8) is a potent and selective BTK inhibitor with an IC50 of 1.2 nM. Target: Others. Smiles: C(CN(C(C=C)=O)C)(=O)C=1C2=C(N=CN=C2NC1)C3=C(C)C(NC(=O)C4=CC=C(C=C4)C5CC5)=CC(F)=C3. References: Pulz R, et al. Design of Potent and Selective Covalent Inhibitors of Bruton's Tyrosine...
| Anwendung: | BTK inhibitor |
| CAS | 2376726-26-8 |
| MW: | 511.55 D |
ab 1.971,00 €
Btk inhibitor 2
Artikelnummer: TGM-T10629-100mg
Description: Btk Inhibitor 2 (BGB-3111 analog) is a BTK inhibitor. Target: BTK. Smiles: NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cc1)[C@@H]1CCCN(C1)C(=O)C=C. References: Cecile M. Krejsa. Methods of Using BTK Inhibitors to Treat Dermatoses. US 20170224688 A1.
| Schlagworte: | BGB-3111 analog |
| Anwendung: | Btk inhibitor |
| CAS | 1558036-85-3 |
| MW: | 431.49 D |
ab 31,00 €
Orelabrutinib
Artikelnummer: TGM-T12317-100mg
Description: Orelabrutinib (ICP-022) is an orally active and irreversible inhibitor of Bruton's tyrosine kinase (BTK). Target: BTK. Smiles: NC(=O)c1ccc(nc1-c1ccc(Oc2ccccc2)cc1)C1CCN(CC1)C(=O)C=C. References: Wei Xu, et al. Safety, Tolerability and Efficacy of Orelabrutinib, Once a Day, to Treat Chinese Patients with...
| Schlagworte: | ICP-022 |
| Anwendung: | Targets Bruton agammaglobulinemia tyrosine kinase [EC:2.7.10.2] (BTK) |
| CAS | 1655504-04-3 |
| MW: | 427.49 D |
ab 83,00 €
Tirabrutinib hydrochloride
Artikelnummer: TGM-T12311-100mg
Description: Tirabrutinib hydrochloride (GS-4059 (hydrochloride)) is a selective and novelBTK with IC50 2.2 nm inhibitor. Target: BTK. Smiles: Cl.CC#CC(=O)N1CC[C@H](C1)n1c2ncnc(N)c2n(-c2ccc(Oc3ccccc3)cc2)c1=O. References: Akintunde Akinleye et al. Ibrutinib and novel BTK inhibitors in clinical development. J Hematol...
| Schlagworte: | ONO-4059 (hydrochloride), GS-4059 (hydrochloride) |
| Anwendung: | Targets Bruton agammaglobulinemia tyrosine kinase [EC:2.7.10.2] (BTK) |
| CAS | 1439901-97-9 |
| MW: | 490.94 D |
ab 31,00 €
Vecabrutinib
Artikelnummer: TGM-T17220-100mg
Description: Vecabrutinib (SNS-062) is a potent, noncovalent inhibitor of BTK (Kd: 0.3 nM) and ITK (Kd: 2.2 nM), with an IC50 of 24 nM for ITK. Target: Tyrosine Kinases, BTK. Smiles: NC(=O)[C@H]1CCN(C[C@@H]1N1CCC[C@@H](Nc2cc(Cl)cc(c2)C(F)(F)F)C1=O)c1ncnc(N)c1F. References: Minke E. Binnerts, et al. Abstract C186:...
| Schlagworte: | SNS-062 |
| Anwendung: | Targets Bruton agammaglobulinemia tyrosine kinase [EC:2.7.10.2] (BTK) |
| CAS | 1510829-06-7 |
| MW: | 529.92 D |
ab 79,00 €
MT-802
Artikelnummer: TGM-T16157-100mg
Description: MT-802 is an effective BTK degrader based on PROTAC technology (DC50: 1 nM). MT-802 has the potential to treat C481S mutant chronic lymphocytic leukemia (CLL). Target: PROTACs, BTK. Smiles: NC1=C2C(=NN(C2=NC=N1)C3CCN(CCOCCOCC(NC=4C=C5C(=CC4)C(=O)N(C5=O)C6C(=O)NC(=O)CC6)=O)CC3)C7=CC=C(OC8=CC=CC=C8)C=C7....
| Anwendung: | BTK degradation driving PROTAC |
| CAS | 2231744-29-7 |
| MW: | 787.82 D |
ab 88,00 €