Zu "K07294" wurden 139 Artikel gefunden!
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NEU
Saroglitazar Magnesium
Artikelnummer: Cay41694-1
Saroglitazar magnesium is a dual agonist of PPARalpha and PPARgamma (EC50s = 0.65 and 3,000 pM, respectively, in a transactivation assay in HepG2 cells). It decreases serum triglyceride, free fatty acid, and glucose levels in a db/db mouse model of diabetes when administered at doses ranging from 0.01 to 3 mg/kg per...
| Schlagworte: | (T-4)-bis[(alphaS)-alpha-(ethoxy-kappaO)-4-[2-[2-methyl-5-[4-(methylthio)phenyl]-1H-pyrrol-1-yl]ethoxy]benzenepropanoato-k... |
| Anwendung: | PPARalpha / PPARgamma dual agonist |
| CAS | 1639792-20-3 |
| MW: | 901.4 D |
ab 48,00 €
Aluminium clofibrate
Artikelnummer: TGM-T21243-25mg
Description: Aluminium clofibrate, a salt of clofibric acid, is a peroxisome proliferator. Target: Others. Smiles: [OH-][Al+3]12(O(C(C)(C)C(=O)[O-]1)C3=CC=C(Cl)C=C3)O(C(C)(C)C(=O)[O-]2)C4=CC=C(Cl)C=C4. References: Takagi A, Sai K, Umemura T, Hasegawa R, Kurokawa Y. Relationship between hepatic peroxisome...
| Schlagworte: | Alufibrate, Atherolip, Alfibrate |
| Anwendung: | Targets peroxisome proliferator-activated receptor alpha (NR1C1, PPARA) |
| CAS | 24818-79-9 |
| MW: | 471.26 D |
1.491,00 €
LT175
Artikelnummer: TGM-T21812-1mg
Description: LT175, a dual PPARalpha/gamma ligand, demonstrates potent insulin-sensitizing effects with reduced adipogenic properties. This orally active partial agonist targets PPARgamma with EC50 values of 0.22 µm for hPPARalpha, 0.26 µm for mPPARalpha, and 0.48 µm for hPPARgamma. LT175 specifically interacts with...
| Anwendung: | PPAR gamma / alpha partial agonist |
| CAS | 862901-87-9 |
| MW: | 318.37 D |
77,00 €
KRP-297
Artikelnummer: TGM-T27749-10mg
Description: KRP297 is a PPAR agonist potentially for the treatment of type 2 diabetes and dyslipidemia. Target: Others. Smiles: C(NCC1=CC=C(C(F)(F)F)C=C1)(=O)C2=C(OC)C=CC(CC3SC(=O)NC3=O)=C2. References: Xu XS, Yan KX, Song H, Lo MW. Quantitative determination of a novel dual PPAR alpha/gamma agonist using on-line...
| Schlagworte: | L 410198, L410198, MK-0767, KRP297 |
| Anwendung: | PPARalpha / PPARgamma dual agonist |
| CAS | 213252-19-8 |
| MW: | 438.42 D |
ab 179,00 €
Peliglitazar
Artikelnummer: TGM-T28354-100mg
Description: Peliglitazar is a activator of alpha/gamma peroxisome proliferator-activated receptor. Target: Others. Smiles: C(COC1=CC=C([C@@H](N(C(OC2=CC=C(OC)C=C2)=O)CC(O)=O)C)C=C1)C=3N=C(OC3C)C4=CC=CC=C4. References: Wang L, Munsick C, Chen S, Bonacorsi S, Cheng PT, Humphreys WG, Zhang D. Metabolism and...
| Schlagworte: | BMS 42670701, BMS 426707-01, BMS-426707-1 |
| Anwendung: | Targets peroxisome proliferator-activated receptor alpha (NR1C1, PPARA) |
| CAS | 331744-64-0 |
| MW: | 530.57 D |
ab 1.786,00 €
GW 9578
Artikelnummer: TGM-T27519-10mg
Description: GW 9578 is a selective and potent PPARalpha agonist with potent lipid-lowering activity for the study of psoriasis, arthritis, alopecia, asthma and type I diabetes. Target: PPAR. Smiles: S(C(C(O)=O)(C)C)C1=CC=C(CCN(C(NC2=C(F)C=C(F)C=C2)=O)CCCCCCC)C=C1. References: P J Brown, et al. A...
| Schlagworte: | GW9578, GW-9578 |
| Anwendung: | PPARalpha agonist |
| CAS | 247923-29-1 |
| MW: | 492.62 D |
ab 74,00 €
MD001
Artikelnummer: TGM-T35800-10mg
Description: MD001 is a dual agonist of peroxisome proliferator-activated receptor alpha (PPARalpha) and PPARgamma.1 It binds to PPARalpha and PPARgamma (Kds = 9.55 and 0.14 µM, respectively) but does not bind to PPARbeta/delta at concentrations up to 500 µM. It increases transcriptional activity of PPARalpha and...
| Anwendung: | Peroxisome proliferator-activated receptor (PPARalpha / PPARgamma) agonist |
| CAS | 2254605-76-8 |
| MW: | 398.41 D |
1.059,00 €
MHY908
Artikelnummer: TGM-T28035-10mg
Description: MHY908, a novel inhibitor of melanogenesis, potently inhibits mushroom tyrosinase activity in a dose-dependent manner. Target: Others. Smiles: O(C(C(O)=O)(C)C)C1=CC=C(C2=NC=3C(S2)=CC=C(Cl)C3)C=C1. References: Kim YR, Lee EK, Kim DH, Kim KM, Lee B, An HJ, Park JW, Moon KM, Park MH, Chung KW, Park JY, Kim...
| Anwendung: | PPARalpha / gamma agonist |
| CAS | 1393371-39-5 |
| MW: | 347.82 D |
ab 117,00 €
Naveglitazar
Artikelnummer: TGM-T33598-100mg
Description: Naveglitazar (LY 519818, LY 9818) is a peroxisome proliferator-activated receptor (PPAR) modulator, which has entered phase II clinical trials for the treatment of type 2 diabetes. Target: Others. Smiles: O(C1=CC=C(OCCCOC2=CC=C(C[C@@H](C(O)=O)OC)C=C2)C=C1)C3=CC=CC=C3. References: Tseng CH, Tseng FH....
| Schlagworte: | LY 9818, LY-519818, LY-9818, LY9818, LY519818, LY 519818 |
| Anwendung: | Targets peroxisome proliferator-activated receptor alpha (NR1C1, PPARA) |
| CAS | 476436-68-7 |
| MW: | 422.47 D |
ab 1.491,00 €
Edaglitazone
Artikelnummer: TGM-T27239-5mg
Description: Edaglitazone (R-483) is an orally active, selective and potent PPARgamma agonist showing affinity for both PPARalpha and PPARgamma. Edaglitazone displays antiplatelet activity and can be used in studies of diabetes mellitus and obesity. Target: PPAR. Smiles:...
| Schlagworte: | Edaglitazone sodium, RO-2052349-000, R-483, RO-2052349-602, BM-13.1258 |
| Anwendung: | PPARgamma agonist |
| CAS | 213411-83-7 |
| MW: | 464.56 D |
350,00 €
AM-3102
Artikelnummer: TGM-T29938-5mg
Description: AM-3102 is an OEA analog that stimulates PPARalpha transcriptional activity and prolongs feeding latency. It is resistant to enzymatic hydrolysis and is as potent as OEA in enhancing transcriptional activity of PPARalpha and reducing food intake in free-feeding rats. AM3102 demonstrates weak affinity...
| Schlagworte: | Methyl oleoylethanolamide, AM 3102, KDS-5104 |
| Anwendung: | PPARalpha activator |
| CAS | 213182-22-0 |
| MW: | 339.56 D |
ab 108,00 €
CAY10767
Artikelnummer: TGM-T37833-1mg
Description: CAY10767 is an agonist of peroxisome proliferator-activated receptor alpha (PPARalpha, EC50= 37 nM in a reporter assay).1It is greater than 2,700-fold selective for PPARalpha over PPARgamma or PPARdelta. Target: Others. Smiles: O(CC1=CC=C(F)C=C1)C2=C(C)C=C(CNC3=CC(C(O)=O)=CC=C3)C=C2. References: Dou,...
| Anwendung: | Peroxisome proliferator-activated receptor alpha (PPARalpha) agonist |
| CAS | 2376590-40-6 |
| MW: | 365.4 D |
ab 151,00 €