Zu "K07294" wurden 145 Artikel gefunden!
Für die Filterung wurden keine Ergebnisse gefunden!
PPARalpha (Peroxisome proliferator-activated receptor...
Artikelnummer: BPS-82837
The PPARalpha (Peroxisome proliferator-activated receptor alpha)-GAL4 Luciferase Reporter HEK293 Cell Lineexpresses firefly luciferase under the control of the GAL4 upstream activation sequence (UAS). It has constitutive expression of human peroxisome proliferator-activated receptor alpha ligand binding domain...
| Schlagworte: | NR1C1, PPARA, PPAR-alpha, Nuclear receptor subfamily 1 group C member 1, Peroxisome proliferator-activated receptor alpha, |
| Anwendung: | PPARalpha agonist screening |
| Spezies-Reaktivität: | human |
9.897,00 €
PPARgamma (Peroxisome proliferator-activated receptor...
Artikelnummer: BPS-82838
The PPARgamma (Peroxisome proliferator-activated receptor gamma)-GAL4 Luciferase Reporter HEK293 Cell Line expresses firefly luciferase under the control of the GAL4 upstream activation sequence (UAS). It has constitutive expression of human peroxisome proliferator-activated receptor gamma ligand binding domain...
| Schlagworte: | NR1C1, PPARA, PPAR-alpha, Nuclear receptor subfamily 1 group C member 1, Peroxisome proliferator-activated receptor alpha, |
| Anwendung: | PPARalpha agonist screening |
| Spezies-Reaktivität: | human |
9.897,00 €
Saroglitazar Magnesium
Artikelnummer: Cay41694-1
Saroglitazar magnesium is a dual agonist of PPARalpha and PPARgamma (EC50s = 0.65 and 3,000 pM, respectively, in a transactivation assay in HepG2 cells). It decreases serum triglyceride, free fatty acid, and glucose levels in a db/db mouse model of diabetes when administered at doses ranging from 0.01 to 3 mg/kg per...
| Schlagworte: | (T-4)-bis[(alphaS)-alpha-(ethoxy-kappaO)-4-[2-[2-methyl-5-[4-(methylthio)phenyl]-1H-pyrrol-1-yl]ethoxy]benzenepropanoato-k... |
| Anwendung: | PPARalpha / PPARgamma dual agonist |
| CAS | 1639792-20-3 |
| MW: | 901.4 D |
ab 48,00 €
GW 6471
Artikelnummer: Cay11697-1
The peroxisome proliferator-activated receptor alpha (PPARalpha) is a nuclear receptor that regulates the expression of genes involved in fatty acid metabolism, lipoprotein synthesis and metabolism, and inflammation. GW 6471 is an antagonist of PPARalpha (IC50 = 240 nM). It drives the displacement of coactivators...
| Schlagworte: | N-[(2S)-2-[[(1Z)-1-methyl-3-oxo-3-[4-(trifluoromethyl)phenyl]-1-propen-1-yl]amino]-3-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)e... |
| Anwendung: | PPARalpha antagonist |
| CAS | 880635-03-0 |
| MW: | 619.7 D |
ab 61,00 €
Muraglitazar
Artikelnummer: TGM-T21587-100mg
Description: Muraglitazar (BMS-298585) is a PPAR alpha/gamma dual agonist for the treatment of type 2 diabetes and associated dyslipidemia. Muraglitazar shows potent activity in vitro at human PPARalpha and PPARgamma with EC50 of 320 nM and 110 nM respectively. Target: PPAR. Smiles:...
| Schlagworte: | Pargluva, BMS-298585 |
| Anwendung: | Targets peroxisome proliferator-activated receptor alpha (NR1C1, PPARA) |
| CAS | 331741-94-7 |
| MW: | 516.54 D |
ab 292,00 €
Aluminium clofibrate
Artikelnummer: TGM-T21243-25mg
Description: Aluminium clofibrate, a salt of clofibric acid, is a peroxisome proliferator. Target: Others. Smiles: [OH-][Al+3]12(O(C(C)(C)C(=O)[O-]1)C3=CC=C(Cl)C=C3)O(C(C)(C)C(=O)[O-]2)C4=CC=C(Cl)C=C4. References: Takagi A, Sai K, Umemura T, Hasegawa R, Kurokawa Y. Relationship between hepatic peroxisome...
| Schlagworte: | Alufibrate, Atherolip, Alfibrate |
| Anwendung: | Targets peroxisome proliferator-activated receptor alpha (NR1C1, PPARA) |
| CAS | 24818-79-9 |
| MW: | 471.26 D |
1.520,00 €
LT175
Artikelnummer: TGM-T21812-1mg
Description: LT175, a dual PPARalpha/gamma ligand, demonstrates potent insulin-sensitizing effects with reduced adipogenic properties. This orally active partial agonist targets PPARgamma with EC50 values of 0.22 µm for hPPARalpha, 0.26 µm for mPPARalpha, and 0.48 µm for hPPARgamma. LT175 specifically interacts with...
| Anwendung: | PPAR gamma / alpha partial agonist |
| CAS | 862901-87-9 |
| MW: | 318.37 D |
77,00 €
KRP-297
Artikelnummer: TGM-T27749-10mg
Description: KRP297 is a PPAR agonist potentially for the treatment of type 2 diabetes and dyslipidemia. Target: Others. Smiles: C(NCC1=CC=C(C(F)(F)F)C=C1)(=O)C2=C(OC)C=CC(CC3SC(=O)NC3=O)=C2. References: Xu XS, Yan KX, Song H, Lo MW. Quantitative determination of a novel dual PPAR alpha/gamma agonist using on-line...
| Schlagworte: | L 410198, L410198, MK-0767, KRP297 |
| Anwendung: | PPARalpha / PPARgamma dual agonist |
| CAS | 213252-19-8 |
| MW: | 438.42 D |
ab 181,00 €
Peliglitazar
Artikelnummer: TGM-T28354-100mg
Description: Peliglitazar is a activator of alpha/gamma peroxisome proliferator-activated receptor. Target: Others. Smiles: C(COC1=CC=C([C@@H](N(C(OC2=CC=C(OC)C=C2)=O)CC(O)=O)C)C=C1)C=3N=C(OC3C)C4=CC=CC=C4. References: Wang L, Munsick C, Chen S, Bonacorsi S, Cheng PT, Humphreys WG, Zhang D. Metabolism and...
| Schlagworte: | BMS 42670701, BMS 426707-01, BMS-426707-1 |
| Anwendung: | Targets peroxisome proliferator-activated receptor alpha (NR1C1, PPARA) |
| CAS | 331744-64-0 |
| MW: | 530.57 D |
ab 1.820,00 €
GW 9578
Artikelnummer: TGM-T27519-10mg
Description: GW 9578 is a selective and potent PPARalpha agonist with potent lipid-lowering activity for the study of psoriasis, arthritis, alopecia, asthma and type I diabetes. Target: PPAR. Smiles: S(C(C(O)=O)(C)C)C1=CC=C(CCN(C(NC2=C(F)C=C(F)C=C2)=O)CCCCCCC)C=C1. References: P J Brown, et al. A...
| Schlagworte: | GW9578, GW-9578 |
| Anwendung: | PPARalpha agonist |
| CAS | 247923-29-1 |
| MW: | 492.62 D |
ab 75,00 €
MD001
Artikelnummer: TGM-T35800-10mg
Description: MD001 is a dual agonist of peroxisome proliferator-activated receptor alpha (PPARalpha) and PPARgamma.1 It binds to PPARalpha and PPARgamma (Kds = 9.55 and 0.14 µM, respectively) but does not bind to PPARbeta/delta at concentrations up to 500 µM. It increases transcriptional activity of PPARalpha and...
| Anwendung: | Peroxisome proliferator-activated receptor (PPARalpha / PPARgamma) agonist |
| CAS | 2254605-76-8 |
| MW: | 398.41 D |
1.080,00 €
MHY908
Artikelnummer: TGM-T28035-10mg
Description: MHY908, a novel inhibitor of melanogenesis, potently inhibits mushroom tyrosinase activity in a dose-dependent manner. Target: Others. Smiles: O(C(C(O)=O)(C)C)C1=CC=C(C2=NC=3C(S2)=CC=C(Cl)C3)C=C1. References: Kim YR, Lee EK, Kim DH, Kim KM, Lee B, An HJ, Park JW, Moon KM, Park MH, Chung KW, Park JY, Kim...
| Anwendung: | PPARalpha / gamma agonist |
| CAS | 1393371-39-5 |
| MW: | 347.82 D |
ab 119,00 €