Zu "K07293" wurden 105 Artikel gefunden!
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SHP-2 (human, recombinant)
Artikelnummer: Cay42002-100
Src homology region 2 domain-containing phosphatase 2 (SHP-2) is a non-receptor protein tyrosine phosphatase (PTP) and a member of the PTP family. It is composed of an N-terminal Src homology region 2 (SH2) domain, a second SH2 domain, a PTP domain, a disordered C-terminal tail, which can serve as a binding site for...
| Schlagworte: | Shp2, Shp2, PTP2C, SHP-2, SHP-2, PTPN11, PTP-1D, PTP-2C, PTP-1D, PTP-2C, SH-PTP2, SH-PTP3, SH-PTP2, SH-PTP3,... |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
ab 1.127,00 €
PHPS1
Artikelnummer: TGM-T28410-100mg
Description: PHPS1 is an inhibitor of Shp2. PHPS1 efficiently inhibits activation of Erk1/2 by the leukemia-associated Shp2 mutant, Shp2-E76K, and blocks the anchorage-independent growth of a variety of human tumor cell lines. Target: Phosphatase. Smiles:...
| Schlagworte: | PHPS-1, PHPS 1 |
| Anwendung: | SHP-2 inhibitor, cell-permeable, phosphotyrosine mimetic |
| CAS | 314291-83-3 |
| MW: | 465.44 D |
ab 40,00 €
SHP099
Artikelnummer: TGM-T3564-100mg
Description: SHP099 (SHP099 free base) free base is an effective, selective, orally bioavailable, and efficacious SHP2 inhibitor (IC50 =0.07 µM and p-ERK modulation in cells IC50 = 0.250 µM). SHP099 shows dose-dependent pathway inhibition and antitumor activity in xenograft models. Target: Phosphatase, PERK....
| Schlagworte: | SHP-099, SHP099 free base, SHP 099 |
| Anwendung: | SHP2 inhibitor |
| CAS | 1801747-42-1 |
| MW: | 352.26 D |
ab 31,00 €
RMC-4630
Artikelnummer: TGM-T39658-100mg
Description: RMC-4630 (SHP2-IN-7) is an inhibitor of SHP2. Target: Phosphatase. Smiles: C[C@@H]1OCC2(CCN(CC2)c2nc(C)c(Sc3ccnc(N)c3Cl)nc2CO)[C@@H]1N. References: Ash JOGALEKAR, et al. 2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric shp2 inhibitors. WO2018013597A1
| Schlagworte: | RMC-4630, SHP2-IN-7 |
| Anwendung: | Targets tyrosine-protein phosphatase non-receptor type 11 [EC:3.1.3.48] (PTPN11, SHP2) |
| CAS | 2172652-48-9 |
| MW: | 450.99 D |
ab 147,00 €
SPI-112
Artikelnummer: TGM-T4340-10mg
Description: SPI-112, the SPI-112 methyl ester analog, can inhibit cellular Shp2 PTP activity. SPI-112 bound to Shp2 by surface plasmon resonance (SPR) and displayed competitive inhibitor kinetics to Shp2. Target: Phosphatase. Smiles: OC(=O)c1cccc(N\N=C2/C(=O)Nc3ccc(cc23)S(=O)(=O)NCc2ccc(F)cc2)c1. References: Chen...
| Anwendung: | Cell-impermeable SHP-2 inhibitor |
| CAS | 1051387-90-6 |
| MW: | 468.46 D |
ab 43,00 €
GDC-1971
Artikelnummer: TGM-T62798-25mg
Description: GDC-1971 (compound 199) is an inhibitor of SHP2. Target: Others. Smiles: N[C@@H]1c2ccccc2OC11CCN(CC1)c1cnc2c(n[nH]c2n1)N1CCCc2ncccc12
| Anwendung: | Targets tyrosine-protein phosphatase non-receptor type 11 [EC:3.1.3.48] (PTPN11, SHP2) |
| CAS | 2377352-49-1 |
| MW: | 454.53 D |
ab 516,00 €
IACS-13909
Artikelnummer: TGM-T9196-100mg
Description: IACS-13909 (BBP-398), a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway. Target: Phosphatase. Smiles: CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl. References: Yuting Sun, et al. Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and...
| Schlagworte: | BBP-398, BBP-398 |
| Anwendung: | Allosteric SHP-2 inhibitor |
| CAS | 2160546-07-4 |
| MW: | 377.27 D |
ab 97,00 €
PTPN11 Protein, Human, Recombinant (T253M & Q257L, His)
Artikelnummer: TGM-TMPH-02277-100ug
Description: Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at 'Tyr-722' resulting in...
| Schlagworte: | SH-PTP2, PTPN11, Protein-tyrosine phosphatase 2C, SH-PTP3, Protein-tyrosine phosphatase 1D, Tyrosine-protein phosphatase... |
| MW: | 73.9 kD |
ab 281,00 €
SHP-2 Protein, Mouse, Recombinant (His)
Artikelnummer: TGM-TMPY-03125-200ug
Description: SHP2, also known as PTPN11, belongs to the protein-tyrosine phosphatase(PTP) family, non-receptor class 2 subfamily. PTPs catalyze the removal of phosphate groups from tyrosine residues by the hydrolysis of phosphoric acid monoesters. They dephosphorylate EGFR, JAK2 and TYK2 kinases, promoting oncogenic...
| Schlagworte: | SHP-2, SH-PTP3, PTP2C, SH-PTP2, PTP1D, Syp, SAP-2, 2700084A17Rik, Shp2, AW536184, protein tyrosine phosphatase,... |
| MW: | 69.5 kD |
903,00 €
Chebulinic acid
Artikelnummer: TGM-TQ0184-100mg
Description: Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity. Target: DNA/RNA Synthesis, ATPase, Proton pump, Antibacterial, TGF-beta/Smad. Smiles:...
| Anwendung: | Bioactive ellagitannin, PTPN9 / PTPN11 inhibitor |
| CAS | 18942-26-2 |
| MW: | 956.68 D |
ab 67,00 €
SHP2 inhibitor LY6
Artikelnummer: TGM-T63993-100mg
Description: SHP2 inhibitor LY6 (LY6) is a potent and selective compound that inhibits SHP2 with an IC50 of 9.8 µM, effectively blocking SHP2-mediated cell signaling and proliferation. Target: Others. Smiles: O=C1N(C=2C(N1)=CC=CC2)C=3CN(CC4=C(OCC)C=C(O)C(C(/C=C/C5=C(Cl)C=C(Cl)C=C5)=O)=C4)CCC3
| Anwendung: | SHP2 inhibitor |
| CAS | 2296718-09-5 |
| MW: | 564.46 D |
ab 1.520,00 €
TNO155
Artikelnummer: TGM-T13176-100mg
Description: TNO155 is a protein tyrosine phosphatase (PTP) non-receptor type 11 (SHP2, src homology region 2 domain phosphatase, PTPN11) inhibitor(IC50 : 0.011 µM),with potential antineoplastic activity. Target: Phosphatase. Smiles: C[C@@H]1OCC2(CCN(CC2)c2cnc(Sc3ccnc(N)c3Cl)c(N)n2)[C@@H]1N. References: TNO155: SHP2...
| Schlagworte: | Batoprotafib |
| Anwendung: | SHP-2 inhibitor |
| CAS | 1801765-04-7 |
| MW: | 421.95 D |
ab 91,00 €