Zu "K07209" wurden 118 Artikel gefunden!
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IKK 16 hydrochloride
Artikelnummer: TGM-T15557-100mg
Description: IKK 16 hydrochloride is a selective inhibitor of IKK2 (IC50: 40 nM), the IKK complex (IC50: 70 nM), and IKK1 IkappaB kinase (IKK) (IC50: 200 nM), as well as leucine-rich repeat kinase-2 (LRRK2, IC50: 50 nM). Target: Others. Smiles: Cl.O=C(NN1CCC(CC1)N1CCCC1)c1ccc(Nc2nccc(n2)-c2cc3ccccc3s2)cc1....
| Anwendung: | IkappaB kinase inhibitor |
| CAS | 1186195-62-9 |
| MW: | 520.09 D |
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BI605906
Artikelnummer: TGM-T14567-100mg
Description: BI605906 is an IKKbeta inhibitor that inhibits tumor necrosis factor alpha-dependent IkappaB degradation and expression of the pro-inflammatory mediator interleukin-6, which can be used to study inflammatory skin diseases such as psoriasis. Target: IkappaB/IKK, IL Receptor. Smiles:...
| Schlagworte: | BI 605906, BI-605906 |
| Anwendung: | IKK beta inhibitor |
| CAS | 960293-88-3 |
| MW: | 432.51 D |
ab 31,00 €
SC-514
Artikelnummer: TGM-T2118-100mg
Description: SC-514 (GK 01140) is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 µM), obstructs NF-kappaB-dependent gene expression. Target: IkappaB/IKK, p38 MAPK, CDK, Aurora Kinase, Serine Protease. Smiles: NC(=O)c1sc(cc1N)-c1ccsc1. References: Kishore N, et al. J Biol Chem, 2003,...
| Schlagworte: | GK 01140 |
| Anwendung: | IKK2 inhibitor |
| CAS | 354812-17-2 |
| MW: | 224.3 D |
ab 31,00 €
PHA-408
Artikelnummer: TGM-T24629-100mg
Description: PHA-408 is a novel potent, highly selective and ATP-competitive inhibitor of IKB kinase-2. Target: Others. Smiles: CN1CCN(CC1)c1cc(C(=O)Nc2ccc3CCc4c(nn(c4-c3c2)-c2ccc(F)cc2)C(N)=O)c(Cl)cn1. References: Lai CY, Su YW, Lin KI, Hsu LC, Chuang TH. Natural Modulators of Endosomal Toll-Like Receptor-Mediated...
| Schlagworte: | PHA 408 |
| Anwendung: | IKKbeta inhibitor |
| CAS | 503555-55-3 |
| MW: | 560.02 D |
ab 1.520,00 €
LY2409881 trihydrochloride
Artikelnummer: TGM-T2081-1mg
Description: LY2409881 trihydrochloride is a novel specific inhibitor of IKK2 (IC50: 30 nM), IC50 for IKK1 and other common kinases is at least one log higher. Target: IkappaB/IKK, Apoptosis. Smiles: Cl.Cl.Cl.CN1CCN(CCCNc2ncc(Cl)c(n2)-c2cc3c(cccc3s2)C(=O)NC2CC2)CC1. References: Deng C, et al. Clin Cancer Res. 2015,...
| Schlagworte: | LY2409881 |
| Anwendung: | IKK2 inhibitor |
| CAS | 946518-60-1 |
| MW: | 594.43 D |
ab 45,00 €
PS-1145
Artikelnummer: TGM-T3094-100mg
Description: PS-1145 (IKK Inhibitor X) is a specific IKK inhibitor with IC50 of 88 nM. Target: IkappaB/IKK, Apoptosis. Smiles: Clc1cc(NC(=O)c2cccnc2)c2[nH]c3cnccc3c2c1. References: Hideshima T, et al. J Biol Chem. 2002, 277(19), 16639-16647.
| Schlagworte: | IKK Inhibitor X |
| Anwendung: | IKKbeta inhibitor |
| CAS | 431898-65-6 |
| MW: | 322.75 D |
ab 42,00 €
TPCA-1
Artikelnummer: TGM-T3049-100mg
Description: TPCA-1 (TPCA1) is an effective and specific IKK-2 inhibitor (IC50: 17.9 nM), shows >22-fold selectivity over IKK-1 and >550-fold selectivity over others kinases and enzymes. Target: Apoptosis, IkappaB/IKK, STAT. Smiles: NC(=O)Nc1sc(cc1C(N)=O)-c1ccc(F)cc1. References: Podolin PL, et al, J Pharmacol Exp...
| Schlagworte: | IKK2 Inhibitor IV, TPCA1, GW683965 |
| Anwendung: | IkappaB kinase-2 inhibitor |
| CAS | 507475-17-4 |
| MW: | 279.29 D |
ab 40,00 €
IKK2-IN-4
Artikelnummer: TGM-T36524-100mg
Description: IKK2-IN-4(IKK2 Inhibitor VI) is a highly potent IKK-2 inhibitor with an IC50 value of 25 nM. IKK2-IN-4 inhibited the production of TNF-alpha in PBMC induced by LPS. Target: IkappaB/IKK, TNF. Smiles: N(C(N)=O)C=1SC(=CC1C(N)=O)C2=CC=CC=C2. References: Baxter A, et, al. Hit-to-lead studies: the discovery...
| Schlagworte: | 5-Phenyl-2-ureidothiophene-3-carboxylic Acid Amide, IKK2 Inhibitor IV |
| Anwendung: | Potent, cell-permeable, reversible IKKbeta inhibitor |
| CAS | 354811-10-2 |
| MW: | 261.3 D |
ab 322,00 €
CAY10657
Artikelnummer: TGM-T38368-10mg
Description: CAY10657 has a wide range of applications in life science related research. Target: Others. Smiles: NC(=O)Nc1cc(sc1C(N)=O)-c1ccc(CN2CCOCC2)cc1
| Schlagworte: | CAY10657 |
| Anwendung: | Potential IKK-2 inhibitor |
| CAS | 494772-86-0 |
| MW: | 360.43 D |
ab 106,00 €
SR 12460
Artikelnummer: TGM-T37449-10mg
Description: SR 12460 is a mimetic of the IkappaB kinase beta (IKKbeta) NEMO/IKKgamma-binding domain (NBD) that inhibits the protein-protein interaction between the IKK complex subunits NF-kappaB essential modulator (NEMO/IKKgamma) and IKKbeta.1It inhibits TNF-alpha-induced NF-kappaB activation in a reporter assay...
| Anwendung: | IKKbeta NBD mimetic |
| CAS | 2055101-66-9 |
| MW: | 325.74 D |
ab 139,00 €
BMS-345541 hydrochloride
Artikelnummer: TGM-T8542-100mg
Description: BMS-345541 hydrochloride is a selective IKK inhibitor, targeting IKK2 and IKK1 with IC50 values of 0.3 µM and 4 µM, respectively. Target: IkappaB/IKK. Smiles: Cl.Cc1cnc2c(NCCN)nc3ccc(C)cc3n12. References: Yang J, et al. BMS-345541 targets inhibitor of kappaB kinase and induces apoptosis in melanoma:...
| Anwendung: | Cell permeable IKK-alpha/beta inhibitor |
| CAS | 547757-23-3 |
| MW: | 291.78 D |
ab 34,00 €
IKBKB Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPH-01531-100ug
Description: Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B...
| Schlagworte: | Inhibitor of nuclear factor kappa-B kinase subunit beta, IKBKB, Nuclear factor NF-kappa-B inhibitor kinase beta,... |
| MW: | 89.1 kD |
ab 491,00 €