Zu "K07203" wurden 206 Artikel gefunden!
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Rapamycin
Artikelnummer: Cay13346-1
Rapamycin is an allosteric inhibitor of the mammalian target of rapamycin (mTOR) complex 1 (mTORC1) originally isolated from S. hygroscopicus. It interacts with FKBP prolyl isomerase 1A (FKBP12) to form a complex that binds to and inhibits the kinase activity of mTORC1. Rapamycin inhibits growth of Rh1 and Rh30...
| Schlagworte: | AY 22989, NSC 226080, Wy 090217,... |
| Anwendung: | mTORC1 blocking |
| CAS | 53123-88-9 |
| MW: | 914.2 D |
ab 52,00 €
Torin 1
Artikelnummer: Cay10997-10
Torin 1 is a potent and selective inhibitor of mTOR (IC50 = 2 and 10 nM for mTORC1 and mTORC2, respectively). It shows over 100-fold selectivity for mTOR over PI3Kalpha and other PI3K-like kinases, including ATM, DNA-PK, and hVps34, as well as 450 other protein kinases. Torin 1, is efficacious at a dose of 20 mg/kg...
| Schlagworte: | 1-[4-[4-(1-oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one |
| Anwendung: | mTor inhibitor |
| CAS | 1222998-36-8 |
| MW: | 607.6 D |
ab 200,00 €
Rapamycin
Artikelnummer: AG-CN2-0025-M001
Isolated from Streptomyces hygroscopicus. Antibiotic. Antibacterial and antifungal properties. Forms a complex with FKBP12 and inhibits the molecular target of rapamycin (mTOR). Inhibits the response to interleukin-2 (IL-2), and thereby blocks activation of T and B cells. Potent immunosuppressant used as an...
| Schlagworte: | Sirolimus, Rapamune, NSC 226080, Antibiotic AY-22989, WY-090217, RAPA, SILA 9268A, CCRIS 9024 |
| Anwendung: | mTOR inhibitor, Immunsuppressant, Apoptosis inducer |
| CAS | 53123-88-9 |
| MW: | 914,2 D |
ab 28,00 €
PQR620
Artikelnummer: Cay26656-1
PQR620 is an inhibitor of mTOR (Ki = 10.8 nM). It is selective for mTOR over PI3K p110alpha (Ki = 4.2 µM) and a panel of 456 other kinases at 10 µM. PQR620 has antiproliferative activity against a panel of 66 cancer cell lines (mean IC50 = 919 nM). It induces cell cycle arrest at the G1 phase in A2058 melanoma and...
| Schlagworte: | 5-[4,6-bis(3-oxa-8-azabicyclo[3.2.1]oct-8-yl)-1,3,5-triazin-2-yl]-4-(difluoromethyl)-2-pyridinamine |
| Anwendung: | mTOR inhibitor |
| CAS | 1927857-56-4 |
| MW: | 445.5 D |
ab 48,00 €
Everolimus
Artikelnummer: TGM-T1784-10mg
Description: Everolimus (SDZ-RAD) is a potent mTOR inhibitor that binds to FKBP-12. It is used alone or in combination with calcineurin inhibitors. Target: Others, Autophagy, mTOR, Apoptosis. Smiles:...
| Schlagworte: | SDZ-RAD, RAD001 |
| Anwendung: | Targets serine/threonine-protein kinase mTOR [EC:2.7.11.1] (MTOR, FRAP, TOR) |
| CAS | 159351-69-6 |
| MW: | 958.22 D |
ab 38,00 €
AZD-8055
Artikelnummer: TGM-T1859-5mg
Description: AZD8055 is an ATP-competitive mTOR inhibitor (IC50: 0.8 nM in MDA-MB-468 cells). It is ~1,000-fold selective for mTOR over all PI3K isoforms. Target: Apoptosis, mTOR, Autophagy. Smiles: C[C@@H]1N(C=2C3=C(N=C(N2)N4[C@@H](C)COCC4)N=C(C=C3)C5=CC(CO)=C(OC)C=C5)CCOC1. References: Chresta CM, et al. AZD8055...
| Anwendung: | mTOR kinase inhibitor |
| CAS | 1009298-09-2 |
| MW: | 465.54 D |
ab 37,00 €
CZ415
Artikelnummer: TGM-T3514-100mg
Description: CZ415 is a potent and highly selective mTOR inhibitor. This compound has a molecular weight of 432.51 g/mol and demonstrates an inhibition constant (IC50) of 5.8 nM against mTOR. Additionally, CZ415 has shown to be efficacious in preclinical models of cancer, indicating its potential therapeutic...
| Anwendung: | mTOR inhibitor |
| CAS | 1429639-50-8 |
| MW: | 459.56 D |
ab 37,00 €
Palomid 529
Artikelnummer: TGM-T2706-100mg
Description: Palomid 529 (SG 00529) has been used in trials studying the treatment of Age-Related Macular Degeneration. Target: mTOR, Apoptosis. Smiles: COc1ccc(COc2cc3oc(=O)c4cc(ccc4c3cc2OC)C(C)O)cc1. References: Xue Q, et al. Cancer Res, 2008, 68(22), 9551-9557.
| Schlagworte: | SG 00529, P529 |
| Anwendung: | mTORC1/2 inhibitor |
| CAS | 914913-88-5 |
| MW: | 406.43 D |
ab 42,00 €
Compound 28
Artikelnummer: TGM-T36307-1mg
Description: Compound 28 (mTOR inhibitor WYE-28) is a selective inhibitor of mTOR (IC50=0.08 nM). Also inhibits PI3Kalpha (IC50 6 nM). Target: Others. Smiles: COC(=O)N1CCC(CC1)n1ncc2c(nc(nc12)-c1ccc(NC(=O)Nc2ccc(CO)cc2)cc1)N1CCOCC1
| Anwendung: | mTOR Inhibitor |
| CAS | 1062172-60-4 |
| MW: | 586.653 D |
ab 108,00 €
mTOR inhibitor-8
Artikelnummer: TGM-T36316-100mg
Description: mTOR inhibitor-8 is a potent mTOR inhibitor and autophagy inducer with antiviral and antitumor activity. mTOR inhibitor-8 inhibits the growth of A549 cells, which can be used to study non-small cell lung cancer. Target: mTOR, Autophagy. Smiles: COc1ccc(cc1)C1CC(=NN1c1nc(cs1)-c1ccncc1)c1ccc(Cl)cc1....
| Schlagworte: | mTOR-IN-8 |
| Anwendung: | mTOR inhibitor |
| CAS | 2489196-70-3 |
| MW: | 446.95 D |
ab 48,00 €
Onatasertib
Artikelnummer: TGM-T3351-100mg
Description: Onatasertib (CC223) is an orally available mTOR inhibitor with potential antitumor activity. Onatasertib inhibits the activity of mTOR, which may result in the induction of tumor cell apoptosis and a decrease in tumor cell proliferation. Onatasertib is a potent mTOR kinase inhibitor (IC50: 16 nM), with...
| Schlagworte: | CC223, CC 223, CC-223 |
| Anwendung: | Targets serine/threonine-protein kinase mTOR [EC:2.7.11.1] (MTOR, FRAP, TOR) |
| CAS | 1228013-30-6 |
| MW: | 397.47 D |
ab 37,00 €
OSI-027
Artikelnummer: TGM-T6319-100mg
Description: OSI-027 (ASP4786) is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, and more than 100-fold selectivity observed for mTOR than PI3Kalpha, PI3Kbeta, PI3Kgamma or DNA-PK. Phase 1. Target: Autophagy, PI3K, mTOR, DNA-PK. Smiles:...
| Schlagworte: | OSI027, ASP4786 |
| Anwendung: | mTORC1 / mTORC2 inhibitor |
| CAS | 936890-98-1 |
| MW: | 406.44 D |
ab 37,00 €