Zu "K07203" wurden 212 Artikel gefunden!
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Rapamycin
Artikelnummer: Cay13346-1
Rapamycin is an allosteric inhibitor of the mammalian target of rapamycin (mTOR) complex 1 (mTORC1) originally isolated from S. hygroscopicus. It interacts with FKBP prolyl isomerase 1A (FKBP12) to form a complex that binds to and inhibits the kinase activity of mTORC1. Rapamycin inhibits growth of Rh1 and Rh30...
| Schlagworte: | AY 22989, NSC 226080, Wy 090217,... |
| Anwendung: | mTORC1 blocking |
| CAS | 53123-88-9 |
| MW: | 914.2 D |
ab 50,00 €
Torin 1
Artikelnummer: Cay10997-10
Torin 1 is a potent and selective inhibitor of mTOR (IC50 = 2 and 10 nM for mTORC1 and mTORC2, respectively). It shows over 100-fold selectivity for mTOR over PI3Kalpha and other PI3K-like kinases, including ATM, DNA-PK, and hVps34, as well as 450 other protein kinases. Torin 1, is efficacious at a dose of 20 mg/kg...
| Schlagworte: | 1-[4-[4-(1-oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one |
| Anwendung: | mTor inhibitor |
| CAS | 1222998-36-8 |
| MW: | 607.6 D |
ab 196,00 €
NEU
PQR620
Artikelnummer: Cay26656-1
PQR620 is an inhibitor of mTOR (Ki = 10.8 nM). It is selective for mTOR over PI3K p110alpha (Ki = 4.2 µM) and a panel of 456 other kinases at 10 µM. PQR620 has antiproliferative activity against a panel of 66 cancer cell lines (mean IC50 = 919 nM). It induces cell cycle arrest at the G1 phase in A2058 melanoma and...
| Schlagworte: | 5-[4,6-bis(3-oxa-8-azabicyclo[3.2.1]oct-8-yl)-1,3,5-triazin-2-yl]-4-(difluoromethyl)-2-pyridinamine |
| Anwendung: | mTOR inhibitor |
| CAS | 1927857-56-4 |
| MW: | 445.5 D |
ab 48,00 €
Everolimus
Artikelnummer: TGM-T1784-10mg
Description: Everolimus (SDZ-RAD) is a potent mTOR inhibitor that binds to FKBP-12. It is used alone or in combination with calcineurin inhibitors. Target: Others, Autophagy, mTOR, Apoptosis. Smiles:...
| Schlagworte: | SDZ-RAD, RAD001 |
| Anwendung: | Targets serine/threonine-protein kinase mTOR [EC:2.7.11.1] (MTOR, FRAP, TOR) |
| CAS | 159351-69-6 |
| MW: | 958.22 D |
ab 37,00 €
Rapamycin-d3
Artikelnummer: TGM-T12691-100mg
Description: Rapamycin-d3 is the deuterium labeled Rapamycin. Rapamycin is a potent and specific inhibitor of mTOR(IC50 of 0.1 nM in HEK293 cells). Smiles:...
| Schlagworte: | Sirolimus-d3, AY-22989-d3 |
| Anwendung: | Immunosuppressant, LC/MS internal standard |
| CAS | 392711-19-2 |
| MW: | 917.19 D |
ab 7.078,00 €
PQR530
Artikelnummer: TGM-T16567-100mg
Description: PQR530 is a highly potent dual pan-PI3K/mTORC1/2 inhibitor. PQR530 inhibited protein kinase B (PKB, pSer473) and ribosomal protein S6 (pS6, pSer235/236) phosphorylation with IC50 values of 0.07 µM. It also showing antitumor activity. Target: mTOR, PI3K. Smiles:...
| Schlagworte: | PQR-530 |
| Anwendung: | PI3Kalpha / mTOR dual inhibitor |
| CAS | 1927857-61-1 |
| MW: | 407.42 D |
ab 48,00 €
Temsirolimus
Artikelnummer: TGM-T2145-2mg
Description: Temsirolimus (CCI-779) is a specific mTOR inhibitor ( IC50: 1.76 µM), used in the treatment of advanced renal cell cancer. Target: Apoptosis, mTOR, Autophagy. Smiles:...
| Schlagworte: | NSC 683864, CCI-779 |
| Anwendung: | Targets serine/threonine-protein kinase mTOR [EC:2.7.11.1] (MTOR, FRAP, TOR) |
| CAS | 162635-04-3 |
| MW: | 1030.29 D |
ab 38,00 €
CZ415
Artikelnummer: TGM-T3514-100mg
Description: CZ415 is a potent and highly selective mTOR inhibitor. This compound has a molecular weight of 432.51 g/mol and demonstrates an inhibition constant (IC50) of 5.8 nM against mTOR. Additionally, CZ415 has shown to be efficacious in preclinical models of cancer, indicating its potential therapeutic...
| Anwendung: | mTOR inhibitor |
| CAS | 1429639-50-8 |
| MW: | 459.56 D |
ab 58,00 €
Palomid 529
Artikelnummer: TGM-T2706-100mg
Description: Palomid 529 (SG 00529) has been used in trials studying the treatment of Age-Related Macular Degeneration. Target: mTOR, Apoptosis. Smiles: COc1ccc(COc2cc3oc(=O)c4cc(ccc4c3cc2OC)C(C)O)cc1. References: Xue Q, et al. Cancer Res, 2008, 68(22), 9551-9557.
| Schlagworte: | SG 00529, P529 |
| Anwendung: | mTORC1/2 inhibitor |
| CAS | 914913-88-5 |
| MW: | 406.43 D |
ab 40,00 €
Compound 28
Artikelnummer: TGM-T36307-1mg
Description: Compound 28 (mTOR inhibitor WYE-28) is a selective inhibitor of mTOR (IC50=0.08 nM). Also inhibits PI3Kalpha (IC50 6 nM). Target: Others. Smiles: COC(=O)N1CCC(CC1)n1ncc2c(nc(nc12)-c1ccc(NC(=O)Nc2ccc(CO)cc2)cc1)N1CCOCC1
| Anwendung: | mTOR Inhibitor |
| CAS | 1062172-60-4 |
| MW: | 586.653 D |
ab 108,00 €
mTOR inhibitor-8
Artikelnummer: TGM-T36316-100mg
Description: mTOR inhibitor-8 is a potent mTOR inhibitor and autophagy inducer with antiviral and antitumor activity. mTOR inhibitor-8 inhibits the growth of A549 cells, which can be used to study non-small cell lung cancer. Target: mTOR, Autophagy. Smiles: COc1ccc(cc1)C1CC(=NN1c1nc(cs1)-c1ccncc1)c1ccc(Cl)cc1....
| Schlagworte: | mTOR-IN-8 |
| Anwendung: | mTOR inhibitor |
| CAS | 2489196-70-3 |
| MW: | 446.95 D |
ab 96,00 €
Compound 401
Artikelnummer: TGM-T3586-100mg
Description: Compound 401 (2-morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one) is a synthetic DNA-PK inhibitor (IC50 = 0.28 µM) that also targets mTOR but not PI3K. Target: DNA-PK. Smiles: O=c1cc(nc2c3ccccc3ccn12)N1CCOCC1. References: Ballou LM,et al. Inhibition of mammalian target of rapamycin signaling by...
| Schlagworte: | 2-morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one |
| Anwendung: | DNA-PK / FRAP inhibitor |
| CAS | 168425-64-7 |
| MW: | 281.31 D |
ab 34,00 €