Zu "K07198" wurden 207 Artikel gefunden!
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Metformin (hydrochloride)
Artikelnummer: Cay13118-5
Metformin is a biguanide with diverse biological activities. Metformin (250 mg/kg, i.p.) increases hepatic AMPK activity and reduces blood glucose by more than 50% in a liver kinase B1-dependent manner in mice fed normal and high-fat diets, respectively, and reduces blood glucose by 40% in ob/ob mice. It reduces...
| Schlagworte: | 1,1-Dimethylbiguanide hydrochloride, N,N-dimethyl-imidodicarbonimidic diamide, monohydrochloride |
| Anwendung: | AMPK activator |
| CAS | 1115-70-4 |
| MW: | 165.6 D |
ab 32,00 €
Anti-PRKAA1
Artikelnummer: ABS-KC-3132.100
Protein function: Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits...
| Schlagworte: | Anti-5'-AMP-activated protein kinase catalytic subunit alpha-1, Anti-AMPK subunit alpha-1, Anti-Acetyl-CoA carboxylase... |
| Anwendung: | IHC |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 206,00 €
Anti-PRKAA1
Artikelnummer: ABS-OC-502.100
Protein function: Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits...
| Schlagworte: | Anti-5'-AMP-activated protein kinase catalytic subunit alpha-1, Anti-AMPK subunit alpha-1, Anti-Acetyl-CoA carboxylase... |
| Anwendung: | IHC |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 206,00 €
Anti-PRKAA1
Artikelnummer: ABS-KC-3363.100
Protein function: Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits...
| Schlagworte: | Anti-5'-AMP-activated protein kinase catalytic subunit alpha-1, Anti-AMPK subunit alpha-1, Anti-Acetyl-CoA carboxylase... |
| Anwendung: | IP |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 206,00 €
Anti-AMPK alpha2
Artikelnummer: E-D-AB-10161L.100
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular...
| Schlagworte: | Anti-Ampk, Anti-Prkaa2, Anti-ACACA kinase, Anti-HMGCR kinase, Anti-AMPK subunit alpha-2, Anti-Acetyl-CoA carboxylase... |
| Anwendung: | WB, IHC, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human,mouse,rat |
ab 109,00 €
BAY-3827
Artikelnummer: Cay41448-10
BAY-3827 is an inhibitor of AMP-activated protein kinase (AMPK, IC50 = 1.4 nM at 10 µM ATP). It is selective for AMPK over Aurora A kinase, FMS-related tyrosine kinase 3 (FLT3), and c-Met (IC50s = 1,324, 124, and 788 nM, respectively), p90 ribosomal S6 kinase 2 (RSK2), RSK3, RSK4, p90 ribosomal S6 kinase 1 (MSK1),...
| Schlagworte: | N-[5-(3,5-dicyano-1,4-dihydro-1,2,6-trimethyl-4-pyridinyl)-6-fluoro-7-methyl-1H-indazol-3-yl]-2-ethyl-benzamide |
| Anwendung: | AMPK inhibitor |
| CAS | 2377576-35-5 |
| MW: | 468.5 D |
ab 144,00 €
AICAR
Artikelnummer: Cay10010241-50
AICAR is an activator of AMP-activated protein kinase (AMPK). It increases AMPK kinase activity in isolated hepatocytes (EC50 = ~500 µM) and reduces HMG-CoA reductase activity and fatty acid and sterol synthesis in these cells. AICAR (0.5 mM) inhibits insulin-stimulated glucose uptake to 62% of control cells and...
| Schlagworte: | Acadesine, AICA-Riboside, NSC 105823, 5-amino-1-beta-D-ribofuranosyl-1H-imidazole-4-carboxamide |
| Anwendung: | AMPK activator |
| CAS | 2627-69-2 |
| MW: | 258.2 D |
ab 65,00 €
YLF-466D
Artikelnummer: TGM-T13368-100mg
Description: YLF-466D (C24) is a novel AMPK activator that inhibits platelet aggregation. Target: AMPK. Smiles: OC(=O)c1cccc(CN2C(=O)\C(=C(/c3ccccc3)c3ccc(Cl)cc3)c3ccccc23)c1. References: Liu Y, et al. Antiplatelet effect of a newly developed AMP-activated protein kinase activator YLF-466D. Eur J Pharmacol. 2015 Aug...
| Schlagworte: | C24 |
| Anwendung: | AMPK activator |
| CAS | 1273323-67-3 |
| MW: | 465.93 D |
ab 31,00 €
ZLN024
Artikelnummer: TGM-T13411-100mg
Description: ZLN024 is an activator of AMPK allosteric. ZLN024 allosterically stimulates active AMPK heterotrimers and the inactive alpha1 subunit truncations alpha1 (1-394) and alpha1 (1-335) but not alpha1 (1-312). Target: AMPK. Smiles: Cc1ccc(OCCSc2ncccn2)c(Br)c1. References: Zhang LN, et al. Novel small-molecule...
| Anwendung: | AMPK activator |
| CAS | 723249-01-2 |
| MW: | 325.22 D |
ab 88,00 €
Phenformin hydrochloride
Artikelnummer: TGM-T1453-1g
Description: Phenformin hydrochloride (Phenformin HCl) is an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity. Target: Potassium Channel, Autophagy, AMPK. Smiles: Cl.NC(=N)NC(=N)NCCc1ccccc1. References: Sakamoto K, et al. Am J Physiol Endocrinol Metab, 2004, 287(2), E310-317.
| Schlagworte: | Phenformin HCl, Phenethylbiguanide hydrochloride |
| Anwendung: | Targets 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.31] (PRKAA, AMPK) |
| CAS | 834-28-6 |
| MW: | 241.72 D |
ab 42,00 €
MK8722
Artikelnummer: TGM-T16099-100mg
Description: MK8722 is an effective and systemic activator of pan-AMPK. Target: AMPK. Smiles: [H][C@]12OC[C@@H](Oc3nc4nc(c(Cl)cc4[nH]3)-c3ccc(cc3)-c3ccccc3)[C@@]1([H])OC[C@H]2O. References: Myers RW, et al. Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiachypertrophy. Science. 2017...
| Anwendung: | AMPK activator |
| CAS | 1394371-71-1 |
| MW: | 449.89 D |
ab 31,00 €
AICAR monophosphate
Artikelnummer: TGM-T21195-1mg
Description: AICAR monophosphate (Aica ribonucleotide) is a purine precursor with antineoplastic activity and can be used in studies about type 2 diabetes. Target: Others. Smiles: NC=1N(C=NC1C(N)=O)[C@@H]2O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]2O. References: Zhang M, et al. Attenuated succinate accumulation relieves...
| Schlagworte: | AICA riboside, Acadesine 5'-monophosphate, Aica ribonucleotide, Z-nucleotide |
| Anwendung: | Cell-permeable AMPK activator |
| CAS | 3031-94-5 |
| MW: | 338.21 D |
ab 88,00 €