Zu "K07198" wurden 208 Artikel gefunden!
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Metformin (hydrochloride)
Artikelnummer: Cay13118-5
Metformin is a biguanide with diverse biological activities. Metformin (250 mg/kg, i.p.) increases hepatic AMPK activity and reduces blood glucose by more than 50% in a liver kinase B1-dependent manner in mice fed normal and high-fat diets, respectively, and reduces blood glucose by 40% in ob/ob mice. It reduces...
| Schlagworte: | 1,1-Dimethylbiguanide hydrochloride, N,N-dimethyl-imidodicarbonimidic diamide, monohydrochloride |
| Anwendung: | AMPK activator |
| CAS | 1115-70-4 |
| MW: | 165.6 D |
ab 31,00 €
NEU
BAY-3827
Artikelnummer: Cay41448-10
BAY-3827 is an inhibitor of AMP-activated protein kinase (AMPK, IC50 = 1.4 nM at 10 µM ATP). It is selective for AMPK over Aurora A kinase, FMS-related tyrosine kinase 3 (FLT3), and c-Met (IC50s = 1,324, 124, and 788 nM, respectively), p90 ribosomal S6 kinase 2 (RSK2), RSK3, RSK4, p90 ribosomal S6 kinase 1 (MSK1),...
| Schlagworte: | N-[5-(3,5-dicyano-1,4-dihydro-1,2,6-trimethyl-4-pyridinyl)-6-fluoro-7-methyl-1H-indazol-3-yl]-2-ethyl-benzamide |
| Anwendung: | AMPK inhibitor |
| CAS | 2377576-35-5 |
| MW: | 468.5 D |
ab 144,00 €
Phenformin hydrochloride
Artikelnummer: TGM-T1453-1g
Description: Phenformin hydrochloride (Phenformin HCl) is an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity. Target: Potassium Channel, Autophagy, AMPK. Smiles: Cl.NC(=N)NC(=N)NCCc1ccccc1. References: Sakamoto K, et al. Am J Physiol Endocrinol Metab, 2004, 287(2), E310-317.
| Schlagworte: | Phenformin HCl, Phenethylbiguanide hydrochloride |
| Anwendung: | Targets 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.31] (PRKAA, AMPK) |
| CAS | 834-28-6 |
| MW: | 241.72 D |
ab 42,00 €
MK8722
Artikelnummer: TGM-T16099-100mg
Description: MK8722 is an effective and systemic activator of pan-AMPK. Target: AMPK. Smiles: [H][C@]12OC[C@@H](Oc3nc4nc(c(Cl)cc4[nH]3)-c3ccc(cc3)-c3ccccc3)[C@@]1([H])OC[C@H]2O. References: Myers RW, et al. Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiachypertrophy. Science. 2017...
| Anwendung: | AMPK activator |
| CAS | 1394371-71-1 |
| MW: | 449.89 D |
ab 32,00 €
AICAR monophosphate
Artikelnummer: TGM-T21195-1mg
Description: AICAR monophosphate (Aica ribonucleotide) is a purine precursor with antineoplastic activity and can be used in studies about type 2 diabetes. Target: Others. Smiles: NC=1N(C=NC1C(N)=O)[C@@H]2O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]2O. References: Zhang M, et al. Attenuated succinate accumulation relieves...
| Schlagworte: | AICA riboside, Acadesine 5'-monophosphate, Aica ribonucleotide, Z-nucleotide |
| Anwendung: | Cell-permeable AMPK activator |
| CAS | 3031-94-5 |
| MW: | 338.21 D |
ab 87,00 €
Phenformin
Artikelnummer: TGM-T20158-25mg
Description: Phenformin (BRN 1977317) is a biguanide compound with anticancer and anti-glycemic activity, inhibits skin tumor growth and promotes keratinocyte differentiation and apoptosis. Target: Apoptosis. Smiles: NC(=N)NC(=N)NCCc1ccccc1. References: Sakamoto K, et al. Activity of LKB1 and AMPK-related kinases in...
| Schlagworte: | Azucaps, Insoral, BRN 1977317, N-Phenethylbiguanide, Debeone |
| Anwendung: | Targets 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.31] (PRKAA, AMPK) |
| CAS | 114-86-3 |
| MW: | 205.26 D |
ab 146,00 €
MK-3903
Artikelnummer: TGM-T5187-100mg
Description: MK-3903, a potent and selective AMPK activator, has an EC50 of 8 nM. Target: AMPK. Smiles: Cc1ccc(Oc2nc3cc(Cl)c(cc3[nH]2)-c2ccc(cc2)-c2ccccc2)cc1C(O)=O. References: Lan P, et al. Hit-to-Lead Optimization and Discovery of 5-((5-([1,1'-Biphenyl]-4-yl)-6-chloro-1H-benzo[d]imidazol-2-yl)oxy)-2-methylbenzoic...
| Schlagworte: | MK 3903 |
| Anwendung: | AMPK activator |
| CAS | 1219737-12-8 |
| MW: | 454.9 D |
ab 37,00 €
GSK621
Artikelnummer: TGM-T6854-100mg
Description: GSK621 is a specific and potent AMPK activator. Target: Autophagy, Apoptosis, AMPK. Smiles: COc1cccc(c1)-n1c(=O)[nH]c2cc(Cl)n(-c3ccc(cc3)-c3cccc(OC)c3O)c2c1=O. References: Sujobert P, et al. Cell Rep. 2015, 11(9), 1446-1457.
| Anwendung: | AMPK activator |
| CAS | 1346607-05-3 |
| MW: | 489.91 D |
ab 50,00 €
O-304
Artikelnummer: TGM-T7362-100mg
Description: O-304 is a pan-activator of AMP-activated protein kinase (AMPK). Target: AMPK. Smiles: Clc1ccc(Cn2sc(NC(=O)c3ccc(Cl)cc3)nc2=O)cc1. References: Steneberg, Pär, Lindahl E , Dahl U , et al. PAN-AMPK activator O304 improves glucose homeostasis and microvascular perfusion in mice and type 2 diabetes...
| Anwendung: | AMPK activator |
| CAS | 1261289-04-6 |
| MW: | 380.25 D |
ab 59,00 €
Metformin-d6 hydrochloride
Artikelnummer: TGM-T73712-10mg
Description: Metformin-d6 hydrochloride (Metformin-d6 hydrochloride) is a deuterated form of Metformin that can be used to study Metformin metabolism in vivo, and is often used as an internal standard for Metformin.ccc_R08 can be used to study HBV infection.ccc_R08 can be used to study HBV infection. Smiles:...
| Schlagworte: | 1,1-Dimethylbiguanide-d6 hydrochloride |
| Anwendung: | Internal standard, AMPK activator |
| CAS | 1185166-01-1 |
| MW: | 171.66 D |
ab 91,00 €
MOTS-c
Artikelnummer: TGM-T77782-50mg
Description: MOTS-c is a mitochondria-derived polypeptide (MDP) that has anti-damage and anti-inflammatory effects by activating the AMPK pathway and inhibiting the MAP kinase-c-fos signaling pathway. Target: Others. Smiles:...
| Anwendung: | Mitochondria-derived peptide, AMPK promoter |
| CAS | 1627580-64-6 |
| MW: | 2174.6 D |
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IMM-H007
Artikelnummer: TGM-T9010-100mg
Description: IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expression. Target: Others, AMPK. Smiles: O(C(C)=O)[C@H]1[C@@H](O[C@H](COC(C)=O)[C@H]1OC(C)=O)N2C=3C(N=C2)=C(NC4=CC(O)=CC=C4)N=CN3. References: Jy C , MD Hong, Hyl F , et al. IMM-H007, a novel small molecule inhibitor for...
| Anwendung: | AMPK activator, TGF-beta1 antagonist |
| CAS | 1221412-23-2 |
| MW: | 485.45 D |
ab 55,00 €