Zu "K06715" wurden 31 Artikel gefunden!
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LAS191859
Artikelnummer: TGM-T27799-1mg
Description: LAS191859 is a CRTH2/DP2 antagonist with IC50 values of 7.6, 9.58, 14 and 15.5nM for recombinant guinea pig, human, rat and mouse CRTH2/DP2 receptors, respectively. LAS191859 has a residence time half-life of 21h at CRTh2 that translates into a long-lasting in vivo efficacy that is independent of plasma...
| Schlagworte: | LAS-191859, LAS 191859 |
| Anwendung: | Prostaglandin D2 receptor 2 antagonist |
| CAS | 1420071-13-1 |
| MW: | 459.46 D |
ab 394,00 €
S-5751
Artikelnummer: TGM-T28651-1mg
Description: S-5751, a prostanoid DP (DP1) antagonist, is used potentially for the treatment of bronchial asthma. Target: Others. Smiles: N(C(=O)C=1C=2C(SC1)=CC=C(O)C2)[C@H]3[C@]4(C(C)(C)[C@](C4)(C[C@@H]3C/C=C\CCCC(O)=O)[H])[H]. References: Arimura A, Yasui K, Kishino J, Asanuma F, Hasegawa H, Kakudo S, Ohtani M,...
| Schlagworte: | S 5751 |
| Anwendung: | Prostaglandin D2 receptor (PTGDR) antagonist |
| CAS | 209268-36-0 |
| MW: | 441.58 D |
ab 122,00 €
MK-7246
Artikelnummer: TGM-TQ0051-10mg
Description: MK-7246 is a potent and specific CRTH2 antagonist (Ki: 2.5 nM). Target: GPR. Smiles: CN([C@@H]1CCc2c(CC(O)=O)c3ccccc3n2C1)S(=O)(=O)c1ccc(F)cc1. References: Gervais FG, et al. Pharmacological characterization of MK-7246, a potent and selective CRTH2 (chemoattractant receptor-homologous molecule expressed...
| Anwendung: | CRTH2/DP2 receptor antagonist |
| CAS | 1218918-62-7 |
| MW: | 416.47 D |
ab 222,00 €
BI-671800
Artikelnummer: TGM-T14565-100mg
Description: BI-671800 (AP-761) is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2). With IC50 values of 4.5 nM and 3.7 nM for PGD2 binding to CRTH2 in hCRTH2 and mCRTH2 transfected cells, respectively. BI-671800 has the potential to treat poorly...
| Schlagworte: | Cmpd A, AP-761 |
| Anwendung: | Prostaglandin D2 receptor CRTH2/GPR44/CD294 antagonist |
| CAS | 1093108-50-9 |
| MW: | 501.5 D |
ab 54,00 €
Human CRTH2 Protein, hFc Tag
Artikelnummer: DIM-PME101428.10
Recombinant human CRTH2 Protein with C-terminal human Fc tag. CRTH2(Met1-His33) hFc(Glu99-Ala330), Protein function: Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)- protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also...
| Schlagworte: | DP2, DL1R, CD294, CRTH2, GPR44 |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| CAS | 12 |
| MW: | 29.9 kD |
ab 129,00 €
PTGDR2 (human) full length protein-synthetic nanodisc
Artikelnummer: DIM-FLP100125.10
Discover a breakthrough in membrane protein research and drug development with DIMA Biotech's Synthetic Nanodiscs. Traditional methods struggle with challenges in obtaining water-soluble and bioactive forms of multi-transmembrane proteins. Our innovative polymer-based Nanodisc platform offers a game-changing...
| Schlagworte: | CD294, CRTH2, PTGDR2, Prostaglandin D2 receptor 2, G-protein coupled receptor 44, Chemoattractant receptor-homologous... |
| Anwendung: | Full length transmembrane protein, FA, ELISA, screening, immunization, cell-based assays, crystallization |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | 43.3 kD |
ab 1.291,00 €
Anti-PTGDR2
Artikelnummer: CSB-PA005651.50
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-CRTH2, Anti-CD294, Anti-PTGDR2, Anti-Prostaglandin D2 receptor 2, Anti-G-protein coupled receptor 44,... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
126,00 €
OC000459
Artikelnummer: Cay12027-25
OC000459 is a potent, selective DP2 antagonist that displaces [3H]prostaglandin D2 ([3H]PGD2) from human recombinant DP2 receptors (Ki = 13 nM), rat recombinant DP2 receptors (Ki = 3 nM), and human native DP2 (Ki = 4 nM, Th2 cell membranes) without interfering with the ligand binding properties of other prostanoid...
| Schlagworte: | 5-fluoro-2-methyl-3-(2-quinolinylmethyl)-1H-indole-1-acetic acid |
| Anwendung: | DP2 antagonist |
| CAS | 851723-84-7 |
| MW: | 348.4 D |
ab 94,00 €
CAY10595
Artikelnummer: Cay10012553-1
The biological effects of prostaglandin D2 (PGD2) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and CRTH2/DP2. In humans, CRTH2/DP2 is expressed on Th2 cells, eosinophils, and basophils where it mediates the chemotactic activity of PGD2. CAY10595, as a racemic mixture, is...
| Schlagworte: | 5-chloro-1'-[5-chloro-2-fluorophenyl)methyl]-2,2',5'-trioxo-spiro[3H-indole-3,3'pyrrolidine]-1(2H)-acetic acid |
| Anwendung: | CRTH2receptor antagonist, DP2 receptor antagonist |
| CAS | 916047-16-0 |
| MW: | 451.2 D |
ab 91,00 €
S-5751
Artikelnummer: Cay10004030-5
S-5751 is an antagonist of the prostaglandin D2 (PGD2) receptor DP1 (Ki = 1.6 nM) that shows at least 20-fold selectivity over receptors for thromboxane and prostacyclin, as well as the PGE2 receptor EP2. Orally administered S-5751 blocks PGD2-induced plasma exudation in the conjunctiva (ED50 = 0.099 mg/kg) and...
| Schlagworte: | (5Z)-7-[(1R,2R,3S,5S)-2-[[(5-hydroxybenzo[b]thien-3-yl)carbonyl]amino]-6,6-dimethylbicyclo[3.1.1]hept-3-yl]-5-heptenoic acid |
| Anwendung: | Prostaglandin D2 receptor (PTGDR) antagonist |
| CAS | 209268-36-0 |
| MW: | 441.6 D |
ab 67,00 €
Setipiprant
Artikelnummer: Cay28291-5
Setipiprant is an orally bioavailable antagonist of the prostaglandin D2 (PGD2, Cay-12010) receptor CRTH2/DP2 (IC50 = 6 nM for the human receptor). It is selective for CRTH2/DP2 over DP1 in a radioligand binding assay (IC50 = 1,290 nM) and the prostaglandin E2 (PGE2, Cay-14010) receptor subtypes EP2 and EP4 in a...
| Schlagworte: | ACT-129968, 8-fluoro-1,2,3,4-tetrahydro-2-(1-naphthalenylcarbonyl)-5H-pyrido[4,3-b]indole-5-acetic acid |
| Anwendung: | CRTH2/CD294 antagonist |
| CAS | 866460-33-5 |
| MW: | 402.4 D |
ab 67,00 €
Anti-CRTH2
Artikelnummer: 600-401-AP0
Anti-CRTH2 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with CRTH2 from other sources has not been determined. Protein function: Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-...
| Schlagworte: | Anti-CD294, Anti-CRTH2, Anti-PTGDR2, Anti-Prostaglandin D2 receptor 2, Anti-G-protein coupled receptor 44,... |
| Anwendung: | ELISA, IHC, IFM, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
834,00 €