Zu "K06640" wurden 46 Artikel gefunden!
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AZ20
Artikelnummer: TGM-T1958-100mg
Description: AZ20 is an effective and specific inhibitor of ATR kinase (IC50: 5 nM, in a cell-free assay), 8-fold selectivity over mTOR. Target: mTOR, ATM/ATR. Smiles: C[C@@H]1COCCN1c1cc(nc(n1)-c1cccc2[nH]ccc12)C1(CC1)S(C)(=O)=O. References: Xavier Jacq, et al. Cancer Res 2012,72(8 Suppl):Abstract nr 1823.
| Anwendung: | ATR inhibitor |
| CAS | 1233339-22-4 |
| MW: | 412.51 D |
ab 33,00 €
VE-821
Artikelnummer: TGM-T3032-100mg
Description: VE-821 (ATR Inhibitor IV) is a selective ATP competitive inhibitor of ATR( Ki/IC50: 13/26 nM in cell-free assays). Target: ATM/ATR. Smiles: CS(=O)(=O)c1ccc(cc1)-c1cnc(N)c(n1)C(=O)Nc1ccccc1. References: Reaper PM, et al. Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR....
| Schlagworte: | ATR Inhibitor IV |
| Anwendung: | ATR inhibitor |
| CAS | 1232410-49-9 |
| MW: | 368.41 D |
ab 31,00 €
Berzosertib
Artikelnummer: TGM-T2669-1mg
Description: Berzosertib (VE-822) is an ATR inhibitor (Ki<0.2 nM) that also inhibits ATM (Ki=34 nM). Berzosertib has antitumor activity and has been used in trials investigating the treatment of ovarian tumors, plasmacytoid tumors of the ovary, solid tumors in adults, advanced solid tumors, and advanced solid...
| Schlagworte: | VE-822, VX-970 |
| Anwendung: | Targets serine/threonine-protein kinase ATR [EC:2.7.11.1] (ATR) |
| CAS | 1232416-25-9 |
| MW: | 463.55 D |
ab 31,00 €
Elimusertib
Artikelnummer: TGM-T7318-100mg
Description: Elimusertib (BAY-1895344) is a potent, highly selective, and orally available ATR inhibitor with an IC50 of 7 nM, demonstrating significant anti-tumor efficacy as a monotherapy and strong combination potential with targeted alpha therapy Radium-223 dichloride. Target: ATM/ATR. Smiles:...
| Schlagworte: | BAY-1895344 |
| Anwendung: | ATR inhibitor |
| CAS | 1876467-74-1 |
| MW: | 375.43 D |
ab 32,00 €
Anti-ATR
Artikelnummer: CSB-PA030128.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-ATR, Anti-FRP1, EC=2.7.11.1, Anti-FRAP-related protein 1, Anti-Serine/threonine-protein kinase ATR, Anti-Ataxia... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 106,00 €
Anti-Phospho-ATR (Ser428)
Artikelnummer: CSB-PA058282.100
Host Species: Rabbit. Isotype: IgG. Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antibodies were produced by immunizing rabbits with...
| Schlagworte: | Anti-phospho-ATR, Anti-phospho-FRP1, EC=2.7.11.1, Anti-phospho-FRAP-related protein 1,... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
330,00 €
Anti-ATR (Ab-428)
Artikelnummer: CSB-PA267100.100
Host Species: Rabbit. Isotype: IgG. Buffer: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antibodies were produced by immunizing rabbits...
| Schlagworte: | Anti-ATR, Anti-FRP1, EC=2.7.11.1, Anti-FRAP-related protein 1, Anti-Serine/threonine-protein kinase ATR, Anti-Ataxia... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
275,00 €
Anti-ATR
Artikelnummer: A300-138A
Protein function: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1,...
| Schlagworte: | Anti-ATR, Anti-FRP1, EC=2.7.11.1, Anti-FRAP-related protein 1, Anti-Serine/threonine-protein kinase ATR, Anti-Ataxia... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 164,00 €
VE-821
Artikelnummer: Cay17587-1
Ataxia-telangiectasia and Rad3-related protein (ATR) is a serine/threonine kinase that activates DNA processes related to the DNA damage response. VE-821 is an ATP-competitive inhibitor of ATR (IC50 = 26 nM). It augments DNA damage and cell death of cancer cells in response to radiation under normal and hypoxic...
| Schlagworte: | ATR Inhibitor IV, 3-amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide |
| Anwendung: | ATR inhibitor |
| CAS | 1232410-49-9 |
| MW: | 368.4 D |
ab 43,00 €
AZD 6738
Artikelnummer: Cay21035-1
AZD 6738 is an orally bioavailable inhibitor of the serine/threonine protein kinase ataxia telangiectasia mutated (ATM) and Rad3-related (ATR, IC50 = 1 nM). It can inhibit ATR substrate Chk1 Ser345 phosphorylation in cells with an IC50 value of 74 nM. AZD 6738 has been shown to inhibit the proliferation of various...
| Schlagworte: | 4-[4-[1-[[S(R)]-S-methylsulfonimidoyl]cyclopropyl]-6-[(3R)-3-methyl-4-morpholinyl]-2-pyrimidinyl]-1H-pyrrolo[2,3-b]pyridine |
| Anwendung: | ATM inhibitor, ATR inhibitor |
| CAS | 1352226-88-0 |
| MW: | 412.5 D |
ab 66,00 €
RAD17-derived Peptide (trifluoroacetate salt)
Artikelnummer: Cay37512-1
RAD17-derived peptide is a peptide substrate for ataxia-telangiectasia and RAD3-related protein/kinase (ATR). It has been used to identify inhibitors of ATR.Formal Name:...
| Schlagworte: | L-alanyl-L-seryl-L-alpha-glutamyl-L-leucyl-L-prolyl-L-alanyl-L-seryl-L-glutaminyl-L-prolyl-L-glutaminyl-L-prolyl-L-phenyla... |
| Anwendung: | ATR peptide substrate |
| MW: | 1814.1 D |
ab 35,00 €
Anti-phospho-ATR (Ser428)
Artikelnummer: ELK-ES6657.100
The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA...
| Schlagworte: | Anti-phospho-ATR, Anti-phospho-FRP1, EC=2.7.11.1, Anti-phospho-FRAP-related protein 1,... |
| Anwendung: | IHC, IF, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, rat, mouse, |
ab 169,00 €