Zu "K06170" wurden 40 Artikel gefunden!
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MK-0752
Artikelnummer: TGM-T2625-100mg
Description: MK-0752, a gamma-secretase inhibitor, reduces Abeta40 production(IC50=5 nM). Target: Gamma-secretase, Beta Amyloid. Smiles: OC(=O)CC[C@H]1CC[C@@](CC1)(c1cc(F)ccc1F)S(=O)(=O)c1ccc(Cl)cc1. References: Cook JJ, et al. J Neurosci, 2010, 30(19), 6743-6750.
| Anwendung: | gamma-secretase inhibitor |
| CAS | 471905-41-6 |
| MW: | 442.9 D |
ab 52,00 €
L-685458
Artikelnummer: TGM-T6870-100mg
Description: L-685458 (L-685,458) is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM. Target: Apoptosis, Gamma-secretase. Smiles: CC(C)C[C@H](NC(=O)[C@@H](C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O. References: Shearman MS, et...
| Schlagworte: | L-685,458 |
| Anwendung: | gamma-secretase inhibitor |
| CAS | 292632-98-5 |
| MW: | 672.85 D |
ab 120,00 €
PSENEN Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPH-01369-100ug
Description: PSENEN Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 14.8 kDa and the accession number is Q9NZ42.
| Schlagworte: | PSENEN, Gamma-secretase subunit PEN-2, Presenilin enhancer protein 2 |
| MW: | 14.8 kD |
ab 781,00 €
NGP555
Artikelnummer: TGM-T16294-100mg
Description: NGP555 is a modulator of gamma-secretase. Target: Gamma-secretase. Smiles: CCc1cc(Nc2nc(cs2)-c2ccc(c(F)c2)-n2cnc(C)c2)c(C)cc1C. References: Kounnas MZ, et al. NGP 555, a gamma-Secretase Modulator, Lowers the Amyloid Biomarker, Abeta42, in Cerebrospinal Fluid while Preventing Alzheimer's Disease...
| Anwendung: | gamma-secretase modulator |
| CAS | 1304630-27-0 |
| MW: | 406.52 D |
ab 71,00 €
MRK-560
Artikelnummer: TGM-T16133-100mg
Description: MRK-560 is an effective and brain-penetrant inhibitor of gamma-secretase. Target: Gamma-secretase. Smiles: Fc1ccc(F)c(c1)[C@]1(CC[C@@H](CC1)NS(=O)(=O)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1. References: Best JD, et al. The novel gamma secretase inhibitor...
| Anwendung: | Potent gamma-secretase inhibitor |
| CAS | 677772-84-8 |
| MW: | 517.92 D |
ab 37,00 €
E 2012
Artikelnummer: TGM-T15184-10mg
Description: E2012 is a gamma-secretase modulator (GSM). E2012 inhibits 3beta-hydroxysterol Delta24-reductase (DHCR24) at the final step in the cholesterol biosynthesis. E 2012 aims at Alzheimer's disease by reduction of amyloid beta-42, and induces cataract following repeated doses in the rat. Target:...
| Anwendung: | gamma-secretase modulator |
| CAS | 870843-42-8 |
| MW: | 419.49 D |
ab 34,00 €
Gamma-secretase subunit PEN-2 (PSENEN), human, recombinant
Artikelnummer: CSB-CF878932HU.100
Organism: Homo sapiens (Human). Source: in vitro E.coli expression system. Expression Region: 1-101aa. Protein Length: Full Length. Tag Info: N-terminal 10xHis-tagged. Target Protein Sequence: MNLERVSNEE KLNLCRKYYL GGFAFLPFLW LVNIFWFFRE AFLVPAYTEQ SQIKGYVWRS AVGFLFWVIV LTSWITIFQI YRPRWGALGD YLSFTIPLGT P. Purity:...
| Schlagworte: | PEN2, PSENEN, MDS033, Gamma-secretase subunit PEN-2, Presenilin enhancer protein 2, Recombinant Human Gamma-secretase... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli in vitro |
| Ursprungsart: | human |
| MW: | 14.8 kD |
ab 1.458,00 €
MK-0752
Artikelnummer: Cay16706-1
gamma-Secretase is a protease complex that cleaves single-pass transmembrane proteins, such as Notch receptors and beta-amyloid precursor protein (APP), within the transmembrane domain. MK-0752 is a potent, reversible inhibitor of gamma-secretase, reducing the cleavage of APP to Abeta40 in human neuroblastoma...
| Schlagworte: | cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)-cyclohexanepropanoic acid |
| Anwendung: | gamma-secretase inhibitor |
| CAS | 471905-41-6 |
| MW: | 442.9 D |
ab 94,00 €
Avagacestat
Artikelnummer: Cay16711-1
gamma-Secretase is a protease complex that cleaves single-pass transmembrane proteins, such as Notch receptors and beta-amyloid precursor protein (APP), within the transmembrane domain. Avagacestat is a potent, orally bioavailable inhibitor of gamma-secretase that more potently inhibits the cleavage of APP to...
| Schlagworte: | BMS 708163,... |
| Anwendung: | gamma-secretase inhibitor |
| CAS | 1146699-66-2 |
| MW: | 520.9 D |
ab 61,00 €
Semagacestat
Artikelnummer: Cay16713-5
Semagacestat is a potent inhibitor of gamma-secretase that blocks the production of Abeta38, Abeta40, and Abeta42 with IC50 values of 12.0, 12.1, and 10.9 nM, respectively. It also blocks Notch signaling (IC50 = 14.1 nM). Semagacestat modulates gamma-secretase activity in vivo, altering Abeta levels in brain,...
| Schlagworte: | LY450139,... |
| Anwendung: | gamma-secretase inhibitor |
| CAS | 425386-60-3 |
| MW: | 361.4 D |
ab 52,00 €
L-685,458
Artikelnummer: Cay14926-1
L-685,458 is an inhibitor of gamma-secretase (IC50 = 17 nM). It is selective for gamma-secretase over HIV-1, cathepsin D, trypsin, HepC3 NS3, papain, and calpain I proteases (IC50s = >1,000 nM). L-685,458 inhibits production of amyloid-beta (1-40) (Abeta40, Cay-21617) and Abeta42 (Cay-20574) in Neuro2A cells...
| Schlagworte: | gamma-Secretase Inhibitor X,... |
| Anwendung: | gamma-secretase inhibitor |
| CAS | 292632-98-5 |
| MW: | 672.9 D |
ab 136,00 €
Anti-PEN2
Artikelnummer: 600-401-DL1
Anti-PEN2 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with PEN2 from other sources has not been determined. Protein function: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of...
| Schlagworte: | Anti-PEN2, Anti-PSENEN, Anti-MDS033, Anti-Gamma-secretase subunit PEN-2, Anti-Presenilin enhancer protein 2 |
| Anwendung: | ELISA, IFM, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
834,00 €