Zu "K06067" wurden 312 Artikel gefunden!
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SAHA
Artikelnummer: Cay10009929-100
SAHA is a histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. It inhibits class I, II, and IV HDACs at 50-200 nM and arrests cell growth in a wide variety of transformed cells in culture at 2.5-5.0 µM.Formal Name:...
| Schlagworte: | Suberoylanilide Hydroxamic Acid, Vorinostat, N1-hydroxy-N8-phenyl-octanediamide |
| Anwendung: | HDAC inhibitor |
| CAS | 149647-78-9 |
| MW: | 264.3 D |
ab 34,00 €
HDAC-1, active human recombinant protein
Artikelnummer: BPS-50051
Active human HDAC1, GenBank Accession No. NM_004964, full length with C-terminal HIS-DDDDK tag (FLAG), MW= 56 kDa, expressed in baculovirus expression system.
| Schlagworte: | HD1, Histone deacetylase 1, Protein deacetylase HDAC1, Protein decrotonylase HDAC1, |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 56 kD |
716,00 €
Trichostatin A
Artikelnummer: Cay89730-1
Trichostatin A is a potent, reversible inhibitor of class I, II, and IV histone deacetylases (HDACs). In human Jurkat T cells, trichostatin A arrests cell cycle progression in G1 and inhibits the activity of HDAC1 with an IC50 value of 70 nM. Trichostatin A selectively inhibits the removal of acetyl groups from the...
| Schlagworte: | TSA, 7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6R-dimethyl-7-oxo-2E,4E-heptadienamide |
| Anwendung: | HDAC inhibitor |
| CAS | 58880-19-6 |
| MW: | 302.4 D |
ab 76,00 €
Nanatinostat
Artikelnummer: TGM-T16270-100mg
Description: Nanatinostat is an effective and class I selective inhibitor of histone deacetylase (IC50: 8 nM). Target: Others. Smiles: [H][C@@]12CN(C[C@]1([H])[C@H]2NCc1ccc2cc(F)ccc2n1)c1ncc(cn1)C(=O)NO. References: Moffat D, et al. Discovery of...
| Schlagworte: | CHR-3996 |
| Anwendung: | Targets histone deacetylase 1/2 [EC:3.5.1.98] (HDAC1_2) |
| CAS | 1256448-47-1 |
| MW: | 394.4 D |
ab 466,00 €
Oxamflatin
Artikelnummer: TGM-T16415-1mg
Description: Oxamflatin is an effective inhibitor of HDAC (IC50: 15.7 nM). Target: HDAC. Smiles: ONC(=O)\C=C\C#Cc1cccc(NS(=O)(=O)c2ccccc2)c1. References: Kim YB, et al. Oxamflatin is a novel antitumor compound that inhibits mammalian histone deacetylase. Oncogene. 1999 Apr 15,18(15):2461-70.
| Schlagworte: | Metacept-3 |
| Anwendung: | HDAC inhibitor |
| CAS | 151720-43-3 |
| MW: | 342.37 D |
ab 189,00 €
Apicidin
Artikelnummer: TGM-T14305-1mg
Description: Apicidin (OSI 2040) is a histone deacetylase (HDAC) inhibitor with antiparasitic and antiproliferative activity. It attenuates memory deficits, inhibits cell growth and proliferation, and induces apoptosis and autophagy by decreasing Abeta load in APP/PS1 mice, making it a valuable tool for leukemia...
| Schlagworte: | OSI 2040 |
| Anwendung: | Antiprotozoal, HDAC inhibitor |
| CAS | 183506-66-3 |
| MW: | 623.78 D |
292,00 €
2-hexyl-4-Pentynoic Acid
Artikelnummer: TGM-T21551-50mg
Description: 2-hexyl-4-Pentynoic Acid, a valproic acid (VPA) derivatives, is a potent and robust HDACs inhibitor with IC50 value of 13 µM. Target: HDAC. Smiles: CCCCCCC(CC#C)C(O)=O. References: Zhao J, et al. Identification of HIVEP2 as a dopaminergic transcription factor related to substance use disorders in rats...
| Anwendung: | HDAC inhibitor |
| CAS | 96017-59-3 |
| MW: | 182.26 D |
ab 58,00 €
BRD6688
Artikelnummer: TGM-T21715-1mg
Description: BRD6688 is a selective HDAC2 inhibitor that acts by enhancing the learning and memory processes. Target: HDAC. Smiles: Nc1ccc(cc1NC(=O)N1CCCC1)-c1ccncc1. References: Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancers[J]. Chemical Science, 2014, 6(1):804-815.
| Anwendung: | HDAC2 inhibitor, nootropic |
| CAS | 1404562-17-9 |
| MW: | 282.34 D |
ab 96,00 €
4-iodo-SAHA
Artikelnummer: TGM-T21749-50mg
Description: 4-Iodo-SAHA (1k), an orally active inhibitor of both class I and class II histone deacetylase (HDAC), exhibits EC50 values of 1.1, 0.95, 0.12, 0.24, 0.85, and 1.3 µM for Skbr3, HT29, U937, JA16, and HL60 cell lines, respectively. This compound holds potential for cancer research purposes [1]. Target:...
| Anwendung: | HDAC inhibitor |
| CAS | 1219807-87-0 |
| MW: | 390.22 D |
ab 218,00 €
HNHA
Artikelnummer: TGM-T21806-1mg
Description: HNHA is an inhibitor of HDAC. Target: HDAC. Smiles: ONC(=O)CCCCCCSc1ccc2ccccc2c1. References: Dong H K , Lee J , Kim K N , et al. Anti-tumor activity of N-hydroxy-7-(2-naphthylthio) heptanomide, a novel histone deacetylase inhibitor[J]. Biochemical & Biophysical Research Communications, 2007,...
| Anwendung: | HDAC inhibitor |
| CAS | 926908-04-5 |
| MW: | 303.42 D |
ab 62,00 €
BML-210
Artikelnummer: TGM-T3204-100mg
Description: BML-210 (CAY10433) is a new-type HDAC inhibitor. Target: HDAC, Apoptosis. Smiles: Nc1ccccc1NC(=O)CCCCCCC(=O)Nc1ccccc1. References: Jayathilaka N, et al. Nucleic Acids Res. 2012 Jul,40(12):5378-88.
| Schlagworte: | CAY10433 |
| Anwendung: | HDAC inhibitor |
| CAS | 537034-17-6 |
| MW: | 339.43 D |
ab 34,00 €
UF010
Artikelnummer: TGM-T3205-100mg
Description: UF010 is a potent and selective HADC inhibitor with IC50 ~0.06 µM, 0.1 µM, 0.5 µM and 1.5 µM for HDACs 3, 2, 1 and 8, respectively. Target: HDAC. Smiles: CCCCNNC(=O)c1ccc(Br)cc1. References: Wang Y, et al. Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively...
| Anwendung: | Class I HDAC inhibitor |
| CAS | 537672-41-6 |
| MW: | 271.15 D |
ab 31,00 €