Zu "K06067" wurden 307 Artikel gefunden!
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SAHA
Artikelnummer: Cay10009929-100
SAHA is a histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. It inhibits class I, II, and IV HDACs at 50-200 nM and arrests cell growth in a wide variety of transformed cells in culture at 2.5-5.0 µM.Formal Name:...
| Schlagworte: | Suberoylanilide Hydroxamic Acid, Vorinostat, N1-hydroxy-N8-phenyl-octanediamide |
| Anwendung: | HDAC inhibitor |
| CAS | 149647-78-9 |
| MW: | 264.3 D |
ab 35,00 €
HDAC-1, active human recombinant protein
Artikelnummer: BPS-50051
Active human HDAC1, GenBank Accession No. NM_004964, full length with C-terminal HIS-DDDDK tag (FLAG), MW= 56 kDa, expressed in baculovirus expression system.
| Schlagworte: | HD1, Histone deacetylase 1, Protein deacetylase HDAC1, Protein decrotonylase HDAC1, |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 56 kD |
730,00 €
Trichostatin A
Artikelnummer: Cay89730-1
Trichostatin A is a potent, reversible inhibitor of class I, II, and IV histone deacetylases (HDACs). In human Jurkat T cells, trichostatin A arrests cell cycle progression in G1 and inhibits the activity of HDAC1 with an IC50 value of 70 nM. Trichostatin A selectively inhibits the removal of acetyl groups from the...
| Schlagworte: | TSA, 7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6R-dimethyl-7-oxo-2E,4E-heptadienamide |
| Anwendung: | HDAC inhibitor |
| CAS | 58880-19-6 |
| MW: | 302.4 D |
ab 77,00 €
Anti-HDAC1
Artikelnummer: ABS-KC-6056.100
Protein function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone...
| Schlagworte: | Anti-Histone deacetylase 1, Anti-HD1, Anti-Protein deacetylase HDAC1, Anti-Protein decrotonylase HDAC1, HDAC1 Antibody |
| Anwendung: | IHC |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human, rat, mouse |
ab 206,00 €
Valproic Acid (sodium salt)
Artikelnummer: Cay13033-10
Valproic acid is an analog of the natural fatty acid valeric acid that inhibits class I histone deacetylases (HDACs) with an IC50 value of approximately 2 mM. It decreases the number of axon branches in sensory neurons isolated from newborn rat dorsal root ganglia, an effect that is reversed by...
| Schlagworte: | 2-Propylvaleric Acid, Valproate, VPA, 2-propyl-pentanoic acid, monosodium salt |
| Anwendung: | HDAC inhibitor |
| CAS | 1069-66-5 |
| MW: | 166.2 D |
ab 52,00 €
Pyroxamide
Artikelnummer: TGM-T7664-100mg
Description: Pyroxamide is an histone deacetylases (HDACs) inhibitor with antineoplastic properties ( HDAC1,IC50: 0.1-0.2 µM). Target: HDAC, Apoptosis. Smiles: ONC(=O)CCCCCCC(=O)Nc1cccnc1. References: Butler L M , Webb Y , Agus D B , et al. Inhibition of transformed cell growth and induction of cellular...
| Anwendung: | Histone deacetylases Inhibitor |
| CAS | 382180-17-8 |
| MW: | 265.31 D |
ab 43,00 €
NSC 3852
Artikelnummer: TGM-T7691-100mg
Description: NSC 3852 is a potent inhibitor of histone deacetylase. Target: HDAC. Smiles: OC1=C2N=CC=CC2=C(C=C1)N=O. References: Jeannine S. Strobl, Christopher W. Seibert, Yunbo Li, Rana Nagarkatti, Sheila M. Mitchell, Alexa C. Rosypal, Dharmendar Rathore, and David S. Lindsay. Inhibition of Toxoplasma gondii and...
| Anwendung: | HDAC inhibitor |
| CAS | 3565-26-2 |
| MW: | 174.16 D |
ab 52,00 €
HDAC-IN-3
Artikelnummer: TGM-T8508-100mg
Description: HDAC-IN-3 (GSK3117391A) is a potent histone deacetylase (HDAC) inhibitor, and treatment chronic inflammatory disorders. Target: HDAC. Smiles: ONC(=O)CCc1ccc(CN[C@@H](C2CCCCC2)C(=O)OC2CCCC2)cn1. References: Davidson Alan Hornsby, et al. Preparation of amino acid-based hydroxamic acids as histone...
| Schlagworte: | GSK3117391A |
| Anwendung: | HDAC inhibitor |
| CAS | 1018673-42-1 |
| MW: | 403.52 D |
ab 42,00 €
HDAC1 Protein, Human, Recombinant (His & SUMO)
Artikelnummer: TGM-TMPH-01471-100ug
Description: HDAC1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 71.1 kDa and the accession number is Q13547.
| Schlagworte: | Protein deacetylase HDAC1, Histone deacetylase 1, Protein decrotonylase HDAC1, HDAC1 |
| MW: | 71.1 kD |
ab 198,00 €
Valproic Acid-d4
Artikelnummer: TGM-TMIJ-0163-1mg
Description: Valproic Acid-d4 is a deuterated compound of Valproic Acid. Valproic Acid has a CAS number of 99-66-1. Valproic Acid is a branched chain fatty acid which potentially enhances central GABAergic neurotransmission and inhibits Na+ channels. Currently, the various molecular mechanisms of action of Valproic...
| Anwendung: | GC-MS, LC-MS internal standard, quantification, class I HDAC inhibitor |
| CAS | 87745-17-3 |
| MW: | 148.24 D |
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Tacedinaline
Artikelnummer: TGM-T1888-100mg
Description: Tacedinaline (CI994) is a selective class I HDAC inhibitor with potential antineoplastic activity. Target: Apoptosis, HDAC. Smiles: N(C(=O)C1=CC=C(NC(C)=O)C=C1)C2=C(N)C=CC=C2. References: Moradei OM, et al. J Med Chem. 2007, 50(23), 5543-5546.
| Schlagworte: | N-acetyldinaline, Acetyldinaline, PD-123654, Goe-5549, CI994 |
| Anwendung: | Targets histone deacetylase 1/2 [EC:3.5.1.98] (HDAC1_2) |
| CAS | 112522-64-2 |
| MW: | 269.3 D |
ab 43,00 €
Pracinostat
Artikelnummer: TGM-T1890-100mg
Description: Pracinostat (SB939) is a novel HDAC inhibitor with improved in vivo properties compared to other HDAC inhibitors currently in Clinicalal trials, allowing oral dosing. Data demonstrate that Pracinostat is a potent and effective anti-tumor drug with potential as an oral therapy for a variety of human...
| Schlagworte: | SB939 |
| Anwendung: | HDAC inhibitor |
| CAS | 929016-96-6 |
| MW: | 358.48 D |
ab 43,00 €