Zu "K05955" wurden 31 Artikel gefunden!
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GGTI298 Trifluoroacetate
Artikelnummer: TGM-T6844-10mg
Description: GGTI298 Trifluoroacetate (GGTI 298 TFA salt) is a geranylgeranyltransferase I inhibitor with ability to arrest human tumor cells in the G1 phase of the cell cycle and induce apoptosis. Target: Apoptosis, Transferase, Ras. Smiles:...
| Schlagworte: | GGTI 298, GGTI 298 TFA salt |
| Anwendung: | GGTase I inhibitor |
| CAS | 1217457-86-7 |
| MW: | 593.66 D |
ab 78,00 €
Tipifarnib (S enantiomer)
Artikelnummer: TGM-T17102-100mg
Description: Tipifarnib S enantiomer ((S)-(-)-R-115777) is the S-enantiomer of Tipifarnib. Tipifarnib is a potent and specific farnesyltransferase inhibitor (IC50: 0.6 nM). Target: Transferase. Smiles: Cn1cncc1[C@](N)(c1ccc(Cl)cc1)c1ccc2n(C)c(=O)cc(-c3cccc(Cl)c3)c2c1. References: Kraus JM, et al. Rational...
| Schlagworte: | Tipifarnib S enantiomer, (S)-(-)-R-115777, IND-58359 S enantiomer, (S)-Tipifarnib |
| Anwendung: | Inactive enantiomer |
| CAS | 192185-71-0 |
| MW: | 489.4 D |
ab 78,00 €
L-778123 hydrochloride
Artikelnummer: TGM-T3182-100mg
Description: The L-778123 hydrochloride is an inhibitor of FPTase (IC50: 2 nM) and GGPTase-I (IC50: 98 nM) in enzyme inhibition determination. Target: Telomerase, Transferase. Smiles: Cl.Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(cc2)C#N)CC1=O. References: Lobell RB, et al. Mol Y Ther. 2002 Jul,1(9):747-58.
| Schlagworte: | L 778123 |
| Anwendung: | Protein farnesyltransferase / geranylgeranyltransferase type-I inhibitor |
| CAS | 253863-00-2 |
| MW: | 442.34 D |
ab 38,00 €
L-778123 free base
Artikelnummer: TGM-T3182L-10mg
Description: L-778123 is an inhibitor of FPTase and GGPTase-I. The combination of L-778123 and radiotherapy at dose level 1 showed acceptable toxicity in patients with locally advanced pancreatic cancer. Target: Others. Smiles: Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(cc2)C#N)CC1=O. References: Ghasemi S, Davaran S, Sharifi...
| Schlagworte: | L-778123, L778123, L 778,123, L-778,123, L 778123 |
| Anwendung: | Dual FTase / GGTase I inhibitor |
| CAS | 183499-57-2 |
| MW: | 405.88 D |
ab 193,00 €
Anti-FNTA
Artikelnummer: CSB-PA064938.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: FNTA. Antigen Species: Human
| Schlagworte: | Anti-FNTA, Anti-FTase-alpha, Anti-GGTase-I-alpha, Anti-CAAX farnesyltransferase subunit alpha, Anti-Ras proteins... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 163,00 €
Gliotoxin
Artikelnummer: Cay11433-1
Gliotoxin is an immunosuppressive mycotoxin produced by pathogenic strains of Aspergillus and other fungi with diverse biological activities. It inhibits 20S proteasomal chymotrypsin activity (IC50 = 10 µM), blocking the degradation of IkappaBalpha and preventing the activation of NF-kappaB. Gliotoxin induces...
| Schlagworte: | Aspergillin, 2,3R,5aS,6S-tetrahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-10H-3,10aR-epidithiopyrazino[1,2-a]indole-1,4-dione |
| Anwendung: | Immunosuppressive mycotoxin |
| CAS | 67-99-2 |
| MW: | 326.4 D |
ab 77,00 €
GGTI 298 (trifluoroacetate salt)
Artikelnummer: Cay16176-1
Post-translational protein prenylation, a process catalyzed by three different enzymes, occurs at the C-terminal of a number of proteins involved in cell growth control and oncogenesis. One of these enzymes, geranylgeranyltransferase I (GGTase I) modifies cysteines of proteins with CAAX terminal sequences,...
| Schlagworte: | N-[4-[[(2R)-2-amino-3-mercaptopropyl]amino]-2-(1-naphthalenyl)benzoyl]-L-leucine, methyl ester, 2,2,2-trifluoroacetate |
| Anwendung: | GGTase I inhibitor |
| CAS | 1217457-86-7 |
| MW: | 593.7 D |
ab 142,00 €
Tipifarnib
Artikelnummer: Cay11747-5
Tipifarnib is a nonpeptidomimetic, CAAX-competitive inhibitor of farnesyltransferase (IC50 = 0.86 nM). It prevents farnesylation of Ras GTPases and has shown potent efficacy in various in vitro and in vivo tumor models.Formal Name:...
| Schlagworte: | R 115777, 6-[(R)-amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone |
| Anwendung: | CAAX-competitive farnesyltransferase inhibitor, Ras GTPase farnesylation inhibitor |
| CAS | 192185-72-1 |
| MW: | 489.4 D |
ab 60,00 €
Gliotoxin-13C13
Artikelnummer: Cay9003827-250
Gliotoxin-13C13 is intended for use as an internal standard for the quantification of gliotoxin (Cay-11433) by GC- or LC-MS. Gliotoxin is an immunosuppressive mycotoxin produced by pathogenic strains of Aspergillus and other fungi with diverse biological activities. It inhibits 20S proteasomal chymotrypsin activity...
| Schlagworte: | Aspergillin-13C13,... |
| Anwendung: | GC-MS, LC-MS internal standard, quantification, immunosuppressive mycotoxin |
| MW: | 339.3 D |
811,00 €
L-778,123 (hydrochloride)
Artikelnummer: Cay22940-5
L-778,123 is a dual inhibitor of farnesyl transferase (FTase, IC50 = 2 nM) and geranylgeranyl transferase type I (GGTase I, IC50 = 98 nM). It inhibits prenylation of the FTase and GGTase I substrates HDJ2 and RAP1A in PSN-1 pancreatic tumor cells (EC50s = 92 and 6,760 nM, respectively). L-778,123 (1-300 µM) also...
| Schlagworte: | 4-[[5-[[4-(3-chlorophenyl)-3-oxo-1-piperazinyl]methyl]-1H-imidazol-1-yl]methyl]-benzonitrile, monohydrochloride |
| Anwendung: | Protein farnesyltransferase / geranylgeranyltransferase type-I inhibitor |
| CAS | 253863-00-2 |
| MW: | 442.3 D |
ab 130,00 €
Anti-FNTA
Artikelnummer: A304-267A
Protein function: Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the...
| Schlagworte: | Anti-FNTA, Anti-FTase-alpha, Anti-GGTase-I-alpha, Anti-CAAX farnesyltransferase subunit alpha, Anti-Ras proteins... |
| Anwendung: | WB, IP, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 164,00 €
FTase Inhibitor II (trifluoroacetate salt)
Artikelnummer: Cay16607-5
Farnesylation involves the utilization of farnesyl pyrophosphate (FPP), an intermediate in the mevalonate pathway, by farnesyltransferase (FTase) to add a lipid, farnesyl, to certain proteins. This post-translational modification is crucial in allowing target proteins, including Ras, to associate with, and function...
| Schlagworte: | Farnesyltransferase Inhibitor II, FTI-II, N-[4-[[(2R)-2-amino-3-mercapto-1-oxopropyl]amino]benzoyl]-L-methionine |
| Anwendung: | Farnesyltransferase inhibitor |
| MW: | 371.5 D |
ab 66,00 €