Zu "K05954" wurden 35 Artikel gefunden!
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B 581
Artikelnummer: TGM-T19790-1mg
Description: B 581 is an inhibitor that specifically blocks farnesylated. Target: Others. Smiles: [C@H](CC1=CC=CC=C1)(C(N[C@@H](CCSC)C(O)=O)=O)NC[C@@H](NC[C@H](CS)N)[C@@H](C)C. References: Cox AD, Garcia AM, Westwick JK, Kowalczyk JJ, Lewis MD, Brenner DA, Der CJ. The CAAX peptidomimetic compound B581 specifically...
| Schlagworte: | B-581, B581 |
| Anwendung: | Potent farnesyltransferase inhibitor |
| CAS | 149759-96-6 |
| MW: | 470.69 D |
ab 181,00 €
Manumycin A
Artikelnummer: TGM-T16011-1mg
Description: Manumycin A is an antibiotic with anticancer activity and is a mammalian thioredoxin reductase-1 (TrxR-1) inhibitor.Manumycin A inhibits the production of IL-1beta, IL-6, and IL-8 in TNF alpha-stimulated THP-1 cells and peripheral blood mononuclear cells in a dose-dependent manner, inducing apoptosis....
| Anwendung: | Rasfarnesyltransferase inhibitor |
| CAS | 52665-74-4 |
| MW: | 550.64 D |
ab 276,00 €
LB42708
Artikelnummer: TGM-T2678-100mg
Description: LB42708 is an orally active farnesyltransferase (FTase) inhibitor (IC50: 0.8/1.2/2.0 nM toward H/N/K-ras). Target: Transferase. Smiles: C(=O)(C=1C(=CN(CC=2N(CC3=CC=C(Br)C=C3)C=NC2)C1)C=4C5=C(C=CC4)C=CC=C5)N6CCOCC6. References: Na HJ, et al. J Immunol. 2004, 173(2), 1276-1283.
| Anwendung: | FTase inhibitor |
| CAS | 226929-39-1 |
| MW: | 555.47 D |
ab 42,00 €
Ftase inhibitor III
Artikelnummer: TGM-T40331-5mg
Description: Ftase Inhibitor III, derived from a phenotypic screen, functions as an anion-dependent inhibitor of Farnesyltransferase. Target: Others. Smiles: Cc1nn(C)c(C)c1C(=O)N1CCN(Cc2nc3ccccc3n2CC(C)(C)C)CC1. References: Bukhtiyarova M, et al. Discovery of an Anion-Dependent Farnesyltransferase Inhibitor from a...
| Anwendung: | Ftase inhibitor |
| CAS | 2710375-18-9 |
| MW: | 422.577 D |
970,00 €
FTI 277 TFA
Artikelnummer: TGM-T41212-25mg
Description: FTI 277 TFA is a prodrug form of FTI 276 that inhibits farnesyltransferase (FTase) (IC50 = 0.5 nM). Inhibits H-Ras and K-Ras processing in whole cells (IC50 values are 0.1 and 10µM respectively) and disrupts constitutive H-Ras-specific activation of MAPK. Causes significant antiproliferative effects in...
| Anwendung: | Farnesyltransferase inhibitor |
| CAS | 1217447-06-7 |
| MW: | 561.64 D |
1.520,00 €
Arglabin
Artikelnummer: TGM-TQ0165-100mg
Description: Arglabin ((+)-Arglabin) is a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor, has anti-atherogenic and anticancer effects. Target: Transferase, NOD, NOD-like Receptor (NLR), Autophagy. Smiles: [H][C@@]12CC[C@]3(C)O[C@@]33CC=C(C)[C@]3([H])[C@@]1([H])OC(=O)C2=C....
| Schlagworte: | (+)-Arglabin |
| Anwendung: | Anticancer compound, Farnesyltransferase inhibitor |
| CAS | 84692-91-1 |
| MW: | 246.3 D |
ab 105,00 €
Manumycin A
Artikelnummer: BVT-0091-M001
Antibiotic, Potent, selective and competitive cell-permeable rasfarnesyltransferase inhibitor (IC50 = 30 nM), Does not affect geranylgeranyltransferase (IC50 = 180 µM), Inhibition is competitive with respect to farnesyl pyrophosphate and non-competitive with respect to Ras, Neutral sphingomyelinase inhibitor, Blocks...
| Anwendung: | Rasfarnesyltransferase inhibitor |
| CAS | 52665-74-4 |
| MW: | 550,6 D |
ab 100,00 €
Manumycin A
Artikelnummer: Cay10010497-1
Manumycin A is an antibiotic that acts as a potent and selective farnesyltransferase (FTase) inhibitor with anti-tumor activity. It inhibits rat brain FTase with a Ki value of 1.2 µM, thereby preventing Ras activation which requires farnesylation at the C-terminus for membrane attachment. It exhibits significant...
| Schlagworte: | NSC 622141, UCF 1C,... |
| Anwendung: | FTase inhibitor |
| CAS | 52665-74-4 |
| MW: | 550.7 D |
ab 152,00 €
Lonafarnib
Artikelnummer: Cay11746-1
Farnesyltransferase drives the post-translational farnesylation of a number of target proteins, including Ras, a component of the MAPK and Akt signaling pathways involved in cell proliferation, and Ras homolog enriched in brain (Rheb), which stimulates mTOR activity. By arresting growth, farnesyltransferase...
| Schlagworte: | Sarasar, SCH 66336,... |
| Anwendung: | Farnesyl transferase inhibitor |
| CAS | 193275-84-2 |
| MW: | 638.8 D |
ab 45,00 €
Arglabin
Artikelnummer: AG-CN2-0458-M001
White to off-white solid. Soluble in dry DMSO, 100% ethanol or methanol. Insoluble in water. Anticancer compound, Farnesyltransferase inhibitor, Potent anti-inflammatory agent, NF-kappaB inhibitor, Inflammasome inhibitor, Antiatherogenic. Prevents the accumulation of lipid containing plaques in arteries.
| Schlagworte: | Arglabine |
| Anwendung: | Anticancer compound, Farnesyltransferase inhibitor |
| CAS | 84692-91-1 |
| MW: | 246,3 D |
ab 83,00 €
LB 42708
Artikelnummer: Cay16428-5
Farnesylation, the post-translational addition of a 15-carbon isoprenyl group, alters the function of several proteins, including Ras proteins. LB 42708 is a potent inhibitor of farnesyltransferase (FTase), blocking farnesylation of H-Ras, N-Ras, and K-Ras4B with IC50 values of 0.8, 1.2, and 2.0 nM, respectively. It...
| Schlagworte: | [1-[[1-[(4-bromophenyl)methyl]-1H-imidazol-5-yl]methyl]-4-(1-naphthalenyl)-1H-pyrrol-3-yl]-4-morpholinyl-methanone |
| Anwendung: | FTase inhibitor |
| CAS | 226929-39-1 |
| MW: | 555.5 D |
ab 61,00 €
FTase Inhibitor II (trifluoroacetate salt)
Artikelnummer: Cay16607-1
Farnesylation involves the utilization of farnesyl pyrophosphate (FPP), an intermediate in the mevalonate pathway, by farnesyltransferase (FTase) to add a lipid, farnesyl, to certain proteins. This post-translational modification is crucial in allowing target proteins, including Ras, to associate with, and function...
| Schlagworte: | Farnesyltransferase Inhibitor II, FTI-II, N-[4-[[(2R)-2-amino-3-mercapto-1-oxopropyl]amino]benzoyl]-L-methionine |
| Anwendung: | Farnesyltransferase inhibitor |
| MW: | 371.5 D |
ab 67,00 €