Zu "K05856" wurden 121 Artikel gefunden!
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PCI 29732
Artikelnummer: TGM-T4337-100mg
Description: PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay. Target: BTK, BCRP, Others. Smiles: Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCCC1. References: Pan Z, etal. Discovery of selective irreversible inhibitors for Bruton's tyrosine...
| Schlagworte: | PCI29732, PCI-29732 |
| Anwendung: | Multi-kinase inhibitor |
| CAS | 330786-25-9 |
| MW: | 371.43 D |
ab 34,00 €
AMG-47a
Artikelnummer: TGM-T7123-100mg
Description: AMG-47a is a potent inhibitor of Lck and T cell proliferation. AMG-47a could promote the degradation of the KRAS oncoprotein. AMG-47a selectively reduced the levels of EGFP-KRASG12V protein but did not affect EGFP protein in cells. Target: JAK, VEGFR, p38 MAPK, Src. Smiles:...
| Anwendung: | Lck/VEGFR2/p38alpha/JAK3 inhibitor |
| CAS | 882663-88-9 |
| MW: | 535.56 D |
ab 38,00 €
Lck inhibitor II
Artikelnummer: TGM-T68349-100mg
Description: Lck inhibitor II is a cell-permeable, ATP binding site-targeting, tri-substituted pyrimidine that acts as a highly potent Lck (lymphocyte specific kinase) inhibitor. Target: Others. Smiles: N(C1=NC(N2C=3C(N=C2)=CC=CC3)=NC(OCCN4CCOCC4)=C1)C5=C(C)C=CC(O)=C5
| Anwendung: | Lck inhibitor |
| CAS | 918870-43-6 |
| MW: | 446.5 D |
ab 1.491,00 €
Lck Inhibitor III
Artikelnummer: TGM-T72586-100mg
Description: Lck Inhibitor III, a potent inhibitor of Lck, exhibits an IC50 value of 867 nM. Additionally, this compound effectively inhibits IL-2 synthesis in Jurkat cells, demonstrating an IC50 of 1.270 µM. Target: Others. Smiles: O.N1=CN(C2=NC(OCCN3CCOCC3)=CC(=N2)NC4=CC(OC)=CC=C4C)C=5C=CC=CC15
| Anwendung: | Lck inhibitor |
| CAS | 1188890-30-3 |
| MW: | 478.54 D |
ab 1.491,00 €
Lck Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPH-02275-100ug
Description: Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the...
| Schlagworte: | T cell-specific protein-tyrosine kinase, Tyrosine-protein kinase Lck, LCK, Proto-oncogene Lck, Protein YT16, p56-LCK,... |
| MW: | 65.2 kD |
ab 193,00 €
Anomalin A
Artikelnummer: TGM-T124676-1mg
Description: Anomalin A is a useful organic compound for research related to life sciences. The catalog number is T124676 and the CAS number is 548740-86-9. Target: Others. Smiles: Cc1c(O)c(O)cc2oc3cc(O)cc(O)c3c(=O)c12
| Anwendung: | Lck inhibitor |
| CAS | 548740-86-9 |
| MW: | 274.228 D |
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RK-24466
Artikelnummer: TGM-T16760-100mg
Description: RK-24466 (KIN 001-51) is a selective and potent Lck inhibitor, targeting Lck (64-509) and LckCD isoforms with IC50 values of less than 1 nM and 2 nM, respectively. Target: Src. Smiles: Nc1ncnc2n(cc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCCC1. References: Seo HH, et al....
| Schlagworte: | KIN 001-51 |
| Anwendung: | LCK inhibitor |
| CAS | 213743-31-8 |
| MW: | 370.45 D |
ab 59,00 €
Lck inhibitor 2
Artikelnummer: TGM-T15725-1mL
Description: Lck inhibitor 2 is a bis-anilinopyrimidine inhibitor of tyrosine kinases including LCK, BTK, LYN, SYK, and TXK [IC50s: 13nM, 9nM, 3nM, 26nM, and 2nM for Lck, Btk, Lyn, Btk, and Txk respectively]. Target: Others. Smiles: Cc1ccc(O)cc1Nc1ccnc(Nc2cccc(c2)C(N)=O)n1. References: Bamborough, et al. Assessment...
| Anwendung: | Lck inhibitor |
| CAS | 944795-06-6 |
| MW: | 335.36 D |
ab 67,00 €
Lck Inhibitor
Artikelnummer: TGM-T15726-100mg
Description: Lck Inhibitor is effective inhibitors of Lck (IC50: 7 nM). Target: Others. Smiles: CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n2c(nc4ccccc24)n(-c2c(C)cccc2C)c3=O)cc1. References: Martin, Matthew W., Newcomb, John, Nunes, Joseph J., et al. Structure-Based Design of Novel...
| Anwendung: | Lck inhibitor |
| CAS | 847950-09-8 |
| MW: | 530.62 D |
ab 89,00 €
PD173955
Artikelnummer: TGM-T3063-100mg
Description: PD173955 is src family-selective tyrosine kinase inhibitor with IC50 of ~22 nM for Src, Yes and Abl kinase, less potent for FGFRalpha and no activity on InsR and PKC. Target: Src, Apoptosis, Bcr-Abl. Smiles: CSc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1. References: Wisniewski D, et al. Cancer...
| Schlagworte: | PD 173955, PD-173955 |
| Anwendung: | Tyrosine kinase inhibitor |
| CAS | 260415-63-2 |
| MW: | 443.35 D |
ab 40,00 €
Emodin
Artikelnummer: TGM-T2869-1mL
Description: Emodin (Frangula emodin) is a naturally occurring anthraquinone present in the roots and barks of numerous plants, exerts antiproliferative effects in Y cells that are regulated by different signaling pathways. Target: Autophagy, SARS-CoV, Casein Kinase. Smiles:...
| Schlagworte: | Frangula emodin |
| Anwendung: | p56lck protein kinase inhibitor |
| CAS | 518-82-1 |
| MW: | 270.24 D |
ab 45,00 €
Tyrosine-protein kinase Lck (LCK), human, recombinant
Artikelnummer: CSB-EP012806HU.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 1-539aa. Protein Length: Full Length of Isoform 3. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: MGCGCSSHPE DDWMENIDVC ENCHYPIVPL DGKGTLLIRN GSEVRDPLVT YEGSNPPASP LQDNLVIALH SYEPSHDGDL GFEKGEQLRI LEQSGEWWKA QSLTTGQEGF IPFNFVAKAN...
| Schlagworte: | LSK, LCK, p56-LCK, EC=2.7.10.2, Protein YT16, Proto-oncogene Lck, Tyrosine-protein kinase Lck, Leukocyte C-terminal Src... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 65.2 kD |
ab 213,00 €