Zu "K05853" wurden 87 Artikel gefunden!
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Thapsigargin
Artikelnummer: Cay10522-1
Thapsigargin is an inhibitor of sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA, IC50 = ~30 nM for the rat liver microsomal enzyme), an ER stress inducer, and a sesquiterpene lactone that has been found in Thapsia. It increases intracellular calcium levels in isolated rat hepatocytes (EC50 = ~80 nM) and...
| Schlagworte: | (3S,3aS,4R,6R,7S,8R)-6-acetoxy-4-(butyryloxy)-3,3a-dihydroxy-3,6,9-trimethyl-8-(((Z)-2-methylbut-2-enoyl)oxy)-2-oxo-2,3,3a... |
| Anwendung: | SERCA inhibitor |
| CAS | 67526-95-8 |
| MW: | 650.8 D |
ab 75,00 €
Thapsigargin (high purity)
Artikelnummer: AG-CN2-0003-M001
Colorless to white amorphous powder. Soluble in DMSO or 100% ethanol. Chemical. CAS: 67526-95-8. Formula: C34H50O12. MW: 650.8. Isolated from Thapsia garganica. Intracellular Ca2+ signaling probe. Specific and sensitive inhibitor of SERCA. Non-TPA/PMA tumor promoter. Histamine release inducer. Apoptosis inducer....
| Anwendung: | SERCA inhibitor, Ca2+ releaser |
| CAS | 67526-95-8 |
| MW: | 650,8 D |
ab 77,00 €
Anti-ATP2A1
Artikelnummer: ATA-HPA066701.100
Polyclonal Antibody against Human ATP2A1, Gene description: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, Alternative Gene Names: ATP2A, SERCA1, Validated applications: IHC, Uniprot ID: O14983, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C. Protein...
| Schlagworte: | Anti-ATP2A1, Anti-SERCA1, Anti-Calcium pump 1, Anti-SR Ca(2+)-ATPase 1, Anti-Endoplasmic reticulum class 1/2 Ca(2+)... |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
477,00 €
N106
Artikelnummer: TGM-T28124-100mg
Description: N106 is an activator of the SUMO-activating enzyme, E1 ligase, and triggers intrinsic sumoylation of SERCA2a. N106 can be used in studies about heart failure. Target: E1/E2/E3 Enzyme. Smiles: COc1ccc(cc1)-c1nnc(Nc2nc3c(OC)cccc3s2)o1. References: Kho C, et al. Small-molecule activation of SERCA2a...
| Schlagworte: | N 106, N-106 |
| Anwendung: | SERCA2A sumoylation activator |
| CAS | 862974-25-2 |
| MW: | 354.38 D |
ab 43,00 €
CDN1163
Artikelnummer: TGM-T7373-100mg
Description: CDN1163 is a small molecule activator of sarco/endoplasmic reticulum Ca2+-ATPase (SERCA). Target: Calcium Channel. Smiles: CC(C)Oc1ccc(cc1)C(=O)Nc1cccc2ccc(C)nc12. References: Kang S , Dahl R , Hsieh W , et al. Small Molecular Allosteric Activator of the Sarco/Endoplasmic Reticulum Ca2+-ATPase (SERCA)...
| Anwendung: | Allosteric SERCA2 activator |
| CAS | 892711-75-0 |
| MW: | 320.39 D |
ab 40,00 €
Mipsagargin
Artikelnummer: TGM-T8683-10mg
Description: Mipsagargin (G-202) is a novel antibiotic that inhibits DNA biosynthesis. Target: Others, Drug-Linker Conjugates for ADC. Smiles: CC1=C2[C@]([C@H](OC(CCCCCCC)=O)[C@H]1OC(/C(=C\C)/C)=O)([C@](OC(C)=O)(C)C[C@H](OC(CCCCCCCCCC...
| Schlagworte: | G-202 |
| Anwendung: | Targets P-type Ca2+ transporter type 2A [EC:7.2.2.10] (ATP2A) |
| CAS | 1245732-48-2 |
| MW: | 1409.52 D |
ab 133,00 €
Thapsigargin
Artikelnummer: TGM-TQ0302-1mg
Description: Thapsigargin is a natural product, an inhibitor of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) and an endoplasmic reticulum stress inducer. Thapsigargin increases cytoplasmic calcium concentration by blocking the ability of cells to pump calcium into the sarcoplasmic and endoplasmic...
| Anwendung: | SERCA inhibitor, Ca2+ releaser |
| CAS | 67526-95-8 |
| MW: | 650.75 D |
ab 81,00 €
Cyclopiazonic acid
Artikelnummer: TGM-T15027-10mg
Description: Cyclopiazonic acid (CPA) is a neurotoxic secondary metabolite (SM) made by A. flavus. Cyclopiazonic acid (CPA) is an endoplasmic reticulum calcium ATPase (Ca2+ATPase, SERCA)nanomolar inhibitor and a potent inducer of cell death in plants. Target: Calcium Channel. Smiles:...
| Anwendung: | SERCA inhibitor, mycotoxin |
| CAS | 18172-33-3 |
| MW: | 336.38 D |
ab 83,00 €
Cyclopiazonic Acid
Artikelnummer: Cay11326-1
Cyclopiazonic acid is a mycotoxin that has been found in Penicillium and Aspergillus and an inhibitor of sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA, IC50 = 0.6 µM). In vivo, cyclopiazonic acid (11-14 mg/kg) induces ptosis, hypothermia, tremor, and cachexia, as well as induces lethality (LD50 = 13 mg/kg),...
| Schlagworte: | CPA, NSC 117181,... |
| Anwendung: | SERCA inhibitor, mycotoxin |
| CAS | 18172-33-3 |
| MW: | 336.4 D |
ab 35,00 €
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1...
Artikelnummer: CSB-CF002332HU1.100
Organism: Homo sapiens (Human). Source: in vitro E.coli expression system. Expression Region: 10-450aa. Protein Length: Partial. Tag Info: N-terminal 10xHis-tagged. Target Protein Sequence: EECLAYFGVS ETTGLTPDQV KRNLEKYGLN ELPAEEGKTL WELVIEQFED LLVRILLLAA CISFVLAWFE EGEETITAFV EPFVILLILI ANAIVGVWQE RNAENAIEAL...
| Schlagworte: | ATP2A1, SERCA1, Calcium pump 1, SR Ca(2+)-ATPase 1, Endoplasmic reticulum class 1/2 Ca(2+) ATPase,... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli in vitro |
| Ursprungsart: | human |
| MW: | 49.5 kD |
ab 799,00 €
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2...
Artikelnummer: CSB-EP002333HU.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 314-756aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: VITTCLALGT RRMAKKNAIV RSLPSVETLG CTSVICSDKT GTLTTNQMSV CRMFILDRVE GDTCSLNEFT ITGSTYAPIG EVHKDDKPVN CHQYDGLVEL ATICALCNDS ALDYNEAKGV YEKVGEATET ALTCLVEKMN...
| Schlagworte: | ATP2B, ATP2A2, SERCA2, EC=7.2.2.10, Calcium pump 2, SR Ca(2+)-ATPase 2, Endoplasmic reticulum class 1/2 Ca(2+) ATPase,... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 52.3 kD |
ab 219,00 €
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2...
Artikelnummer: CSB-EP002333HUc7.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 314-756aa. Protein Length: Partial. Tag Info: C-terminal 6xHis-tagged. Target Protein Sequence: VITTCLALGT RRMAKKNAIV RSLPSVETLG CTSVICSDKT GTLTTNQMSV CRMFILDRVE GDTCSLNEFT ITGSTYAPIG EVHKDDKPVN CHQYDGLVEL ATICALCNDS ALDYNEAKGV YEKVGEATET ALTCLVEKMN...
| Schlagworte: | ATP2B, ATP2A2, SERCA2, EC=7.2.2.10, Calcium pump 2, SR Ca(2+)-ATPase 2, Endoplasmic reticulum class 1/2 Ca(2+) ATPase,... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 55.2 kD |
ab 219,00 €