Zu "K05725" wurden 183 Artikel gefunden!
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PND-1186
Artikelnummer: BPS-82815-1
PND-1186 (VS-4718) is a potent, highly-specific and reversible inhibitor of FAK with an IC50 of 1.5 nM. PND-1186 selectively promotes tumor cell apoptosis.1
| Schlagworte: | PND-1186, VS-4718, SR-2516 |
| Anwendung: | FAK inhibitor |
| CAS | 1061353-68-1 |
| MW: | 501,50 D |
ab 303,00 €
Anti-PTK2
Artikelnummer: ABS-KC-6148.100
Protein function: Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for...
| Schlagworte: | Anti-Focal adhesion kinase 1, Anti-FADK 1, Anti-Focal adhesion kinase-related nonkinase, Anti-FRNK, Anti-Protein... |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 232,00 €
FAK inhibitor 2
Artikelnummer: TGM-T11260-100mg
Description: FAK inhibitor 2, antitumor and anti-angiogenesis activitiesis ,is a potent focal adhesion kinase (FAK) inhibitor with an IC50 of 0.07 nM . Target: FAK. Smiles: CNC(=O)c1ccccc1Nc1nc(Nc2ccc(cc2)C(=O)N2CCN(CC2)C(=S)SCCN(C)C)ncc1C(F)(F)F. References: Su Y, et al. Discovery of 2,4-diarylaminopyrimidine...
| Anwendung: | FAK inhibitor |
| CAS | 2354405-14-2 |
| MW: | 646.75 D |
ab 1.229,00 €
FAK inhibitor 5
Artikelnummer: TGM-T11261-100mg
Description: FAK inhibitor 5 is a novel allosteric FAK inhibitor, with IC50 values in the low micromolar range. Target: Others. Smiles: C(C)N1C=2C=3C(N(C)S(=O)(=O)C2C=N1)=CC=C(C3)C4=CC=C(CC)C=C4. References: Iwatani M, et al. Discovery and characterization of novel allosteric FAK inhibitors. Eur J Med Chem. 2013...
| Anwendung: | FAK inhibitor |
| CAS | 1426683-30-8 |
| MW: | 367.46 D |
ab 1.520,00 €
PF-573228
Artikelnummer: TGM-T2001-5mg
Description: PF-573228 is an ATP-competitive FAK inhibitor. In a cell-free assay, the IC50 of FAK is 4 nM. Target: FAK, Apoptosis. Smiles: CS(=O)(=O)c1cccc(CNc2nc(Nc3ccc4NC(=O)CCc4c3)ncc2C(F)(F)F)c1. References: Slack-Davis JK, et al. J Biol Chem, 2007, 282(20), 14845-14852.
| Schlagworte: | PF 573228 |
| Anwendung: | PTK2 inhibitor |
| CAS | 869288-64-2 |
| MW: | 491.49 D |
ab 45,00 €
FAK inhibitor 6
Artikelnummer: TGM-T63123-100mg
Description: Compound 26F effectively optimizes enzyme inhibition (IC50 = 28.2 nM) while demonstrating relatively low cytotoxicity (IC50 = 3.32 µM). It induces apoptosis in MDA-MB-231 cells in a dose-dependent manner and efficiently arrests these cells in the G0/G1 phase. Target: Others. Smiles:...
| Anwendung: | FAK inhibitor |
| CAS | 2410056-27-6 |
| MW: | 477.55 D |
ab 1.520,00 €
PF-562271 besylate
Artikelnummer: TGM-T6177-100mg
Description: PF-562271 besylate (PF-00562271 Besylate) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs. Target: CDK, FAK, PYK2. Smiles:...
| Schlagworte: | PF-00562271 Besylate |
| Anwendung: | FAK inhibitor |
| CAS | 939791-38-5 |
| MW: | 665.66 D |
ab 33,00 €
Y15
Artikelnummer: TGM-T7119-100mg
Description: Y15 (1,2,4,5-Benzenetetramine tetrahydrochlor) is a potent and specificsmall-molecule FAK scaffolding inhibitor that inhibits its autophosphorylation activity, blocks tumor growth. Target: FAK. Smiles: Cl.Cl.Cl.Cl.Nc1cc(N)c(N)cc1N. References: O'Brien S, Golubovskaya VM, Conroy J,et al.FAK inhibition...
| Schlagworte: | FAK Inhibitor 14, 1,2,4,5-Benzenetetramine tetrahydrochlor |
| Anwendung: | FAK1 autophosphorylation inhibitor |
| CAS | 4506-66-5 |
| MW: | 284.01 D |
ab 42,00 €
PND-1186
Artikelnummer: TGM-T1950-100mg
Description: PND-1186 (VS-4718) is a specific and reversible FAK inhibitor with an IC50 of 1.5 nM. Target: Apoptosis, FAK. Smiles: CNC(=O)c1ccccc1Nc1cc(Nc2ccc(cc2OC)N2CCOCC2)ncc1C(F)(F)F. References: Tanjoni I, et al. Cancer Biol Ther. 2010, 9(10), 764-777.
| Schlagworte: | VS-4718, SR-2516, PND 1186, PND1186 |
| Anwendung: | FAK inhibitor |
| CAS | 1061353-68-1 |
| MW: | 501.5 D |
ab 48,00 €
NVP-TAE 226
Artikelnummer: TGM-T1918-100mg
Description: NVP-TAE 226 (TAE226) is a potent FAK inhibitor (IC50: 5.5 nM), exhibiting even greater efficacy against Pyk2 (IC50: 3.5 nM), and is 10- to 100-fold less effective against IGF-1R, InsR, c-Met, and ALK. Target: IGF-1R, FAK, Apoptosis, c-Met/HGFR, PYK2. Smiles:...
| Schlagworte: | TAE226 |
| Anwendung: | FAK inhibitor |
| CAS | 761437-28-9 |
| MW: | 468.94 D |
ab 42,00 €
GSK215
Artikelnummer: TGM-T67843-100mg
Description: GSK215 is a potent and selective PROTAC focal adhesion kinase (FAK) degrader (pDC50= 8.4), designed using the FAK inhibitor VS-4718 and a binder for the VHL E3 ligase, capable of inducing rapid and prolonged FAK degradation. Target: FAK, PROTACs. Smiles:...
| Anwendung: | FAK (PTK2) degradation driving PROTAC |
| CAS | 2743427-26-9 |
| MW: | 985.13 D |
ab 126,00 €
GSK215
Artikelnummer: Cay40835-10
GSK215 is a proteolysis-targeting chimera (PROTAC) composed of the focal adhesion kinase (FAK) inhibitor PND1186 (Cay-17668) linked to the von-Hippel Lindau (VHL) E3 ligase ligand VHL-021. It binds to the FAK kinase domain (IC50 = 15.8 nM) and induces FAK degradation in A549 lung cancer cells with a 50% degradation...
| Schlagworte: | (2S,4R)-4-hydroxy-1-((S)-2-(2-(4-(3-methoxy-4-((4-((2-(methylcarbamoyl)phenyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino... |
| Anwendung: | FAK (PTK2) degradation driving PROTAC |
| CAS | 2743427-26-9 |
| MW: | 985.1 D |
ab 157,00 €