Zu "K05725" wurden 192 Artikel gefunden!
Für die Filterung wurden keine Ergebnisse gefunden!
PF-573228
Artikelnummer: TGM-T2001-5mg
Description: PF-573228 is an ATP-competitive FAK inhibitor. In a cell-free assay, the IC50 of FAK is 4 nM. Target: FAK, Apoptosis. Smiles: CS(=O)(=O)c1cccc(CNc2nc(Nc3ccc4NC(=O)CCc4c3)ncc2C(F)(F)F)c1. References: Slack-Davis JK, et al. J Biol Chem, 2007, 282(20), 14845-14852.
| Schlagworte: | PF 573228 |
| Anwendung: | PTK2 inhibitor |
| CAS | 869288-64-2 |
| MW: | 491.49 D |
ab 45,00 €
FAK inhibitor 6
Artikelnummer: TGM-T63123-100mg
Description: Compound 26F effectively optimizes enzyme inhibition (IC50 = 28.2 nM) while demonstrating relatively low cytotoxicity (IC50 = 3.32 µM). It induces apoptosis in MDA-MB-231 cells in a dose-dependent manner and efficiently arrests these cells in the G0/G1 phase. Target: Others. Smiles:...
| Anwendung: | FAK inhibitor |
| CAS | 2410056-27-6 |
| MW: | 477.55 D |
ab 1.491,00 €
PF-562271 besylate
Artikelnummer: TGM-T6177-100mg
Description: PF-562271 besylate (PF-00562271 Besylate) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs. Target: CDK, FAK, PYK2. Smiles:...
| Schlagworte: | PF-00562271 Besylate |
| Anwendung: | FAK inhibitor |
| CAS | 939791-38-5 |
| MW: | 665.66 D |
ab 52,00 €
Y15
Artikelnummer: TGM-T7119-100mg
Description: Y15 (1,2,4,5-Benzenetetramine tetrahydrochlor) is a potent and specificsmall-molecule FAK scaffolding inhibitor that inhibits its autophosphorylation activity, blocks tumor growth. Target: FAK. Smiles: Cl.Cl.Cl.Cl.Nc1cc(N)c(N)cc1N. References: O'Brien S, Golubovskaya VM, Conroy J,et al.FAK inhibition...
| Schlagworte: | FAK Inhibitor 14, 1,2,4,5-Benzenetetramine tetrahydrochlor |
| Anwendung: | FAK1 autophosphorylation inhibitor |
| CAS | 4506-66-5 |
| MW: | 284.01 D |
ab 40,00 €
PND-1186
Artikelnummer: TGM-T1950-100mg
Description: PND-1186 (VS-4718) is a specific and reversible FAK inhibitor with an IC50 of 1.5 nM. Target: Apoptosis, FAK. Smiles: CNC(=O)c1ccccc1Nc1cc(Nc2ccc(cc2OC)N2CCOCC2)ncc1C(F)(F)F. References: Tanjoni I, et al. Cancer Biol Ther. 2010, 9(10), 764-777.
| Schlagworte: | VS-4718, SR-2516, PND 1186, PND1186 |
| Anwendung: | FAK inhibitor |
| CAS | 1061353-68-1 |
| MW: | 501.5 D |
ab 48,00 €
NVP-TAE 226
Artikelnummer: TGM-T1918-100mg
Description: NVP-TAE 226 (TAE226) is a potent FAK inhibitor (IC50: 5.5 nM), exhibiting even greater efficacy against Pyk2 (IC50: 3.5 nM), and is 10- to 100-fold less effective against IGF-1R, InsR, c-Met, and ALK. Target: IGF-1R, FAK, Apoptosis, c-Met/HGFR, PYK2. Smiles:...
| Schlagworte: | TAE226 |
| Anwendung: | FAK inhibitor |
| CAS | 761437-28-9 |
| MW: | 468.94 D |
ab 41,00 €
GSK215
Artikelnummer: TGM-T67843-100mg
Description: GSK215 is a potent and selective PROTAC focal adhesion kinase (FAK) degrader (pDC50= 8.4), designed using the FAK inhibitor VS-4718 and a binder for the VHL E3 ligase, capable of inducing rapid and prolonged FAK degradation. Target: FAK, PROTACs. Smiles:...
| Anwendung: | FAK (PTK2) degradation driving PROTAC |
| CAS | 2743427-26-9 |
| MW: | 985.13 D |
ab 124,00 €
GSK215
Artikelnummer: Cay40835-10
GSK215 is a proteolysis-targeting chimera (PROTAC) composed of the focal adhesion kinase (FAK) inhibitor PND1186 (Cay-17668) linked to the von-Hippel Lindau (VHL) E3 ligase ligand VHL-021. It binds to the FAK kinase domain (IC50 = 15.8 nM) and induces FAK degradation in A549 lung cancer cells with a 50% degradation...
| Schlagworte: | (2S,4R)-4-hydroxy-1-((S)-2-(2-(4-(3-methoxy-4-((4-((2-(methylcarbamoyl)phenyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino... |
| Anwendung: | FAK (PTK2) degradation driving PROTAC |
| CAS | 2743427-26-9 |
| MW: | 985.1 D |
ab 154,00 €
FAK inhibitor 2
Artikelnummer: TGM-T11260-100mg
Description: FAK inhibitor 2, antitumor and anti-angiogenesis activitiesis ,is a potent focal adhesion kinase (FAK) inhibitor with an IC50 of 0.07 nM . Target: FAK. Smiles: CNC(=O)c1ccccc1Nc1nc(Nc2ccc(cc2)C(=O)N2CCN(CC2)C(=S)SCCN(C)C)ncc1C(F)(F)F. References: Su Y, et al. Discovery of 2,4-diarylaminopyrimidine...
| Anwendung: | FAK inhibitor |
| CAS | 2354405-14-2 |
| MW: | 646.75 D |
ab 1.206,00 €
FAK inhibitor 5
Artikelnummer: TGM-T11261-100mg
Description: FAK inhibitor 5 is a novel allosteric FAK inhibitor, with IC50 values in the low micromolar range. Target: Others. Smiles: C(C)N1C=2C=3C(N(C)S(=O)(=O)C2C=N1)=CC=C(C3)C4=CC=C(CC)C=C4. References: Iwatani M, et al. Discovery and characterization of novel allosteric FAK inhibitors. Eur J Med Chem. 2013...
| Anwendung: | FAK inhibitor |
| CAS | 1426683-30-8 |
| MW: | 367.46 D |
ab 1.491,00 €
Focal adhesion kinase 1 (PTK2), partial, chicken,...
Artikelnummer: CSB-RP144494CH.1
Organism: Gallus gallus (Chicken). Source: E.coli. Expression Region: 376-683aa. Protein Length: Partial. Tag Info: N-terminal GST-tagged. Target Protein Sequence: LANNEKQGVR SHTVSVSETD DYAEIIDEED TYTMPSTRDY EIQRERIELG RCIGEGQFGD VHQGIYMSPE NPAMAVAIKT CKNCTSDSVR EKFLQEALTM RQFDHPHIVK LIGVITENPV WIIMELCTLG ELRSFLQVRK...
| Schlagworte: | FAK, FRNK, PTK2, FADK 1, p125FAK, pp125FAK, EC=2.7.10.2, p41/p43FRNK, Focal adhesion kinase 1, Protein-tyrosine kinase 2,... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | chicken |
| MW: | 62.3 kD |
ab 354,00 €
Anti-PTK2
Artikelnummer: CSB-PA002465.50
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-FAK, Anti-FRNK, Anti-FADK 1, Anti-p125FAK, Anti-PPP1R71, Anti-pp125FAK, EC=2.7.10.2, Anti-Focal adhesion kinase 1,... |
| Anwendung: | ELISA, WB, IHC, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
106,00 €