Zu "K05704" wurden 173 Artikel gefunden!
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1-NA-PP1
Artikelnummer: Cay10954-10
1-NA-PP1 is a reversible, cell-permeable inhibitor of Src-family tyrosine kinases that have been mutated, by a single base substitution, to become 'analog sensitive' (as), as compared to the wild-type kinase. 1-NA-PP1 was first developed to optimally inhibit v-Src-as1, with an I338G substitution, preferentially over...
| Schlagworte: | 1-Naphthyl-PP1, PP1 Analog, 1-(1,1-dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| CAS | 221243-82-9 |
| MW: | 317.4 D |
ab 31,00 €
Src Inhibitor 1
Artikelnummer: TGM-T3593-100mg
Description: Src Inhibitor 1 (Src Kinase Inhibitor 1) is a potent and selective dual site Src tyrosine kinase inhibitor. Target: Src. Smiles: N(C=1C2=C(C=C(OC)C(OC)=C2)N=CN1)C3=CC=C(OC4=CC=CC=C4)C=C3. References: Tian G, et al. Structural determinants for potent, selective dual site inhibition of human pp60c-src by...
| Schlagworte: | Src Kinase Inhibitor 1, Src-l1 |
| Anwendung: | Src inhibitor |
| CAS | 179248-59-0 |
| MW: | 373.4 D |
ab 33,00 €
PP2
Artikelnummer: TGM-T6266-100mg
Description: PP2 (AG 1879,AGL 1879) is a effective inhibitor of Lck/Fyn (IC50:4/5 nM) , ~100-fold less potent to EGFR, inactive for ZAP-70, PKA and JAK2. Target: EGFR, Tyrosine Kinases, Src, JAK. Smiles: NC1=C2C(=NN(C(C)(C)C)C2=NC=N1)C3=CC=C(Cl)C=C3. References: Hanke JH, et al. J Biol Chem, 1996, 271(2), 695-701.
| Schlagworte: | AG 1879,AGL 1879, AGL 1879 |
| Anwendung: | Tyrosine kinase inhibitor |
| CAS | 172889-27-9 |
| MW: | 301.77 D |
ab 39,00 €
RK-20448
Artikelnummer: TGM-T71819-10mg
Description: RK-20448 is an ATP-competitive inhibitor of Lck, Src, KDR/VEGF2R, and Tie-2. It also inhibits BLK, Csk, Fyn, and Lyn. RK-20448 is the cis isomer of A-419259. Target: Others. Smiles: NC1=C2C(=CN(C2=NC=N1)[C@@H]3CC[C@@H](CC3)N4CCN(C)CC4)C5=CC=C(OC6=CC=CC=C6)C=C5
| Anwendung: | ATP-competitive Lck / Src / VEGF2R / Tie-2 inhibitor |
| CAS | 479501-40-1 |
| MW: | 482.62 D |
ab 108,00 €
SU6656
Artikelnummer: TGM-T6997-100mg
Description: SU 6656 is a selective inhibitor of Src family kinases, with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively. Target: FAK, Akt, Src. Smiles: C(=C1C=2C(NC1=O)=CC=C(S(N(C)C)(=O)=O)C2)C3=CC4=C(N3)CCCC4. References: Blake RA, et al. Mol Cell Biol. 2000, 20(23), 9018-9027.
| Anwendung: | Src kinase inhibitor |
| CAS | 330161-87-0 |
| MW: | 371.45 D |
ab 34,00 €
PD0166285 dihydrochloride
Artikelnummer: TGM-T6931L-1mg
Description: PD-166285 is an effective and broadly active inhibitor of protein tyrosine kinase. Target: Others. Smiles: O=C1C(C2=C(C=CC=C2Cl)Cl)=CC3=C(N1C)N=C(NC4=CC=C(C=C4)OCCN(CC)CC)N=C3.Cl.Cl. References: Leijen S, Beijnen JH, Schellens JH. Abrogation of the G2 checkpoint by inhibition of Wee-1 kinase results in...
| Schlagworte: | PD-166285 |
| Anwendung: | Tyrosine kinase inhibitor |
| CAS | 212391-63-4 |
| MW: | 585.35 D |
91,00 €
Src Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPH-01977-100ug
Description: Src Protein, Human, Recombinant (His) is expressed in E. coli.
| Schlagworte: | Proto-oncogene tyrosine-protein kinase Src, pp60c-src, SRC, Proto-oncogene c-Src |
| MW: | 64.2 kD |
ab 352,00 €
Src Protein, Human, Recombinant (His & GST)
Artikelnummer: TGM-TMPY-04384-100ug
Description: Src Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 87.7 kDa and the accession number is P12931-1.
| Schlagworte: | SRC proto-oncogene, non-receptor tyrosine kinase, ASV, SRC1, p60-Src, c-SRC |
| MW: | 87.7 kD |
ab 313,00 €
WH-4-023
Artikelnummer: TGM-T1811-100mg
Description: WH-4-023 (Dual LCK/SRC inhibitor) is a potent and orally active Lck/Src inhibitor. It also potently inhibits SIK. Target: Src. Smiles: COc1ccc(N(C(=O)Oc2c(C)cccc2C)c2ccnc(Nc3ccc(cc3)N3CCN(C)CC3)n2)c(OC)c1. References: Martin MW, et al. J Med Chem. 2006, 49(16), 4981-4991.
| Schlagworte: | KIN112, KIN001-112, Dual LCK/SRC inhibitor |
| Anwendung: | Lck / Src inhibitor |
| CAS | 837422-57-8 |
| MW: | 568.67 D |
ab 47,00 €
KX1-004
Artikelnummer: TGM-T1812-100mg
Description: KX1-004, a potential protective drug for NIHL, is an effective small molecule inhibitor of Src-PTK. Target: Src. Smiles: OC1=CC=CC(CNC(=O)C2=CC3=CC(F)=CC=C3N2)=C1. References: Harris KC, et al. Hear Res. 2005 Oct,208(1-2):14-25.
| Schlagworte: | KX1 004, KX1004 |
| Anwendung: | Src inhibitor |
| CAS | 518058-84-9 |
| MW: | 284.29 D |
ab 38,00 €
PP1
Artikelnummer: TGM-T6196-100mg
Description: PP1 (AGL 1872), a specific and effective Src inhibitor, is with IC50 for Lck/Fyn is 5 nM/ 6 nM, respectively. Target: Src, EGFR, Bcr-Abl, Apoptosis, c-Kit. Smiles: NC1=C2C(=NN(C(C)(C)C)C2=NC=N1)C3=CC=C(C)C=C3. References: Hanke JH, et al. J Biol Chem, 1996, 271(2), 695-701.
| Schlagworte: | AGL 1872, EI 275 |
| Anwendung: | Tyrosine kinase inhibitor |
| CAS | 172889-26-8 |
| MW: | 281.36 D |
ab 34,00 €
Src Inhibitor 3
Artikelnummer: TGM-T13000-100mg
Description: Src Inhibitor 3 is an effective inhibitor of c-terminal Src kinase (IC50 <3 nM in CSK HTRF, <4 nM in Caliper assay). Src Inhibitor 3 increases T cell proliferation induced by T cell receptor signaling. Target: Src, Others. Smiles:...
| Anwendung: | Src inhibitor |
| CAS | 2380027-49-4 |
| MW: | 671.12 D |
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