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Zu "K05638" wurden 131 Artikel gefunden!
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Artikelnummer: Cay600590-96
Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that plays a key role in maintaining redox homeostasis via its interaction with a cysteine-rich protein Kelch-like ECH-associated protein 1 (Keap1). In resting cells, Nrf2 and Keap1 form a tight complex, which is targeted for degradation by...
Schlagworte: | GABPA, HEBP1, NF-E2-related factor 2, Nuclear Factor Erythroid 2-related factor 2 |
Anwendung: | DNA binding assay |
674,00 €
Artikelnummer: TGM-T16331-100mg
Description: NK-252 is a potential activator of Nrf2. It has great Nrf2-activating potential. Target: Nrf2, Others. Smiles: O=C(NCc1ccccn1)Nc1nnc(o1)-c1ccco1. References: Shimozono R et al. Nrf2 activators attenuate the progression of nonalcoholic steatohepatitis-related fibrosis in a dietary rat model. Mol...
Anwendung: | Nrf2 activator |
CAS | 1414963-82-8 |
MW: | 285.26 D |
ab 35,00 €
Artikelnummer: TGM-T2841-100mg
Description: Plumbagin (Plumbaein) is a yellow dye, formally derived from naphthoquinone. It is named after the plant genus Plumbago, from which it was originally isolated. It is also commonly found in the carnivorous plant genera Drosera and Nepenthes. It is also a component of the black walnut drupe. Target: ROS....
Schlagworte: | Plumbaein, 2-Methyljuglone, Plumbagone, Plumbagine |
Anwendung: | Nrf2 activator |
CAS | 481-42-5 |
MW: | 188.18 D |
ab 33,00 €
Artikelnummer: TGM-T3235-100mg
Description: Rebaudioside A (Reb A) is a novel agent of glycoside clathration of pharmacons, acts as alpha-glucosidase inhibitor. Target: Glucosidase, Endogenous Metabolite. Smiles:...
Schlagworte: | Glycoside A3, Stevioside A3, Reb-A 97, Reb A |
Anwendung: | Glucosylated steviol glycoside, non-glycemic sweetener, Nrf2 activator |
CAS | 58543-16-1 |
MW: | 967.01 D |
ab 33,00 €
Artikelnummer: TGM-T36614-10mg
Description: Nrf2 activation of the antioxidant response element (ARE) is central to cytoprotective gene expression against oxidative and/or electrophilic stress. Unless activated by inflammatory, environmental, or oxidative stressors, Nrf2 is sequestered in the cytoplasm by its repressor, Keap1. Because of its...
Anwendung: | Sulforaphane metabolite, Nrf2 activator, ARE gene expression inducer |
CAS | 334829-66-2 |
MW: | 340.47 D |
ab 110,00 €
Artikelnummer: TGM-T41302-100mg
Description: Itaconate-alkyne (ITalk) is a bioorthogonal probe for quantitative, site-specific chemoproteomic profiling of itaconate in inflammatory macrophages, facilitating biochemical evaluation and proteomic analysis of its direct targets. Target: Others. Smiles: C(CC(C(O)=O)=C)(OCCCCCCC#C)=O. References: Wei...
Schlagworte: | ITalk |
Anwendung: | Click chemistry, itaconate prodrug derivative |
CAS | 2454181-83-8 |
MW: | 238.28 D |
ab 67,00 €
Artikelnummer: TGM-T4580-100mg
Description: 4-Octyl Itaconate, a cell-permeable derivative of Itaconate, is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 and inhibits phosphorylation of STING. Target: Nrf2. Smiles: C(CC(C(O)=O)=C)(OCCCCCCCC)=O. References: Mills EL, et al. Itaconate is an anti-inflammatory metabolite...
Anwendung: | Prodrug, Nrf2 stabilization |
CAS | 3133-16-2 |
MW: | 242.31 D |
ab 33,00 €
Artikelnummer: TGM-T8979-100mg
Description: AEM1 is an inhibitor of deregulated NRF2 transcriptional activity in cancer. AEM1 acts by broadly decreasing the expression of NRF2 controlled genes, sensitizing A549 cells to various chemotherapeutic agents, and inhibiting the growth of A549 cells in vitro and in vivo. Target: Nrf2. Smiles:...
Anwendung: | Nrf2-induced gene transcription inhibitor |
CAS | 1030123-90-0 |
MW: | 379.41 D |
ab 49,00 €
Artikelnummer: TGM-T8281-10mg
Description: (R)-Sulforaphane (L-Sulforaphane) is a potent inducer of the Keap1/Nrf2/ARE pathway. Target: Nrf2. Smiles: C(CCN=C=S)CS(C)=O. References: De Nicola GR, et al. Novel gram-scale production of enantiopure R-sulforaphane from Tuscan black kale seeds. Molecules. 2014 May 27,19(6):6975-86.
Schlagworte: | L-Sulforaphane |
Anwendung: | Nrf2 activator, Chemopreventive agent |
CAS | 142825-10-3 |
MW: | 177.29 D |
ab 57,00 €
Artikelnummer: TGM-TMPH-01788-100ug
Description: NFE2L2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 42.9 kDa and the accession number is Q16236.
Schlagworte: | NFE2L2, Nuclear factor erythroid 2-related factor 2, Nuclear factor, erythroid derived 2, like 2, HEBP1 |
MW: | 42.9 kD |
ab 284,00 €
Artikelnummer: TGM-TQ0120-100mg
Description: CDDO-Im (TP-235) is an activator of Nrf2 and PPAR (Kis: 232/344 nM for PPARalpha/PPARgamma). Target: PPAR, Others, Ferroptosis, Nrf2. Smiles: [H][C@@]12CC(C)(C)CC[C@@]1(CC[C@]1(C)[C@]2([H])C(=O)C=C2[C@@]1(C)CC[C@@]1([H])C(C)(C)C(=O)C(=C[C@]21C)C#N)C(=O)n1ccnc1. References: Place AE, et al. The novel...
Schlagworte: | CDDO-Imidazolide, RTA-403, TP-235 |
Anwendung: | Nrf2 signaling activator |
CAS | 443104-02-7 |
MW: | 541.72 D |
ab 34,00 €
Artikelnummer: TGM-T12078-1mg
Description: ML334 (LH601A) is a transmembrane and potent NRF2 activator that inhibits Keap1-NRF2 protein interactions to ameliorate myocardial infarction-induced cardiac fibrosis by inhibiting cardiac fibroblast activation and proliferation. Target: Nrf2. Smiles:...
Schlagworte: | LH601A |
Anwendung: | Nrf2-Keap1 protein-protein interaction inhibitor |
CAS | 1432500-66-7 |
MW: | 446.49 D |
51,00 €