Zu "K05638" wurden 121 Artikel gefunden!
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Iberin
Artikelnummer: Cay14016-10
Iberin is a natural isothiocyanate found in cruciferous plants. When introduced into the daily diet of rats or added to rat hepatocytes (40 µM), it induces the expression of phase II detoxification enzymes, including quinone reductase and glutathione S-transferase. In addition, iberin activates the nuclear factor...
| Schlagworte: | NSC 321801, 1-isothiocyanato-3-(methylsulfinyl)-propane |
| Anwendung: | Natural isothiocyanate, phase II detoxification enzyme inducer, Nrf2 activator |
| CAS | 505-44-2 |
| MW: | 163.3 D |
ab 44,00 €
Nrf2 Transcription Factor Assay Kit
Artikelnummer: Cay600590-96
Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that plays a key role in maintaining redox homeostasis via its interaction with a cysteine-rich protein Kelch-like ECH-associated protein 1 (Keap1). In resting cells, Nrf2 and Keap1 form a tight complex, which is targeted for degradation by...
| Schlagworte: | GABPA, HEBP1, NF-E2-related factor 2, Nuclear Factor Erythroid 2-related factor 2 |
| Anwendung: | DNA binding assay |
675,00 €
L-Sulforaphane
Artikelnummer: Cay14797-10
L-Sulforaphane is an isothiocyanate derived from the natural compound glucoraphanin, which is abundant in cruciferous vegetables, including broccoli. It has powerful antioxidant, anti-inflammatory, and anti-carcinogenic effects. L-Sulforaphane, at 40 µM, activates nuclear factor erythroid 2-related factor 2- (Nrf2)...
| Schlagworte: | (R)-Sulforaphane, 1-isothiocyanato-4-[(R)-methylsulfinyl]-butane |
| Anwendung: | Nrf2 activator, Chemopreventive agent |
| CAS | 142825-10-3 |
| MW: | 177.3 D |
ab 62,00 €
4-octyl Itaconate
Artikelnummer: Cay25374-25
4-octyl Itaconate is a prodrug form of itaconate, an endogenous cellular metabolite produced via decarboxylation of cis-aconitate by the enzyme encoded by IRG1. It is hydrolyzed to itaconate by esterases in C2C12 cells and LPS-activated mouse macrophages where it acts as a regulator of macrophage function with...
| Schlagworte: | 2-methylene-butanedioic acid, 4-octyl ester |
| Anwendung: | Prodrug, Nrf2 stabilization |
| CAS | 3133-16-2 |
| MW: | 242.3 D |
ab 55,00 €
DL-Sulforaphane N-acetyl-L-cysteine
Artikelnummer: TGM-T36614-10mg
Description: Nrf2 activation of the antioxidant response element (ARE) is central to cytoprotective gene expression against oxidative and/or electrophilic stress. Unless activated by inflammatory, environmental, or oxidative stressors, Nrf2 is sequestered in the cytoplasm by its repressor, Keap1. Because of its...
| Anwendung: | Sulforaphane metabolite, Nrf2 activator, ARE gene expression inducer |
| CAS | 334829-66-2 |
| MW: | 340.47 D |
ab 108,00 €
Itaconate-alkyne
Artikelnummer: TGM-T41302-100mg
Description: Itaconate-alkyne (ITalk) is a bioorthogonal probe for quantitative, site-specific chemoproteomic profiling of itaconate in inflammatory macrophages, facilitating biochemical evaluation and proteomic analysis of its direct targets. Target: Others. Smiles: C(CC(C(O)=O)=C)(OCCCCCCC#C)=O. References: Wei...
| Schlagworte: | ITalk |
| Anwendung: | Click chemistry, itaconate prodrug derivative |
| CAS | 2454181-83-8 |
| MW: | 238.28 D |
ab 67,00 €
4-Octyl itaconate
Artikelnummer: TGM-T4580-100mg
Description: 4-Octyl Itaconate, a cell-permeable derivative of Itaconate, is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 and inhibits phosphorylation of STING. Target: Nrf2. Smiles: C(CC(C(O)=O)=C)(OCCCCCCCC)=O. References: Mills EL, et al. Itaconate is an anti-inflammatory metabolite...
| Anwendung: | Prodrug, Nrf2 stabilization |
| CAS | 3133-16-2 |
| MW: | 242.31 D |
ab 31,00 €
Omaveloxolone
Artikelnummer: TGM-T6919-100mg
Description: Omaveloxolone (RTA-408) (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-kappaB signaling. Phase 2. Target: Nrf2, STING, Apoptosis, Others. Smiles:...
| Schlagworte: | RTA-408 |
| Anwendung: | Targets nuclear factor erythroid 2-related factor 2 (NFE2L2, NRF2) |
| CAS | 1474034-05-3 |
| MW: | 554.71 D |
ab 40,00 €
AEM1
Artikelnummer: TGM-T8979-100mg
Description: AEM1 is an inhibitor of deregulated NRF2 transcriptional activity in cancer. AEM1 acts by broadly decreasing the expression of NRF2 controlled genes, sensitizing A549 cells to various chemotherapeutic agents, and inhibiting the growth of A549 cells in vitro and in vivo. Target: Nrf2. Smiles:...
| Anwendung: | Nrf2-induced gene transcription inhibitor |
| CAS | 1030123-90-0 |
| MW: | 379.41 D |
ab 46,00 €
(R)-Sulforaphane
Artikelnummer: TGM-T8281-10mg
Description: (R)-Sulforaphane (L-Sulforaphane) is a potent inducer of the Keap1/Nrf2/ARE pathway. Target: Nrf2. Smiles: C(CCN=C=S)CS(C)=O. References: De Nicola GR, et al. Novel gram-scale production of enantiopure R-sulforaphane from Tuscan black kale seeds. Molecules. 2014 May 27,19(6):6975-86.
| Schlagworte: | L-Sulforaphane |
| Anwendung: | Nrf2 activator, Chemopreventive agent |
| CAS | 142825-10-3 |
| MW: | 177.29 D |
ab 57,00 €
NFE2L2 Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPH-01788-100ug
Description: NFE2L2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 42.9 kDa and the accession number is Q16236.
| Schlagworte: | NFE2L2, Nuclear factor erythroid 2-related factor 2, Nuclear factor, erythroid derived 2, like 2, HEBP1 |
| MW: | 42.9 kD |
ab 281,00 €
CDDO-Im
Artikelnummer: TGM-TQ0120-100mg
Description: CDDO-Im (TP-235) is an activator of Nrf2 and PPAR (Kis: 232/344 nM for PPARalpha/PPARgamma). Target: PPAR, Others, Ferroptosis, Nrf2. Smiles: [H][C@@]12CC(C)(C)CC[C@@]1(CC[C@]1(C)[C@]2([H])C(=O)C=C2[C@@]1(C)CC[C@@]1([H])C(C)(C)C(=O)C(=C[C@]21C)C#N)C(=O)n1ccnc1. References: Place AE, et al. The novel...
| Schlagworte: | CDDO-Imidazolide, RTA-403, TP-235 |
| Anwendung: | Nrf2 signaling activator |
| CAS | 443104-02-7 |
| MW: | 541.72 D |
ab 31,00 €