Zu "K05613" wurden 46 Artikel gefunden!
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(R)-AS-1
Artikelnummer: Cay41673-1
(R)-AS-1 is a positive allosteric modulator of excitatory amino acid transporter 2 (EAAT2, EC50 = 11 nM in a glutamate uptake assay). It is selective for EAAT2 over EAAT1, EAAT3, and a panel of 30 other ion channels, transporters, receptors, and enzymes. (R)-AS-1 (60 and 90 mg/kg) increases spontaneous locomotor...
| Schlagworte: | alphaR-methyl-2,5-dioxo-N-(phenylmethyl)-1-pyrrolidineacetamide |
| Anwendung: | EAAT2 positive allosteric modulator |
| CAS | 2506367-95-7 |
| MW: | 260.3 D |
ab 54,00 €
LDN-212320
Artikelnummer: TGM-T15728-100mg
Description: LDN-212320 (OSU-0212320) is a glutamate transporter EAAT2 activator. It also enhances EAAT2 levels by > 6 fold at concentrations < 5 µM after 24 h. Target: transporter. Smiles: Cc1ccccc1CSc1ccc(nn1)-c1ccccn1. References: Xing X, et al. Structure-activity relationship study of pyridazine derivatives as...
| Schlagworte: | LDN-0212320, OSU-0212320, LDN/OSU-0212320 |
| Anwendung: | EAAT2 expression activator |
| CAS | 894002-50-7 |
| MW: | 293.39 D |
ab 40,00 €
GT 949
Artikelnummer: TGM-T15446-100mg
Description: GT 949 is a selective excitatory positive allosteric modulator of amino acid transporter-2 (EAAT2) with an EC50 of 0.26 nM. Target: transporter. Smiles: COc1ccc2[nH]c(=O)c(cc2c1)C(N1CCN(CC1)C1CCCCC1)c1nnnn1CCc1ccccc1. References: Kortagere S, et al. Identification of Novel Allosteric Modulators of...
| Anwendung: | EEAT2 positive allosteric modulator |
| CAS | 460330-27-2 |
| MW: | 527.66 D |
ab 40,00 €
Excitatory amino acid transporter 2 (Slc1a2), partial,...
Artikelnummer: CSB-EP021433MO.1
Organism: Mus musculus (Mouse). Source: E.coli. Expression Region: 143-238aa. Protein Length: Partial. Tag Info: N-terminal GST-tagged. Target Protein Sequence: HPGNPKLKKQ LGPGKKNDEV SSLDAFLDLI RNLFPENLVQ ACFQQIQTVT KKVLVAPPSE EANTTKAVIS MLNETMNEAP EETKIVIKKG LEFKDG. Purity: Greater than 90% as determined by...
| Schlagworte: | Eaat2, GLT-1, Slc1a2, Solute carrier family 1 member 2, Excitatory amino acid transporter 2, Sodium-dependent... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | mouse |
| MW: | 37.6 kD |
ab 292,00 €
Excitatory amino acid transporter 2 (Slc1a2), partial,...
Artikelnummer: CSB-YP021433MO.1
Organism: Mus musculus (Mouse). Source: Yeast. Expression Region: 143-238aa. Protein Length: Partial. Tag Info: N-terminal GST-tagged. Target Protein Sequence: HPGNPKLKKQ LGPGKKNDEV SSLDAFLDLI RNLFPENLVQ ACFQQIQTVT KKVLVAPPSE EANTTKAVIS MLNETMNEAP EETKIVIKKG LEFKDG. Purity: Greater than 90% as determined by...
| Schlagworte: | Eaat2, GLT-1, Slc1a2, Solute carrier family 1 member 2, Excitatory amino acid transporter 2, Sodium-dependent... |
| Anwendung: | Activity not tested |
| Exprimiert in: | Yeast |
| Ursprungsart: | mouse |
| MW: | 37.6 kD |
ab 347,00 €
Anti-SLC1A2
Artikelnummer: CSB-PA109577.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: SLC1A2. Antigen Species: Human
| Schlagworte: | Anti-EAAT2, Anti-SLC1A2, Anti-Solute carrier family 1 member 2, Anti-Glutamate/aspartate transporter II, Anti-Excitatory... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 167,00 €
Anti-SLC1A2
Artikelnummer: CSB-PA302626.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen....
| Schlagworte: | Anti-EAAT2, Anti-SLC1A2, Anti-Solute carrier family 1 member 2, Anti-Glutamate/aspartate transporter II, Anti-Excitatory... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 126,00 €
DL-TBOA
Artikelnummer: Cay29632-10
DL-TBOA is an inhibitor of excitatory amino acid transporters (EAATs), with IC50 values of 67 and 5.5 µM for glutamate uptake in COS-1 cells expressing human EAAT1 and EAAT2, respectively. It inhibits inward currents induced by L-aspartate in EAAT4-expressing Xenopus oocytes (Ki = 4.4 µM) and by L-glutamate in...
| Schlagworte: | DL-threo-beta-Benzyloxyaspartate, rel-3R-(phenylmethoxy)-D-aspartic acid |
| Anwendung: | Excitatory amino acid transporter (EAAT) inhibitor |
| CAS | 205309-81-5 |
| MW: | 239.2 D |
ab 252,00 €
TFB-TBOA (hydrate)
Artikelnummer: Cay31417-10
TFB-TBOA is an inhibitor of excitatory amino acid transporter 1 (EAAT1) and EAAT2 with IC50 values of 22 and 17 nM for EAAT1 and EAAT2, respectively, in a glutamate uptake assay using COS-1 cells. It is selective for EAAT1 and EAAT2 over EAAT3 (IC50 = 300 nM), as well as the choline, dopamine, GABA, norepinephrine,...
| Schlagworte: | CF3-Bza-TBOA, 3S-[[3-[[4-(trifluoromethyl)benzoyl]amino]phenyl]methoxy]-(3S)-L-aspartic acid, monohydrate |
| Anwendung: | EAAT1 / EAAT2 inhibitor |
| MW: | 426.3 D |
ab 85,00 €
Anti-EAAT2
Artikelnummer: NSJ-R30166
0.5mg/ml if reconstituted with 0.2ml sterile DI water.
| Schlagworte: | Anti-EAAT2, Anti-SLC1A2, Anti-Solute carrier family 1 member 2, Anti-Glutamate/aspartate transporter II, Anti-Excitatory... |
| Anwendung: | WB, IF, IHC (paraffin) |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
772,00 €
LDN-0212320
Artikelnummer: Cay21650-10
LDN-0212320 is an activator of excitatory amino acid transporter 2 (EAAT2) that increases expression of EAAT2 in PA-EAAT2 cells in a concentration- and time-dependent manner (EC50 = 1.83 µM). It selectively increases EAAT2 protein levels over EAAT1 and EAAT3 protein levels and increases glutamate uptake in primary...
| Schlagworte: | OSU-0212320, 3-[[(2-methylphenyl)methyl]thio]-6-(2-pyridinyl)-pyridazine |
| Anwendung: | EAAT2 expression activator |
| CAS | 894002-50-7 |
| MW: | 293.4 D |
ab 85,00 €
Dihydrokainic Acid
Artikelnummer: Cay28478-1
Dihydrokainic acid (DHK) is an inhibitor of excitatory amino acid transporter 2 (EAAT2, Ki = 23 µM for glutamate uptake by COS cells expressing EAAT2). It is selective for EAAT2 over EAAT1 and EAAT3 (Ki = >3 mM for both). DHK microinfusion (5 nmol) into the rat infralimbic cortex reduces the time spent immobile in...
| Schlagworte: | DHK, (2S,3S,4R)-2-carboxy-4-(1-methylethyl)-3-pyrrolidineacetic acid |
| Anwendung: | EAAT2 inhibitor |
| CAS | 52497-36-6 |
| MW: | 215.2 D |
ab 52,00 €