Zu "K05361" wurden 75 Artikel gefunden!
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(1S,3R)-RSL3
Artikelnummer: Cay19288-5
(1S,3R)-RSL3 is a ferroptosis inducer and is canonically known as an inhibitor of glutathione peroxidase 4 (GPX4). It inhibits GPX4 in a context-dependent manner: (1S,3R)-RSL3 inhibits GPX4 in the presence of cell cytosol or recombinant human 14-3-3epsilon, an adaptor protein, but does not inhibit recombinant human...
| Schlagworte: | (1S,3R)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1H-pyrido[3,4-b]indole-3-carboxylic acid,... |
| Anwendung: | GPX4 inhibitor |
| CAS | 1219810-16-8 |
| MW: | 440.9 D |
ab 43,00 €
RSL3
Artikelnummer: TGM-T3646-100mg
Description: RSL3 (RSL3 1S) is an inhibitor of GPX4, and inhibits system xc- that blocks GSH synthesis (IC50=100 nM). RSL3 is a VDAC-independent activator of ferroptosis that is selective for tumor cells carrying oncogenic RAS. Target: GPX, Glutathione Peroxidase, Ferroptosis. Smiles:...
| Schlagworte: | 1S,3R-RSL3, RSL3 1S |
| Anwendung: | GPX4 inhibitor |
| CAS | 1219810-16-8 |
| MW: | 440.88 D |
ab 33,00 €
Liproxstatin-1 analog
Artikelnummer: TGM-T38551-10mg
Description: Liproxstatin-1 analog is a potent ferroptosis inhibitor, derived from liproxstatin-1 with a similar structure. It effectively inhibits ferroptotic cell death, with an IC50 value of 22 nM. Target: Others. Smiles: N=1C=2C=CC=CC2NC3(C1NC(C)(C)C)CCNCC3. References: Friedmann Angeli JP, et al. Inactivation...
| Anwendung: | Ferroptosis inhibitor analog |
| CAS | 1170643-61-4 |
| MW: | 272.39 D |
ab 179,00 €
PKUMDL-LC-101-D04
Artikelnummer: TGM-T36935-100mg
Description: PKUMDL-LC-101-D04 is a potent allosteric activator of glutathione peroxidase 4 (GPX4), a regulator of ferroptosis. GPX4 activity was increased to 150% of control levels when used at a concentration of 20 µM in a cell-free assay, and at a concentration of 61 µM in wild-type, but not Gpx4-/-, mouse...
| Schlagworte: | GPX4-Activator-1d4, PKUMDL-LC-101-D04 |
| Anwendung: | GPX4 allosteric activator |
| CAS | 2143896-83-5 |
| MW: | 378.94 D |
ab 78,00 €
JKE-1674
Artikelnummer: TGM-T37314-100mg
Description: JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4). JKE-1674 is an active metabolite of the GPX4 inhibitor ML-210. Target: GPX. Smiles: O\N=C(/C[N+]([O-])=O)C(=O)N1CCN(CC1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1. References: Kathman SG, et al. A masked zinger to block GPX4. Nat Chem Biol. 2020,16(5):482-483.
| Anwendung: | Glutathione peroxidase 4 (GPX4) inhibitor |
| CAS | 2421119-60-8 |
| MW: | 451.3 D |
ab 48,00 €
FIN56
Artikelnummer: TGM-T4066-100mg
Description: FIN56, a specific inducer of ferroptosis, is identified by its IUPAC name [1,3,8-trihydroxy-6-methylanthracen-9(10H)-one]. Target: Ferroptosis. Smiles: ON=C1c2cc(ccc2-c2ccc(cc12)S(=O)(=O)NC1CCCCC1)S(=O)(=O)NC1CCCCC1. References: Shimada K, et al. Global survey of cell death mechanisms reveals metabolic...
| Anwendung: | Ferroptosis inducer |
| CAS | 1083162-61-1 |
| MW: | 517.66 D |
ab 35,00 €
BCP-T.A
Artikelnummer: TGM-T62827-10mg
Description: BCP-T.A is an ferroptosis inducer that acts by binding to GPX4. Target: GPX, Ferroptosis. Smiles: O=C(C=1N=C(C#C)SC1)N2CCN(CC2)C(C3=CC=C(Cl)C=C3)C4=CC=C(Cl)C=C4. References: Endri Karaj, et al. Design, Synthesis, and Monoamine Oxidase B Selective Inhibitory Activity of N-Arylated Heliamine Analogues. J...
| Anwendung: | Ferroptosis inducer |
| CAS | 2786829-70-5 |
| MW: | 456.39 D |
ab 77,00 €
N6F11
Artikelnummer: TGM-T77745-100mg
Description: N6F11 is a novel, selective and potent inducer of ferroptosis with anticancer and antitumour activity that promotes GPX4 degradation by binding to TRIM25 in cancer cells.N6F11 can be used to study pancreatic cancer. Target: GPX. Smiles: ClCC1=NC2=C(SC(=C2)C2=CC=C(Cl)C=C2)C(=O)N1. References: Li J, et...
| Anwendung: | Ferroptosis inducer, GPX4 degradation inducer |
| CAS | 851398-76-0 |
| MW: | 311.19 D |
ab 190,00 €
GPX4-IN-5
Artikelnummer: TGM-T77755-100mg
Description: GPX4-IN-5 is a small molecule covalent GPX4 inhibitor (IC50: 0.12 µM) with antitumour activity.GPX4-IN-5 induces ferroptosis and can be used for the prevention and treatment of triple-negative breast cancer (TNBC). Target: GPX. Smiles: O=C(N(C1=CC=C2OCCOC2=C1)C3=CC(OC)=C(F)C(OC)=C3)CCl. References: Chen...
| Anwendung: | Covalent GPX4 inhibitor |
| CAS | 2922824-09-5 |
| MW: | 381.78 D |
ab 62,00 €
GPX4 Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPY-06701-100ug
Description: GPX4 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 20.59 kDa and the accession number is P36969.
| Schlagworte: | GluA4, PHGPx, GPx-4, MCSP, GLUR4, snPHGPx, GLURD, snGPx, NEDSGA, GSHPx-4, GLUR4C |
| MW: | 20.59 kD |
ab 581,00 €
FINO2
Artikelnummer: TGM-T60084-100mg
Description: FINO2 is a potent ferroptosis-inducing compound that inhibits GPX4 activity. It functions as a stable oxidant, effectively oxidizing ferrous iron and demonstrating stability across varying pH levels. Furthermore, FINO2 induces widespread lipid peroxidation. Target: Ferroptosis. Smiles:...
| Anwendung: | Ferroptosis-inducing peroxide compound |
| CAS | 869298-31-7 |
| MW: | 256.38 D |
ab 52,00 €
GPX4-IN-3
Artikelnummer: TGM-T63729-10mg
Description: GPX4-IN-3 (26a) is a potent inhibitor of glutathione peroxidase 4 (GPX4), selectively inducing ferroptosis, with a 71.7% inhibition rate at a concentration of 1 µM [1]. Target: Others. Smiles: C(N(C(CCl)=O)C1=CC=C(C=C1)C2=CN=CO2)(C(NCCC3=CC=CC=C3)=O)C=4C=5C(SC4)=CC=CC5
| Anwendung: | GPX4 inhibitor |
| CAS | 2761004-85-5 |
| MW: | 530.04 D |
ab 137,00 €