Zu "K05222" wurden 98 Artikel gefunden!
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QX-314 chloride
Artikelnummer: TGM-T12608-100mg
Description: QX-314 chloride is a membrane-impermeable, permanently charged blocker of the sodium channel. Target: Sodium Channel. Smiles: [Cl-].CC[N+](CC)(CC)CC(=O)Nc1c(C)cccc1C. References: Rivera-Acevedo RE, et al. The quaternary lidocaine derivative, QX-314, exerts biphasic effects on transient receptor...
| Anwendung: | Sodium channel blocker |
| CAS | 5369-03-9 |
| MW: | 298.85 D |
ab 48,00 €
JYL 1421
Artikelnummer: TGM-T15634-100mg
Description: JYL 1421 (SC 0030) is an antagonist of TRPV1 receptor (IC50 = 8 nM). Target: TRP/TRPV Channel. Smiles: CC(C)(C)c1ccc(CNC(=S)NCc2ccc(NS(C)(=O)=O)c(F)c2)cc1. References: Jakab B, et al. Pharmacological characterization of the TRPV1 receptor antagonist JYL1421 (SC0030) in vitro and in vivo in the rat. Eur...
| Schlagworte: | SC 0030 |
| Anwendung: | Selective TRPV1 receptor antagonist |
| CAS | 401907-26-4 |
| MW: | 423.57 D |
ab 751,00 €
Mavatrep
Artikelnummer: TGM-T16014-100mg
Description: Mavatrep (JNJ-39439335) is a selective antagonist of TRPV1 with Ki of 6.5 nM and can be used for studies about inflammatory pain. Target: TRP/TRPV Channel. Smiles: CC(C)(O)c1ccccc1-c1ccc2nc(\C=C\c3ccc(cc3)C(F)(F)F)[nH]c2c1. References: Parsons WH, et al. Benzo[d]imidazole Transient Receptor Potential...
| Schlagworte: | JNJ-39439335 |
| Anwendung: | Targets transient receptor potential cation channel subfamily V member 1 (TRPV1) |
| CAS | 956274-94-5 |
| MW: | 422.44 D |
ab 59,00 €
Dihydrocapsaicin
Artikelnummer: TGM-T2163-100mg
Description: Dihydrocapsaicin (CCRIS1589) is isolated from Capsicum fruit. Capsaicin is the primary active component of the heat and pain-eliciting lipid soluble fraction of the Capsicum pepper. Like capsaicin, dihydrocapsaicin is an irritant. Capsaicin is found in natural hot pepper extracts along with a number of...
| Schlagworte: | 8-Methyl-N-vanillylnonanamide, 6,7-Dihydrocapsaicin, CCRIS1589 |
| Anwendung: | Natural product, VR1 agonist |
| CAS | 19408-84-5 |
| MW: | 307.43 D |
ab 48,00 €
A 784168
Artikelnummer: TGM-T21750-5mg
Description: A-784168, a potent and orally active inhibitor of vanilloid receptor type 1 (TRPV1), acts on a ligand-gated nonselective cation channel pivotal in integrating pain stimuli including endogenous lipids, capsaicin, heat, and low pH. It demonstrates commendable central nervous system (CNS) penetration upon...
| Anwendung: | TRPV1 antagonist |
| CAS | 824982-41-4 |
| MW: | 479.4 D |
421,00 €
Piperine
Artikelnummer: TGM-T3002-100mg
Description: Piperine (Bioperine) , a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders. Target: Endogenous Metabolite, P-gp, Autophagy, P450. Smiles: O=C(\C=C\C=C\C1=CC2=C(OCO2)C=C1)N1CCCCC1. References: Bhardwaj RK, et al. J Pharmacol Exp Ther, 2002, 302(2),...
| Schlagworte: | Bioperine, 1-Piperoylpiperidine |
| Anwendung: | TRPV1 activator, MAO-A / MAO-B inhibitor |
| CAS | 94-62-2 |
| MW: | 285.34 D |
ab 30,00 €
Resiniferatoxin
Artikelnummer: TGM-T34295-1mg
Description: Resiniferatoxin ([3H]resiniferatoxin) inhibits the production of Th1 cytokines, contributing to the defense against T. spiralis infection, and can be used in studies about the modulator of the immune response. Target: IL Receptor. Smiles:...
| Schlagworte: | [3H]resiniferatoxin, RTX |
| Anwendung: | Highly potent TRPV1 agonist |
| CAS | 57444-62-9 |
| MW: | 628.71 D |
446,00 €
![[6]-Gingerol](https://www.biomol.com/media/image/b7/25/06/TGM-T3405-1mL_200x200.png "[6]-Gingerol")
[6]-Gingerol
Artikelnummer: TGM-T3405-1mL
Description: [6]-Gingerol ((S)-(+)-[6]Gingerol), an antioxidant, protects HL-60 cells from oxidative stress. It has protective effects for Yous tumors in the pancreas, ovaries, breast tissue, the bowel, among other tissues. Target: Apoptosis, AMPK. Smiles: CCCCC[C@H](O)CC(=O)CCc1ccc(O)c(OC)c1. References:...
| Schlagworte: | gingerol, 6-Gingerol, (S)-(+)-[6]Gingerol |
| Anwendung: | TRPV1 & TRPA1 activator |
| CAS | 23513-14-6 |
| MW: | 294.39 D |
ab 56,00 €
PDDHV
Artikelnummer: TGM-T37086-1mg
Description: PDDHV is a resiniferatoxin-type phorboid vanilloid with capsaicin-like selectivity for the cloned rat transient receptor potential cation channel subfamily V member 1 (TRPV1), formerly known as vanilloid receptor 1. It induces Ca2+-uptake by rat dorsal root ganglion neurons with an EC50 value of 70 nM....
| Anwendung: | TRPV1 agonist |
| CAS | 179469-40-0 |
| MW: | 837.09 D |
154,00 €
CAY10568
Artikelnummer: TGM-T37670-100mg
Description: Most local anesthetics act by abolishing voltage gated sodium channel currents indiscriminately in all populations of neurons. Selective analgesia through TRPV1-mediated entry of a cationic lidocaine derivative, QX314, was recently reported. CAY10568 is a physically smaller, less hydrophobic version of...
| Anwendung: | Metabolic studies |
| CAS | 22913-17-3 |
| MW: | 320.174 D |
ab 91,00 €
TETRAHYDROPIPERINE
Artikelnummer: TGM-T5786-100mg
Description: Tetrahydropiperine (Cosmoperine) is a natural product derived from piperine, can be used to treat convulsion, epilepsy, relieve pain, and control insects. Target: P450, TRP/TRPV Channel. Smiles: O=C(CCCCc1ccc2OCOc2c1)N1CCCCC1. References: Edwin Andrés Correa, H?Gest?Tt E D , Sterner O , et al. In vitro...
| Schlagworte: | Cosmoperine |
| Anwendung: | TRPV1 agonist |
| CAS | 23434-88-0 |
| MW: | 289.37 D |
ab 41,00 €
SB-366791
Artikelnummer: TGM-T6977-100mg
Description: SB-366791 is a new and selective cinnamide TRPV1 antagonist. Target: TRP/TRPV Channel. Smiles: COC1=CC=CC(NC(=O)\C=C\C2=CC=C(Cl)C=C2)=C1. References: Gunthorpe MJ,et al. Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist. Neuropharmacology....
| Schlagworte: | SB366791 |
| Anwendung: | TRPV1 antagonist |
| CAS | 472981-92-3 |
| MW: | 287.74 D |
ab 33,00 €