Zu "K05220" wurden 57 Artikel gefunden!
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Brilliant blue G-250
Artikelnummer: TGM-T20731-100mg
Description: Brilliant blue G-250 (Acid blue 90, Coomassie Brilliant Blue G) is an antagonist of the P2X7 purinergic receptor. Target: P2X Receptor. Smiles: O=S(C1=CC=CC(CN(CC)C2=CC=C(/C(C3=CC=C(NC4=CC=C(OCC)C=C4)C=C3)=C5C(C)=C/C(C=C/5)=[N+](CC)\CC6=CC=CC(S(=O)([O-])=O)=C6)C(C)=C2)=C1)([O-])=O.[Na+]. References:...
| Schlagworte: | Acid blue 90, Coomassie Brilliant Blue G, Brilliant Blue G, BBG |
| Anwendung: | Targets P2X purinoceptor 7 (P2RX7) |
| CAS | 6104-58-1 |
| MW: | 854.02 D |
ab 37,00 €
A 438079 hydrochloride
Artikelnummer: TGM-T2673-100mg
Description: A 438079 hydrochloride (A-438079 HCl) is a potent and selective P2X7 receptor antagonist with pIC50 of 6.9. Target: P2X Receptor. Smiles: Cl.Clc1cccc(-c2nnnn2Cc2cccnc2)c1Cl. References: McGaraughty S, et al. Neuroscience. 2007, 146(4), 1817-1828.
| Schlagworte: | A 438079 (hydrochloride), A-438079 HCl, A-438079 hydrochloride |
| Anwendung: | P2X7 antagonist |
| CAS | 899431-18-6 |
| MW: | 342.61 D |
ab 42,00 €
A-804598
Artikelnummer: TGM-T3639-100mg
Description: A-804598 is a competitive and selective P2X7 receptor antagonist (IC50: 10 nM, rat, 9 nM, mouse, 11 nM, human). Target: P2X Receptor. Smiles: C[C@H](N(C(=N)NC#N)c1cccc2ncccc12)c1ccccc1. References: Donnelly-Roberts DL, et al. Neuropharmacology. 2009 Jan,56(1):223-9.
| Schlagworte: | A 804598 |
| Anwendung: | P2X7 antagonist |
| CAS | 1125758-85-1 |
| MW: | 315.37 D |
ab 25,00 €
A-740003
Artikelnummer: TGM-T3690-100mg
Description: A-740003 (A 740003) is an effective and specific P2X7 receptor antagonist (IC50: 18/40 nM, for rat/human). It can reduce nociception in animal models of persistent neuropathic and inflammatory pain, and also reduce neuroblastoma tumor growth in mice. Target: P2X Receptor. Smiles:...
| Schlagworte: | A 740003 |
| Anwendung: | P2RX7 antagonist |
| CAS | 861393-28-4 |
| MW: | 474.55 D |
ab 34,00 €
JNJ-47965567
Artikelnummer: TGM-T4298-100mg
Description: JNJ-47965567 (JNJ-479655) is a selective antagonist of the purinergic receptor P2X subtype 7 (P2X7), a ligand-gated ion channel(with pKis of 7.9 and 8.7 for human and rat P2X7, respectively). Target: P2X Receptor. Smiles: O=C(NCC1(CCOCC1)N1CCN(CC1)c1ccccc1)c1cccnc1Sc1ccccc1. References: Pharmacological...
| Schlagworte: | JNJ-479655 |
| Anwendung: | P2X7 antagonist |
| CAS | 1428327-31-4 |
| MW: | 488.64 D |
ab 34,00 €
GW791343 dihydrochloride
Artikelnummer: TGM-T7805-100mg
Description: GW791343 dihydrochloride (GW791343 (HCl)) is a P2X7 allosteric modulator. Target: P2X Receptor. Smiles: Cl.Cl.Cc1ccc(CN2CCNCC2)cc1NC(=O)CNc1ccc(F)c(F)c1. References: A D Michel, L J Chambers, D S Walter. Negative and positive allosteric modulators of the P2X7 receptor [J]. British Journal of...
| Schlagworte: | GW791343 (HCl) |
| Anwendung: | Allosteric purinergic P2X7 receptor modulator |
| CAS | 1019779-04-4 |
| MW: | 447.35 D |
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BzATP triethylammonium salt
Artikelnummer: TGM-TP2226-10mg
Description: BzATP triethylammonium salt is a P2X7 receptor agonist. Target: P2X Receptor. Smiles: O[C@H]1[C@H](N2C=NC3=C2N=CN=C3N)O[C@H](COP(OP(OP([O-])(O)=O)(O)=O)(O)=O)[C@H]1OC(C4=CC=C(C(C5=CC=CC=C5)=O)C=C4)=O.[NH4+]. References: Ji Z, et al. Involvement of P2X7 Receptor in Proliferation and Migration of Human...
| Anwendung: | Prototypic P2X7 receptor agonist |
| CAS | 112898-15-4 |
| MW: | 1018.96 D |
ab 42,00 €
A 839977
Artikelnummer: TGM-T14076-1mg
Description: A-839977 is a selective P2X7 receptor antagonist with anti-inflammatory and analgesic properties, inhibiting BzATP-induced calcium efflux from the P2X7 receptor, and is used in the study of renal fibrosis. Target: P2X Receptor, Calcium Channel. Smiles: Clc1cccc(c1Cl)-n1nnnc1NCc1ccccc1Oc1ccccn1....
| Schlagworte: | A-839977, A839977 |
| Anwendung: | P2X7 receptor antagonist |
| CAS | 870061-27-1 |
| MW: | 413.26 D |
ab 38,00 €
AZ10606120 dihydrochloride
Artikelnummer: TGM-T14366-10mg
Description: AZ10606120 dihydrochloride is a selectable, potent, high-affinity receptor antagonist with K D values of 1.4 and 19 nM at human and rat P2X 7 receptors, respectively. AZ10606120 dihydrochloride inhibits tumor growth and has anti-angiogenic activity. AZ 10606120 acts as a negative allosteric modulator...
| Anwendung: | P2X7 receptor antagonist |
| CAS | 607378-18-7 |
| MW: | 495.48 D |
ab 60,00 €
Human P2RX7 Protein, hFc Tag
Artikelnummer: DIM-PME100377.10
Recombinant human P2RX7 protein with N-terminal human Fc tag. hFc(Glu99-Ala330) P2RX7(Ser47-Val334), Protein function: Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in...
| Schlagworte: | P2X7 |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | 59.2 kD |
ab 118,00 €
P2RX7 (human) full length protein-synthetic nanodisc
Artikelnummer: DIM-FLP100049.10
Discover a breakthrough in membrane protein research and drug development with DIMA Biotech's Synthetic Nanodiscs. Traditional methods struggle with challenges in obtaining water-soluble and bioactive forms of multi-transmembrane proteins. Our innovative polymer-based Nanodisc platform offers a game-changing...
| Schlagworte: | P2X7, P2RX7, ATP receptor, P2Z receptor, P2X purinoceptor 7, Purinergic receptor, P2X7, Human P2RX7 full length... |
| Anwendung: | Full length transmembrane protein, FA, ELISA, screening, immunization, cell-based assays, crystallization |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | 68.4 kD |
ab 1.291,00 €
BzATP (triethylammonium salt)
Artikelnummer: Cay15577-1
The P2X purinergic receptors are ligand-gated ion channels that are activated by extracellular ATP. BzATP (ammonium salt) is an activator of the P2X receptors that exhibits 5-30-fold greater potency at the P2X7 receptor than ATP. It activates the human, rat, and mouse receptors with EC50 values of 0.7, 3.6, and 285...
| Schlagworte: | (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-(((hydroxy((hydroxy(phosphonooxy)phosphoryl)oxy)phosphoryl)oxy)methyl)... |
| Anwendung: | P2X receptor activator |
| MW: | 816.6 D |
61,00 €