Zu "K05217" wurden 34 Artikel gefunden!
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Sivopixant
Artikelnummer: TGM-T40045-100mg
Description: Sivopixant (S-600918) (S-600918) is a potent and selective antagonist of P2X3 receptor (P2X3 IC 50 =4.2 nM, P2X2/3 IC 50 =1100 nM). Sivopixant shows strong analgesic effect . Target: P2X Receptor. Smiles: C(N1\C(=N\C2=CC=C(OC3=CC=CC=N3)C=C2)\NC(=O)N(C[C@@H](C(O)=O)C)C1=O)C4=CC=C(Cl)C=C4. References: Kai...
| Schlagworte: | Sivopixant, S-600918 |
| Anwendung: | Targets P2X purinoceptor 3 (P2RX3) |
| CAS | 2414285-40-6 |
| MW: | 507.93 D |
ab 88,00 €
RO-3
Artikelnummer: TGM-T5513-100mg
Description: RO3 is a selective antagonist of homomeric P2X3 and heteromeric P2X2/3 receptor. Target: P2X Receptor. Smiles: COc1cc(Cc2cnc(N)nc2N)c(cc1OC)C(C)C. References: Gever J R , Cockayne D A , Dillon M P , et al. Pharmacology of P2X channels[J]. Pflügers Archiv European Journal of Physiology, 2006, 452(5):513-37.
| Anwendung: | Purinergic receptor P2X3 /P2X2/3 dual antagonist |
| CAS | 1026582-88-6 |
| MW: | 302.37 D |
ab 48,00 €
Eliapixant
Artikelnummer: TGM-T9519-100mg
Description: Eliapixant (BAY 1817080) (BAY 1817080) is a potent and selective P2X3 receptor antagonist, with an IC50 of 8 nM. Eliapixant can be used for the research of refractory chronic cough. Target: P2X Receptor. Smiles: C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F. References: Spinaci...
| Schlagworte: | BAY 1817080 |
| Anwendung: | Targets P2X purinoceptor 3 (P2RX3) |
| CAS | 1948229-21-7 |
| MW: | 478.49 D |
ab 134,00 €
AF-353 hydrochloride
Artikelnummer: TGM-T85192-10mg
Description: This novel compound is an orally bioavailable antagonist of P2X3/P2X2/3 receptors, exhibiting potent activity with a pIC50 of 8 in both human and rat, and a pIC50 of 7.3 specifically for the human P2X2/3 receptor. It demonstrates high brain penetration, evidenced by a brain to plasma ratio of 6, and...
| Schlagworte: | P2X3 Purinergic Receptor Antagonist, AF353, P2X2/3 Purinergic Receptor Antagonist, AF353 |
| Anwendung: | P2X3 receptor antagonist |
| CAS | 927887-18-1 |
| MW: | 436.68 D |
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A-317491
Artikelnummer: TGM-TQ0002-100mg
Description: A-317491 (ABT 202) is a non-nucleotide P2X3 ( Ki: 22 nM) and P2X2/3 receptor (Ki: 9 nM) antagonist, which inhibits calcium flux mediated by the receptors. Target: P2X Receptor. Smiles: OC(=O)c1cc(C(O)=O)c(cc1C(O)=O)C(=O)N(Cc1cccc(Oc2ccccc2)c1)[C@H]1CCCc2ccccc12. References: Jarvis MF,et al. A-317491, a...
| Schlagworte: | ABT 202 |
| Anwendung: | Non-nucleotide P2X3 / P2X2/3 receptor antagonist |
| CAS | 475205-49-3 |
| MW: | 565.57 D |
ab 31,00 €
Gefapixant citrate
Artikelnummer: TGM-T63846-100mg
Description: Gefapixant citrate is an orally active P2X3 receptor (P2X3R) antagonist that acts on human homologous recombinant hP2X3 (IC50: ~30 nM) and hP2X2/3 (IC50: 100-200 nM). Gefapixant citrate can be used to study chronic cough and knee osteoarthritis. Target: Others. Smiles:...
| Anwendung: | Targets P2X purinoceptor 3 (P2RX3) |
| CAS | 2310299-91-1 |
| MW: | 545.52 D |
ab 58,00 €
Camlipixant
Artikelnummer: TGM-T67885-100mg
Description: Camlipixant (BLU-5937) is an orally active purine P2X3 receptor antagonist that is potent, selective and competitive. camlipixant has an IC50 of 25 nM for the hP2X3 homotrimer. camlipixant can be used for the treatment of respiratory disorders and Camlipixant has a strong cough suppressant effect....
| Schlagworte: | BLU-5937 |
| Anwendung: | Targets P2X purinoceptor 3 (P2RX3) |
| CAS | 1621164-74-6 |
| MW: | 458.46 D |
ab 97,00 €
Anti-P2RX3
Artikelnummer: CSB-PA005140.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-P2X3, Anti-P2RX3, Anti-ATP receptor, Anti-P2X purinoceptor 3, Anti-Purinergic receptor, ATP receptor antibody,... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 126,00 €
Anti-P2RX3
Artikelnummer: CSB-PA056352.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: P2RX3. Antigen Species: Human
| Schlagworte: | Anti-P2X3, Anti-P2RX3, Anti-ATP receptor, Anti-P2X purinoceptor 3, Anti-Purinergic receptor, ATP receptor antibody,... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 167,00 €
Gefapixant
Artikelnummer: Cay40825-1
Gefapixant is an allosteric antagonist of the purinergic P2X3 receptor. It inhibits agonist-induced P2X3 and P2X2/3 currents in 1321N1 cells co-expressing human P2X2 and P2X3 (IC50s = 153 and 220 nM, respectively) but does not inhibit P2X2 currents in the same cells at 10 µM. In vivo, gefapixant (30 mg/kg) increases...
| Schlagworte: | AF-219, MK-7264, Ro 4926219, 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)-benzenesulfonamide |
| Anwendung: | P2X3 receptor antagonist, analgesic, antitussive |
| CAS | 1015787-98-0 |
| MW: | 353.4 D |
ab 40,00 €
alpha,beta-Methyleneadenosine 5'-triphosphate (sodium salt)
Artikelnummer: Cay10008956-10
alpha,beta-Methyleneadenosine 5'-triphosphate (alphabeta-methylene ATP) is a phosphonic analog of ATP that is characterized by the replacement of the bridging oxygen atom between the alpha- and beta-phosphate groups with methylene. It is an agonist of P2X purinoceptors P2X1 and P2X3 (EC50 = ~1 µM) and is ~1,000-fold...
| Schlagworte: | alphabeta-methylene ATP, 5'-[hydrogen P-[[hydroxy(phosphonooxy)phosphinyl]methyl]phosphonate] adenosine, trisodium salt |
| Anwendung: | P2X1 / P2X3 agonist |
| CAS | 1343364-54-4 |
| MW: | 571.2 D |
ab 85,00 €
AF-353 (hydrochloride)
Artikelnummer: Cay23034-5
AF-353 is a noncompetitive dual antagonist of the purinoreceptors P2X3 and P2X2/3 (IC50s = 10 and 79.4 nM, respectively). It is selective for P2X3 and P2X2/3 over P2X1, P2X2, P2X4, P2X5, and P2X7 (IC50 = >10 µM for all). It inhibits calcium flux in CHO-K1 cells expressing the rat P2X3 receptor and in 1321N1 cells...
| Schlagworte: | Ro-4, 5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinediamine |
| Anwendung: | P2X3 receptor antagonist |
| CAS | 927887-18-1 |
| MW: | 436.7 D |
ab 52,00 €