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Zu "K05184" wurden 32 Artikel gefunden!
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Artikelnummer: Cay26417-50
U-93631 is a GABAA receptor ligand. It accelerates decay of GABA-induced currents in HEK293 cells expressing rat alpha1beta2, beta2gamma2, and alpha1gamma2 subunit-containing GABAA receptors when used at a concentration of 5 µM. U-93631 inhibits radioligand binding to the picrotoxin site on alpha1beta2gamma2...
Schlagworte: | 4,5-dihydro-4,4-dimethyl-imidazo[1,5-a]quinoxaline-3-carboxylic acid, 1,1-dimethylethyl ester |
Anwendung: | GABA(A) receptor ligand |
CAS | 152273-12-6 |
MW: | 299.4 D |
ab 172,00 €
Artikelnummer: Cay16930-5
Allopregnanolone (Cay-16930) is an analytical reference standard categorized as a GABAA and GABAC receptor positive allosteric modulator. Allopregnanolone has anxiolytic-like and anticonvulsant activities in rodents. Formulations containing allopregnanolone have been used in the treatment of postpartum depression....
Schlagworte: | 3alpha,5alpha-tetrahydro Progesterone, 3alpha,5alpha-THP, ALLO, 3alpha-hydroxy-5alpha-pregnan-20-one |
Anwendung: | Endogenous inhibitory pregnane neurosteroid |
CAS | 516-54-1 |
MW: | 318.5 D |
ab 54,00 €
Artikelnummer: Cay28411-25
Bretazenil is a positive allosteric modulator of GABAA receptors with anticonvulsant and anxiolytic activity. It potentiates GABA-gated chloride currents in rat cortical neurons and in HEK293 cells expressing alpha1beta1gamma2 subunit-containing GABAA receptors (EC50s = 60 and 10 nM, respectively). Bretazenil...
Schlagworte: | Ro 16-6028, (13aS)-8-bromo-11,12,13,13a-tetrahydro-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic... |
Anwendung: | GABA-A receptor positive allosteric modulator |
CAS | 84379-13-5 |
MW: | 418.3 D |
ab 50,00 €
Artikelnummer: 200-301-F33
Anti-GABA-A receptor delta Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with GABA-A receptor delta from mouse and rat based on 100% homology with the immunizing sequence. No cross-reactivity against GABA-A-R-Beta 2 or -Beta3. Cross-reactivity with GABA-A...
Schlagworte: | Anti-Gabrd, Anti-GABA(A) receptor subunit delta, Anti-Gamma-aminobutyric acid receptor subunit delta |
Anwendung: | ELISA, IHC, IFM, WB |
Wirt: | Mouse |
Spezies-Reaktivität: | rat, mouse |
698,00 €
-30 %
Rabattaktion
Artikelnummer: ARG22235.50
Protein function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. [The UniProt Consortium]
Schlagworte: | Anti-Gabrd, Anti-GABA(A) receptor subunit delta, Anti-Gamma-aminobutyric acid receptor subunit delta |
Anwendung: | WB, IHC, ICC, IF |
Wirt: | Mouse |
Spezies-Reaktivität: | human, mouse, rat |
520,00 €
364,00 €
Artikelnummer: Cay10600-1
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative,...
Schlagworte: | gamma-Aminobutyric Acid A Receptor |
Anwendung: | ICC, IHC, WB |
Wirt: | Rabbit |
Spezies-Reaktivität: | rat |
564,00 €
Artikelnummer: Cay17588-5
Ionotropic GABAA receptors are ligand-gated ion channels that facilitate the passing of chloride ions across the cell membrane and promote an inhibitory influence on target neurons. These receptors are the major targets for benzodiazepines and related anxiolytic drugs. 6-(4-Methoxyphenyl)-3-pyridazinamine is an...
Schlagworte: | 6-(4-methoxyphenyl)-3-pyridazinamine |
Anwendung: | GABAA receptor antagonist |
CAS | 4776-87-8 |
MW: | 201.2 D |
ab 84,00 €
Artikelnummer: Cay18431-25
3beta,5alpha-THDOC is a neurosteroid. It inhibits seizures induced by pilocarpine, but not pentylenetetrazol (PTZ, Cay-18682), in mice (ED50s = 45.9 and >100 mg/kg, respectively). 3beta,5alpha-THDOC has been found in the urine of women during the third trimester of pregnancy.Formal Name:...
Schlagworte: | 3beta,21-dihydroxy-5alpha-Pregnan-20-one, 3beta,5alpha-Tetrahydrodeoxycorticosterone, 3beta,5alpha-Tetrahydroprogesterone,... |
Anwendung: | GABAA receptor modulator control |
CAS | 567-01-1 |
MW: | 334.5 D |
ab 43,00 €
Artikelnummer: Cay20919-25
Ganaxolone (Cay-20919) is an analytical reference standard categorized as a GABAA receptor positive allosteric modulator. Ganaxolone has anticonvulsant activity in mice. Ganaxolone is regulated as a Schedule V compound in the United States. This product is intended for research and forensic applications.Formal Name:...
Schlagworte: | CCD 1042, (3alpha,5alpha)-3-hydroxy-3-methyl-pregnan-20-one |
Anwendung: | Allopregnanolone analog |
CAS | 38398-32-2 |
MW: | 332.5 D |
ab 43,00 €
Artikelnummer: Cay15999-5
Etifoxine is a positive allosteric modulator of alpha1beta2gamma2 and alpha1beta3gamma2 subunit-containing GABAA receptors. It selectively increases GABA-induced currents in X. laevis oocytes expressing alpha1beta2gamma2 or alpha1beta3gamma2 over alpha1beta1gamma2 subunit-containing receptors at 20 µM. Etifoxine...
Schlagworte: | Etafenoxine, HOE 36-801, 6-chloro-N-ethyl-4-methyl-4-phenyl-4H-3, 1-benzoxazin-2-amine |
Anwendung: | Anxiolytic, Positive allosteric GABA(A) receptor modulator |
CAS | 21715-46-8 |
MW: | 300.8 D |
ab 115,00 €
Artikelnummer: Cay26524-50
(+)-Kavain is a kavalactone and the major constituent of the pepper plant kava (P. methysticum) and has diverse biological activities. It is a positive allosteric modulator of alpha4beta2delta subunit-containing GABAA receptors with EC50 values of 25 and 59 µM in the presence and absence of 300 µM (+)-kavain,...
Schlagworte: | Kawain, NSC 112162, (6R)-5,6-dihydro-4-methoxy-6-[(1E)-2-phenylethenyl]-2H-pyran-2-one |
Anwendung: | Bioactive kavalactone, alpha4beta2delta GABA(A) receptor PAM (positive allosteric modulator) |
CAS | 500-64-1 |
MW: | 230.3 D |
ab 43,00 €
Artikelnummer: Cay33437-50
Chlormethiazole is a potentiator of GABAA receptors. It potentiates GABA-induced currents in L-M(TK-) cells expressing alpha1beta1gamma2 or alpha1beta2gamma2 subunit-containing GABAA receptors with EC50 values of 0.8 and 3.4 µM, respectively. Chlormethiazole protects against seizures induced by maximal electroshock...
Schlagworte: | Clomethiazole, 5-(2-chloroethyl)-4-methyl-thiazole, monohydrochloride |
Anwendung: | GABAA receptors potentiator |
CAS | 6001-74-7 |
MW: | 198.1 D |
ab 50,00 €