Zu "K05121" wurden 112 Artikel gefunden!
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Tie2 Inhibitor 7
Artikelnummer: TGM-T36718-1mg
Description: Tie2 Inhibitor 7 blocks Tie2 kinase activity with a Ki value of 1.3 µM. It has been shown to inhibit angiopoietin 1-induced Tie2 autophosphorylation and downstream signaling with an IC50 value of 0.3 µM. This compound can prevent endothelial cell tube formation and aberrant vessel growth in a rat model...
| Anwendung: | Tie2 inhibitor |
| CAS | 1020412-97-8 |
| MW: | 529.63 D |
ab 574,00 €
BAY-826
Artikelnummer: TGM-T38930-1mg
Description: BAY-826 is a novel, potent and selective TIE-2 inhibitor that inhibits TIE-2 phosphorylation and can be used to study tumors. Target: Tie-2. Smiles: Cc1cc(C)c(cc1NC(=O)c1cc(cc(c1)S(F)(F)(F)(F)F)C#N)-n1ccn2nc(cc12)-c1cccnc1. References: Schneider H,et al. Novel TIE-2 inhibitor BAY-826 displays in vivo...
| Anwendung: | Tie2 inhibitor |
| CAS | 1448316-08-2 |
| MW: | 558.53 D |
69,00 €
EOC317
Artikelnummer: TGM-T4318-100mg
Description: EOC317 (ACTB-1003) is an oral kinase inhibitor with IC50 values of 6 nM, 2 nM, and 4 nM for FGFR1, VEGFR2, and Tie-2, respectively. Target: FGFR, VEGFR, Tie-2. Smiles: COCc1c(CN2CCOCC2)n2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)c(F)c1. References: Patel K, et al. ACTB-1003: An oral kinase...
| Schlagworte: | ACTB1003, ACTB 1003, ACTB-1003 |
| Anwendung: | Multi-kinase inhibitor |
| CAS | 939805-30-8 |
| MW: | 591.53 D |
ab 93,00 €
Pexmetinib
Artikelnummer: TGM-T6934-100mg
Description: Pexmetinib (ARRY-614) (ARRY-614) is a potent, orally bioavailable, dual p38 MAPK/Tie-2 inhibitor with IC50 of 4 nM/18 nM in a HEK-293 cell line. Phase 1. Target: Autophagy, p38 MAPK, Tie-2. Smiles: Cc1ccc(cc1)-n1nc(cc1NC(=O)NCc1cc(F)ccc1Oc1ccc2n(CCO)ncc2c1)C(C)(C)C. References: Koch K. 2013 AACR...
| Schlagworte: | ARRY-614 |
| Anwendung: | Tie2 inhibitor, p38 MAPK inhibitor |
| CAS | 945614-12-0 |
| MW: | 556.63 D |
ab 55,00 €
TIE2 Protein, Human, Recombinant (hFc)
Artikelnummer: TGM-TMPJ-00642-10ug
Description: TIE2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 120-150 KDa and the accession number is Q02763-1.
| Schlagworte: | soluble TIE2 variant 2, CD202b, TEK tyrosine kinase, endothelial, EC 2.7.10, Tie2, hTIE2, VMCM, p140 TEK, angiopoietin-1... |
| MW: | 150 kD |
ab 60,00 €
TIE2 Protein, Human, Recombinant (aa 23-745, His)
Artikelnummer: TGM-TMPJ-00643-10ug
Description: TIE2 Protein, Human, Recombinant (aa 23-745, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 100-120 KDa and the accession number is Q02763-1.
| Schlagworte: | EC 2.7.10, EC 2.7.10.1, angiopoietin-1 receptor, Tie-2, soluble TIE2 variant 1, CD202b antigen, VMCM, CD202b, TEK tyrosine... |
| MW: | 120 kD |
ab 52,00 €
TIE2 Protein, Rhesus, Recombinant (His)
Artikelnummer: TGM-TMPY-05049-100ug
Description: TIE2 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 84.2 kDa and the accession number is G7NFP9.
| Schlagworte: | TEK tyrosine kinase, endothelial |
| MW: | 84.2 kD |
ab 599,00 €
TIE2 Protein, Mouse, Recombinant (His), Biotinylated
Artikelnummer: TGM-TMPY-06974-100ug
Description: TIE2 Protein, Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 82.03 kDa and the accession number is Q02858.
| Schlagworte: | Hyk, Tie-2, Cd202b, TEK tyrosine kinase, endothelial, STK1, Tie2, AA517024 |
| MW: | 82.03 kD |
ab 397,00 €
TIE2 Protein, Rat, Recombinant (hFc)
Artikelnummer: TGM-TMPY-02508-200ug
Description: TIE2 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 108 kDa and the accession number is A6JRG8.
| Schlagworte: | TEK tyrosine kinase, endothelial |
| MW: | 108 kD |
599,00 €
TIE2 Protein, Human, Recombinant (His & GST)
Artikelnummer: TGM-TMPY-04545-50ug
Description: TIE2 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 68.3 kDa and the accession number is Q02763-1.
| Schlagworte: | TEK tyrosine kinase, endothelial, VMCM, CD202B, VMCM1, TIE-2, TIE2 |
| MW: | 68.3 kD |
397,00 €
TIE2 Protein, Mouse, Recombinant (aa 770-1122, His & GST)
Artikelnummer: TGM-TMPY-04575-50ug
Description: TIE2 Protein, Mouse, Recombinant (aa 770-1122, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 68.2kDa and the accession number is Q02858.
| Schlagworte: | AA517024, STK1, Cd202b, TEK tyrosine kinase, endothelial, Hyk, Tie2, Tie-2 |
| MW: | 68.2 kD |
397,00 €
Tie2 kinase inhibitor 1
Artikelnummer: TGM-T6335-100mg
Description: Tie2 kinase inhibitor 1 (Tie2 kinase inhibitor), an optimized compound of SB-203580, is selective to Tie2 with IC50 of 0.25 µM, which is 200-fold more effective than p38. Target: Tie-2. Smiles: COc1ccc2cc(ccc2c1)-c1[nH]c(nc1-c1ccncc1)-c1ccc(cc1)S(C)=O. References: Semones M, et al. Bioorg Med Chem Lett,...
| Schlagworte: | Tie2 kinase inhibitor |
| Anwendung: | Tie2 kinase inhibitor |
| CAS | 948557-43-5 |
| MW: | 439.53 D |
ab 60,00 €