Zu "K05119" wurden 151 Artikel gefunden!

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ALK-IN-1
ALK-IN-1

Artikelnummer: TGM-T3059-100mg

Description: ALK-IN-1 (AP26113) is a potent ALK inhibitor with IC50 of 0.62 nM in a cell-free assay, demonstrated ability overcome Crizotinib resistance mediated by a L1196M mutation. Phase 2. Target: ALK, EGFR, IGF-1R. Smiles: N(C1=C(P(C)(C)=O)C=CC=C1)C2=NC(NC3=C(OC)C=C(C=C3)N4CCC(N(C)C)CC4)=NC=C2Cl. References:...
Schlagworte: AP26113, Brigatinib, AP26113-analog
Anwendung: ALK inhibitor
CAS 1197958-12-5
MW: 529.01 D
ab 42,00 €
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X-376
X-376

Artikelnummer: TGM-T3550-100mg

Description: X-376 (Ensartinib) is an orally available small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with potential antineoplastic activity. Upon oral administration, X-396 binds to and inhibits ALK kinase, ALK fusion proteins, and ALK point mutation variants. Inhibition...
Schlagworte: X-396, Ensartinib
Anwendung: ALK inhibitor
CAS 1365267-27-1
MW: 547.41 D
ab 33,00 €
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Brigatinib
Brigatinib

Artikelnummer: TGM-T3621-100mg

Description: Brigatinib (AP-26113) is a highly potent and selective inhibitor of ALK. Target: FLT, IGF-1R, EGFR, ROS, ALK. Smiles: COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1)N1CCC(CC1)N1CCN(C)CC1. References: Wei-Sheng Huang, et al. J Med Chem, 2016, 59(10):4948-4964.
Schlagworte: AP-26113
Anwendung: Targets anaplastic lymphoma kinase [EC:2.7.10.1] (ALK, CD246)
CAS 1197953-54-0
MW: 584.09 D
ab 33,00 €
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ALK inhibitor 2
ALK inhibitor 2

Artikelnummer: TGM-T3041-100mg

Description: ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase. Target: ALK, FAK. Smiles: CNS(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(cc2OC)N2CCN(C)CC2)ncc1Cl. References: A Dose Finding Study With Oral LDK378 in Patients With Tumors Characterized by Genetic Abnormalities in Anaplastic Lymphoma Kinase...
Anwendung: ALK inhibitor
CAS 761438-38-4
MW: 518.03 D
ab 119,00 €
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CEP-37440
CEP-37440

Artikelnummer: TGM-T2655-1mg

Description: CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK). Target: FAK, ALK. Smiles: CNC(=O)c1ccccc1Nc1nc(Nc2ccc3C[C@@H](CCCc3c2OC)N2CCN(CCO)CC2)ncc1Cl. References: Iragavarapu C, et al. J Hematol Oncol. 2015 Feb 27,8(1):17.
Schlagworte: CEP37440
Anwendung: FAK1 & ALK inhibitor
CAS 1391712-60-9
MW: 580.12 D
ab 34,00 €
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Ensartinib
Ensartinib

Artikelnummer: TGM-T37585-100mg

Description: Ensartinib (X-396) is a potent dual ALK/MET inhibitor with IC50 values of <0.4 nM for ALK and 0.74 nM for MET. Target: Others. Smiles: C(=O)(N1C[C@@H](C)N[C@@H](C)C1)C2=CC=C(NC(=O)C3=CC(O[C@H](C)C4=C(Cl)C(F)=CC=C4Cl)=C(N)N=N3)C=C2. References: Lovly CM, et al. Insights into ALK-driven cancers revealed...
Anwendung: Targets anaplastic lymphoma kinase [EC:2.7.10.1] (ALK, CD246)
CAS 1370651-20-9
MW: 561.44 D
ab 1.822,00 €
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HG-14-10-04
HG-14-10-04

Artikelnummer: TGM-T4015-100mg

Description: HG-14-10-04 is a potent and specific ALK (anaplastic lymphoma kinase) inhibitor. Target: ALK. Smiles: COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12)N1CCC(CC1)N1CCN(C)CC1. References: U.S. Pat. Appl. Publ. (2012), US 20120028924 A1
Anwendung: ALK inhibitor
CAS 1356962-34-9
MW: 532.08 D
ab 55,00 €
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Alectinib hydrochloride
Alectinib hydrochloride

Artikelnummer: TGM-T8387-100mg

Description: Alectinib hydrochloride (RO5424802 Hydrochloride) is a selective, and orally available inhibitor of ALK( IC50 : 1.9 nM). Target: ALK. Smiles: Cl.CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1N1CCC(CC1)N1CCOCC1. References: Sakamoto H, et al. CH5424802, a selective ALK inhibitor capable of blocking the...
Schlagworte: CH5424802 (Hydrochloride), RO5424802 (Hydrochloride), AF-802 (Hydrochloride)
Anwendung: Antineoplastic, Anaplastic lymphoma kinase (ALK) inhibitor
CAS 1256589-74-8
MW: 519.08 D
ab 39,00 €
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ALK Protein, Mouse, Recombinant (hFc)
ALK Protein, Mouse, Recombinant (hFc)

Artikelnummer: TGM-TMPK-00927-100ug

Description: Anaplastic lymphoma kinase (ALK) is mostly known for its oncogenic role in several human cancers. Recent evidences clearly indicate new roles of ALK and its genetic aberrations (e.g. gene rearrangements and mutations) in immune evasion, innate and cell-mediated immunity. New ALK-related immunotherapy...
Schlagworte: Anaplastic lymphoma kinase, ALK tyrosine kinase receptor, CD246
MW: 101.11 kD
ab 401,00 €
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ASP3026
ASP3026

Artikelnummer: TGM-T1962-100mg

Description: ASP3026 has been used in trials studying the treatment of Solid Tumor, B-Cell Lymphoma, Advanced Malignancies, Positive for Anaplastic Lymphoma Kinase, and Positive for Proto-Oncogene Tyrosine-Protein Kinase ROS. Target: Apoptosis, ALK. Smiles:...
Schlagworte: ASP 3026
Anwendung: ALK / ACK inhibitor
CAS 1097917-15-1
MW: 580.74 D
ab 37,00 €
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CEP-28122
CEP-28122

Artikelnummer: TGM-T2612-10mg

Description: CEP-28122 is a highly potent and selective, orally active ALK inhibitor. Target: ALK. Smiles: N([C@@H]1[C@@]2(C[C@]([C@@H]1C(N)=O)(C=C2)[H])[H])C3=NC(NC=4C(OC)=C5C(=CC4)CC[C@@H](CC5)N6CCOCC6)=NC=C3Cl. References: Abate F, et al. Leukemia. 2015 Jun,29(6):1390-401.
Anwendung: ALK inhibitor
CAS 1022958-60-6
MW: 539.07 D
ab 52,00 €
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Alectinib
Alectinib

Artikelnummer: TGM-T1936-100mg

Description: Alectinib (RG-7853) is an orally available inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with antineoplastic activity. Target: Tyrosine Kinases, ALK, VEGFR. Smiles: CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1N1CCC(CC1)N1CCOCC1. References: Sakamoto H, et al. Cancer...
Schlagworte: AF-802, CH5424802, AF802, RG-7853
Anwendung: Targets anaplastic lymphoma kinase [EC:2.7.10.1] (ALK, CD246)
CAS 1256580-46-7
MW: 482.62 D
ab 41,00 €
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