Zu "K05119" wurden 149 Artikel gefunden!
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EML4-ALK kinase inhibitor 1
Artikelnummer: TGM-T11184-100mg
Description: EML4-ALK kinase inhibitor 1 (EML4 ALK kinase inhibitor 1) is a potent oral active inhibitor of echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK), with an IC50 of 1 nM. Target: ALK. Smiles:...
| Schlagworte: | EML4-ALK kinase inhibitor 1, EML4 ALK kinase inhibitor 1 |
| Anwendung: | EML4-ALK kinase inhibitor |
| CAS | 1373409-08-5 |
| MW: | 580.76 D |
ab 86,00 €
ALK inhibitor 1
Artikelnummer: TGM-T10285-100mg
Description: ALK inhibitor 1 is a selective ALK kinase inhibitor. Target: IGF-1R, FAK, ALK. Smiles: CNS(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(cc2OC)N2CCN(C)CC2)ncc1Br. References: A Dose Finding Study With Oral LDK378 in Patients With Tumors Characterized by Genetic Abnormalities in Anaplastic Lymphoma Kinase (ALK).
| Anwendung: | ALK inhibitor |
| CAS | 761436-81-1 |
| MW: | 562.48 D |
ab 78,00 €
ALK-IN-1
Artikelnummer: TGM-T3059-100mg
Description: ALK-IN-1 (AP26113) is a potent ALK inhibitor with IC50 of 0.62 nM in a cell-free assay, demonstrated ability overcome Crizotinib resistance mediated by a L1196M mutation. Phase 2. Target: ALK, EGFR, IGF-1R. Smiles: N(C1=C(P(C)(C)=O)C=CC=C1)C2=NC(NC3=C(OC)C=C(C=C3)N4CCC(N(C)C)CC4)=NC=C2Cl. References:...
| Schlagworte: | AP26113, Brigatinib, AP26113-analog |
| Anwendung: | ALK inhibitor |
| CAS | 1197958-12-5 |
| MW: | 529.01 D |
ab 40,00 €
X-376
Artikelnummer: TGM-T3550-100mg
Description: X-376 (Ensartinib) is an orally available small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with potential antineoplastic activity. Upon oral administration, X-396 binds to and inhibits ALK kinase, ALK fusion proteins, and ALK point mutation variants. Inhibition...
| Schlagworte: | X-396, Ensartinib |
| Anwendung: | ALK inhibitor |
| CAS | 1365267-27-1 |
| MW: | 547.41 D |
ab 31,00 €
Brigatinib
Artikelnummer: TGM-T3621-100mg
Description: Brigatinib (AP-26113) is a highly potent and selective inhibitor of ALK. Target: FLT, IGF-1R, EGFR, ROS, ALK. Smiles: COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1)N1CCC(CC1)N1CCN(C)CC1. References: Wei-Sheng Huang, et al. J Med Chem, 2016, 59(10):4948-4964.
| Schlagworte: | AP-26113 |
| Anwendung: | Targets anaplastic lymphoma kinase [EC:2.7.10.1] (ALK, CD246) |
| CAS | 1197953-54-0 |
| MW: | 584.09 D |
ab 31,00 €
ALK inhibitor 2
Artikelnummer: TGM-T3041-100mg
Description: ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase. Target: ALK, FAK. Smiles: CNS(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(cc2OC)N2CCN(C)CC2)ncc1Cl. References: A Dose Finding Study With Oral LDK378 in Patients With Tumors Characterized by Genetic Abnormalities in Anaplastic Lymphoma Kinase...
| Anwendung: | ALK inhibitor |
| CAS | 761438-38-4 |
| MW: | 518.03 D |
ab 115,00 €
CEP-37440
Artikelnummer: TGM-T2655-1mg
Description: CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK). Target: FAK, ALK. Smiles: CNC(=O)c1ccccc1Nc1nc(Nc2ccc3C[C@@H](CCCc3c2OC)N2CCN(CCO)CC2)ncc1Cl. References: Iragavarapu C, et al. J Hematol Oncol. 2015 Feb 27,8(1):17.
| Schlagworte: | CEP37440 |
| Anwendung: | FAK1 & ALK inhibitor |
| CAS | 1391712-60-9 |
| MW: | 580.12 D |
ab 32,00 €
Ensartinib
Artikelnummer: TGM-T37585-100mg
Description: Ensartinib (X-396) is a potent dual ALK/MET inhibitor with IC50 values of <0.4 nM for ALK and 0.74 nM for MET. Target: Others. Smiles: C(=O)(N1C[C@@H](C)N[C@@H](C)C1)C2=CC=C(NC(=O)C3=CC(O[C@H](C)C4=C(Cl)C(F)=CC=C4Cl)=C(N)N=N3)C=C2. References: Lovly CM, et al. Insights into ALK-driven cancers revealed...
| Anwendung: | Targets anaplastic lymphoma kinase [EC:2.7.10.1] (ALK, CD246) |
| CAS | 1370651-20-9 |
| MW: | 561.44 D |
ab 1.786,00 €
HG-14-10-04
Artikelnummer: TGM-T4015-100mg
Description: HG-14-10-04 is a potent and specific ALK (anaplastic lymphoma kinase) inhibitor. Target: ALK. Smiles: COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12)N1CCC(CC1)N1CCN(C)CC1. References: U.S. Pat. Appl. Publ. (2012), US 20120028924 A1
| Anwendung: | ALK inhibitor |
| CAS | 1356962-34-9 |
| MW: | 532.08 D |
ab 54,00 €
Alectinib hydrochloride
Artikelnummer: TGM-T8387-100mg
Description: Alectinib hydrochloride (RO5424802 Hydrochloride) is a selective, and orally available inhibitor of ALK( IC50 : 1.9 nM). Target: ALK. Smiles: Cl.CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1N1CCC(CC1)N1CCOCC1. References: Sakamoto H, et al. CH5424802, a selective ALK inhibitor capable of blocking the...
| Schlagworte: | CH5424802 (Hydrochloride), RO5424802 (Hydrochloride), AF-802 (Hydrochloride) |
| Anwendung: | Antineoplastic, Anaplastic lymphoma kinase (ALK) inhibitor |
| CAS | 1256589-74-8 |
| MW: | 519.08 D |
ab 37,00 €
ALK Protein, Mouse, Recombinant (hFc)
Artikelnummer: TGM-TMPK-00927-100ug
Description: Anaplastic lymphoma kinase (ALK) is mostly known for its oncogenic role in several human cancers. Recent evidences clearly indicate new roles of ALK and its genetic aberrations (e.g. gene rearrangements and mutations) in immune evasion, innate and cell-mediated immunity. New ALK-related immunotherapy...
| Schlagworte: | Anaplastic lymphoma kinase, ALK tyrosine kinase receptor, CD246 |
| MW: | 101.11 kD |
ab 385,00 €
ASP3026
Artikelnummer: TGM-T1962-100mg
Description: ASP3026 has been used in trials studying the treatment of Solid Tumor, B-Cell Lymphoma, Advanced Malignancies, Positive for Anaplastic Lymphoma Kinase, and Positive for Proto-Oncogene Tyrosine-Protein Kinase ROS. Target: Apoptosis, ALK. Smiles:...
| Schlagworte: | ASP 3026 |
| Anwendung: | ALK / ACK inhibitor |
| CAS | 1097917-15-1 |
| MW: | 580.74 D |
ab 35,00 €