Zu "K05099" wurden 254 Artikel gefunden!
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BAY-474
Artikelnummer: Cay41451-1
BAY-474 is an inhibitor of c-Met (IC50 = 98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Sparingly soluble: 1-10 mg/ml. SMILES: N#CC1=C(C)NC(C)=C(C1C2=CC3=C(NN=C3C)C=C2)C#N. InChi Code:...
| Schlagworte: | 1,4-dihydro-2,6-dimethyl-4-(3-methyl-1H-indazol-5-yl)-3,5-pyridinedicarbonitrile |
| Anwendung: | c-Met inhibitor |
| CAS | 1033767-86-0 |
| MW: | 289.3 D |
ab 59,00 €
c-Met inhibitor 1
Artikelnummer: TGM-T10655-100mg
Description: c-Met inhibitor 1 is a c-Met receptor signaling pathway inhibitor, used for the treatment of cancer including glioblastoma, gastric, and pancreatic cancer. Target: c-Met/HGFR. Smiles: Cn1cc(cn1)-c1ccc2nnc(Sc3ccc4nn(C)cc4c3)n2n1. References: PCT Int. Appl. (2012), WO 2012015677 A1 20120202.
| Anwendung: | c-Met inhibitor |
| CAS | 1357072-61-7 |
| MW: | 362.41 D |
ab 78,00 €
AMG-337
Artikelnummer: TGM-T3209-100mg
Description: AMG-337 is an effective and highly specific ATP-competitive MET kinase inhibitor. In enzymatic assays, AMG-337(AMG337) inhibits MET kinase activity (IC50: < 5 nM). Target: c-Met/HGFR. Smiles: COCCOc1cnc2ccn([C@H](C)c3nnc4c(F)cc(cn34)-c3cnn(C)c3)c(=O)c2c1. References: Hughes PE, et al. Mol Cancer Ther....
| Schlagworte: | AMG337 |
| Anwendung: | c-Met inhibitor |
| CAS | 1173699-31-4 |
| MW: | 463.46 D |
ab 36,00 €
PF-04217903
Artikelnummer: TGM-T2676-100mg
Description: MET Tyrosine Kinase Inhibitor PF-04217903 is an orally bioavailabe, small-molecule tyrosine kinase inhibitor with potential antineoplastic activity. Target: c-Met/HGFR. Smiles: OCCn1cc(cn1)-c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1. References: Timofeevski SL, et al. Biochemistry, 2009, 48(23), 5339-5349.
| Anwendung: | c-Met kinase inhibitor |
| CAS | 956905-27-4 |
| MW: | 372.38 D |
ab 35,00 €
NVP-BVU972
Artikelnummer: TGM-T2680-100mg
Description: NVP-BVU972 is a selective and potent Met inhibitor with IC50 of 14 nM. Target: c-Met/HGFR. Smiles: Cn1cc(cn1)-c1ccc2ncc(Cc3ccc4ncccc4c3)n2n1. References: Tiedt R, et al. Cancer Res. 2011, 71(15), 5255-5264.
| Anwendung: | Met kinase inhibitor |
| CAS | 1185763-69-2 |
| MW: | 340.38 D |
ab 42,00 €
Terevalefim
Artikelnummer: TGM-T37596-100mg
Description: Terevalefim (ANG-3777) is an hepatocyte growth factor (HGF) mimetic. Terevalefim selectively activates the c-Met receptor. Target: c-Met/HGFR. Smiles: C(=C/c1cccs1)\c1cc[nH]n1. References: Jonathan S Bromberg, et al. Renal Function Improvement Following ANG-3777 Treatment in Patients at High Risk for...
| Anwendung: | Targets proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1] (MET, HGFR) |
| CAS | 1070881-42-3 |
| MW: | 176.24 D |
ab 53,00 €
CEP-40783
Artikelnummer: TGM-T4426-100mg
Description: CEP-40783 (RXDX-106) is an effective, specific and orally active AXL/c-Met inhibitor (IC50: 7/12 nM). It also inhibits MER and TYRO3 (IC50: 29/19 nM). Target: c-Met/HGFR, TAM Receptor. Smiles: COc1cc2nccc(Oc3ccc(NC(=O)c4cn(C(C)C)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC. References: Miknyoczki S, Cheng M,...
| Schlagworte: | RXDX-106, CEP 40783 |
| Anwendung: | AXL / c-Met inhibitor |
| CAS | 1437321-24-8 |
| MW: | 588.56 D |
ab 34,00 €
Glumetinib
Artikelnummer: TGM-T5414-100mg
Description: Glumetinib (SCC244) is a novel potent and selective inhibitor of c-Met kinase (IC50: 0.42 nM). Target: c-Met/HGFR. Smiles: Cn1cc(cn1)-c1cnc2cnn(c2c1)S(=O)(=O)c1cnc2ccc(cn12)-c1cnn(C)c1. References: Ai J, et al. Preclinical Evaluation of SCC244 (Glumetinib), a Novel, Potent, and Highly Selective...
| Schlagworte: | SCC244 |
| Anwendung: | Potent c-Met inhibitor |
| CAS | 1642581-63-2 |
| MW: | 459.48 D |
ab 52,00 €
SAR125844
Artikelnummer: TGM-T5467-100mg
Description: SAR125844, a potent and highly selective inhibitor of the MET receptor tyrosine kinase (RTK), for intravenous administration. (IC50 value of 4.2 nmol/L). Target: Apoptosis, c-Met/HGFR. Smiles: Fc1ccc(cc1)-c1ccc2nnc(Sc3ccc4nc(NC(=O)NCCN5CCOCC5)sc4c3)n2n1. References: Egile C, et al. The selective...
| Schlagworte: | SAR125884 |
| Anwendung: | c-Met inhibitor |
| CAS | 1116743-46-4 |
| MW: | 550.63 D |
ab 34,00 €
AMG-208
Artikelnummer: TGM-T6260-100mg
Description: AMG-208 is a highly selective c-Met inhibitor with IC50 of 9 nM. Phase 1. Target: c-Met/HGFR, P450. Smiles: COc1ccc2c(OCc3nnc4ccc(nn34)-c3ccccc3)ccnc2c1. References: Albrecht BK, et al. J Med Chem. 2008, 51(10), 2879-2882.
| Schlagworte: | AMG 208 |
| Anwendung: | Potent c-Met inhibitor, VEGFR2 inhibitor |
| CAS | 1002304-34-8 |
| MW: | 383.4 D |
ab 42,00 €
SCR-1481B1
Artikelnummer: TGM-T5349-100mg
Description: SCR-1481B1 (c-Met inhibitor 2) has activity against cancers dependent on Met activation and also has activity against cancers as a VEGFR inhibitor. Target: c-Met/HGFR, VEGFR. Smiles: NC(CO)(CO)CO.NC(CO)(CO)CO.Nc1nccc(Oc2ccc(NC(=O)c3cn(COP(O)(O)=O)cc(-c4ccc(F)cc4)c3=O)cc2F)c1Cl. References: Robert M....
| Schlagworte: | c-Met inhibitor 2 |
| Anwendung: | Pyridone, MET inhibitor |
| CAS | 1174161-86-4 |
| MW: | 821.12 D |
ab 35,00 €
NPS-1034
Artikelnummer: TGM-T6907-100mg
Description: NPS-1034 is a dual Met/Axl inhibitor with IC50 of 48 nM and 10.3 nM, respectively. Target: TAM Receptor, Apoptosis, c-Met/HGFR. Smiles: Cc1c(C(=O)Nc2ccc(Oc3ccnc4[nH]cc(-c5ccccc5)c34)c(F)c2)c(=O)n(-c2ccc(F)cc2)n1C. References: Rho JK, et al. Cancer Res. 2014, 74(1), 253-262.
| Schlagworte: | NPS 1034, NPS1034 |
| Anwendung: | MET inhibitor |
| CAS | 1221713-92-3 |
| MW: | 551.54 D |
ab 35,00 €