Zu "K05098" wurden 323 Artikel gefunden!
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NEU
AG-13958
Artikelnummer: Cay41352-1
AG-13958 is an antagonist of VEGFR2 (Ki = 0.3 nM). It inhibits VEGF-induced proliferation of human umbilical vein endothelial cells (HUVECs, IC50 = 0.31 nM).Formal Name: N-[2-fluoro-5-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]amino]phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide. CAS Number: 319460-94-1....
| Schlagworte: | N-[2-fluoro-5-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]amino]phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide |
| Anwendung: | VEGFR2 antagonist |
| CAS | 319460-94-1 |
| MW: | 467.5 D |
ab 88,00 €
NEU
JNJ-38158471
Artikelnummer: Cay41361-10
JNJ-38158471 is an inhibitor of VEGFR2 (IC50 = 42 nM). It is selective for VEGFR2 over the PDGFR family kinases CSF-1 receptor tyrosine kinase (FMS), PDGFRalpha, FMS-related tyrosine kinase 3 (FLT3), and KIT (IC50s = 624, 1,109, 4,810, and 511 nM, respectively) and VEGFR family kinases VEGFR1 and VEGFR3 (IC50s =...
| Schlagworte: | N-[4-[[6-amino-5-[(methoxyimino)methyl]-4-pyrimidinyl]oxy]-2-chlorophenyl]-N'-ethyl-urea |
| Anwendung: | VEGFR2 inhibitor |
| CAS | 951151-97-6 |
| MW: | 364.8 D |
ab 272,00 €
OSI-930
Artikelnummer: TGM-T2624-100mg
Description: OSI-930, an orally active inhibitor of c-Kit and the vascular endothelial growth factor receptor-2 (VEGFR-2), targets cancer cell proliferation and blood vessel growth (angiogenesis) in tumors. Target: Apoptosis, FLT, Raf, c-Fms, Src, CSF-1R, c-Kit, VEGFR. Smiles:...
| Schlagworte: | OSI 930 |
| Anwendung: | Kit / VEGFR2 dual inhibitor |
| CAS | 728033-96-3 |
| MW: | 443.44 D |
ab 47,00 €
Chiauranib
Artikelnummer: TGM-T35570-100mg
Description: Chiauranib is a multi-target inhibitor against tumor angiogenesis and exhibits potent anticancer effects. Chiauranib potently inhibits the angiogenesis-related kinases (VEGFR1, VEGFR2, VEGFR3, PDGFRalpha and c-Kit), mitosis-related kinase Aurora B, and chronic inflammation-related kinase CSF1R, with...
| Schlagworte: | CS2164 |
| Anwendung: | Multi-kinase inhibitor |
| CAS | 1256349-48-0 |
| MW: | 435.47 D |
ab 81,00 €
SU5205
Artikelnummer: TGM-T3566-1mL
Description: SU5205 is a VEGFR2 inhibitor. Target: VEGFR. Smiles: Fc1ccc(C=C2C(=O)Nc3ccccc23)cc1. References: Tian XF, et al. PACE4 regulates apoptosis in human pancreatic cancer Panc 1 cells via the mitochondrial signaling pathway. Mol Med Rep. 2016 Dec,14(6):5205-5210.
| Schlagworte: | SU 5205 |
| Anwendung: | VEGFR2 inhibitor |
| CAS | 3476-86-6 |
| MW: | 239.24 D |
ab 30,00 €
4,4'-Bis(4-aminophenoxy)biphenyl
Artikelnummer: TGM-T35355-25mg
Description: 4,4'-Bis(4-aminophenoxy)biphenyl is a monomer for polyimide production. Target: Others. Smiles: O(C1=CC=C(C=C1)C2=CC=C(OC3=CC=C(N)C=C3)C=C2)C4=CC=C(N)C=C4
| Anwendung: | VEGFR2 / Met / RET / Axl / Ron / PDGFR / FGFR1 / FLT1/3/4 inhibitor |
| CAS | 13080-85-8 |
| MW: | 368.43 D |
78,00 €
BFH772
Artikelnummer: TGM-T3599-100mg
Description: BFH772, a structure analogue of BAW2881, is a potent and selective VEGF inhibitor. BFH772 is highly effective at targeting VEGFR2 kinase with an IC50 value of 3 nM. BFH772 inhibits the ligand induced autophosphorylation of RET, PDGFR, and KIT kinases, with IC50 values ranging between 30 and 160 nM....
| Schlagworte: | BFH-722 |
| Anwendung: | VEGFR2 inhibitor |
| CAS | 890128-81-1 |
| MW: | 439.39 D |
ab 38,00 €
VEGFR2 Kinase Inhibitor II
Artikelnummer: TGM-T37079-1mg
Description: Vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR and FLK1) is a receptor tyrosine kinase that regulates angiogenesis, vascular development, and embryonic hematopoiesis in response to VEGF isoforms A, C, and D. VEGFR2 kinase inhibitor II is a reversible, cell-permeable inhibitor...
| Anwendung: | VEGFR2 Kinase inhibitor |
| CAS | 288144-20-7 |
| MW: | 343.22 D |
ab 208,00 €
Su1498
Artikelnummer: TGM-T3980-100mg
Description: Su1498 (Tyrphostin SU 1498) is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2 (VEGFR2, aka FLK1, IC50 = 700 nM), having negligible activity at several other serine/threonine and tyrosine kinases.1, 2 It effectively blocks signaling through VEGFR2 both in vitro and in vivo.1, 3 SU...
| Schlagworte: | AG 1498, Tyrphostin SU 1498 |
| Anwendung: | VEGFR2 inhibitor |
| CAS | 168835-82-3 |
| MW: | 390.52 D |
ab 34,00 €
SU5408
Artikelnummer: TGM-T4026-100mg
Description: SU5408 (VEGFR2 Kinase Inhibitor I) is a potent, cell-permeable inhibitor of the VEGFR2 kinase. Target: VEGFR. Smiles: CCOC(=O)c1c(C)[nH]c(\C=C2\C(=O)Nc3ccccc23)c1C. References: Sun L, et al. Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kiN/Ase...
| Schlagworte: | VEGFR2 Kinase Inhibitor I |
| Anwendung: | Mouse VEGFR2 inhibitor |
| CAS | 15966-93-5 |
| MW: | 310.35 D |
ab 63,00 €
JK-P3
Artikelnummer: TGM-T4425-100mg
Description: JK-P3 is a pyrazole-based inhibitor of VEGFR-2 (IC50: 7.8 µM). JK-P3 inhibits FGFR 1/3 kinase activity in vitro, but has no effect on FGFR signaling in cell-based assays. The compound blocks wound healing and tube formation in HUVEC without effecting endothelial cell proliferation. Target: VEGFR....
| Anwendung: | VEGFR2 inhibitor |
| CAS | 942655-44-9 |
| MW: | 323.35 D |
ab 54,00 €
Arenobufagin
Artikelnummer: TGM-T5A2455-100mg
Description: Arenobufagin, a natural bufadienolide from toad venom, exhibits potent antineoplastic activity against HCC HepG2 cells and corresponding multidrug-resistant HepG2/ADM cells. Target: Others. Smiles: C[C@@]12[C@H](CC[C@]1(O)[C@@H]1CC[C@@H]3C[C@@H](O)CC[C@]3(C)[C@H]1[C@H](O)C2=O)c1ccc(=O)oc1. References:...
| Anwendung: | VEGFR2 inhibitor |
| CAS | 464-74-4 |
| MW: | 416.51 D |
ab 66,00 €