Zu "K05092" wurden 218 Artikel gefunden!
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FLT3-IN-3
Artikelnummer: Cay36106-1
FLT3-IN-3 is an inhibitor of FMS-related tyrosine kinase 3 (FLT3). It inhibits wild-type, FLT3D835Y, and FLT3 bearing internal-tandem duplication (FLT3-ITD, IC50s = 13, 8, and 3 nM, respectively). FLT3-IN-3 suppresses the growth of MV4-11 acute myeloid leukemia (AML) cells that express FLT3-ITD (GI50 = 7 nM). It...
| Schlagworte: | SAN50900, N2-(trans-4-aminocyclohexyl)-9-cyclopentyl-N6-[4-(4-morpholinylmethyl)phenyl]-9H-purine-2,6-diamine |
| Anwendung: | FLT3 inhibitor |
| CAS | 2229050-90-0 |
| MW: | 490.6 D |
ab 86,00 €
Gilteritinib
Artikelnummer: TGM-T4409-100mg
Description: Gilteritinib (ASP2215) is a potent inhibitor of FMS-related tyrosine kinase 3 (FLT3) and AXL tyrosine kinase receptors (IC50 = 0.29 nM and <1 nM, respectively). In preclinical studies, gilteritinib demonstrated strong antileukemic and antitumor effects. Gilteritinib is currently in several Phase 3...
| Schlagworte: | ASP2215 |
| Anwendung: | Targets fms-related tyrosine kinase 3 [EC:2.7.10.1] (FLT3, FLK2, CD135) |
| CAS | 1254053-43-4 |
| MW: | 552.71 D |
ab 34,00 €
CCT241736
Artikelnummer: TGM-T4428-100mg
Description: CCT241736 is an orally bioavailable dual FLT3/Aurora kinase inhibitor that also inhibits clinically relevant FLT3-resistant mutants including FLT3-ITD and FLT3, CCT241736, an advanced analog of CCT137690, is a preclinical development candidate for the treatment of human malignancies, and in particular...
| Anwendung: | FLT3 inhibitor, Aurora kinase inhibitor |
| CAS | 1402709-93-6 |
| MW: | 456.37 D |
ab 54,00 €
FLT3 kinase inhibitor 2HCl
Artikelnummer: TGM-T50072-100mg
Description: 3-amino-1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one dihydrochloride is used in the synthesis of various compounds. Target: Others. Smiles: Cl.Cl.NCCC(=O)N1CCC[C@H](C1)n1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc12
| Anwendung: | FLT3 kinase inhibitor |
| CAS | 2411178-94-2 |
| MW: | 530.449 D |
ab 93,00 €
Gilteritinib hemifumarate
Artikelnummer: TGM-T71973-100mg
Description: Gilteritinib hemifumarate (ASP2215 hemifumarate) is a potent ATP-competitive dual FLT3 (IC50: 0.29 nM) and AXL (IC50: 0.73 nM) inhibitor for the treatment of relapsed or refractory FLT3 mutant AML. Target: TAM Receptor, FLT. Smiles:...
| Schlagworte: | ASP2215 hemifumarate |
| Anwendung: | Targets fms-related tyrosine kinase 3 [EC:2.7.10.1] (FLT3, FLK2, CD135) |
| CAS | 1254053-84-3 |
| MW: | 610.75 D |
ab 34,00 €
Dovitinib lactate
Artikelnummer: TGM-T7104-100mg
Description: Dovitinib lactate (TKI-258 lactate)(TKI258) lactate is a potent inhibitor of fibroblast growth factor receptor 3 (FGFR3) (IC50 :5 nM). Target: VEGFR, c-Kit, FGFR, FLT, PDGFR. Smiles: CC(O)C(O)=O.CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O. References: Eucker J , Zang C , Zhou Y , et al....
| Schlagworte: | CHIR-258 lactate, TKI-258 lactate |
| Anwendung: | Receptor tyrosine kinase inhibitor |
| CAS | 692737-80-7 |
| MW: | 482.51 D |
ab 47,00 €
Quizartinib HCl
Artikelnummer: TGM-T71400-100mg
Description: Quizartinib, also know as AC220 and AC010220, is an orally available FLT3 / STK1 inhibitor with potential antineoplastic activity. Class III receptor tyrosine kinase inhibitor AC220 selectively inhibits class III receptor tyrosine kinases, including FMS-related tyrosine kinase 3 (FLT3/STK1),...
| Anwendung: | Targets fms-related tyrosine kinase 3 [EC:2.7.10.1] (FLT3, FLK2, CD135) |
| CAS | 1132827-21-4 |
| MW: | 633.589 D |
ab 1.491,00 €
5'-Fluoroindirubinoxime
Artikelnummer: TGM-T8317-100mg
Description: 5'-Fluoroindirubinoxime (5'-FIO) is a potent FLT3 inhibitor( IC50 : 15 nM). Target: FLT. Smiles: O\N=C1\C(\Nc2ccccc\12)=C1/C(=O)Nc2ccc(F)cc12. References: Kim SA, et al. Antitumor activity of novel indirubin derivatives in rat tumor model. Clin Cancer Res. 2007 Jan 1,13(1):253-9.
| Schlagworte: | 5'-FIO |
| Anwendung: | FLT3 kinase inhibitor |
| CAS | 861214-33-7 |
| MW: | 295.27 D |
ab 42,00 €
FLT3 Protein, Human, Recombinant (T227M, His)
Artikelnummer: TGM-TMPY-01247-100ug
Description: FLT3 Protein, Human, Recombinant (T227M, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59.7 kDa and the accession number is P36888-1.
| Schlagworte: | fms-related tyrosine kinase 3, STK1, CD135, FLK-2, FLK2 |
| MW: | 59.7 kD |
ab 441,00 €
FLT3 Protein, Human, Recombinant (His & Avi), Biotinylated
Artikelnummer: TGM-TMPK-00416-100ug
Description: FLT3 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in CHO mammalian cells with C-His-Avi tag. The predicted molecular weight is 61.20 kDa and the accession number is P36888-1.
| Schlagworte: | CD135, FLT-3, STK-1, FLK2 |
| MW: | 61.20 kD |
ab 798,00 €
FLT3 Protein, Mouse, Recombinant (hFc)
Artikelnummer: TGM-TMPK-00929-100ug
Description: Flt-3 Ligand, also known as FL, is an alpha -helical cytokine that promotes the differentiation of multiple hematopoietic cell lineages.Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins. FLT3...
| Schlagworte: | FLT3LG, Flt3L, FL, SL cytokine, Flt3 ligand |
| MW: | 84.78 kD |
ab 477,00 €
FLT3 Protein, Human, Recombinant (hFc)
Artikelnummer: TGM-TMPY-05738-1mg
Description: FLT3 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 85.06 kDa and the accession number is P36888-1.
| Schlagworte: | CD135, FLK2, FLK-2, STK1, fms-related tyrosine kinase 3 |
| MW: | 85.06 kD |
ab 389,00 €