Zu "K05091" wurden 455 Artikel gefunden!
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Olverembatinib
Artikelnummer: TGM-T3071-100mg
Description: Olverembatinib (GZD 824) is an orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT, IC50: 0.34 nM) and Bcr-Abl(T315I, IC50: 0.68 nM). Target: Bcr-Abl. Smiles: CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4[nH]ncc4c3)cc2C(F)(F)F)CC1. References: Ren X, et al. J Med Chem. 2013, 56(3), 879-894.
| Schlagworte: | GZD 824 |
| Anwendung: | Targets abelson tyrosine-protein kinase 1 [EC:2.7.10.2] (ABL1) |
| CAS | 1257628-77-5 |
| MW: | 532.56 D |
ab 31,00 €
Multi-kinase inhibitor 1
Artikelnummer: TGM-T4191-100mg
Description: Multi-kinase inhibitor 1 (Multi-kinase inhibitor I) is a Multi-kinase inhibitor. Target: c-Kit, Others, Bcr-Abl, PDGFR. Smiles: N(C1=CC(C2=CC=C(C(NCCO)=O)C=C2)=NC=N1)C3=CC=C(OC(F)(F)F)C=C3. References: Chang Hsu Y, et al. Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the...
| Schlagworte: | Multi-kinase inhibitor I |
| Anwendung: | Multi-kinase inhibitor |
| CAS | 778274-97-8 |
| MW: | 418.37 D |
ab 33,00 €
AZD3229
Artikelnummer: TGM-T5409-100mg
Description: AZD3229 is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors. It demonstrates potent single-digit nM growth inhibition across a broad cell panel. Target: c-Kit. Smiles: COCCOc1cc(F)c2c(Nc3ccc(NC(=O)Cn4cc(nn4)C(C)C)cc3)ncnc2c1. References: Kettle JG, et al. Discovery...
| Anwendung: | c-Kit-driven cell proliferation inhibitor |
| CAS | 2248003-60-1 |
| MW: | 479.51 D |
ab 61,00 €
Toceranib Phosphate
Artikelnummer: TGM-T7394-100mg
Description: Toceranib Phosphate (SU11654 phosphate), is a selective inhibitor of the tyrosine kinase activity of several members of the split kinase RTK family, including Flk-1/KDR, PDGFR. Target: Tyrosinase, PDGFR, VEGFR, c-Kit. Smiles: OP(O)(O)=O.Cc1[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c(C)c1C(=O)NCCN1CCCC1....
| Schlagworte: | SU11654 phosphate, PHA 291639 phosphate |
| Anwendung: | Targets proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1] (KIT, SCFR, CD117) |
| CAS | 874819-74-6 |
| MW: | 494.45 D |
ab 41,00 €
BLU-263
Artikelnummer: TGM-T9295-100mg
Description: BLU-263 is an investigational, potent, and selective oral small molecule inhibitor of KIT with sub-nanomolar potency against D816V-mutant KIT. Target: c-Kit. Smiles: C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(CCO)c1
| Anwendung: | Targets proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1] (KIT, SCFR, CD117) |
| CAS | 2505078-08-8 |
| MW: | 528.58 D |
ab 98,00 €
HM43239
Artikelnummer: TGM-T9428-100mg
Description: HM43239 is an orally active and selective FLT3 inhibitor with IC 50 s of 1.1 nM, 1.8 nM and 1.0 nM for FLT3 WT, FLT3 internal tandem duplication (ITD) and FLT3 D835Y kinases, respectively. HM43239 directly inhibits the kinase activity of FLT3 as a reversible Type I inhibitor and effectively modulates...
| Schlagworte: | Tuspetinib |
| Anwendung: | Targets fms-related tyrosine kinase 3 [EC:2.7.10.1] (FLT3, FLK2, CD135) |
| CAS | 2294874-49-8 |
| MW: | 501.07 D |
ab 63,00 €
CD117 Protein, Human, Recombinant (hFc)
Artikelnummer: TGM-TMPJ-00402-10ug
Description: C-Kit/SCF R is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the protein kinase superfamily and CSF-1/PDGF receptor subfamily. SCF R expression...
| Schlagworte: | SCFR, KIT, CD117, p145 c-kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, Piebald trait protein, PBT,... |
| MW: | 140 kD |
ab 63,00 €
CD117 Protein, Mouse, Recombinant (His)
Artikelnummer: TGM-TMPK-00777-100ug
Description: The c-kit proto-oncogen (CD 117) has been shown to be present in several cell types including normal and neoplastic hemopoietic cells. Among normal BM cells, CD117 expression has been found in about half of the CD34 precursors including progenitors committed to the erythroid, granulo-monocytic, and...
| Schlagworte: | SCFR, KIT, CD117, c-kit, ckit, PBT |
| MW: | 56.63 kD |
ab 477,00 €
CD117 Protein, Human, Recombinant (His & Avi), Biotinylated
Artikelnummer: TGM-TMPK-00805-100ug
Description: The c-kit proto-oncogen (CD 117) has been shown to be present in several cell types including normal and neoplastic hemopoietic cells. Among normal BM cells, CD117 expression has been found in about half of the CD34 precursors including progenitors committed to the erythroid, granulo-monocytic, and...
| Schlagworte: | EC 2.7.10.1, c-kit, SCFR, KIT, ckit, PBT, CD117, EC 2.7.10 |
| MW: | 58.60 kD |
ab 798,00 €
c-Kit Protein, Human, Recombinant (His & Avi), Biotinylated
Artikelnummer: TGM-TMPY-06656-100ug
Description: c-Kit Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 58.50 kDa and the accession number is P10721-2.
| Schlagworte: | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, PBT, C-Kit, SCFR, CD117 |
| MW: | 58.50 kD |
ab 587,00 €
c-Kit Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPY-01935-100ug
Description: c-Kit Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 56.7 kDa and the accession number is P10721-2.
| Schlagworte: | PBT, C-Kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, SCFR, CD117 |
| MW: | 56.7 kD |
ab 378,00 €
c-Kit Protein, Mouse, Recombinant (hFc)
Artikelnummer: TGM-TMPY-01801-100ug
Description: c-Kit Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 82.5 kDa and the accession number is P05532-1.
| Schlagworte: | Tr-kit, c-KIT, Bs, Gsfsco1, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, W, SCO1, Gsfsco5, Fdc, CD117,... |
| MW: | 82.5 kD |
587,00 €