Zu "K05091" wurden 448 Artikel gefunden!
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Anti-KIT, recombinant clone 6D4
Artikelnummer: CSB-RA012375MA1HU.100
Protein function: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In...
| Schlagworte: | Anti-PBT, Anti-KIT, Anti-SCFR, Anti-CD117, Anti-p145 c-kit, EC=2.7.10.1, Anti-Proto-oncogene c-Kit, Anti-Piebald trait... |
| Anwendung: | ELISA, IHC, FC |
| Wirt: | Human |
| Spezies-Reaktivität: | human |
ab 186,00 €
![Elab Fluor(R)700 Anti-Human CD117/c-Kit Antibody[104D2]](https://www.biomol.com/media/image/db/80/7e/E-AB-F1150M1-20_200x200.jpg "Elab Fluor(R)700 Anti-Human CD117/c-Kit Antibody[104D2]")
Elab Fluor(R)700 Anti-Human CD117/c-Kit Antibody[104D2]
Artikelnummer: E-AB-F1150M1.100
CD117 is a 145 kD protein tyrosine kinase also known as c-Kit. It is a receptor for stem cell factor or c-Kit ligand. CD117 is expressed on pluripotent hematopoietic progenitor cells (approximately 1-4% bone marrow cells), mast cells, and acute myeloid leukemia cells (AML). CD117 binding of c-Kit ligand induces...
| Schlagworte: | Anti-PBT, Anti-KIT, Anti-SCFR, Anti-CD117, Anti-p145 c-kit, EC=2.7.10.1, Anti-Proto-oncogene c-Kit, Anti-Piebald trait... |
| Anwendung: | FC, FCM |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 117,00 €
KIT (human), recombinant protein
Artikelnummer: ABS-PP-564.20
| Schlagworte: | Mast/stem cell growth factor receptor Kit, SCFR, Piebald trait protein, PBT, Proto-oncogene c-Kit, Tyrosine-protein kinase... |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 33 kD |
ab 90,00 €
Anti-KIT
Artikelnummer: ABS-KC-3413.100
Protein function: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In...
| Schlagworte: | Anti-Mast/stem cell growth factor receptor Kit, Anti-SCFR, Anti-Piebald trait protein, Anti-PBT, Anti-Proto-oncogene... |
| Anwendung: | IHC |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 206,00 €
Anti-CD117/c-kit (Capture/Detector)
Artikelnummer: E-AN004460P.1
The c-Kit proto-oncogene is the cellular homolog of the transforming gene of a feline retrovirus (v-Kit). The c-kit protein includes characteristics of a protein kinase transmembrane receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Protein function:...
| Schlagworte: | Anti-Sl, Anti-Kit, Anti-SCFR, Anti-CD117, EC=2.7.10.1, Anti-Proto-oncogene c-Kit, Anti-Tyrosine-protein kinase Kit,... |
| Anwendung: | ELISA Capture/Detector |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human,mouse |
ab 158,00 €
ISCK03
Artikelnummer: TGM-T3452-100mg
Description: ISCK03 is a selective SCF/c-Kit inhibitor. Target: c-Kit. Smiles: CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-n1ccnc1. References: Na YJ, et al. [4-t-butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in...
| Anwendung: | Cell-permeable inhibitor of SCF-mediated c-kit activation |
| CAS | 945526-43-2 |
| MW: | 355.45 D |
ab 34,00 €
Olverembatinib
Artikelnummer: TGM-T3071-100mg
Description: Olverembatinib (GZD 824) is an orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT, IC50: 0.34 nM) and Bcr-Abl(T315I, IC50: 0.68 nM). Target: Bcr-Abl. Smiles: CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4[nH]ncc4c3)cc2C(F)(F)F)CC1. References: Ren X, et al. J Med Chem. 2013, 56(3), 879-894.
| Schlagworte: | GZD 824 |
| Anwendung: | Targets abelson tyrosine-protein kinase 1 [EC:2.7.10.2] (ABL1) |
| CAS | 1257628-77-5 |
| MW: | 532.56 D |
ab 31,00 €
Multi-kinase inhibitor 1
Artikelnummer: TGM-T4191-100mg
Description: Multi-kinase inhibitor 1 (Multi-kinase inhibitor I) is a Multi-kinase inhibitor. Target: c-Kit, Others, Bcr-Abl, PDGFR. Smiles: N(C1=CC(C2=CC=C(C(NCCO)=O)C=C2)=NC=N1)C3=CC=C(OC(F)(F)F)C=C3. References: Chang Hsu Y, et al. Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the...
| Schlagworte: | Multi-kinase inhibitor I |
| Anwendung: | Multi-kinase inhibitor |
| CAS | 778274-97-8 |
| MW: | 418.37 D |
ab 34,00 €
AZD3229
Artikelnummer: TGM-T5409-100mg
Description: AZD3229 is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors. It demonstrates potent single-digit nM growth inhibition across a broad cell panel. Target: c-Kit. Smiles: COCCOc1cc(F)c2c(Nc3ccc(NC(=O)Cn4cc(nn4)C(C)C)cc3)ncnc2c1. References: Kettle JG, et al. Discovery...
| Anwendung: | c-Kit-driven cell proliferation inhibitor |
| CAS | 2248003-60-1 |
| MW: | 479.51 D |
ab 38,00 €
Nilotinib hydrochloride dihydrate
Artikelnummer: TGM-T68338-100mg
Description: Nilotinib hydrochloride dihydrate is a small-molecule tyrosine kinase inhibitor approved for the treatment of imatinib-resistant chronic myelogenous leukemia. Target: Others. Smiles: O=C(C1=CC=C(C)C(NC2=NC(C3=CN=CC=C3)=CC=N2)=C1)NC4=CC(C(F)(F)F)=CC(N5C=NC(C)=C5)=C4.Cl.O.O
| Anwendung: | Targets abelson tyrosine-protein kinase 1 [EC:2.7.10.2] (ABL1) |
| CAS | 923289-71-8 |
| MW: | 602.02 D |
ab 1.520,00 €
Pazopanib Hydrochloride
Artikelnummer: TGM-T6930-100mg
Description: Pazopanib Hydrochloride (Votrient HCl) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM in cell-free assays, respectively. Target: FGFR, VEGFR, c-Kit, c-Fms, Autophagy, PDGFR. Smiles:...
| Schlagworte: | GW786034, Pazopanib HCl, GW786034 HCl, Votrient HCl, Armala |
| Anwendung: | Targets FMS-like tyrosine kinase 1 [EC:2.7.10.1] (FLT1, VEGFR1) |
| CAS | 635702-64-6 |
| MW: | 473.98 D |
ab 48,00 €
Toceranib Phosphate
Artikelnummer: TGM-T7394-100mg
Description: Toceranib Phosphate (SU11654 phosphate), is a selective inhibitor of the tyrosine kinase activity of several members of the split kinase RTK family, including Flk-1/KDR, PDGFR. Target: Tyrosinase, PDGFR, VEGFR, c-Kit. Smiles: OP(O)(O)=O.Cc1[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c(C)c1C(=O)NCCN1CCCC1....
| Schlagworte: | SU11654 phosphate, PHA 291639 phosphate |
| Anwendung: | Targets proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1] (KIT, SCFR, CD117) |
| CAS | 874819-74-6 |
| MW: | 494.45 D |
ab 42,00 €