Zu "K05090" wurden 201 Artikel gefunden!
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Ki20227
Artikelnummer: TGM-T4315-100mg
Description: Ki-20227 is a specific c-Fms tyrosine kinase(CSF1R) inhibitor (IC50: 2 nM). It also has certain inhibitory against VEGFR2(IC50: 12 nM) and c-Kit/PDGFRbeta(IC50: 451/217 nM), respectively. Target: c-Fms, CSF-1R, PDGFR, c-Kit, VEGFR. Smiles: COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1NC(=O)NC(C)c1nccs1....
| Anwendung: | CSF-1 receptor inhibitor |
| CAS | 623142-96-1 |
| MW: | 480.54 D |
ab 39,00 €
Sotuletinib
Artikelnummer: TGM-T6119-100mg
Description: Sotuletinib (BLZ945) is an orally active, effective and specific CSF-1R inhibitor (IC50: 1 nM), >1000-fold selective against its closest receptor tyrosine kinase homologs. Target: c-Fms, CSF-1R. Smiles: CNC(=O)c1cc(Oc2ccc3nc(N[C@@H]4CCCC[C@H]4O)sc3c2)ccn1. References: Pyonteck SM, et al. Nat Med. 2013,...
| Schlagworte: | BLZ945 |
| Anwendung: | Anticancer compound, CSF-1R / c-Fms inhibitor |
| CAS | 953769-46-5 |
| MW: | 398.48 D |
ab 32,00 €
cFMS Receptor Inhibitor II
Artikelnummer: TGM-T5586-100mg
Description: cFMS Receptor Inhibitor II is a CSF1R kinase (FMS Receptor, colony stimulating factor 1 receptor, Macrophage colony-stimulating factor receptor) inhibitor with an IC50 of 2.8 nM, demonstrating significant selectivity over other kinases. This compound also exhibits notable CSF1R inhibition with an IC50...
| Anwendung: | cFMS (CSF1R) inhibitor |
| CAS | 959860-85-6 |
| MW: | 368.43 D |
ab 42,00 €
Pexidartinib hydrochloride
Artikelnummer: TGM-T62788-2mg
Description: Pexidartinib hydrochloride (PLX-3397 hydrochloride) is a potent, selective, orally active, ATP-competitive inhibitor of colony-stimulating factor 1 (CSF1R or M-CSFR) (IC50: 20 nM) and c-Kit (IC50: 10 nM), with 10-100 times greater selectivity for these targets compared to FLT3 (IC50: 160 nM), KDR...
| Anwendung: | Targets macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1] (CSF1R, FMS, CD115) |
| CAS | 2040295-03-0 |
| MW: | 454.28 D |
31,00 €
PLX5622
Artikelnummer: TGM-T7100-100mg
Description: PLX5622 is a highly selective, brain-penetrant, and orally active CSF1R inhibitor. Target: c-Fms, CSF-1R. Smiles: COc1ncc(F)cc1CNc1ccc(Cc2c[nH]c3ncc(C)cc23)c(F)n1. References: Rosin JM, Vora SR, Kurrasch DM.Depletion of embryonic microglia using the CSF1R inhibitor PLX5622 has adverse sex-specific...
| Schlagworte: | PLX-5622 |
| Anwendung: | CSF1R inhibitor |
| CAS | 1303420-67-8 |
| MW: | 395.41 D |
ab 84,00 €
GTP-14564
Artikelnummer: TGM-T71857-100mg
Description: GTP-14564 is a novel tyrosine kinase inhibitor that also inhibits wt-FLT3 and ITD-FLT3. GTP-14564 inhibits the growth of interleukin-3-independent Ba/F1 expressing ITD-FLT3 at 3 µ m, whereas a 30-fold higher concentration of GTP-14564 is required to inhibit the FLT3 ligand-dependent growth (wt-FLT3) of...
| Anwendung: | Class III receptor tyrosine kinase inhibitor |
| CAS | 34823-86-4 |
| MW: | 234.25 D |
ab 39,00 €
Emactuzumab
Artikelnummer: TGM-T76776-100mg
Description: Emactuzumab(RG 7155) is a monoclonal antibody against colony-stimulating factor-1 receptor targeting tumor-associated macrophages (TAMs) Emactuzumab has antitumor activity and inhibits activation of colony-stimulating factor 1 receptor (CSF1R) Emactuzumab has a high affinity for CSF-1R with a Ki value...
| Schlagworte: | RG 7155, RO 5509554 |
| Anwendung: | Targets macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1] (CSF1R, FMS, CD115) |
| CAS | 1448221-67-7 |
ab 321,00 €
CSF1R Protein (Met1-Glu512), Human, Recombinant (His)
Artikelnummer: TGM-TMPY-01037-100ug
Description: CSF1R Protein (Met1-Glu512), Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 56 kDa and the accession number is P07333-1.
| Schlagworte: | C-FMS, FMS, colony stimulating factor 1 receptor, CSFR, M-CSF-R, MCSF Receptor, HDLS, FIM2, CSF-1R, CD115 |
| MW: | 56 kD |
ab 223,00 €
M-CSFR/CSF1R/CD115 Protein, Human, Recombinant (His & Avi)
Artikelnummer: TGM-TMPK-00414-100ug
Description: M-CSFR/CSF1R/CD115 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 57.4 kDa and the accession number is P07333-1.
| Schlagworte: | FMSFIM2, HDLS, M-CSF R, FMS, M-CSFR, CSF1R, CSF-1-R, FIM2, MCSFR, CD115, CSFR, C-FMS |
| MW: | 57.4 kD |
ab 226,00 €
M-CSFR/CSF1R/CD115 Protein, Human, Recombinant (His &...
Artikelnummer: TGM-TMPK-00415-100ug
Description: M-CSFR/CSF1R/CD115 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 57.4 kDa and the accession number is P07333-1.
| Schlagworte: | MCSFR, HDLS, CSF1R, FIM2, C-FMS, M-CSF R, CSF-1-R, CSFR, FMSFIM2, CD115, FMS, M-CSFR |
| MW: | 57.4 kD |
ab 798,00 €
CSF1R Protein, Human, Recombinant
Artikelnummer: TGM-TMPY-00881-200ug
Description: CSF1R Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 55.1 kDa and the accession number is P07333-1.
| Schlagworte: | colony stimulating factor 1 receptor, CSF-1R, M-CSF-R, HDLS, FMS, MCSF Receptor, CD115, CSFR, FIM2, C-FMS |
| MW: | 55.1 kD |
587,00 €
CSF1R Protein, Feline, Recombinant (His & SUMO)
Artikelnummer: TGM-TMPH-00354-100ug
Description: CSF1R Protein, Feline, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 70.8 kDa and the accession number is P13369.
| Schlagworte: | CSF-1R, Proto-oncogene c-Fms, CSF-1-R, CSF1R, M-CSF-R, FMS, CD115, CSF-1 receptor, Macrophage colony-stimulating factor 1... |
| MW: | 70.8 kD |
ab 352,00 €