Zu "K05089" wurden 225 Artikel gefunden!
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Dovitinib lactate hydrate
Artikelnummer: TGM-T6479-100mg
Description: Dovitinib lactate hydrate (TKI258) is the Lactate of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGFR1 and...
| Schlagworte: | Dovitinib (TKI258) Lactate, Dovitinib Lactate, TKI258 |
| Anwendung: | Targets fms-related tyrosine kinase 3 [EC:2.7.10.1] (FLT3, FLK2, CD135) |
| CAS | 915769-50-5 |
| MW: | 482.51 D |
ab 49,00 €
Tivozanib hydrochloride hydrate
Artikelnummer: TGM-T63505-100mg
Description: Tivozanib hydrochloride hydrate (AV-951 hydrochloride hydrate) is an orally active, selective, and potent vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor that inhibits VEGFR-1, VEGFR-2, and VEGFR-3. Target: VEGFR. Smiles:...
| Schlagworte: | KRN951 hydrochloride hydrate, AV-951 hydrochloride hydrate |
| Anwendung: | Targets FMS-like tyrosine kinase 1 [EC:2.7.10.1] (FLT1, VEGFR1) |
| CAS | 682745-41-1 |
| MW: | 509.34 D |
ab 54,00 €
CP-673451
Artikelnummer: TGM-T6091-100mg
Description: CP-673451 is a specific inhibitor of PDGFRalpha/beta (IC50: 10/1 nM) with antiangiogenic and antitumor activity and the selectivity is higher 450-fold than other angiogenic receptors. Target: PDGFR, VEGFR, c-Kit. Smiles: COCCOc1ccc2n(cnc2c1)-c1ccc2cccc(N3CCC(N)CC3)c2n1. References: Roberts WG, et al....
| Anwendung: | PDGFRbeta inhibitor |
| CAS | 343787-29-1 |
| MW: | 417.5 D |
ab 45,00 €
Dasatinib
Artikelnummer: TGM-T1448-50mg
Description: Dasatinib (BMS-354825) is an orally active, ATP-competitive tyrosine kinase inhibitor that targets Src and Bcr-Abl (Ki=16/30 pM), with antitumor activity, used in the treatment of leukemia and lymphoma. Target: c-Kit, Autophagy, Bcr-Abl, Apoptosis, Src. Smiles:...
| Schlagworte: | BMS-354825 |
| Anwendung: | Targets abelson tyrosine-protein kinase 1 [EC:2.7.10.2] (ABL1) |
| CAS | 302962-49-8 |
| MW: | 488.01 D |
ab 38,00 €
AG 1295
Artikelnummer: TGM-T14137-100mg
Description: AG 1295, a selective inhibitor of platelet-derived growth factor receptor (PDGFR) tyrosine-kinase, effectively halts PDGFR autophosphorylation without impacting the autophosphorylation of the EGF receptor[1][2][3][4]. Target: PDGFR. Smiles: Cc1cc2ncc(nc2cc1C)-c1ccccc1. References: Kovalenko M, et al....
| Anwendung: | PDGF receptor kinase inhibitor |
| CAS | 71897-07-9 |
| MW: | 234.3 D |
ab 46,00 €
Vatalanib free base
Artikelnummer: TGM-T17219-100mg
Description: Vatalanib is a VEGFR2/KDR inhibitor (IC50: 37 nM). Target: VEGFR. Smiles: ClC1=CC=C(NC2=NN=C(CC3=CC=NC=C3)C3=CC=CC=C23)C=C1
| Anwendung: | Targets platelet-derived growth factor receptor beta [EC:2.7.10.1] (PDGFRB, CD140B) |
| CAS | 212141-54-3 |
| MW: | 346.81 D |
ab 42,00 €
JNJ-10198409
Artikelnummer: TGM-T15616-100mg
Description: JNJ- 10198409 is a relatively selective and ATP competitive PDGF-RTK inhibitor (IC50=2 nM). JNJ-10198409 has good activity against PDGFR-beta kinase (IC50=4.2 nM) and PDGFR-alpha kinase (IC50=45 nM). It is a dual-mechanism, antiangiogenic, and tumor cell antiproliferative agent. Target: PDGFR. Smiles:...
| Schlagworte: | JNJ-10198409 |
| Anwendung: | PDGF-BB inhibitor |
| CAS | 627518-40-5 |
| MW: | 325.34 D |
ab 30,00 €
Dasatinib monohydrate
Artikelnummer: TGM-T1448L-100mg
Description: Dasatinib monohydrate (BMS-354825 Monohydrate) is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib monohydrate binds to and inhibits the growth-promoting activities of these kinases. Apparently, because of its less stringent binding affinity for...
| Schlagworte: | BMS-354825 Monohydrate |
| Anwendung: | Targets abelson tyrosine-protein kinase 1 [EC:2.7.10.2] (ABL1) |
| CAS | 863127-77-9 |
| MW: | 506.03 D |
ab 34,00 €
Tandutinib
Artikelnummer: TGM-T1667-100mg
Description: Tandutinib (CT53518) (MLN518, CT53518), an effective FLT3 antagonist (IC50: 0.22 µM), can also inhibit c-Kit and PDGFR, 15-20 fold higher potency for FLT3 versus CSF-1R and >100-fold selectivity for the same target versus FGFR, EGFR, and KDR. Target: c-Kit, CSF-1R, Src, FLT, PDGFR, Apoptosis....
| Schlagworte: | NSC726292, CT53518, MLN518 |
| Anwendung: | Targets fms-related tyrosine kinase 3 [EC:2.7.10.1] (FLT3, FLK2, CD135) |
| CAS | 387867-13-2 |
| MW: | 562.7 D |
ab 40,00 €
JI-101
Artikelnummer: TGM-T3476-100mg
Description: JI-101 (CGI-1842) is an oral multi-kinase inhibitor that targets vascular endothelial growth factor receptor type 2 (VEGFR-2), platelet derived growth factor receptor beta (PDGFR-beta), and ephrin type-B receptor 4 (EphB4). Target: VEGFR, PDGFR, Ephrin Receptor. Smiles:...
| Schlagworte: | CGI-1842, JI 101 |
| Anwendung: | VEGFR2 inhibitor |
| CAS | 900573-88-8 |
| MW: | 466.33 D |
ab 31,00 €
(E/Z)-AG490
Artikelnummer: TGM-T60624-200mg
Description: (E/Z)-AG490 ((E/Z)-Tyrphostin AG490) is a racemic compound comprising the isomers (E)-AG490 and (Z)-AG490. (E)-AG490 functions as a tyrosine kinase inhibitor, targeting EGFR, Stat-3, and JAK2/3. Target: Others. Smiles: C(=C(C(NCC1=CC=CC=C1)=O)C#N)C2=CC(O)=C(O)C=C2
| Anwendung: | PDGF receptor autophosphorylation inhibitor |
| CAS | 134036-52-5 |
| MW: | 294.3 D |
1.229,00 €
Orantinib
Artikelnummer: TGM-T6184-100mg
Description: Orantinib (NSC 702827) , a excellent effective against PDGFR autophosphorylation with Ki of 8 nM, also highly inhibits Flk-1 and FGFR1 trans-phosphorylation. It shows little effect against IGF-1R, Met, Src, Lck, Zap70, Abl and CDK2 and does not suppresses EGFR. Target: Apoptosis, PDGFR, VEGFR, FGFR....
| Schlagworte: | SU6668, NSC 702827, TSU-68 |
| Anwendung: | Tyrosine kinase inhibitor |
| CAS | 252916-29-3 |
| MW: | 310.35 D |
ab 46,00 €