Zu "K05087" wurden 173 Artikel gefunden!
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Anti-IGF1R
Artikelnummer: ABS-KC-1335.100
Protein function: Receptor tyrosine kinase which mediates actions of insulin- like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of...
| Schlagworte: | Anti-Insulin-like growth factor 1 receptor, Anti-Insulin-like growth factor I receptor, Anti-IGF-I receptor, Anti-CD... |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human, mouse |
ab 232,00 €
Anti-IGF1R
Artikelnummer: ABS-KC-1545.100
Protein function: Receptor tyrosine kinase which mediates actions of insulin- like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of...
| Schlagworte: | Anti-Insulin-like growth factor 1 receptor, Anti-Insulin-like growth factor I receptor, Anti-IGF-I receptor, Anti-CD... |
| Anwendung: | IP |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 206,00 €
BMS-536924
Artikelnummer: TGM-T6419-1mg
Description: BMS-536924 (BMS 536924) is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/2. Target: Src, IGF-1R, FAK, MEK, Apoptosis. Smiles: Cc1cc(cc2nc([nH]c12)-c1c(NC[C@@H](O)c2cccc(Cl)c2)cc[nH]c1=O)N1CCOCC1....
| Schlagworte: | CS-0117, HY-10262, BMS 536924, HY-10262 |
| Anwendung: | IGF1R / insulin receptor inhibitor |
| CAS | 468740-43-4 |
| MW: | 479.96 D |
ab 34,00 €
IGF1R/CD221 Protein, Human, Recombinant (His & Avi)
Artikelnummer: TGM-TMPK-00455-100ug
Description: The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the...
| Schlagworte: | IGF-1R, IGF-I R, IGF-I receptor, MGC142172, MGC142170, MGC18216, CD221, JTK13, IGFR, IGFIR, IGF1R |
| MW: | 105.8 kD |
ab 485,00 €
IGF1R/CD221 Protein, Human, Recombinant (aa 31-932, His &...
Artikelnummer: TGM-TMPK-00456-100ug
Description: The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the...
| Schlagworte: | IGF-1R, IGF-I receptor, IGF1R, MGC142170, IGFR, IGFIR, MGC18216, JTK13, IGF-I R, CD221, MGC142172 |
| MW: | 105.8 kD |
ab 814,00 €
IGF1R/CD221 Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPY-00834-100ug
Description: IGF1R/CD221 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 81 kDa and the accession number is P08069.
| Schlagworte: | IGFIR, IGFR, IGF-I R, IGF1 Receptor, JTK13, CD221, insulin-like growth factor 1 receptor |
| MW: | 81 kD |
ab 345,00 €
IGF1R/CD221 Protein, Mouse, Recombinant (His)
Artikelnummer: TGM-TMPY-06195-100ug
Description: IGF1R/CD221 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 105.2 kDa and the accession number is E9QNX9.
| Schlagworte: | A330103N21Rik, D930020L01, hyft, insulin-like growth factor 1 receptor, CD221, IGF-1R |
| MW: | 105.2 kD |
ab 699,00 €
IGF1R/CD221 Protein, Human, Recombinant (His & GST)
Artikelnummer: TGM-TMPY-04360-50ug
Description: IGF1R/CD221 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 74.6 kDa and the accession number is P08069.
| Schlagworte: | IGF1 Receptor, insulin-like growth factor 1 receptor, JTK13, IGF-I R, IGFIR, IGFR, CD221 |
| MW: | 74.6 kD |
497,00 €
AZD-3463
Artikelnummer: TGM-T1967-100mg
Description: AZD-3463 (ALK/IGF1R inhibitor), an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency. Target: ALK, Apoptosis, Autophagy, IGF-1R. Smiles: COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12)N1CCC(N)CC1. References: 104th AACR meeting, 2013, Abst 919.
| Schlagworte: | ALK/IGF1R inhibitor |
| Anwendung: | ALK inhibitor, IGF1R inhibitor |
| CAS | 1356962-20-3 |
| MW: | 448.95 D |
ab 48,00 €
Linsitinib
Artikelnummer: TGM-T6017-100mg
Description: OSI-906 (Linsitinib (OSI-906)) is an orally bioavailable small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity. Linsitinib selectively inhibits IGF-1R, which may result in the inhibition of tumor cell proliferation and the induction of...
| Schlagworte: | OSI-906 |
| Anwendung: | Targets insulin-like growth factor 1 receptor [EC:2.7.10.1] (IGF1R, CD221) |
| CAS | 867160-71-2 |
| MW: | 421.49 D |
ab 34,00 €
Tyrphostin AG 538
Artikelnummer: TGM-T67707-100mg
Description: Tyrphostin AG 538 is a chalcone compound, an IGF-1 receptor kinase inhibitor (IC50 : for 400 nM) that is potent, cell-permeable, reversible, and competitive. Target: IGF-1R. Smiles: C(/C(=C/C1=CC(O)=C(O)C=C1)/C#N)(=O)C2=CC(O)=C(O)C=C2. References: Blum G, et al. Substrate competitive inhibitors of IGF-1...
| Schlagworte: | AG 538 |
| Anwendung: | IGF1R inhibitor |
| CAS | 133550-18-2 |
| MW: | 297.26 D |
ab 100,00 €
NVP-ADW742
Artikelnummer: TGM-T6079-100mg
Description: NVP-ADW742 (ADW) is an IGF-1R inhibitor with IC50 of 0.17 µM, >16-fold more potent against IGF-1R than InsR, little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit. Target: IGF-1R, Apoptosis. Smiles: Nc1ncnc2n(cc(-c3cccc(OCc4ccccc4)c3)c12)C1CC(CN2CCCC2)C1. References: Mitsiades CS, et al. Cancer...
| Schlagworte: | ADW, GSK 552602A, ADW742 |
| Anwendung: | IGF-1R inhibitor |
| CAS | 475488-23-4 |
| MW: | 453.58 D |
ab 48,00 €