Zu "K05087" wurden 188 Artikel gefunden!
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AZ7550
Artikelnummer: TGM-T13564-100mg
Description: AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 µM). Target: ALK, BTK, MLK, IGF-1R, ACK, EGFR, FLT, Drug Metabolite, MNK, Tyrosine Kinases, FAK, PYK2. Smiles: CN1C=C(C=2C1=CC=CC2)C3=NC(NC4=C(OC)C=C(N(CCNC)C)C(NC(C=C)=O)=C4)=NC=C3. References: Finlay MR, et...
| Anwendung: | AZ 9291 active metabolite, IGF1R inhibitor |
| CAS | 1421373-99-0 |
| MW: | 485.58 D |
ab 130,00 €
XL228
Artikelnummer: TGM-T17267-100mg
Description: XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively). Target: Src, Bcr-Abl, Aurora Kinase, IGF-1R. Smiles: CC(C)c1cc(CNc2nc(Nc3cc([nH]n3)C3CC3)cc(n2)N2CCN(C)CC2)on1. References: Cortes J, et al. Preliminary...
| Anwendung: | IGF1R / FGFR1-3 inhibitor |
| CAS | 898280-07-4 |
| MW: | 437.54 D |
ab 51,00 €
GSK1838705A
Artikelnummer: TGM-T3079-10mg
Description: GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 nM) and ALK (IC50: 0.5 nM), respectively, and little inhibition to other protein kinases. Target: IGF-1R, S6 Kinase, ALK, JNK. Smiles: CNC(=O)c1c(F)cccc1Nc1nc(Nc2cc3N(CCc3cc2OC)C(=O)CN(C)C)nc2[nH]ccc12....
| Anwendung: | IGF-1R / IR inhibitor |
| CAS | 1116235-97-2 |
| MW: | 532.57 D |
ab 34,00 €
IGF-1R inhibitor-2
Artikelnummer: TGM-T38502-5mg
Description: IGF-1R inhibitor-2 (example 121) is a compound that inhibits the insulin-like growth factor-1 receptor (IGF-1R), potentially reversing the transformed phenotype of tumor cells and increasing their susceptibility to apoptosis. Target: Others. Smiles:...
| Anwendung: | IGF-1R inhibitor |
| CAS | 1116236-15-7 |
| MW: | 461.501 D |
951,00 €
NT157
Artikelnummer: TGM-T4605-100mg
Description: NT157 is a small molecule tyrphostin targeting IRS protein and has the potential to inhibit IGF-1R and STAT3 signaling pathways in TME cancer cells and stromal cells, resulting in decreased cancer cell survival. Target: IGF-1R, STAT. Smiles: C(=C/C(NCC1=CC(O)=C(O)C(O)=C1)=S)\C2=CC(Br)=C(O)C(O)=C2....
| Anwendung: | IGF-1R signaling inhibitor |
| CAS | 1384426-12-3 |
| MW: | 412.26 D |
ab 50,00 €
AEW541 HCl
Artikelnummer: TGM-T69682-10mg
Description: AEW541, also known as NVP-AEW541, is a novel, potent IGF-IR kinase inhibitor. NVP-AEW541 is capable of distinguishing between the IGF-IR (IC50 = 0.086 microM) and the closely related InsR (IC50 = 2.3 microM) in cells. NVP- AEW541 abrogates IGF-I-mediated survival and colony formation in soft agar at...
| Anwendung: | IGF-1R kinase inhibitor |
| CAS | 2320261-63-8 |
| MW: | 439.56 D |
ab 193,00 €
IGF1R/CD221 Protein, Human, Recombinant (His & Avi)
Artikelnummer: TGM-TMPK-00455-100ug
Description: The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the...
| Schlagworte: | IGF-1R, IGF-I R, IGF-I receptor, MGC142172, MGC142170, MGC18216, CD221, JTK13, IGFR, IGFIR, IGF1R |
| MW: | 105.8 kD |
ab 477,00 €
IGF1R/CD221 Protein, Human, Recombinant (aa 31-932, His &...
Artikelnummer: TGM-TMPK-00456-100ug
Description: The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the...
| Schlagworte: | IGF-1R, IGF-I receptor, IGF1R, MGC142170, IGFR, IGFIR, MGC18216, JTK13, IGF-I R, CD221, MGC142172 |
| MW: | 105.8 kD |
ab 798,00 €
IGF1R/CD221 Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPY-00834-100ug
Description: IGF1R/CD221 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 81 kDa and the accession number is P08069.
| Schlagworte: | IGFIR, IGFR, IGF-I R, IGF1 Receptor, JTK13, CD221, insulin-like growth factor 1 receptor |
| MW: | 81 kD |
ab 338,00 €
IGF1R/CD221 Protein, Mouse, Recombinant (His)
Artikelnummer: TGM-TMPY-06195-100ug
Description: IGF1R/CD221 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 105.2 kDa and the accession number is E9QNX9.
| Schlagworte: | A330103N21Rik, D930020L01, hyft, insulin-like growth factor 1 receptor, CD221, IGF-1R |
| MW: | 105.2 kD |
ab 686,00 €
IGF1R/CD221 Protein, Human, Recombinant (His & GST)
Artikelnummer: TGM-TMPY-04360-50ug
Description: IGF1R/CD221 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 74.6 kDa and the accession number is P08069.
| Schlagworte: | IGF1 Receptor, insulin-like growth factor 1 receptor, JTK13, IGF-I R, IGFIR, IGFR, CD221 |
| MW: | 74.6 kD |
487,00 €
AZD-3463
Artikelnummer: TGM-T1967-100mg
Description: AZD-3463 (ALK/IGF1R inhibitor), an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency. Target: ALK, Apoptosis, Autophagy, IGF-1R. Smiles: COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12)N1CCC(N)CC1. References: 104th AACR meeting, 2013, Abst 919.
| Schlagworte: | ALK/IGF1R inhibitor |
| Anwendung: | ALK inhibitor, IGF1R inhibitor |
| CAS | 1356962-20-3 |
| MW: | 448.95 D |
ab 48,00 €