Zu "K05083" wurden 493 Artikel gefunden!
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AG-825
Artikelnummer: TGM-T14138-100mg
Description: AG-825(Tyrphostin C15) is a selective and competitive ErbB2 inhibitor that inhibits tyrosine phosphorylation with an IC50 value of 0.35 µM.AG-825 (Tyrphostin C15) inhibits HER2 and shows anticancer activity in a mouse xenograft model of breast cancer.AG-825 ( Tyrphostin C15) is a potentially active...
| Schlagworte: | Tyrphostin AG-825 |
| Anwendung: | HER-2/neu inhibitor |
| CAS | 149092-50-2 |
| MW: | 397.47 D |
ab 31,00 €
Nelipepimut-S
Artikelnummer: TGM-T33626-100mg
Description: Nelipepimut-S, as an immunogenic peptide from the HER2 protein, is highly expressed in breast cancer. Smiles: [C@H](CC1=CC=CC=C1)(C(N[C@@H](CC(C)C)C(O)=O)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@H](CC2=CC=CC=C2)NC([C@@H](NC([C@H](CCCCN)N)=O)[C@H](CC)C)=O)=O)=O)CO)=O)CC(C)C)=O)C)=O. References:...
| Schlagworte: | NeuVax vaccine, E75 peptide, NeuVax |
| Anwendung: | Targets receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1] (ERBB2, HER2, CD340) |
| CAS | 160212-35-1 |
| MW: | 995.21 D |
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Trastuzumab emtansine
Artikelnummer: TGM-T36647-10mg
Description: Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that combines the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of DM1, a microtubule-inhibitory derivative of maytansine, and is utilized in the investigation of advanced breast...
| Anwendung: | Targets receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1] (ERBB2, HER2, CD340) |
| CAS | 1018448-65-1 |
ab 1.294,00 €
Tucatinib hemiethanolate
Artikelnummer: TGM-T36648-100mg
Description: Tucatinib (Irbinitinib) hemiethanolate is a potent, orally active, and selective HER2 inhibitor with an IC50 of 8 nM. Target: HER. Smiles: CCO.Cc1cc(Nc2ncnc3ccc(NC4=NC(C)(C)CO4)cc23)ccc1Oc1ccn2ncnc2c1.Cc1cc(Nc2ncnc3ccc(NC4=NC(C)(C)CO4)cc23)ccc1Oc1ccn2ncnc2c1. References: Moulder-Thompson S, et al. Phase...
| Schlagworte: | ONT-380 hemiethanolate, ARRY-380 hemiethanolate, Irbinitinib hemiethanolate |
| Anwendung: | Targets receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1] (ERBB2, HER2, CD340) |
| CAS | 1429755-56-5 |
| MW: | 1007.11 D |
ab 40,00 €
CP-724714
Artikelnummer: TGM-T4014-100mg
Description: CP-724714 (CP724714) is an effective and selective HER2/ErbB2 inhibitor (IC50: 10 nM), >640-fold selectivity against EGFR, Abl, InsR, PDGFR, IRG-1R, Src, VEGFR2, c-Met etc. Target: EGFR, Apoptosis. Smiles: COCC(=O)NC\C=C\c1ccc2ncnc(Nc3ccc(Oc4ccc(C)nc4)c(C)c3)c2c1. References: Jani JP, et al. Discovery...
| Schlagworte: | CP 724714, CP724714 |
| Anwendung: | ErbB2 inhibitor |
| CAS | 383432-38-0 |
| MW: | 469.54 D |
ab 37,00 €
TAS0728
Artikelnummer: TGM-T7819-100mg
Description: TAS0728 is a HER2 inhibitor, with antitumor activity. Target: HER, EGFR. Smiles: CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(C)c1C. References: Irie H, Ito K, Fujioka Y,et al.TAS0728, A Covalent-binding, HER2-selective Kinase Inhibitor Shows Potent Antitumor Activity in...
| Anwendung: | Covalent HER2 inhibitor |
| CAS | 2088323-16-2 |
| MW: | 504.58 D |
ab 71,00 €
EGFR/ErbB-2 inhibitor-1
Artikelnummer: TGM-T79861-100mg
Description: EGFR/ErbB-2 inhibitor-1 is a selective ErbB2/HER2 inhibitor that effectively blocks ErbB2 and HER2 signaling. Target: EGFR. Smiles: FC1=CC=CC(=C1)COC2=CC=C(C=C2Cl)NC=3N=CN=C4SC(=CC43)C=5SC=CC5. References: Rheault TR, et al. Thienopyrimidine-based dual EGFR/ErbB-2 inhibitors. Bioorg Med Chem Lett. 2009...
| Anwendung: | ErbB2/HER2 inhibitor |
| CAS | 1135150-79-6 |
| MW: | 467.97 D |
ab 190,00 €
HER2/ERBB2 Protein, Human, Recombinant
Artikelnummer: TGM-TMPY-00167-100ug
Description: HER2/ERBB2 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 70 kDa and the accession number is P04626-1.
| Schlagworte: | NEU, HERVWENV, CD340, HER2, HERV7Q, erb-b2 receptor tyrosine kinase 2, HER-2/neu, ENVW, HER-2, HERVW, ENV, MLN 19, MLN19,... |
| MW: | 70 kD |
ab 493,00 €
HER2/ERBB2 Protein, Human, Recombinant (hFc & Avi),...
Artikelnummer: TGM-TMPJ-00776-100ug
Description: HER2/ERBB2 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-Fc-Avi tag. The predicted molecular weight is 120-140 KDa and the accession number is P04626.
| Schlagworte: | NGL, Tyrosine kinase-type cell surface receptor HER2, MLN19, EGFR2, TKR1, Proto-oncogene Neu, Metastatic lymph node gene... |
| MW: | 140 kD |
ab 347,00 €
HER2/ERBB2 Protein, Human, Recombinant (aa 23-652, hFc)
Artikelnummer: TGM-TMPJ-00777-10ug
Description: HER2/ERBB2 Protein, Human, Recombinant (aa 23-652, hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 120-145 KDa and the accession number is P04626.
| Schlagworte: | TKR1, Proto-oncogene Neu, EGFR2, Tyrosine kinase-type cell surface receptor HER2, Metastatic lymph node gene 19 protein,... |
| MW: | 145 kD |
ab 113,00 €
HER2/ERBB2 Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPJ-00778-10ug
Description: HER2/ERBB2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 90-120 KDa and the accession number is P04626.
| Schlagworte: | Receptor tyrosine-protein kinase erbB-2, MLN19, EGFR2, NGL, Proto-oncogene Neu, Tyrosine kinase-type cell surface receptor... |
| MW: | 120 kD |
ab 74,00 €
Trastuzumab
Artikelnummer: TGM-T9912-100mg
Description: Trastuzumab is a humanized monoclonal antibody for patients with invasive breast cancers that overexpress HER2. Trastuzumab has been clinically used to treat HER2 Positive Metastatic Breast Cancer and HER2 Positive Gastric Cancer. Target: EGFR, ADC Antibody. References: Zazo S, et al. Generation,...
| MW: | 145.53 kD |
ab 153,00 €