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Zu "K05082" wurden 27 Artikel gefunden!
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NEU
Artikelnummer: CSB-EP014755HU.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 26-491aa. Protein Length: Extracellular Domain. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: QDVSLLASDS EPLKCFSRTF EDLTCFWDEE EAAPSGTYQL LYAYPREKPR ACPLSSQSMP HFGTRYVCQF PDQEEVRLFF PLHLWVKNVF LNQTRTQRVL FVDSVGLPAP PSIIKAMGGS QPGELQISWE...
Schlagworte: | MPL, TPOR, TPO-R, CD110, Proto-oncogene c-Mpl, Thrombopoietin receptor, Myeloproliferative leukemia protein, Recombinant... |
Anwendung: | Activity not tested |
Exprimiert in: | E.coli |
Ursprungsart: | human |
MW: | 56.5 kD |
ab 213,00 €
NEU
Artikelnummer: DIM-PME100588.10
Recombinant Human c-MPL with C-terminal human Fc tag. c-MPL(Gln26-Ala490) hFc(Glu99-Ala330), Protein function: Receptor for thrombopoietin that acts as a primary regulator of megakaryopoiesis and platelet production. May represent a regulatory molecule specific for TPO-R-dependent immune responses. [The UniProt...
Schlagworte: | C-MPL, CD110, MPLV, THCYT2, THPOR, TPOR |
Exprimiert in: | Human cells |
Ursprungsart: | human |
CAS | 12 |
MW: | 78.5 kD |
ab 115,00 €
Artikelnummer: NSJ-F54100-0.05ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. Myeloproliferative leukemia protein (MPL) is the receptor for Thrombopoietin. May represent a regulatory molecule specific for TPO-R-dependent immune responses. [UniProt] Protein function: Receptor for thrombopoietin that acts as a primary regulator of megakaryopoiesis and...
Schlagworte: | Anti-MPL, Anti-TPOR, Anti-TPO-R, Anti-CD110, Anti-Proto-oncogene c-Mpl, Anti-Thrombopoietin receptor,... |
Anwendung: | WB |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
ab 326,00 €
Artikelnummer: Cay26533-1
Lusutrombopag is an agonist of the thrombopoietin receptor. It induces proliferation of Ba/F3 cells expressing human MPL, the gene for the thrombopoietin receptor, with an EC50 value of 84 nM but not of those expressing mouse Mpl. Lusutrombopag (0.3-10 mg/kg per day) increases the number of circulating platelets in...
Schlagworte: | (2E)-3-[2,6-dichloro-4-[[[4-[3-[(1S)-1-(hexyloxy)ethyl]-2-methoxyphenyl]-2-thiazolyl]amino]carbonyl]phenyl]-2-methyl-2-pro... |
Anwendung: | Thrombopoietin receptor agonist |
CAS | 1110766-97-6 |
MW: | 591.5 D |
ab 61,00 €
Artikelnummer: Cay13247-1
Eltrombopag is an orally bioavailable nonpeptide agonist of the thrombopoietin receptor (EC50 = 0.27 µM in a reporter assay) and an iron chelator. It increases STAT5 phosphorylation in N2C-Tpo cells when used at a concentration of 30 µM and p42/44 MAPK phosphorylation when used at 10 µM. Eltrombopag binds to the...
Schlagworte: | SB 497115,... |
Anwendung: | TpoR agonist |
CAS | 496775-61-2 |
MW: | 442.5 D |
ab 43,00 €
Artikelnummer: Cay26114-1
Eltrombopag-13C4 is intended for use as an internal standard for the quantification of eltrombopag (Cay-13247) by GC- or LC-MS. Eltrombopag is an orally bioavailable nonpeptide agonist of the thrombopoietin receptor (EC50 = 0.27 µM in a reporter assay) and an iron chelator. It increases STAT5 phosphorylation in...
Schlagworte: | (Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-(methyl-13C)-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene-3,4,5-13C3)hydrazineyl)-2'-hydroxy... |
Anwendung: | GC-MS, LC-MS, internal standard, TpoR agonist |
MW: | 446.4 D |
ab 310,00 €
Artikelnummer: ARG82349.96
Protein function: Receptor for thrombopoietin that acts as a primary regulator of megakaryopoiesis and platelet production. May represent a regulatory molecule specific for TPO-R-dependent immune responses. [The UniProt Consortium]
Schlagworte: | Mpl, Tpor, TPO-R, CD110, Proto-oncogene c-Mpl, Thrombopoietin receptor, Myeloproliferative leukemia protein |
Anwendung: | ELISA |
Spezies-Reaktivität: | mouse |
1.416,00 €
Artikelnummer: Cay26535-10
Avatrombopag is an agonist of the thrombopoietin receptor. It induces proliferation of Ba/F3 cells expressing the thrombopoietin receptor (EC50 = 3.3 nM) and induces differentiation of hematopoietic progenitor cells into megakaryotes. Avatrombopag is species-specific, inducing STAT5 phosphorylation in human and...
Schlagworte: | AKR 501, AS 1670542, YM477,... |
Anwendung: | Thrombopoietin receptor agonist |
CAS | 570406-98-3 |
MW: | 649.7 D |
ab 125,00 €
Artikelnummer: IB-IB20001
This assay utilizes proprietary human cells that provide constitutive expression fo the Human Thrombopoietin Receptor (TPOR). TPOR, also known as MPL or CD110, is a member of the type I cytokine receptor superfamily. Thrombopoietin (TPO), the physiological activator of TPOR, is a glycoprotein that regulates...
Schlagworte: | MPL, TPOR, CD110, TPO-R, Proto-oncogene c-Mpl, Thrombopoietin receptor, Myeloproliferative leukemia protein |
Anwendung: | Functional activity screening |
Spezies-Reaktivität: | human |
ab 1.448,00 €
Artikelnummer: IB-IB20002
This assay utilizes proprietary human cells that provide constitutive expression fo the Human Thrombopoietin Receptor (TPOR). TPOR, also known as MPL or CD110, is a member of the type I cytokine receptor superfamily. Thrombopoietin (TPO), the physiological activator of TPOR, is a glycoprotein that regulates...
Schlagworte: | MPL, TPOR, CD110, TPO-R, Proto-oncogene c-Mpl, Thrombopoietin receptor, Myeloproliferative leukemia protein |
Anwendung: | Functional activity screening |
Spezies-Reaktivität: | human |
3.802,00 €
NEU
Artikelnummer: CSB-YP014755HU.1
Organism: Homo sapiens (Human). Source: Yeast. Expression Region: 26-491aa. Protein Length: Extracellular Domain. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: QDVSLLASDS EPLKCFSRTF EDLTCFWDEE EAAPSGTYQL LYAYPREKPR ACPLSSQSMP HFGTRYVCQF PDQEEVRLFF PLHLWVKNVF LNQTRTQRVL FVDSVGLPAP PSIIKAMGGS QPGELQISWE...
Schlagworte: | MPL, TPOR, TPO-R, CD110, Proto-oncogene c-Mpl, Thrombopoietin receptor, Myeloproliferative leukemia protein, Recombinant... |
Anwendung: | Activity not tested |
Exprimiert in: | Yeast |
Ursprungsart: | human |
MW: | 54.5 kD |
ab 235,00 €
Artikelnummer: E-AB-91618.120
In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with...
Schlagworte: | MPL, TPOR, CD110, TPO-R, Proto-oncogene c-Mpl, Thrombopoietin receptor, Myeloproliferative leukemia protein,... |
Anwendung: | WB, IF |
Wirt: | Rabbit |
Spezies-Reaktivität: | human, mouse, rat |
ab 198,00 €