Zu "K05031" wurden 107 Artikel gefunden!
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A-1596586
Artikelnummer: Cay41316-5
A-1596586 is a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) bearing the F508 deletion (F508del) mutation. It increases CFTR levels in CFBE41o- bronchial epithelial cells expressing F508del-CFTR fused to HRP (EC50 = 0.13 µM) and the transepithelial current in primary human bronchial...
| Schlagworte: | 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-[(2R,4R)-2-(3,4-dimethoxyphenyl)-3,4-dihydro-7-methoxy-2H-1-benzopyran-4-yl]-cyclo... |
| Anwendung: | F508del-CFTR corrector |
| CAS | 1918142-34-3 |
| MW: | 539.5 D |
ab 67,00 €
Icenticaftor
Artikelnummer: TGM-T9499-100mg
Description: Icenticaftor (QBW251) is an orally active potentiator of the CFTR channel. Target: CFTR. Smiles: COc1nc(C(=O)NC[C@](C)(O)C(F)(F)F)c(N)cc1C(F)(F)F. References: Darren Le Grand, et al. Discovery of Icenticaftor (QBW251), a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator with Clinical...
| Schlagworte: | QBW251 |
| Anwendung: | Targets cystic fibrosis transmembrane conductance regulator [EC:5.6.1.6] (CFTR, ABCC7) |
| CAS | 1334546-77-8 |
| MW: | 361.24 D |
ab 161,00 €
Olacaftor
Artikelnummer: TGM-T25898-100mg
Description: Olacaftor, also known as VX-440, is a protein modulator of cystic fibrosis transmembrane regulator (CFTR). Target: Others. Smiles: CC(C)COc1cc(F)cc(c1)-c1ccc(C(=O)NS(=O)(=O)c2ccccc2)c(n1)N1C[C@@H](C)CC1(C)C
| Schlagworte: | VX440, VX 440, VX-440 |
| Anwendung: | Targets cystic fibrosis transmembrane conductance regulator [EC:5.6.1.6] (CFTR, ABCC7) |
| CAS | 1897384-89-2 |
| MW: | 539.66 D |
ab 1.671,00 €
PPQ-102
Artikelnummer: TGM-T1874-100mg
Description: PPQ-102 (CFTR Inhibitor), an effective CFTR inhibitor, can completely inhibit CFTR chloride current (IC50: 90 nM). Target: Autophagy, CFTR. Smiles: Cc1ccc(o1)C1Nc2ccccc2-n2c1c1n(C)c(=O)n(C)c(=O)c1c2-c1ccccc1. References: Tradtrantip L, et al. J Med Chem. 2009 Oct 22,52(20):6447-55.
| Schlagworte: | PPQ 102, PPQ102, CFTR Inhibitor |
| Anwendung: | CFTR inhibitor |
| CAS | 931706-15-9 |
| MW: | 438.48 D |
ab 34,00 €
Elexacaftor
Artikelnummer: TGM-T14935-100mg
Description: Elexacaftor (VX-445) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR) and it also facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface. Target: Autophagy, CFTR. Smiles:...
| Schlagworte: | VX-445 |
| Anwendung: | Targets cystic fibrosis transmembrane conductance regulator [EC:5.6.1.6] (CFTR, ABCC7) |
| CAS | 2216712-66-0 |
| MW: | 597.65 D |
ab 88,00 €
Nesolicaftor
Artikelnummer: TGM-T16681-100mg
Description: Nesolicaftor (PTI-428) specifically enhances cystic fibrosis transmembrane conductance regulator protein synthesis. Target: CFTR, Autophagy. Smiles: C[C@@H](O)c1nnc(o1)[C@H]1C[C@@H](C1)NC(=O)c1cc(no1)-c1ccccc1. References: Mijnders M, et al. Correcting CFTR folding defects by small-molecule correctors...
| Schlagworte: | PTI-428 |
| Anwendung: | Targets cystic fibrosis transmembrane conductance regulator [EC:5.6.1.6] (CFTR, ABCC7) |
| CAS | 1953130-87-4 |
| MW: | 354.36 D |
ab 97,00 €
Bamocaftor
Artikelnummer: TGM-T30293-100mg
Description: Bamocaftor is a CFTR channel (DeltaF508-CFTR mutation) corrector for CF transmembrane conductance regulators designed to restore F508del-CFTR protein function. Combined use of tezacaftor and VX-561 for the treatment of cystic fibrosis patients with F508del/MF. Target: CFTR. Smiles:...
| Schlagworte: | VX-659 |
| Anwendung: | Targets cystic fibrosis transmembrane conductance regulator [EC:5.6.1.6] (CFTR, ABCC7) |
| CAS | 2204245-48-5 |
| MW: | 591.65 D |
ab 371,00 €
Ivacaftor-D9
Artikelnummer: TGM-T27098-100mg
Description: CTP-656, a cystic fibrosis transmembrane conductance regulator (CFTR) channel activator, is used potentially for the treatment of cystic fibrosis. Smiles: C(C)(C)(C)C1=C(NC(=O)C=2C(=O)C=3C(NC2)=CC=CC3)C=C(O)C(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=C1
| Schlagworte: | deutivacaftor, CTP-656 |
| Anwendung: | Targets cystic fibrosis transmembrane conductance regulator [EC:5.6.1.6] (CFTR, ABCC7) |
| CAS | 1413431-07-8 |
| MW: | 401.55 D |
ab 1.520,00 €
KM11060
Artikelnummer: TGM-T3135-100mg
Description: KM11060 is a novel corrector of the F508del-CFTR trafficking defect, Correcting F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma membrane. Target: CFTR, Autophagy. Smiles: Clc1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccnc2cc(Cl)ccc12. References: Robert R, et al. Mol Pharmacol. 2008...
| Anwendung: | CFTR F508del processing correction |
| CAS | 774549-97-2 |
| MW: | 422.33 D |
ab 31,00 €
Phloxine B
Artikelnummer: TGM-T37756-100g
Description: Phloxine B is a red dye, the USP grade of which is used as a color additive for food, drugs, and cosmetics. It has also been used as an alternative to Gram staining, to differentiate between Gram-negative and Gram-positive bacteria. At 100 µg/ml, it can inhibit methicillin-resistant S. aureus growth in...
| Anwendung: | CFTR modulator, red dye, Gram staining alternative |
| CAS | 18472-87-2 |
| MW: | 808.65 D |
ab 122,00 €
Posenacaftor
Artikelnummer: TGM-T62630-100mg
Description: Posenacaftor (PTI-801) is a cystic fibrosis transmembrane regulatory protein (CFTR) regulator that corrects the folding and transport of CFTR proteins, facilitating research on cystic fibrosis (CF). Target: Others. Smiles: O([C@H](C)C1CCOCC1)C=2C3=C(N=C(C=C3C(O)=O)C4=C(C)C=5C(O4)=CC=CC5)C(C)=CC2
| Anwendung: | Targets cystic fibrosis transmembrane conductance regulator [EC:5.6.1.6] (CFTR, ABCC7) |
| CAS | 2095064-05-2 |
| MW: | 445.51 D |
ab 1.520,00 €
GLPG1837
Artikelnummer: TGM-T7083-100mg
Description: GLPG1837 (ABBV-974) is an effective CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively. Target: Autophagy, CFTR. Smiles: CC1(C)Cc2c(sc(NC(=O)c3cc[nH]n3)c2C(N)=O)C(C)(C)O1. References: Van der Plas SE, et al. Discovery of...
| Schlagworte: | ABBV-974 |
| Anwendung: | CFTR potentiator |
| CAS | 1654725-02-6 |
| MW: | 348.42 D |
ab 31,00 €