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Zu "K05004" wurden 39 Artikel gefunden!
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Artikelnummer: Cay15302-100
Minoxidil is a pyrimidine derivative that was originally developed as an anti-hypertensive agent and unexpectedly found to stimulate hair growth. Minoxidil directly affects arteriolar smooth muscle to decrease vascular resistance in part by opening ATP-sensitive potassium channels. It can activate cyclooxygenase 1...
Schlagworte: | Loniten, U-10858, 6-(1-piperidinyl)-2,4-pyrimidinediamine 3-oxide |
Anwendung: | Kir6.2 opener, Cox1 activator |
CAS | 38304-91-5 |
MW: | 209.3 D |
ab 84,00 €
Artikelnummer: Cay14601-10
(±)-Cromakalim is a prototypical activator of the ATP-sensitive potassium channel, SUR2-Kir6, that displays anti-ischemic (EC25 = 8.9 µM) and cardioprotective (IC50 = 0.03 µM) effects in rat hearts. (±)-Cromakalim has also been shown to relax bladder smooth muscle in vitro. It has been used to investigate potassium...
Schlagworte: | BRL 34915, (3R,4S)-rel-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile |
Anwendung: | SUR2-Kir6 activator |
CAS | 94470-67-4 |
MW: | 286.3 D |
ab 163,00 €
Artikelnummer: Cay15009-5
Glyburide is a sulfonylurea and an inhibitor of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 (IC50 = 4.3 nM). It binds to microsomes derived from RINm5F pancreatic beta-cells (Kd = 0.3 nM) and inhibits 86Rb+ efflux from intact RINm5 cells with a half-maximal inhibition (K0.5) value...
Schlagworte: | Glibenclamide, 5-chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxy-benzamide,... |
Anwendung: | Antidiabetic, K+ channel inhibitor |
CAS | 52169-36-5 |
MW: | 532.1 D |
ab 129,00 €
Artikelnummer: Cay18460-250
Nicorandil is an activator of sulfonylurea receptor 2B (SUR2B) linked to ATP-sensitive potassium channel Kir6.2 (EC50 = ~10 µM) and a nitric oxide (NO) donor. It is selective for SUR2B/Kir6.2 over the SUR2A/Kir6.2 channel (EC50 = >500 µM). Nicorandil activates soluble guanylate cyclase in a cell-free assay and...
Schlagworte: | 2-Nicotinamidoethyl nitrate, SG-75, N-[2-(nitrooxy)ethyl]-3-pyridinecarboxamide |
Anwendung: | ATP-sensitive potassium channel (SUR1/Kir6.2) opener, Nitric oxide donor |
CAS | 65141-46-0 |
MW: | 211.2 D |
ab 43,00 €
Artikelnummer: Cay17563-5
Minoxidil-d10 is intended for use as an internal standard for the quantification of minoxidil (Cay-15302) by GC- or LC-MS. Minoxidil is a pyrimidine derivative that was originally developed as an anti-hypertensive agent and unexpectedly found to stimulate hair growth. Minoxidil directly affects arteriolar smooth...
Schlagworte: | Loniten-d10, U-10858-d10, 6-(1-piperidinyl-d10)-2,4-pyrimidinediamine 3-oxide |
Anwendung: | Internal standard |
CAS | 1020718-66-4 |
MW: | 219.3 D |
ab 130,00 €
Artikelnummer: Cay29596-500
Gliquidone is a second generation sulfonylurea that selectively inhibits ATP-sensitive potassium channel currents (IKATP) in pancreatic beta-cells (IC50s = 0.45, 119.1, and 149.7 µM for HIT-T15 cells, cardiomyocytes, and vascular smooth muscle cells, respectively). It is also a peroxisome proliferator-activated...
Schlagworte: | AR-DF 26,... |
Anwendung: | IKATP inhibitor, PPARgamma agonist |
CAS | 33342-05-1 |
MW: | 527.6 D |
ab 43,00 €
Artikelnummer: ARG64391.100
Protein function: This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium, as external potassium is...
Schlagworte: | Anti-IKATP, Anti-KCNJ11, Anti-Inward rectifier K(+) channel Kir6.2, Anti-ATP-sensitive inward rectifier potassium channel... |
Anwendung: | ELISA, IHC (paraffin), WB |
Wirt: | Goat |
Spezies-Reaktivität: | human |
784,00 €
Artikelnummer: ARG64439.100
Protein function: This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium, as external potassium is...
Schlagworte: | Anti-IKATP, Anti-KCNJ11, Anti-Inward rectifier K(+) channel Kir6.2, Anti-ATP-sensitive inward rectifier potassium channel... |
Anwendung: | ELISA, IHC (paraffin), WB |
Wirt: | Goat |
Spezies-Reaktivität: | human |
784,00 €
Artikelnummer: NSJ-R33115-100UG
0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Inwardly rectifying potassium channel KIR6.2, potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11) Protein function: This receptor is controlled by G proteins. Inward rectifier...
Schlagworte: | Anti-IKATP, Anti-KCNJ11, Anti-Inward rectifier K(+) channel Kir6.2, Anti-ATP-sensitive inward rectifier potassium channel... |
Anwendung: | WB, IHC, ELISA (peptide) |
Wirt: | Goat |
Spezies-Reaktivität: | human |
755,00 €
Artikelnummer: NSJ-R33975-100UG
0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Potassium inwardly-rectifying channel, subfamily J, member 11, Kcnj11 Protein function: This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a...
Schlagworte: | Anti-IKATP, Anti-KCNJ11, Anti-Inward rectifier K(+) channel Kir6.2, Anti-ATP-sensitive inward rectifier potassium channel... |
Anwendung: | WB, IHC, ELISA (peptide) |
Wirt: | Goat |
Spezies-Reaktivität: | human |
755,00 €
Artikelnummer: E-AB-11188.120
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a...
Schlagworte: | Anti-IKATP, Anti-KCNJ11, Anti-Inward rectifier K(+) channel Kir6.2, Anti-ATP-sensitive inward rectifier potassium channel... |
Anwendung: | IHC, ELISA |
Wirt: | Rabbit |
Spezies-Reaktivität: | human, mouse, rat |
ab 71,00 €
Artikelnummer: E-AB-14986.120
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a...
Schlagworte: | Anti-IKATP, Anti-KCNJ11, Anti-Inward rectifier K(+) channel Kir6.2, Anti-ATP-sensitive inward rectifier potassium channel... |
Anwendung: | IHC, ELISA |
Wirt: | Rabbit |
Spezies-Reaktivität: | human, mouse, rat |
ab 71,00 €