Zu "K05004" wurden 45 Artikel gefunden!
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Cromakalim
Artikelnummer: TGM-T21478-1mg
Description: Cromakalim (BRL 34915) is an ATP-dependent K(+) channel opener and a smooth muscle relaxant.Cromakalim has antiepileptic and anticonvulsant activity and may be useful in studies of asthma and disorders associated with vasodilation. Target: Potassium Channel. Smiles:...
| Schlagworte: | BRL-34915, BRL 34915, (±)-Cromakalim, BRL34915 |
| Anwendung: | SUR2-Kir6 activator |
| CAS | 94470-67-4 |
| MW: | 286.33 D |
30,00 €
MINOXIDIL-d10
Artikelnummer: TGM-TMID-0127-1mg
Description: MINOXIDIL-d10 is a deuterated compound of MINOXIDIL. MINOXIDIL has a CAS number of 38304-91-5. Minoxidil is an orally administered vasodilator with hair growth stimulatory and antihypertensive effects. Smiles: [2H]C1([2H])N(c2cc(N)[n+]([O-])c(N)n2)C([2H])([2H])C([2H])([2H])C([2H])([2H])C1([2H])[2H]
| Anwendung: | Internal standard |
| CAS | 1020718-66-4 |
| MW: | 219.31 D |
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Anti-KCNJ11
Artikelnummer: CSB-PA003100.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-IKATP, Anti-KCNJ11, Anti-Inward rectifier K(+) channel Kir6.2, Anti-ATP-sensitive inward rectifier potassium channel... |
| Anwendung: | ELISA, WB, IHC, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 126,00 €
Anti-Phospho-KCNJ11 (Thr224)
Artikelnummer: CSB-PA209100.100
Host Species: Rabbit. Isotype: IgG. Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antibodies were produced by immunizing rabbits with...
| Schlagworte: | Anti-phospho-IKATP, Anti-phospho-KCNJ11, Anti-phospho-Inward rectifier K(+) channel Kir6.2, Anti-phospho-ATP-sensitive... |
| Anwendung: | ELISA, WB, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
340,00 €
Anti-KCNJ11
Artikelnummer: CSB-PA746124.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: KCNJ11. Antigen Species: Human
| Schlagworte: | Anti-IKATP, Anti-KCNJ11, Anti-Inward rectifier K(+) channel Kir6.2, Anti-ATP-sensitive inward rectifier potassium channel... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 167,00 €
Anti-KCNJ11
Artikelnummer: CSB-PA907180.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: KCNJ11. Antigen Species: Human
| Schlagworte: | Anti-IKATP, Anti-KCNJ11, Anti-Inward rectifier K(+) channel Kir6.2, Anti-ATP-sensitive inward rectifier potassium channel... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 167,00 €
Minoxidil
Artikelnummer: Cay15302-100
Minoxidil is a pyrimidine derivative that was originally developed as an anti-hypertensive agent and unexpectedly found to stimulate hair growth. Minoxidil directly affects arteriolar smooth muscle to decrease vascular resistance in part by opening ATP-sensitive potassium channels. It can activate cyclooxygenase 1...
| Schlagworte: | Loniten, U-10858, 6-(1-piperidinyl)-2,4-pyrimidinediamine 3-oxide |
| Anwendung: | Kir6.2 opener, Cox1 activator |
| CAS | 38304-91-5 |
| MW: | 209.3 D |
ab 85,00 €
(±)-Cromakalim
Artikelnummer: Cay14601-10
(±)-Cromakalim is a prototypical activator of the ATP-sensitive potassium channel, SUR2-Kir6, that displays anti-ischemic (EC25 = 8.9 µM) and cardioprotective (IC50 = 0.03 µM) effects in rat hearts. (±)-Cromakalim has also been shown to relax bladder smooth muscle in vitro. It has been used to investigate potassium...
| Schlagworte: | BRL 34915, (3R,4S)-rel-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile |
| Anwendung: | SUR2-Kir6 activator |
| CAS | 94470-67-4 |
| MW: | 286.3 D |
ab 166,00 €
Glyburide (potassium salt)
Artikelnummer: Cay15009-5
Glyburide is a sulfonylurea and an inhibitor of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 (IC50 = 4.3 nM). It binds to microsomes derived from RINm5F pancreatic beta-cells (Kd = 0.3 nM) and inhibits 86Rb+ efflux from intact RINm5 cells with a half-maximal inhibition (K0.5) value...
| Schlagworte: | Glibenclamide, 5-chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxy-benzamide,... |
| Anwendung: | Antidiabetic, K+ channel inhibitor |
| CAS | 52169-36-5 |
| MW: | 532.1 D |
ab 132,00 €
Nicorandil
Artikelnummer: Cay18460-250
Nicorandil is an activator of sulfonylurea receptor 2B (SUR2B) linked to ATP-sensitive potassium channel Kir6.2 (EC50 = ~10 µM) and a nitric oxide (NO) donor. It is selective for SUR2B/Kir6.2 over the SUR2A/Kir6.2 channel (EC50 = >500 µM). Nicorandil activates soluble guanylate cyclase in a cell-free assay and...
| Schlagworte: | 2-Nicotinamidoethyl nitrate, SG-75, N-[2-(nitrooxy)ethyl]-3-pyridinecarboxamide |
| Anwendung: | ATP-sensitive potassium channel (SUR1/Kir6.2) opener, nitric oxide donor |
| CAS | 65141-46-0 |
| MW: | 211.2 D |
ab 44,00 €
Minoxidil-d10
Artikelnummer: Cay17563-5
Minoxidil-d10 is intended for use as an internal standard for the quantification of minoxidil (Cay-15302) by GC- or LC-MS. Minoxidil is a pyrimidine derivative that was originally developed as an anti-hypertensive agent and unexpectedly found to stimulate hair growth. Minoxidil directly affects arteriolar smooth...
| Schlagworte: | Loniten-d10, U-10858-d10, 6-(1-piperidinyl-d10)-2,4-pyrimidinediamine 3-oxide |
| Anwendung: | Internal standard |
| CAS | 1020718-66-4 |
| MW: | 219.3 D |
ab 133,00 €
Gliquidone
Artikelnummer: Cay29596-500
Gliquidone is a second generation sulfonylurea that selectively inhibits ATP-sensitive potassium channel currents (IKATP) in pancreatic beta-cells (IC50s = 0.45, 119.1, and 149.7 µM for HIT-T15 cells, cardiomyocytes, and vascular smooth muscle cells, respectively). It is also a peroxisome proliferator-activated...
| Schlagworte: | AR-DF 26,... |
| Anwendung: | IKATP inhibitor, PPARgamma agonist |
| CAS | 33342-05-1 |
| MW: | 527.6 D |
ab 44,00 €