Zu "K04984" wurden 51 Artikel gefunden!
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1´-S-1´-Acetoxychavicol Acetate
Artikelnummer: LKT-A0917.10
1'-(S)-1'-Acetoxychavicol acetate (galangal acetate) displays a wide variety of beneficial properties, including antioxidative, anti-obesity, antibacterial, anti-parasitic, chemopreventative, and chemotherapeutic activities. This compound is best known for its ability to inhibit xanthine oxidase, but also activates...
| Schlagworte: | Galangal acetate,(-), Galangal acetate,(S), [4-[(1S)-1-acetyloxyprop-2-enyl]phenyl] acetate |
| Anwendung: | TRPA1 agonist, xanthine oxidase inhibitor. |
| CAS | 52946-22-2 |
| MW: | 234.25 D |
ab 150,00 €
PF-04745637
Artikelnummer: LKT-P200637.1
PF-04745637 is a selective antagonist for TRPA1 receptor. SMILES: C1CCC(C1)(C2=CC=C(C=C2)Cl)C(=O)NCC(CC3=CC=CC=C3)N4CCC(CC4)(C(F)(F)F)O
| Schlagworte: | 1-(4-chlorophenyl)-N-[2-[4-hydroxy-4-(trifluoromethyl)piperidin-1-yl]-3-phenylpropyl]cyclopentane-1-carboxamide |
| Anwendung: | TRPA1 antagonist |
| CAS | 1917294-46-2 |
| MW: | 509.01 D |
ab 99,00 €
A-967079
Artikelnummer: TGM-T7205-10mg
Description: A 967079 is a potent, selective, and bioavailable inhibitor of the TRPA1 channel, with IC50 values of 67 and 289 nM for the human and rat isoforms, respectively. Target: TRP/TRPV Channel. Smiles: CC\C(=N/O)\C(\C)=C\c1ccc(F)cc1. References: McGaraughty S, Chu KL, Perner RJ,et al.TRPA1 modulation of...
| Anwendung: | TRPA1 inhibitor |
| CAS | 1170613-55-4 |
| MW: | 207.24 D |
ab 49,00 €
PF-4840154
Artikelnummer: TGM-T4385-100mg
Description: PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel, eliciting TrpA1-mediated nocifensive behavior in mouse, with EC50 values of 97 nM and 23 nM for [rTrpA1] and [hTrpA1], respectively. Target: TRP/TRPV Channel. Smiles: CC(C)CNc1nc(ncc1C(=O)NCc1ccccc1)N1CCN(CC2CCCOC2)CC1....
| Anwendung: | TRPA1 agonist |
| CAS | 1332708-14-1 |
| MW: | 466.62 D |
ab 111,00 €
Supercinnamaldehyde
Artikelnummer: TGM-T78082-100mg
Description: Supercinnamaldehyde is a transient receptor potential anchor protein 1 (TRPA1) activator with thousands of anticancer and antimicrobial activities.Supercinnamaldehyde inhibits NF-kappaB signaling, induces cytoprotective responses and suppresses inflammatory responses through Nrf2...
| Anwendung: | TRPA1 activator |
| CAS | 70351-51-8 |
| MW: | 201.22 D |
ab 42,00 €
BAY-390
Artikelnummer: TGM-T73432-25mg
Description: BAY-390 is a brain-penetrating, species-agnostic inhibitor of TRPA1, exhibiting selective inhibition of human and rat TRPA1 with IC50 values of 16 nM for hTRPA1 FLIPR, 82 nM for hTRPA1 Ephys, 63 nM for rTRPA1 FLIPR, and 35 nM for rDRG Ephys. It holds potential for inflammation research applications....
| Anwendung: | TRPA1 inhibitor |
| CAS | 2741956-55-6 |
| MW: | 277.26 D |
1.358,00 €
Saikosaponin F
Artikelnummer: TGM-T8174-100mg
Description: Saikosaponin F is a natural compound found in Bupleurum (B.) falcatum L. Target: Others. Smiles:...
| Anwendung: | TRPA1 antagonist, triterpenoid saponin |
| CAS | 62687-63-2 |
| MW: | 929.14 D |
ab 49,00 €
ASP7663
Artikelnummer: TGM-T8410-100mg
Description: ASP7663 is a TRPA1 Receptor Agonist and exhibiting an abdominal analgesic effect in vivo. Target: TRP/TRPV Channel. Smiles: CC(C)CN1C(=O)\C(=C\C(O)=O)c2cccc(F)c12. References: Kojima R , Nozawa K , Doihara H , et al. Effects of novel TRPA1 receptor agonist ASP7663 in models of drug-induced constipation...
| Anwendung: | TRPA1 agonist |
| CAS | 1190217-35-6 |
| MW: | 263.26 D |
ab 34,00 €
TRPA1 Protein, Rat, Recombinant (His & Myc)
Artikelnummer: TGM-TMPH-03389-100ug
Description: TRPA1 Protein, Rat, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 27.3 kDa and the accession number is Q6RI86.
| Schlagworte: | Ankyrin-like with transmembrane domains protein 1, Trpa1, Transient receptor potential cation channel subfamily A member... |
| MW: | 27.3 kD |
ab 281,00 €
Optovin
Artikelnummer: TGM-T6617-100mg
Description: Optovin is a TRPA1 activator, which is reversibly photoactivated. Target: TRP/TRPV Channel. Smiles: Cc1cc(\C=C2/SC(=S)NC2=O)c(C)n1-c1cccnc1. References: Kokel D, et al. Nat Chem Biol. 2013, 9(4), 257-263.
| Anwendung: | Photoactivatable TRPA1 ligand |
| CAS | 348575-88-2 |
| MW: | 315.41 D |
ab 34,00 €
HC-030031
Artikelnummer: TGM-T6530-100mg
Description: HC-030031 (TOSLAB 829227) is a potent TRPA1 inhibitor, which antagonizes AITC- and formalin-evoked calcium influx with IC50s of 6.2±0.2 and 5.3±0.2 µM, respectively. Target: TRP/TRPV Channel. Smiles: CC(C)c1ccc(NC(=O)Cn2cnc3n(C)c(=O)n(C)c(=O)c23)cc1. References: McNamara CR, et al. Proc Natl Acad Sci,...
| Schlagworte: | TOSLAB 829227, HC030031 |
| Anwendung: | TRPA1 blocker |
| CAS | 349085-38-7 |
| MW: | 355.39 D |
ab 46,00 €
BAY-390
Artikelnummer: Cay41313-1
BAY-390 is an inhibitor of transient receptor potential ankyrin 1 (TRPA1, IC50s = 16 and 63 nM for the human and rat receptor, respectively). It is selective for TRPA1 over a variety of receptors, ion channels, transporters, and enzymes at 10 µM but weakly inhibits estrogen receptor alpha (ERalpha), progesterone...
| Schlagworte: | 2R-[(4-fluorophenyl)amino]-1R-(trifluoromethyl)-cyclohexanol |
| Anwendung: | TRPA1 inhibitor |
| CAS | 2741956-55-6 |
| MW: | 277.3 D |
ab 35,00 €