Zu "K04983" wurden 54 Artikel gefunden!
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WS-12
Artikelnummer: TGM-T7416-5mg
Description: WS-12 is a potent TRPM8 agonist that acts as a cooling agent (EC50 : 193 nM). Target: TRP/TRPV Channel. Smiles: C(NC1=CC=C(OC)C=C1)(=O)[C@H]2[C@H]([C@H](C)C)CC[C@@H](C)C2. References: Beck B , Bidaux G , Bavencoffe A , et al. Prospects for prostate cancer imaging and therapy using high-affinity TRPM8...
| Anwendung: | TRPM8 agonist |
| CAS | 68489-09-8 |
| MW: | 289.41 D |
ab 31,00 €
ICILIN
Artikelnummer: TGM-T1814-5mg
Description: ICILIN (AG-3-5) is a synthetic TRPM8 ion channel super-agonist. Target: TRP/TRPV Channel. Smiles: Oc1ccccc1N1CC=C(NC1=O)c1cccc(c1)[N+]([O-])=O. References: Lee S, et al. Biochem Biophys Res Commun. 2013 Nov 29,441(4):1005-10.
| Schlagworte: | AG-3-5 |
| Anwendung: | CMR1 super agonist, TRPM8 super agonist |
| CAS | 36945-98-9 |
| MW: | 311.29 D |
ab 31,00 €
AMG 333
Artikelnummer: TGM-T5479-100mg
Description: AMG 333 is TRPM8 antagonist with an IC50 of 13 nM,a Clinical Candidate for the Treatment of Migraine. Target: TRP/TRPV Channel. Smiles: OC(=O)c1ccc(nc1)C(=O)N[C@@H](c1ccc(OC(F)(F)F)c(F)c1)c1ncccc1F. References: Horne DB, et al. Discovery of TRPM8 Antagonist (...
| Schlagworte: | AMG-333 |
| Anwendung: | TRPM8 antagonist |
| CAS | 1416799-28-4 |
| MW: | 453.32 D |
ab 31,00 €
Menthol
Artikelnummer: TGM-T5723-100mg
Description: Menthol (DL-Menthol) is an organic compound made synthetically or obtained from peppermint or mint oils with flavoring and local anesthetic properties. Target: Calcium Channel, Others. Smiles: CC(C)C1CCC(C)CC1O. References: Kozlovich S, Chen G, Watson CJ,et al.The role of L- and D-menthol in the...
| Schlagworte: | DL-Menthol |
| Anwendung: | Targets transient receptor potential cation channel subfamily M member 8 (TRPM8) |
| CAS | 1490-04-6 |
| MW: | 156.26 D |
ab 42,00 €
TC-I2000
Artikelnummer: TGM-T8449-100mg
Description: TC-I2000 is an TRPM8 channel blocker. Inhibits icilin-induced TRPM8 channel activation in rTRPM8-expressing CHO cells with IC50 of 53 nM. Target: TRP/TRPV Channel. Smiles: Fc1ccc(NC(=O)N2CCc3ccccc3C2c2ccc(cc2)C(F)(F)F)cc1. References: Tamayo N A , Bo Y , Gore V , et al. Fused Piperidines as a Novel...
| Anwendung: | TRPM8 antagonist |
| CAS | 1159996-20-9 |
| MW: | 414.4 D |
ab 31,00 €
AMTB hydrochloride
Artikelnummer: TGM-T19723-100mg
Description: AMTB hydrochloride (AMTB HCl) is a novel TRPM8 channel blocker and is effective for pain and urinary diseases. AMTB can act on the bladder afferent pathway to attenuate the bladder micturition reflex and nociceptive reflex responses in the rat. Target: TRP/TRPV Channel. Smiles:...
| Schlagworte: | AMTB |
| Anwendung: | TRPM8 antagonist |
| CAS | 926023-82-7 |
| MW: | 430.99 D |
ab 31,00 €
Icilin
Artikelnummer: Cay10137-50
Nociceptive sensory peripheral neurons often express both heat sensitive (VR1) and cold-sensitive (CMR1 (rat), TRPM8 (human)) receptors that are part of the transient receptor potential (TRP) superfamily. Icilin is a synthetic CMR1/TRPM8 super agonist that is 2.5-fold more efficacious and nearly 200-fold more potent...
| Schlagworte: | AG 3-5, 3,6-dihydro-1-(2-hydroxyphenyl)-4-(3-nitrophenyl)-2(1H)-pyrimidinone |
| Anwendung: | CMR1 super agonist, TRPM8 super agonist |
| CAS | 36945-98-9 |
| MW: | 311.3 D |
ab 69,00 €
PF-05105679
Artikelnummer: TGM-T16483-1mg
Description: PF-05105679 is a selective TRPM8 antagonist (IC50 = 103 nM). PF-05105679 can be used in research on cold-related pain. Target: TRP/TRPV Channel. Smiles: C[C@@H](N(Cc1cccc(c1)C(O)=O)C(=O)c1cnc2ccccc2c1)c1ccc(F)cc1. References: Andrews MD, et al. Discovery of a Selective TRPM8 Antagonist with Clinical...
| Anwendung: | TRPM8 antagonist |
| CAS | 1398583-31-7 |
| MW: | 428.45 D |
ab 42,00 €
(-)-Menthol
Artikelnummer: TGM-T1407-1g
Description: (-)-Menthol (Levomenthol) is a levo isomer of menthol, an organic compound made synthetically or obtained from peppermint or mint oils with flavoring and local anesthetic properties. When added to pharmaceuticals and foods, menthol functions as a fortifier for peppermint flavors. It also has a...
| Schlagworte: | Menthomenthol, Menthacamphor, L-Menthol, Levomenthol |
| Anwendung: | Targets transient receptor potential cation channel subfamily M member 8 (TRPM8) |
| CAS | 2216-51-5 |
| MW: | 156.27 D |
ab 31,00 €
Transient receptor potential cation channel subfamily M...
Artikelnummer: CSB-MP768757HU1.1
Organism: Homo sapiens (Human). Source: Mammalian cell. Expression Region: 690-1104aa. Protein Length: Partial. Tag Info: C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions). Target Protein Sequence: TKNWKIILCL FIIPLVGCGF VSFRKKPVDK HKKLLWYYVA FFTSPFVVFS WNVVFYIAFL LLFAYVLLMD...
| Schlagworte: | TRPM8, Trp-p8, LTRPC6, LTrpC6, LTrpC-6, Transient receptor potential p8, Long transient receptor potential channel 6,... |
| Anwendung: | Activity not tested |
| Exprimiert in: | Mammalian cells |
| Ursprungsart: | human |
| MW: | 50.5 kD |
ab 579,00 €
Anti-TRPM8
Artikelnummer: CSB-PA072616.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: TRPM8. Antigen Species: Human
| Schlagworte: | Anti-TRPM8, Anti-LTRPC6, Anti-LTrpC6, Anti-Trp-p8, Anti-LTrpC-6, Anti-Transient receptor potential p8, Anti-Long transient... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 167,00 €
Anti-TRPM8
Artikelnummer: CSB-PA969456.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: TRPM8. Antigen Species: Human
| Schlagworte: | Anti-TRPM8, Anti-LTRPC6, Anti-LTrpC6, Anti-Trp-p8, Anti-LTrpC-6, Anti-Transient receptor potential p8, Anti-Long transient... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 167,00 €