Zu "K04945" wurden 39 Artikel gefunden!
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NS6180
Artikelnummer: TGM-T1752-100mg
Description: NS6180 is a potent and selective KCa3.1 channel inhibitor(IC50= 9 nM). It prevents T-cell activation and inflammation. Target: Potassium Channel. Smiles: FC(F)(F)c1cccc(CN2C(=O)CSc3ccccc23)c1. References: Strobak D, et al. Br J Pharmacol. 2013 Jan,168(2):432-44.
| Anwendung: | KCa3.1 channel blocker |
| CAS | 353262-04-1 |
| MW: | 323.33 D |
ab 33,00 €
SKA-121
Artikelnummer: TGM-T16891-1mL
Description: SKA-121 is a selective KCa3.1 activator (EC50s: 109 nM and 4.4 µM for KCa3.1 and KCa2.3, respectively). Target: Others. Smiles: Cc1cc2nc(N)oc2c2ccccc12. References: Coleman N, et al. New positive Ca2+-activated K+ channel gating modulators with selectivity for KCa3.1.Mol Pharmacol. 2014 Sep,86(3):342-57.
| Anwendung: | KCNN4 / IKCa1 / KCa3.1 modulator |
| CAS | 1820708-73-3 |
| MW: | 198.22 D |
ab 84,00 €
Senicapoc
Artikelnummer: TGM-T3528-100mg
Description: Senicapoc (ICA-17043) is a potent inhibitor of the Gardos channel that ameliorates RBC dehydration in the SAD mouse. It blocks Ca2+-induced rubidium flux from human RBCs with an IC50 value of 11 ± 2 nM (CLT IC50 = 100 ± 12 nM) and inhibits RBC dehydration with an IC50 of 30 ± 20 nM. Senicapoc is used in...
| Schlagworte: | ICA-17043 |
| Anwendung: | Targets phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta |
| CAS | 289656-45-7 |
| MW: | 323.34 D |
ab 54,00 €
NS309
Artikelnummer: TGM-T4612-100mg
Description: NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 µM for SK channels and 10-90 nM for IK channels). It can also activate voltage-gated Kv11.1 channels (hERG, IC50 = 1 µM), but does not, however, affect...
| Anwendung: | SK/KCa2 & IK/KCa3.1 channel activator |
| CAS | 18711-16-5 |
| MW: | 231.04 D |
ab 54,00 €
SKA-31
Artikelnummer: TGM-T5180-100mg
Description: SKA-31 (Naphtho[1,2-d]thiazol-2-ylamine) is an activator of KCa3.1 and KCa2 channels (EC50s: 260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively). Target: Potassium Channel. Smiles: Nc1nc2c(ccc3ccccc23)s1. References: Sankaranarayanan A, Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new...
| Schlagworte: | Naphtho[1,2-d]thiazol-2-ylamine, SKA 31, SKA31 |
| Anwendung: | KCa2/3 channel activator |
| CAS | 40172-65-4 |
| MW: | 200.26 D |
ab 33,00 €
TRAM-34
Artikelnummer: TGM-T6186-100mg
Description: TRAM-34 (Triarylmethane-34) (Kd=20 nM), an effective and specific inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1), does not block cytochrome P450. The selective activity of TRAM-34(TRAM 34) is 200 to 1500-fold than other ion channels. Target: Potassium Channel,...
| Schlagworte: | Triarylmethane-34, TRAM 34 |
| Anwendung: | Membrane-permeable KCNN4 inhibitor |
| CAS | 289905-88-0 |
| MW: | 344.84 D |
ab 45,00 €
Anti-KCNN4
Artikelnummer: CSB-PA484256.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: KCNN4. Antigen Species: Human
| Schlagworte: | Anti-SK4, Anti-IK1, Anti-KCa4, Anti-IKCa1, Anti-KCNN4, Anti-SKCa4, Anti-SKCa 4, Anti-KCa3.1, Anti-Putative Gardos channel,... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 167,00 €
Anti-KCNN4
Artikelnummer: CSB-PA980762.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: KCNN4. Antigen Species: Human
| Schlagworte: | Anti-SK4, Anti-IK1, Anti-KCa4, Anti-IKCa1, Anti-KCNN4, Anti-SKCa4, Anti-SKCa 4, Anti-KCa3.1, Anti-Putative Gardos channel,... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 167,00 €
Intermediate conductance calcium-activated potassium...
Artikelnummer: CSB-CF012086HU.100
Organism: Homo sapiens (Human). Source: in vitro E.coli expression system. Expression Region: 1-427aa. Protein Length: Full Length. Tag Info: N-terminal 10xHis-tagged. Target Protein Sequence: MGGDLVLGLG ALRRRKRLLE QEKSLAGWAL VLAGTGIGLM VLHAEMLWFG GCSWALYLFL VKCTISISTF LLLCLIVAFH AKEVQLFMTD NGLRDWRVAL TGRQAAQIVL...
| Schlagworte: | IK1, SK4, KCa4, IKCa1, SKCa4, KCNN4, KCa3.1, SKCa 4, Putative Gardos channel, Intermediate conductance calcium-activated... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli in vitro |
| Ursprungsart: | human |
| MW: | 53.7 kD |
ab 1.458,00 €
TRAM-34
Artikelnummer: Cay23385-5
TRAM-34 is a membrane-permeable inhibitor of the intermediate-conductance calcium-activated potassium channel (IKCa1/KCa3.1). It blocks IKCa1 (Kds = 20 and 25 nM for the cloned and native channel in COS-7 cells and human T lymphocytes, respectively) with 200- to 1,500-fold selectivity for IKCa1 over Kv (Kv1.1-Kv1.5,...
| Schlagworte: | 1-[(2-chlorophenyl)diphenylmethyl]-1H-pyrazole |
| Anwendung: | Membrane-permeable KCNN4 inhibitor |
| CAS | 289905-88-0 |
| MW: | 344.8 D |
ab 52,00 €
Senicapoc
Artikelnummer: Cay29679-50
Senicapoc is an inhibitor of intermediate conductance calcium-activated potassium (IKCa1/KCa3.1) channels. It inhibits rubidium efflux from and dehydration of isolated human red blood cells (RBCs) induced by the calcium ionophore A23187 (Cay-11016, IC50s = 11 and 30 nM, respectively). Senicapoc (10 mg/kg twice per...
| Schlagworte: | ICA-17043, 4-fluoro-alpha-(4-fluorophenyl)-alpha-phenyl-benzeneacetamide |
| Anwendung: | KCNN4 (IKCa1/KCa3.1) inhibitor |
| CAS | 289656-45-7 |
| MW: | 323.3 D |
ab 44,00 €
NS 309
Artikelnummer: Cay18889-5
NS 309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 µM for SK channels and 10-90 nM for IK channels). It can also activate voltage-gated Kv11.1 channels (hERG, IC50 = 1 µM), but does not, however, affect large...
| Schlagworte: | 6,7-dichloro-1H-indole-2,3-dione 3-oxime |
| Anwendung: | SK/KCa2 & IK/KCa3.1 channel activator |
| CAS | 18711-16-5 |
| MW: | 231 D |
ab 67,00 €