Zu "K04913" wurden 15 Artikel gefunden!
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ML335
Artikelnummer: TGM-T4224-100mg
Description: ML335 is a selective activator of TREK-1 and TREK-2. Target: Potassium Channel. Smiles: CS(=O)(=O)Nc1ccc(cc1)C(=O)NCc1ccc(Cl)cc1Cl. References: Lolicato M, et al. K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site. Nature. 2017 Jul 20,547(7663):364-368.
| Anwendung: | K2P2.1/TREK1 / K2P10.1/TREK2 activator |
| CAS | 825658-06-8 |
| MW: | 373.25 D |
ab 57,00 €
Bupivacaine hydrochloride monohydrate
Artikelnummer: TGM-T80641-100mg
Description: Bupivacaine hydrochloride monohydrate is a potent NMDA receptor inhibitor of sodium, L-calcium, and potassium channels.Bupivacaine hydrochloride monohydrate inhibits SCN5A channels and is commonly used in the study of chronic pain. Target: Sodium Channel, Calcium Channel, NMDAR, Potassium Channel....
| Anwendung: | TREK-1 channel inhibitor |
| CAS | 73360-54-0 |
| MW: | 342.9 D |
ab 194,00 €
BL-1249
Artikelnummer: TGM-T14666-100mg
Description: BL-1249 is a selective and potent non-steroidal potassium channel activator with anti-inflammatory activity that activates K2P2.1 (TREK-1) and K2P10.1 (TREK-2). Target: Potassium Channel. Smiles: C1CCc2c(C1)cccc2Nc1ccccc1-c1nnn[nH]1. References: Pope L, et al. Protein and Chemical Determinants of...
| Anwendung: | Mechanosensitive K2P channel activator |
| CAS | 18200-13-0 |
| MW: | 291.35 D |
ab 48,00 €
Potassium channel subfamily K member 2 (KCNK2), partial,...
Artikelnummer: CSB-YP012070HU.1
Organism: Homo sapiens (Human). Source: Yeast. Expression Region: 1-143aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: MLPSASRERP GYRAGVAAPD LLDPKSAAQN SKPRLSFSTK PTVLASRVES DTTINVMKWK TVSTIFLVVV LYLIIGATVF KALEQPHEIS QRTTIVIQKQ TFISQHSCVN STELDELIQQ IVAAINAGII PLGNTSNQIS...
| Schlagworte: | TREK, KCNK2, TREK-1 K(+) channel subunit, Two pore potassium channel TPKC1, Potassium channel subfamily K member 2, Two... |
| Anwendung: | Activity not tested |
| Exprimiert in: | Yeast |
| Ursprungsart: | human |
| MW: | 17.7 kD |
ab 242,00 €
BL 1249
Artikelnummer: Cay37426-1
BL 1249 is an activator of mechanosensitive two-pore domain potassium channels (K2P). It selectively induces currents in Xenopus oocytes expressing K2P2.1/TREK-1 or K2P10.1/TREK-2 over Xenopus oocytes expressing K2P4.1/TRAAK, K2P3.1/TASK1, K2P3.2/TASK2, K2P3.3/TASK3, K2P18.1/TRESK, K2P13.1/THIK1, or K2P1.1/TWIK-1 at...
| Schlagworte: | 5,6,7,8-tetrahydro-N-[2-(2H-tetrazol-5-yl)phenyl]-1-naphthalenamine |
| Anwendung: | Mechanosensitive K2P channel activator |
| CAS | 18200-13-0 |
| MW: | 291.4 D |
ab 66,00 €
ML-335
Artikelnummer: Cay27635-10
ML-335 is an activator of the two-pore domain potassium channels K2P2.1/TREK1 and K2P10.1/TREK2 (EC50s = 14.3 and 5.2 µM, respectively, in Xenopus oocytes). It is selective for K2P2.1/TREK1 and K2P10.1/TREK2 channels over K2P4.1/TRAAK channels. ML-335 activates K2P2.1/TREK1 by binding to the C-type gate, which is...
| Schlagworte: | N-[(2,4-dichlorophenyl)methyl]-4-[(methylsulfonyl)amino]-benzamide |
| Anwendung: | K2P2.1/TREK1 / K2P10.1/TREK2 activator |
| CAS | 825658-06-8 |
| MW: | 373.3 D |
ab 85,00 €
C3001a
Artikelnummer: Cay31064-10
C3001a is an activator of the two-pore domain potassium channels K2P2.1/TREK1 and K2P10.1/TREK2. It increases current amplitude in HEK293T cells expressing K2P2.1/TREK1 or K2P10.1/TREK2 (EC50s = 12.81 and 11.31 µM, respectively, for the human channels). C3001a is selective for K2P2.1/TREK1 and K2P10.1/TREK2 over a...
| Schlagworte: | (1S,3R)-3-[[[4-(6-methyl-2-benzothiazolyl)phenyl]amino]carbonyl]-cyclopentanecarboxylic acid |
| Anwendung: | K2P2.1/TREK1 / K2P10.1/TREK2 activator |
| CAS | 2415154-29-7 |
| MW: | 380.5 D |
ab 111,00 €
Spadin (trifluoroacetate salt)
Artikelnummer: Cay36762-1
Spadin is an inhibitor of the two-pore domain potassium channel K2P2.1/TREK1 (Ki = 10 nM in homogenates from COS-7 cells expressing K2P2.1/TREK1) that corresponds to amino acids 12-28 of human sortilin, also known as the neurotensin-3 receptor (NTS3). It also binds to sortilin in C13NJ microglial cells (Ki = 8 nM)....
| Schlagworte: | YAPLPRWSGPIGVSWGLR,... |
| Anwendung: | K2P2.1/TREK1 inhibitor |
| MW: | 2012.3 D |
ab 254,00 €
PE 22-28 (acetate)
Artikelnummer: Cay39986-1
PE 22-28 is a peptide inhibitor of the two-pore domain potassium channel K2P2.1/TREK1 (IC50 = 0.1 nM in HEK293 cells expressing the human channel) and a fragment of spadin (Cay-36762). It is selective for K2P2.1/TREK1 over K2P10.1 /TREK2, K2P13.1/TRAAK, K2P18.1/TRESK, and K2P3.1/TASK1 in HEK293 cells expressing the...
| Schlagworte: | Gly-Val-Ser-Trp-Gly-Leu-Arg-OH, glycyl-L-valyl-L-seryl-L-tryptophylglycyl-L-leucyl-L-arginine, acetate |
| Anwendung: | K2P2.1/TREK1 peptide inhibitor |
| MW: | 773.9 D |
ab 122,00 €
KCNK2, Human potassium channel, subfamily K, member 2,...
Artikelnummer: VHPS-4775
Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....
| Schlagworte: | TREK, KCNK2, TREK-1 K(+) channel subunit, Two pore potassium channel TPKC1, Potassium channel subfamily K member 2, Two... |
| Anwendung: | RNA quantification |
44,00 €
Kcnk2, Mouse potassium channel, subfamily K, member 2,...
Artikelnummer: VMPS-3276
Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....
| Schlagworte: | TREK1, Kcnk2 |
| Anwendung: | RNA quantification |
44,00 €
Kcnk2, Rat potassium channel, subfamily K, member 2, Real...
Artikelnummer: VRPS-3122
Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....
| Schlagworte: | Kcnk2, rCG_20236, 2P domain potassium channel KCNK2, Tandem pore domain potassium channel TREK-1, Potassium channel,... |
| Anwendung: | RNA quantification |
53,00 €