Zu "K04905" wurden 30 Artikel gefunden!
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Sematilide hydrochloride
Artikelnummer: TGM-T3574-100mg
Description: Sematilide hydrochloride (CK-1752) is a class III antiarrhythmic. It is a selectively delayed rectifier K+ current (IKr) channel blocker. It inhibits rapidly activating Ik in guinea pig atrial myocytes, resulting in the prolongation of refractoriness and action potential duration. Target: Potassium...
| Schlagworte: | CK-1752, Sematilide HCl, CK-1752A |
| Anwendung: | Targets potassium voltage-gated channel Eag-related subfamily H member 2 (KCNH2, KV11.1) |
| CAS | 101526-62-9 |
| MW: | 349.87 D |
ab 33,00 €
Cyclovirobuxine D
Artikelnummer: TGM-T2974-20mg
Description: Cyclovirobuxine D (Bebuxine) is extracted from Buxus microphylla. Target: mTOR, Autophagy, Apoptosis, Akt, Others. Smiles: [H][C@]1([C@H](C)NC)[C@H](O)C[C@@]2(C)[C@]3([H])CC[C@]4([H])[C@]5(C[C@@]35CC[C@]12C)CC[C@H](NC)C4(C)C. References: Hu D, et al. Eur J Pharmacol, 2007, 569(1-2), 103-109.
| Schlagworte: | Cyclovirobuxin D, CVB-D, Bebuxine |
| Anwendung: | KCNH2 blocker |
| CAS | 860-79-7 |
| MW: | 402.66 D |
50,00 €
NS1643
Artikelnummer: TGM-T3192-100mg
Description: NS1643 is a potent human ether-a-go-go related gene (hERG) KV11.1 channel activator with EC50 of 10.5 µM. Target: HER, Autophagy, Potassium Channel. Smiles: Oc1ccc(cc1NC(=O)Nc1cc(ccc1O)C(F)(F)F)C(F)(F)F. References: Casis O, et al. Mol Pharmacol. 2006 Feb,69(2):658-65.
| Anwendung: | KCNH2 activator |
| CAS | 448895-37-2 |
| MW: | 380.24 D |
ab 35,00 €
E-4031
Artikelnummer: TGM-T7198-100mg
Description: E-4031 is a methanesulfonanilide class III antiarrhythmic agent that prolongs cardiac action potential duration by blocking ERG K+ channels (IC50 = 29 nM). Target: EGFR, Potassium Channel. Smiles: Cl.Cl.Cc1cccc(CCN2CCC(CC2)C(=O)c2ccc(NS(C)(=O)=O)cc2)n1. References: David Z , Julia B , Gerlind F , et...
| Anwendung: | ERG K+ channel blocking |
| CAS | 113559-13-0 |
| MW: | 474.44 D |
ab 38,00 €
Azimilide Dihydrochloride
Artikelnummer: TGM-T7505-100mg
Description: Azimilide Dihydrochloride (NE-10064 Dihydrochloride), a novel class III antiarrhythmic agent, blocks both the slowly activating (IKs) and rapidly activating (IKr) components of the delayed rectifier potassium current. Target: Potassium Channel. Smiles:...
| Schlagworte: | NE-10064 Dihydrochloride |
| Anwendung: | Targets potassium voltage-gated channel Eag-related subfamily H member 2 (KCNH2, KV11.1) |
| CAS | 149888-94-8 |
| MW: | 530.88 D |
ab 43,00 €
SLU-10482
Artikelnummer: TGM-T83887-10mg
Description: SLU-10482, an antiparasitic agent, effectively reduces C. parvum parasitic load in HCT-8 cells with an EC50 value of 0.07 µM. It exhibits lower affinity for human ether-a-go-go (hERG, Kd = 43 µM) compared to its counterpart, SLU-2633. When administered in vivo at dosages of 5 and 15 mg/kg twice daily,...
| Anwendung: | Antiparasitic agent |
| CAS | 2755451-45-5 |
| MW: | 408.35 D |
ab 64,00 €
Anti-KCNH2
Artikelnummer: CSB-PA100870.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: KCNH2. Antigen Species: Human
| Schlagworte: | Anti-ERG, Anti-hERG1, Anti-ERG-1, Anti-KCNH2, Anti-H-ERG, Anti-hERG-1, Anti-Eag homolog, Anti-Eag-related protein 1,... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 163,00 €
NS 1643
Artikelnummer: Cay20343-5
NS 1643 is an activator of the human ether-a-go-go related gene (ERG1, KCNH2, hERG) KV11.1 channel (EC50 = 10.5 µM). It also activates the KV11.2 (ERG2, KCNH6) channel, but evokes a distinctly different response from that of KV11.1. NS 1643 is commonly used in cells or isolated tissues.Formal Name:...
| Schlagworte: | N,N'-bis[2-hydroxy-5-(trifluoromethyl)phenyl]-urea |
| Anwendung: | KCNH2 activator |
| CAS | 448895-37-2 |
| MW: | 380.2 D |
ab 60,00 €
Anti-KCNH2 / ERG-1
Artikelnummer: NSJ-RQ7086
0.5mg/ml if reconstituted with 0.2ml sterile DI water. KCNH2, also known as ERG-1, H-ERG or KV11.1, encodes the pore-forming subunit of a rapidly activating-delayed rectifier potassium channel. It is mapped to 7q36.1. KCNH2 forms the major portion of one of the ion channel proteins (the 'rapid' delayed rectifier...
| Schlagworte: | Anti-ERG, Anti-KCNH2, Anti-H-ERG, Anti-hERG1, Anti-ERG-1, Anti-hERG-1, Anti-Eag homolog, Anti-Eag-related protein 1,... |
| Anwendung: | WB, FC, Direct ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
755,00 €
Amiodarone (hydrochloride)
Artikelnummer: Cay15213-500
Amiodarone is a class III antiarrhythmic agent, in that it prolongs both cardiac action potential and refractoriness by blocking potassium currents. It inhibits the voltage-gated potassium channel hERG, also known as KCNH2, with an IC50 value of 1 µM. In addition, amiodarone binds with high affinity to the sigma-1...
| Schlagworte: | (2-butyl-3-benzofuranyl)[4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]-methanone, monohydrochloride |
| Anwendung: | Ion channel blocker |
| CAS | 19774-82-4 |
| MW: | 681.8 D |
ab 43,00 €
E-4031 (hydrochloride)
Artikelnummer: Cay15203-5
Voltage-gated potassium ERG channels (Kv11.1), encoded by the ether-a-go-go related gene, mediate the inwardly rectifying potassium (K+) current that repolarizes myocardial cells, gut smooth muscle cells, and interstitial cells of Cajal. E-4031 is a methanesulfonanilide class III antiarrhythmic agent that prolongs...
| Schlagworte: | N-[4-[[1-[2-(6-methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]-methanesulfonamide, dihydrochloride |
| Anwendung: | ERG K+ channel blocking |
| CAS | 113559-13-0 |
| MW: | 474.4 D |
ab 109,00 €
Dofetilide-d4
Artikelnummer: Cay26451-1
Dofetilide-d4 is intended for use as an internal standard for the quantification of dofetilide (Cay-15045) by GC- or LC-MS. Dofetilide is a class III antiarrhythmic agent that prolongs cardiac action potential duration by selectively inhibiting the rapidly activating inward rectifying component of net delayed...
| Schlagworte: | N-[4-[2-[methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl-1,1,2,2-d4]amino]ethyl]phenyl]-methanesulfonamide |
| Anwendung: | GC-MS, LC-MS, Quantification, Internal standard, Voltage-gated potassium channel (KCNH2) blocker |
| CAS | 1189700-56-8 |
| MW: | 445.6 D |
ab 205,00 €