Zu "K04905" wurden 38 Artikel gefunden!
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Cyclovirobuxine D
Artikelnummer: TGM-T2974-20mg
Description: Cyclovirobuxine D (Bebuxine) is extracted from Buxus microphylla. Target: mTOR, Autophagy, Apoptosis, Akt, Others. Smiles: [H][C@]1([C@H](C)NC)[C@H](O)C[C@@]2(C)[C@]3([H])CC[C@]4([H])[C@]5(C[C@@]35CC[C@]12C)CC[C@H](NC)C4(C)C. References: Hu D, et al. Eur J Pharmacol, 2007, 569(1-2), 103-109.
| Schlagworte: | Cyclovirobuxin D, CVB-D, Bebuxine |
| Anwendung: | KCNH2 blocker |
| CAS | 860-79-7 |
| MW: | 402.66 D |
49,00 €
NS1643
Artikelnummer: TGM-T3192-100mg
Description: NS1643 is a potent human ether-a-go-go related gene (hERG) KV11.1 channel activator with EC50 of 10.5 µM. Target: HER, Autophagy, Potassium Channel. Smiles: Oc1ccc(cc1NC(=O)Nc1cc(ccc1O)C(F)(F)F)C(F)(F)F. References: Casis O, et al. Mol Pharmacol. 2006 Feb,69(2):658-65.
| Anwendung: | KCNH2 activator |
| CAS | 448895-37-2 |
| MW: | 380.24 D |
ab 31,00 €
E-4031
Artikelnummer: TGM-T7198-100mg
Description: E-4031 is a methanesulfonanilide class III antiarrhythmic agent that prolongs cardiac action potential duration by blocking ERG K+ channels (IC50 = 29 nM). Target: EGFR, Potassium Channel. Smiles: Cl.Cl.Cc1cccc(CCN2CCC(CC2)C(=O)c2ccc(NS(C)(=O)=O)cc2)n1. References: David Z , Julia B , Gerlind F , et...
| Anwendung: | ERG K+ channel blocking |
| CAS | 113559-13-0 |
| MW: | 474.44 D |
ab 40,00 €
Azimilide Dihydrochloride
Artikelnummer: TGM-T7505-100mg
Description: Azimilide Dihydrochloride (NE-10064 Dihydrochloride), a novel class III antiarrhythmic agent, blocks both the slowly activating (IKs) and rapidly activating (IKr) components of the delayed rectifier potassium current. Target: Potassium Channel. Smiles:...
| Schlagworte: | NE-10064 Dihydrochloride |
| Anwendung: | Targets potassium voltage-gated channel Eag-related subfamily H member 2 (KCNH2, KV11.1) |
| CAS | 149888-94-8 |
| MW: | 530.88 D |
ab 43,00 €
SLU-10482
Artikelnummer: TGM-T83887-10mg
Description: SLU-10482, an antiparasitic agent, effectively reduces C. parvum parasitic load in HCT-8 cells with an EC50 value of 0.07 µM. It exhibits lower affinity for human ether-a-go-go (hERG, Kd = 43 µM) compared to its counterpart, SLU-2633. When administered in vivo at dosages of 5 and 15 mg/kg twice daily,...
| Anwendung: | Antiparasitic agent |
| CAS | 2755451-45-5 |
| MW: | 408.35 D |
ab 65,00 €
Ibutilide Fumarate
Artikelnummer: TGM-T6541-100mg
Description: Ibutilide Fumarate (U70226E) is the fumarate salt form of ibutilide, a class III antiarrhythmic agent. Ibutilide exerts its effect by activating a slow, inward, predominately sodium current rather than by blocking outward potassium currents. This results in prolongation of atrial and ventricular action...
| Schlagworte: | Corvert Fumarate, U70226E |
| Anwendung: | Targets potassium voltage-gated channel Eag-related subfamily H member 2 (KCNH2, KV11.1) |
| CAS | 122647-32-9 |
| MW: | 885.23 D |
ab 49,00 €
Dofetilide
Artikelnummer: TGM-T6476-100mg
Description: Dofetilide (UK 68789) is a sulfonamide class III antiarrhythmic agent and potassium channel blocker. Dofetilide selectively blocks cardiac ion channels of the rapid component of the delayed rectifier potassium current Ikr. This antiarrhythmic agent prolongs cardiac action potential duration and...
| Schlagworte: | UK 68789, UK-68798, Tikosyn |
| Anwendung: | Targets potassium voltage-gated channel Eag-related subfamily H member 2 (KCNH2, KV11.1) |
| CAS | 115256-11-6 |
| MW: | 441.56 D |
ab 49,00 €
Ibutilide
Artikelnummer: TGM-T61685-100mg
Description: Ibutilide (U70226E free base) is a potent antiarrhythmic compound that extends the action potential duration. It effectively blocks the rapidly activating delayed rectifier potassium current (I Kr ) in AT-1 cells [1]. Target: Others. Smiles: C(CCCN(CCCCCCC)CC)(O)C1=CC=C(NS(C)(=O)=O)C=C1
| Anwendung: | Targets potassium voltage-gated channel Eag-related subfamily H member 2 (KCNH2, KV11.1) |
| CAS | 122647-31-8 |
| MW: | 384.58 D |
ab 1.520,00 €
Ambasilide
Artikelnummer: TGM-T25074-100mg
Description: Ambasilide is a class III antiarrhythmic compound, potassium channel blocker, which acts by altering conductance rather than by affecting the gating mechanism. Target: Others. Smiles: C(=O)(N1CC2CN(CC3=CC=CC=C3)CC(C1)C2)C4=CC=C(N)C=C4. References: Bosch RF, Milek IV, Popovic K, Mermi J, Mewis C,...
| Schlagworte: | Ambasilidum |
| Anwendung: | Targets potassium voltage-gated channel Eag-related subfamily H member 2 (KCNH2, KV11.1) |
| CAS | 83991-25-7 |
| MW: | 335.44 D |
ab 1.520,00 €
Anti-KCNH2
Artikelnummer: CSB-PA100870.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: KCNH2. Antigen Species: Human
| Schlagworte: | Anti-ERG, Anti-hERG1, Anti-ERG-1, Anti-KCNH2, Anti-H-ERG, Anti-hERG-1, Anti-Eag homolog, Anti-Eag-related protein 1,... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 167,00 €
Amiodarone (hydrochloride)
Artikelnummer: Cay15213-500
Amiodarone is a class III antiarrhythmic agent, in that it prolongs both cardiac action potential and refractoriness by blocking potassium currents. It inhibits the voltage-gated potassium channel hERG, also known as KCNH2, with an IC50 value of 1 µM. In addition, amiodarone binds with high affinity to the sigma-1...
| Schlagworte: | (2-butyl-3-benzofuranyl)[4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]-methanone, monohydrochloride |
| Anwendung: | Ion channel blocker |
| CAS | 19774-82-4 |
| MW: | 681.8 D |
ab 44,00 €
E-4031 (hydrochloride)
Artikelnummer: Cay15203-5
Voltage-gated potassium ERG channels (Kv11.1), encoded by the ether-a-go-go related gene, mediate the inwardly rectifying potassium (K+) current that repolarizes myocardial cells, gut smooth muscle cells, and interstitial cells of Cajal. E-4031 is a methanesulfonanilide class III antiarrhythmic agent that prolongs...
| Schlagworte: | N-[4-[[1-[2-(6-methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]-methanesulfonamide, dihydrochloride |
| Anwendung: | ERG K+ channel blocking |
| CAS | 113559-13-0 |
| MW: | 474.4 D |
ab 111,00 €