Zu "K04855" wurden 37 Artikel gefunden!
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ABT-639
Artikelnummer: TGM-T3703-100mg
Description: ABT-639 is a potent and selective T-type calcium channel blocker. Target: Calcium Channel. Smiles: [H][C@]12CCCN1CCN(C2)C(=O)c1cc(c(F)cc1Cl)S(=O)(=O)Nc1ccccc1F. References: Jarvis MF, et al. Biochem Pharmacol. 2014 Jun 15,89(4):536-44.
| Schlagworte: | ABT 639 |
| Anwendung: | T-type calcium channel blocker |
| CAS | 1235560-28-7 |
| MW: | 455.91 D |
ab 46,00 €
(2R/S)-6-PNG
Artikelnummer: TGM-T37427-1mg
Description: (2R/S)-6-PNG (6-Prenylnaringenin) is a novel natural histone deacetylase inhibitor with anticancer and antitumor activity, and it blocks T-type calcium channels to reduce neuropathic and visceral pain in mice. Target: HDAC, Calcium Channel. Smiles: CC(C)=CCc1c(O)cc2OC(CC(=O)c2c1O)c1ccc(O)cc1....
| Schlagworte: | 6-Prenylnaringenin, (±)-6-Prenylnaringenin |
| Anwendung: | Bioactive flavonoid |
| CAS | 68682-01-9 |
| MW: | 340.37 D |
ab 97,00 €
Anti-CACNA1H
Artikelnummer: CSB-PA004342.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-Voltage-gated calcium channel subunit alpha Cav3.2, Anti-Low-voltage-activated calcium channel alpha1 3.2 subunit,... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 126,00 €
Anti-CACNA1H
Artikelnummer: CSB-PA154566.100
Host Species: Rabbit. Isotype: IgG. Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by...
| Schlagworte: | Anti-Voltage-gated calcium channel subunit alpha Cav3.2, Anti-Low-voltage-activated calcium channel alpha1 3.2 subunit,... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
283,00 €
Aranidipine
Artikelnummer: Cay40813-10
Aranidipine is an antagonist of voltage-gated calcium channel Cav3.2. It inhibits inward currents in Xenopus oocytes expressing human Cav3.2 channels when used at a concentration of 10 µM. Aranidipine (10 mg/kg) decreases mean blood pressure and increases heart rate in spontaneously hypertensive rats (SHRs). It...
| Schlagworte: | MPC-1304, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-yridinedicarboxylic acid, 3-methyl 5-(2-oxopropyl) ester |
| Anwendung: | Cav3.2 antagonist |
| CAS | 86780-90-7 |
| MW: | 388.4 D |
ab 71,00 €
Mibefradil (hydrochloride)
Artikelnummer: Cay15037-25
Mibefradil is a general calcium channel blocker that shows modest selectivity for T-type channels over L-type channels (IC50 = 2.7 and 18.6 µM, respectively). It is a potent vasodilator, increasing coronary artery flow with an EC50 value of 54 nM. Mibefradil has minimal negative inotropic effects, supporting its use...
| Schlagworte: | Posicor, Ro 40-5967,... |
| Anwendung: | Calcium channel blocker, Vasodilator |
| CAS | 116666-63-8 |
| MW: | 568.6 D |
ab 145,00 €
Ethosuximide
Artikelnummer: Cay23947-500
Ethosuximide is an anticonvulsant. It increases glucose, fructose-1,6-bisphosphate, and pyruvate levels in rat brain when administered at a dose of 200 mg/kg. Ethosuximide (400 mg/kg) reduces the severity of audiogenic seizures in a rat model of barbiturate withdrawal-induced convulsions. It also inhibits tonic...
| Schlagworte: | CI-366, NSC 64013, 3-ethyl-3-methyl-2,5-pyrrolidinedione |
| Anwendung: | Calcium channel T type blocker, Anticonvulsant |
| CAS | 77-67-8 |
| MW: | 141.2 D |
ab 57,00 €
Flunarizine (hydrochloride)
Artikelnummer: Cay20385-1
Flunarizine is a calcium antagonist that acts as a potent dilator of peripheral vessels without having calcium-blocking actions in the heart. It reduces calcium fluxes in vascular smooth muscle by blocking both voltage-dependent calcium channels and receptor-operated channels. Flunarizine also acts as a dopamine D2...
| Schlagworte: | 1-[bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenyl-2-propen-1-yl]-piperazine, dihydrochloride |
| Anwendung: | Calcium channel T type blocker |
| CAS | 30484-77-6 |
| MW: | 477.4 D |
ab 49,00 €
(±)-6-Prenylnaringenin
Artikelnummer: Cay34499-1
(±)-6-Prenylnaringenin ((±)-6-PN) is a flavonoid that has been found in the hop plant, H. lupulus, and has diverse biological activities. It inhibits the T-type voltage-gated calcium (Cav) channel Cav3.2 and high-voltage-activated calcium currents in whole-cell patch-clamp assays using HEK293 cells (IC50s = 0.912...
| Schlagworte: | (±)-6-PN, 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one |
| Anwendung: | Bioactive flavonoid |
| CAS | 68682-01-9 |
| MW: | 340.4 D |
ab 106,00 €
Anti-CAV3.2, clone S55-10
Artikelnummer: 200-301-F11
Anti-CAV3.2 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with CAV3.2 from Human, Rat, and Mouse based on 100% homology with the immunizing sequence. No cross-reactivity against Cav1.3. Cross-reactivity with CAV3.2 from other sources has not been determined....
| Schlagworte: | Anti-CACNA1H, Anti-Voltage-gated calcium channel subunit alpha Cav3.2, Anti-Low-voltage-activated calcium channel alpha1... |
| Anwendung: | IHC, IFM, IP, WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human, mouse, rat |
737,00 €
Anti-CACNA1H
Artikelnummer: 600-401-AA3
Anti-CACNA1H antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. CACNA1H antibody is human, mouse and rat reactive. Multiple isoforms of CACNA1H are known to exist. Protein function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable...
| Schlagworte: | Anti-CACNA1H, Anti-Voltage-gated calcium channel subunit alpha Cav3.2, Anti-Low-voltage-activated calcium channel alpha1... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
834,00 €
Penfluridol
Artikelnummer: Cay26071-1
Penfluridol is a first generation typical antipsychotic that binds to dopamine receptors (IC50 = 5.6 nM). It binds to dopamine D4 receptors and also to serotonin (5-HT) receptors (Kis = 31 and 63.1 nM, respectively). Penfluridol (1.25 and 2.5 mg/kg) inhibits stereotypic behavior induced by apomorphine (Cay-16094) in...
| Schlagworte: | R-16341, 1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]-4-piperidinol |
| Anwendung: | Calcium channel T type blocker, Dopamine D4 receptor ligand, Serotonin (5-HT) receptor ligand |
| CAS | 26864-56-2 |
| MW: | 524 D |
ab 52,00 €