Zu "K04853" wurden 30 Artikel gefunden!
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Darodipine
Artikelnummer: Cay41667-5
Darodipine is a calcium channel inhibitor. It selectively inhibits calcium-induced contractions of isolated rabbit aorta (pD2 = 8.8) over norepinephrine-, serotonin-, or angiotensin II-induced contractions at 10 µM. In vivo, continuous infusion of darodipine (2 µg/kg per minute) increases cerebral tissue oxygenation...
| Schlagworte: | PY 108-068, 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid, 3,5-diethyl ester |
| Anwendung: | Calcium channel inhibitor |
| CAS | 72803-02-2 |
| MW: | 371.4 D |
ab 75,00 €
Amlodipine
Artikelnummer: Cay14838-500
Amlodipine is a dihydropyridine L-type calcium channel blocker that selectively inhibits calcium influx in cardiac and vascular smooth muscle. Acting as a vasodilator, amlodipine reduces blood pressure by relaxing the smooth muscle in the arterial wall, decreasing total peripheral resistance. It inhibits...
| Schlagworte: | Intervask, Pelmec, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid,... |
| Anwendung: | L-type calcium channel blocker |
| CAS | 88150-42-9 |
| MW: | 408.9 D |
ab 92,00 €
(±)-Verapamil hydrochloride
Artikelnummer: CDX-V0007-M100
White powder. Soluble in methanol (50 mg/ml), ethanol or water. Verapamil hydrochloride is an alpha-adrenergic receptor (alpha-AR) antagonist and calcium channel protein inhibitor that blocks the L-type Ca2+ channels in smooth and cardiac muscle cells. Verapamil is an antiarrhythmic agent and vasodilator known to...
| Schlagworte: | Manidon |
| Anwendung: | Calcium channel L type blocker |
| CAS | 152-11-4 |
| MW: | 491,06 D |
ab 37,00 €
Isradipine
Artikelnummer: Cay17536-25
Isradipine is a selective L-type calcium channel blocker with long-acting antihypertensive activity. It demonstrates an EC50 value of 1.4 nM for relaxation of depolarization-induced contractions of rabbit aorta and an EC25 value of 0.45 nM for reduction in rate of spontaneously beating guinea pig right atria. By...
| Schlagworte: | PN 200-110, 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid, 3-methyl... |
| Anwendung: | L-type calcium channel blocker |
| CAS | 75695-93-1 |
| MW: | 371.4 D |
ab 60,00 €
Felodipine
Artikelnummer: Cay17535-50
Felodipine is an inhibitor of L-type calcium channels. It induces relaxation of precontracted isolated porcine coronary artery segments (EC50 = 0.15 nM), which highly express L-type calcium channels. Felodipine is selective for L-type calcium channels over N-, R-, and P/Q-type channels at 10 µM, as well as the...
| Schlagworte: | H 154/82, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid, 3-ethyl 5-methyl ester |
| Anwendung: | L-type calcium channel blocker |
| CAS | 72509-76-3 |
| MW: | 384.3 D |
ab 43,00 €
(±)-Verapamil-d3 (hydrochloride)
Artikelnummer: Cay18452-500
(±)-Verapamil-d3 (hydrochloride) (Cay-18452) is intended for use as an internal standard for the quantification of verapamil (Cay-14288) by GC- or LC-MS. Verapamil is the prototypical blocker of L-type calcium channels that produces excitation-contraction uncoupling in cardiac muscle by preventing the slow-inward...
| Schlagworte: | 5-((3,4-dimethoxyphenethyl)(methyl-d3)amino)-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile, monohydrochloride |
| Anwendung: | MS, Internal control, Calcium channel L type blocker, KCNJ6, KCNA10, KCNA3, KCNA7, KCNC2 blocker |
| CAS | 2714485-49-9 |
| MW: | 494.1 D |
ab 66,00 €
Nilvadipine
Artikelnummer: Cay21243-25
Nilvadipine is a dihydropyridine L-type calcium channel blocker. It is selective for L-type over N-, P/Q-, and R-type calcium channels at 10 µM. Nilvadipine (10 mg/kg per day, p.o.) inhibits increases in systolic blood pressure induced by chronic intravenous infusion of the peptide vasoconstrictor endothelin in...
| Schlagworte: | (±)-Nilvadipine, CL 287,389, FK-235, FR34235, SKF 102362,... |
| Anwendung: | Calcium channel L-type blocker |
| CAS | 75530-68-6 |
| MW: | 385.4 D |
ab 43,00 €
Nitrendipine
Artikelnummer: Cay17549-100
Nitrendipine is a dihydropyridine used as an antihypertensive agent due to its ability to block L-type and T-type calcium channels, which play key roles in excitation-contraction coupling in cardiac and vascular smooth muscle cells, producing vasodilatory actions. It also binds to adenosine A1, A2A, and A3 receptors...
| Schlagworte: | 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3-ethyl 5-methyl ester |
| Anwendung: | T/L-type calcium channel blocker |
| CAS | 39562-70-4 |
| MW: | 360.4 D |
ab 43,00 €
(R)-(+)-BAY-K-8644
Artikelnummer: Cay15263-5
BAY-K-8644, originally described as a modulator of potential operated calcium channels, exists as two enantiomers that have opposite actions. (R)-(+)-BAY-K-8644 is an L-type channel blocker that has negative inotropic and vasodilatory effects at 1 µM. Intracerebroventricular administration of this enantiomer has no...
| Schlagworte: | NI 105, R 4407, (4R)-1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid |
| Anwendung: | L-type channel blocker |
| CAS | 98791-67-4 |
| MW: | 356.3 D |
ab 147,00 €
Nicardipine (hydrochloride)
Artikelnummer: Cay17537-10
Nicardipine is a dihydropyridine L-type calcium channel antagonist that displays antihypertensive and antianginal activity. It is reported to inhibit adenosine A1, A2A, and A3 receptors with Ki values of 19.6, 63.8, and 3.25 µM, respectively, and can inhibit cytochrome P450 3A4 catalytic activity with an IC50 value...
| Schlagworte: | RS 69216, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3-methyl... |
| Anwendung: | L-type calcium channel antagonist |
| CAS | 54527-84-3 |
| MW: | 516 D |
ab 43,00 €
Bepridil (hydrochloride)
Artikelnummer: Cay19645-50
Bepridil is a dihydropyridine that has anti-anginal and anti-arrhythmic actions by blocking calcium channels in heart and smooth muscle. It is recognized as a non-selective channel blocker, altering myocardial Ca2+, Na+, and K+ currents. For example, it blocks voltage-gated Ca2+ (Cav3.2) and K+ (hERG and KCNQ4)...
| Schlagworte: | beta-[(2-methylpropoxy)methyl]-N-phenyl-N-(phenylmethyl)-1-pyrrolidineethanamine, monohydrochloride |
| Anwendung: | Calcium channel blocker |
| CAS | 68099-86-5 |
| MW: | 403 D |
ab 43,00 €
Nimodipine
Artikelnummer: LKT-N3448.500
A calcium channel antagonist.
| Anwendung: | Ca channel antagonist |
| CAS | 66085-59-4 |
| MW: | 418,44 D |
ab 167,00 €