Zu "K04842" wurden 24 Artikel gefunden!
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Anti-SCN10A
Artikelnummer: CSB-PA146616.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: SCN10A. Antigen Species: Human
| Schlagworte: | Anti-PN3, Anti-hPN3, Anti-SCN10A, Anti-Peripheral nerve sodium channel 3, Anti-Sodium channel protein type X subunit... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 163,00 €
Anti-SCN10A
Artikelnummer: CSB-PA251062.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: SCN10A. Antigen Species: Human
| Schlagworte: | Anti-PN3, Anti-hPN3, Anti-SCN10A, Anti-Peripheral nerve sodium channel 3, Anti-Sodium channel protein type X subunit... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 163,00 €
Suzetrigine
Artikelnummer: Cay40799-1
Suzetrigine is an inhibitor of voltage-gated sodium channel 1.8 (Nav1.8, IC50 = 0.7 nM for the human channel). It is selective for Nav1.8 over a panel of eight additional voltage-gated sodium channels (IC50s = >10,000 nM for all).Formal Name:...
| Schlagworte: | VX-548,... |
| Anwendung: | Nav1.8 blocker, analgesic |
| CAS | 2649467-58-1 |
| MW: | 473.4 D |
ab 360,00 €
A-803467
Artikelnummer: Cay10012588-100
Nav1.8 is a tetrodotoxin-resistant (TTX-R) sodium channel with high activation threshold and slow inactivating kinetics that is highly expressed in small-diameter sensory neurons and has been implicated in signaling various types of pain. A-803467 is a sodium channel blocker with high-affinity and selectivity for...
| Schlagworte: | 5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furancarboxamide |
| Anwendung: | Nav1.8 sodium channel inhibitor |
| CAS | 944261-79-4 |
| MW: | 357.8 D |
ab 50,00 €
Lamotrigine
Artikelnummer: Cay15428-25
Lamotrigine is an anticonvulsant. It inhibits voltage-gated sodium channels (Nav) in HEK293 cells expressing recombinant human Nav1.2, Nav1.5, or Nav1.8 (IC50s = 10, 62, and 96 µM, respectively), as well as high voltage-activated calcium currents in isolated rat cortical neurons (IC50 = 12.3 µM), an effect that can...
| Schlagworte: | BW 430C, Epilepax, Lamictal, LTG, 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine |
| Anwendung: | Voltage-gated sodium channel inhibitor |
| CAS | 84057-84-1 |
| MW: | 256.1 D |
ab 77,00 €
Ambroxol (hydrochloride)
Artikelnummer: Cay19377-25
Ambroxol is an expectorant and active metabolite of bromhexine. It decreases short-circuit currents in electrically stimulated isolated canine tracheal epithelial cells when applied submucosally (IC50 = 60 nM). It inhibits the voltage-gated sodium channel Nav1.2 in isolated dorsal root neurons (IC50 = 110 µM for the...
| Schlagworte: | NA 872, trans-4-[[(2-amino-3,5-dibromophenyl)methyl]amino]-cyclohexanol, monohydrochloride |
| Anwendung: | Sodium channel blocker |
| CAS | 23828-92-4 |
| MW: | 414.6 D |
ab 50,00 €
(-)-Ropivacaine-d7 (hydrochloride)
Artikelnummer: Cay26495-1
(-)-Ropivacaine-d7 is intended for use as an internal standard for the quantification of (-)-ropivacaine (Cay-21422) by GC- or LC-MS. (-)-Ropivacaine is a potent and reversible blocker of sodium channels in nerve fibers. In vivo, (-)-ropivacaine induces complete impairment of proprioception, motor function, and...
| Schlagworte: | (S)-Ropivacaine-d7, (S)-N-(2,6-dimethylphenyl)-1-(propyl-d7)piperidine-2-carboxamide, monohydrochloride |
| Anwendung: | GC-MS, LC-MS, Quantification, Internal standard, Sodium channel blocker |
| CAS | 1217667-10-1 |
| MW: | 317.9 D |
ab 139,00 €
-30 %
Rabattaktion
Anti-Nav1.8 Na+ Channel, clone S134-12
Artikelnummer: ARG56141.50
Protein function: Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium- selective channel through which sodium ions may pass in...
| Schlagworte: | Anti-Sns, Anti-PN3, Anti-Scn10a, Anti-Sensory neuron sodium channel, Anti-Peripheral nerve sodium channel 3, Anti-Sodium... |
| Anwendung: | ICC, IF, IHC (paraffin), WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human, mouse, rat |
628,00 €
439,60 €
Nav1.8/beta2 - HEK293 Cell Line
Artikelnummer: BPS-60521
Stable recombinant HEK293 cell line expressing tetracycline-inducible human Nav1.8 (Genbank #NP_006505.2) fused to Green Fluorescent Protein (GFP) [Ex. ~395 nm, 475 nm, em ~510 nm] and the human sodium channel beta2 subunit (Genbank #NM_004588, SCN2B). Nav1.8 is also known as tetrodotoxin-resistant voltage-gated...
| Schlagworte: | PN3, hPN3, SCN10A, Peripheral nerve sodium channel 3, Sodium channel protein type X subunit alpha, Sodium channel protein... |
| Anwendung: | Drug compound screening, FC, antigen |
| Wirt: | human cells |
| Spezies-Reaktivität: | human |
11.769,00 €
Anti-NAV1.8, clone S134-12
Artikelnummer: 200-301-G22
Anti-NAV1.8 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with NAV1.8 from human, mouse, and rat based on 100% homology with the immunizing sequence. No cross reactivity against other Nav channels. Cross-reactivity with NAV1.8 from other sources has not been...
| Schlagworte: | Anti-Sns, Anti-PN3, Anti-Scn10a, Anti-Sensory neuron sodium channel, Anti-Peripheral nerve sodium channel 3, Anti-Sodium... |
| Anwendung: | IHC, IFM, WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human, mouse, rat |
698,00 €
PF-01247324
Artikelnummer: Cay22111-1
PF-01247324 is a blocker of the tetrodotoxin-resistant (TTX-R) sodium channel Nav1.8 (IC50 = 0.19 µM for human Nav1.8). It is selective for Nav1.8 over Nav1.1, Nav1.2, Nav1.5, and Nav1.7 channels (IC50s = 13, 12.8, 9, and 19 µM, respectively) as well as ether-a-go-go (ERG) potassium channels (IC50 = 30 µM)....
| Schlagworte: | 6-amino-N-methyl-5-(2,3,5-trichlorophenyl)-2-pyridinecarboxamide |
| Anwendung: | NaV1.8 channel blocker |
| CAS | 875051-72-2 |
| MW: | 330.6 D |
ab 44,00 €
Raxatrigine (hydrochloride)
Artikelnummer: Cay23490-10
Raxatrigine is an inhibitor of voltage-gated sodium channels (Nav, IC50s = 22, 13, 23, 10, 84, 15, 32, and 6 µM for Nav1.1-Nav1.8 channels in a FLIPR membrane potential assay using HEK293 cells). Its activity is state-dependent at the Nav1.7 channel, with a nine-fold increase in potency for the open/inactivated...
| Schlagworte: | GSK1014802A, (2S)-5R-[4-[(2-fluorophenyl)methoxy]phenyl]-2-pyrrolidinecarboxamide, monohydrochloride |
| Anwendung: | Voltage-gated sodium channel inhibitor |
| CAS | 934240-31-0 |
| MW: | 350.8 D |
ab 50,00 €