Zu "K04837" wurden 24 Artikel gefunden!
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Tocainide
Artikelnummer: Cay41592-10
Tocainide is an antiarrhythmic agent and a derivative of the local anesthetic lidocaine. It inhibits voltage-gated sodium channel 1.4 (Nav1.4) in HEK293 cells expressing the human channel (IC50s = 699 and 182 µM at 0.1 and 10 Hz, respectively). Tocainide reduces the action potential duration at 50% repolarization in...
| Schlagworte: | (R,S)-Tocainide, W-36095, 2-amino-N-(2,6-dimethylphenyl)-propanamide |
| Anwendung: | Antiarrhythmic agent, sodium channel blocker |
| CAS | 41708-72-9 |
| MW: | 192.3 D |
ab 54,00 €
Anti-SCN4A
Artikelnummer: CSB-PA615738.100
Host Species: Rabbit. Isotype: IgG. Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by...
| Schlagworte: | Anti-SkM1, Anti-SCN4A, Anti-Sodium channel protein type 4 subunit alpha, Anti-Sodium channel protein type IV subunit... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
275,00 €
Quinidine
Artikelnummer: Cay20356-5
Quinidine is a stereoisomer of the antimalarial agent quinine (Cay-23958) and a class Ia antiarrhythmic agent. Quinidine blocks the voltage-gated sodium (Nav) channel Nav1.5 in a use-dependent manner. It decreases the amplitude and duration of action potentials in isolated canine ventricular myocytes. It inhibits...
| Schlagworte: | (+)-Quinidine, beta-Quinidine, 6'-methoxy-cinchonan-9S-ol |
| Anwendung: | Antiarrhythmic, Antimalarial, Sodium channel blocker |
| CAS | 56-54-2 |
| MW: | 324.4 D |
ab 77,00 €
10,11-dihydro-10-hydroxy Carbamazepine
Artikelnummer: Cay18467-50
10,11-dihydro-10-hydroxy Carbamazepine is an antiepileptic agent and active metabolite of the prodrug oxcarbazepine (Cay-17340). It is a racemic mixture of (R)- and (S)-10,11-dihydro-10-hydroxy carbamazepine. (S)-10,11-dihydro-10-hydroxy Carbamazepine protects against seizures induced by maximal electroshock (MES)...
| Schlagworte: | 10,11-hydroxy-10,11 Dihydrocarbamezer, BIA 2-005, GP 47779, Licarbazepine,... |
| Anwendung: | Anticonvulsant, voltage-gated sodium channel SCN1A, SCN2A, SCN3A, SCN4A, SCN5A, SCN8A, SCN9A blocker |
| CAS | 29331-92-8 |
| MW: | 254.3 D |
ab 68,00 €
Flecainide (acetate)
Artikelnummer: Cay20388-5
Flecainide is an inhibitor of cardiac late sodium current (INa, IC50 = 3.4 µM) and delayed-rectifier potassium current (IKr, IC50 = 1.5 µM). Formulations containing flecainide have been used in the treatment of arrhythmias and sodium-dependent calcium overload associated with myocardial ischemia and heart...
| Schlagworte: | N-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)-benzamide, monoacetate |
| Anwendung: | Antiarrhythmic, Sodium channel blocker |
| CAS | 54143-56-5 |
| MW: | 474.4 D |
ab 43,00 €
Fosphenytoin (sodium salt)
Artikelnummer: Cay23889-50
Fosphenytoin is a prodrug of phenytoin that is rapidly converted to phenytoin, a voltage-gated sodium channel blocker, in vivo. It induces less tissue damage compared with two other phenytoin prodrugs in rats following subcutaneous and intramuscular administration. Fosphenytoin has anticonvulsant activity in a mouse...
| Schlagworte: | ACC-9653, Cl-982, 5,5-diphenyl-3-[(phosphonooxy)methyl]-2,4-imidazolidinedione, disodium salt |
| Anwendung: | Voltage-gated sodium channel blocker prodrug |
| CAS | 92134-98-0 |
| MW: | 406.2 D |
ab 60,00 €
Rufinamide
Artikelnummer: Cay18870-50
Lennox-Gastaut syndrome (LGS) is a severe pediatric epilepsy syndrome characterized by multiple seizure types. Rufinamide is an anticonvulsant. It inhibits the activation of voltage-gated sodium channel 1.1 (Nav1.1) when used at a concentration of 100 µM. Rufinamide inhibits Nav1.1, but not Nav1.2, Nav1.3, and...
| Schlagworte: | CGP 33101, RUF 331, 1-[(2,6-difluorophenyl)methyl]-1H-1,2,3-triazole-4-carboxamide |
| Anwendung: | Antiepileptic |
| CAS | 106308-44-5 |
| MW: | 238.2 D |
ab 43,00 €
Raxatrigine (hydrochloride)
Artikelnummer: Cay23490-1
Raxatrigine is an inhibitor of voltage-gated sodium channels (Nav, IC50s = 22, 13, 23, 10, 84, 15, 32, and 6 µM for Nav1.1-Nav1.8 channels in a FLIPR membrane potential assay using HEK293 cells). Its activity is state-dependent at the Nav1.7 channel, with a nine-fold increase in potency for the open/inactivated...
| Schlagworte: | GSK1014802A, (2S)-5R-[4-[(2-fluorophenyl)methoxy]phenyl]-2-pyrrolidinecarboxamide, monohydrochloride |
| Anwendung: | Voltage-gated sodium channel inhibitor |
| CAS | 934240-31-0 |
| MW: | 350.8 D |
ab 50,00 €
Oxcarbazepine
Artikelnummer: Cay17340-50
Oxcarbazepine is a prodrug form of the antiepileptic compound 10,11-dihydro-10-hydroxy carbamazepine (Cay-18467). It inhibits high-frequency repetitive firing of rat spinal cord neurons when used at a concentration of 1 µM. Oxcarbazepine protects against electroshock-induced tonic hindlimb extension (ED50 = 10-20...
| Schlagworte: | GP47680, 10,11-dihydro-10-oxo-5H-dibenz[b,f]azepine-5-carboxamide |
| Anwendung: | 10-hydroxycarbazepine prodrug, voltage-gated sodium channel blocker |
| CAS | 28721-07-5 |
| MW: | 252.3 D |
ab 43,00 €
Eslicarbazepine Acetate
Artikelnummer: Cay23656-5
Eslicarbazepine acetate is a sodium channel blocker (IC50 = 138 nM in a radioligand binding assay). It inhibits sodium uptake in a dose-dependent manner in rat cortical synaptosomes at concentrations ranging from 30-300 µM. In vivo, oral and i.p. administration of eslicarbazepine acetate is protective against...
| Schlagworte: | BIA 2-093, (10S)-10-(acetyloxy)-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide |
| Anwendung: | Sodium channel blocker |
| CAS | 236395-14-5 |
| MW: | 296.3 D |
ab 125,00 €
Brevetoxin 3
Artikelnummer: LKT-B6918.1
Brevetoxins are lipid-soluble polyether neurotoxins produced by the dinoflagellate Karenia brevis. Brevetoxins act as agonists, binding the neurotoxin site 5 on SCN4A/Nav1.4 and SCN5A/Nav1.5 voltage-gated Na+ channels in skeletal muscle and cardiac tissue, producing a channel opening effect, this activity results in...
| Schlagworte: | PbTx-3 |
| Anwendung: | SCN4A/Nav1.4 / SCN5A/Nav1.5 agonist |
| CAS | 85079-48-7 |
| MW: | 897.2 D |
ab 862,00 €
Zonisamide
Artikelnummer: Cay24183-500
Zonisamide is a broad-spectrum sulfonamide antiepileptic agent. It selectively blocks the repeated firing of sodium channels (IC50 = 2 µg/ml) at low concentrations in mouse embryo spinal cord neurons, and it blocks spontaneous channel firing at concentrations above 10 µg/ml. In rat cerebral cortex neurons,...
| Schlagworte: | CI-912, PD 110843, 1,2-benzisoxazole-3-methanesulfonamide |
| Anwendung: | Antiepileptic |
| CAS | 68291-97-4 |
| MW: | 212.2 D |
ab 77,00 €