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Zu "K04834" wurden 43 Artikel gefunden!
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Artikelnummer: Cay38904-1
Levobupivacaine-d9 is intended for use as an internal standard for the quantification of levobupivacaine (Cay-31596) by GC- or LC-MS. Levobupivacaine is a sodium channel blocker and local anesthetic, as well as the levorotary stereoisomer of bupivacaine (Cay-16618). It inhibits cardiac sodium channel currents (INa)...
Schlagworte: | (S)-(-)-Bupivacaine-d9, 1-butyl-d9-N-(2,6-dimethylphenyl)-(2S)-2-piperidinecarboxamide, monohydrochloride |
Anwendung: | GC-MS, LC-MS internal standard, quantification, sodium channel blocker, local anesthetic |
MW: | 333.9 D |
ab 82,00 €
Artikelnummer: Cay35008-1
Eslicarbazepine is a voltage-gated sodium channel (Nav) inhibitor and an active metabolite of the prodrug eslicarbazepine acetate (Cay-23656). It enhances slow activation of voltage-gated sodium channels, reducing channel availability. Eslicarbazepine is protective against seizures induced by maximal electroshock...
Schlagworte: | (S)-Licarbazepine, BIA 2-194, CGP 13751, (10S)-10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide |
Anwendung: | Eslicarbazepine acetate active metabolite, voltage-gated sodium channel inhibitor |
CAS | 104746-04-5 |
MW: | 254.3 D |
ab 48,00 €
Artikelnummer: Cay29399-100
Fenvalerate is a pyrethroid ester insecticide and acaricide. It is a slow activator of voltage-gated sodium channel 1.8 (Nav1.8). It induces mortality in pyrethroid-susceptible and -resistant strains of M. domestica (LD50s = 0.014-5 µg/fly). Fenvalerate also induces mortality in tobacco budworm larvae but is...
Schlagworte: | 4-chloro-alpha-(1-methylethyl)-benzeneacetic acid, cyano(3-phenoxyphenyl)methyl ester |
Anwendung: | Antiparasitic, insecticide, Nav1.8 slow activator |
CAS | 51630-58-1 |
MW: | 419.9 D |
ab 44,00 €
Artikelnummer: Cay21871-1
Propafenone is a class I antiarrhythmic agent. It inhibits calcium currents (ICa) in isolated guinea pig ventricular myocytes (IC50 = 5 µM), as well as ATP-sensitive potassium currents (IKATP) in isolated rabbit atrial and ventricular monocytes (IC50s = 1.26 and 4.94 µM, respectively). Propafenone also blocks sodium...
Schlagworte: | 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-1-propanone, monohydrochloride |
Anwendung: | Sodium channel blocker |
CAS | 34183-22-7 |
MW: | 377.9 D |
ab 43,00 €
Artikelnummer: Cay15428-10
Lamotrigine is an anticonvulsant. It inhibits voltage-gated sodium channels (Nav) in HEK293 cells expressing recombinant human Nav1.2, Nav1.5, or Nav1.8 (IC50s = 10, 62, and 96 µM, respectively), as well as high voltage-activated calcium currents in isolated rat cortical neurons (IC50 = 12.3 µM), an effect that can...
Schlagworte: | BW 430C, Epilepax, Lamictal, LTG, 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine |
Anwendung: | Voltage-gated sodium channel inhibitor |
CAS | 84057-84-1 |
MW: | 256.1 D |
ab 77,00 €
Artikelnummer: Cay23782-5
Mexiletine is a voltage-gated sodium channel blocker and class Ib antiarrhythmic agent that preferentially binds to open/inactive channels. It inhibits aconitine-induced dysrhythmias in mice with ED50 values of 57 and 107 mg/kg for intraperitoneal and oral administration, respectively. Mexiletine decreases or...
Schlagworte: | Ko 1173, 1-(2,6-dimethylphenoxy)-2-propanamine, monohydrochloride |
Anwendung: | Sodium channel blocker |
CAS | 5370-01-4 |
MW: | 215.7 D |
ab 43,00 €
Artikelnummer: Cay10011498-100
Brevetoxin B is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. It binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50 = 15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal,...
Schlagworte: | Brevetoxin 2, BTX-B, GbTx-2, PbTx-2, brevetoxin B |
Anwendung: | Polyketide neurotoxin |
CAS | 79580-28-2 |
MW: | 895.1 D |
369,00 €
Artikelnummer: 200-301-G19
Anti-Nav1.2 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with Nav1.2 from Mouse, Human, and Rat based on 100% homology with the immunizing sequence. Cross-reactivity with Nav1.2 from other sources has not been determined. Ion Channels research. Protein...
Schlagworte: | Anti-Scn2a, Anti-Scn2a1, Anti-Sodium channel protein type 2 subunit alpha, Anti-Sodium channel protein type II subunit... |
Anwendung: | IHC, IFM, IP, WB |
Wirt: | Mouse |
Spezies-Reaktivität: | human, mouse, rat |
698,00 €
Artikelnummer: Cay26495-500
(-)-Ropivacaine-d7 is intended for use as an internal standard for the quantification of (-)-ropivacaine (Cay-21422) by GC- or LC-MS. (-)-Ropivacaine is a potent and reversible blocker of sodium channels in nerve fibers. In vivo, (-)-ropivacaine induces complete impairment of proprioception, motor function, and...
Schlagworte: | (S)-Ropivacaine-d7, (S)-N-(2,6-dimethylphenyl)-1-(propyl-d7)piperidine-2-carboxamide, monohydrochloride |
Anwendung: | GC-MS, LC-MS, Quantification, Internal standard, Sodium channel blocker |
CAS | 1217667-10-1 |
MW: | 317.9 D |
ab 139,00 €
Artikelnummer: Cay37196-1
Lamotrigine-d3 is intended for use as an internal standard for the quantification of lamotrigine (Cay-15428) by GC- or LC-MS. Lamotrigine is an anticonvulsant. It inhibits voltage-gated sodium channels (Nav) in HEK293 cells expressing recombinant human Nav1.2, Nav1.5, or Nav1.8 (IC50s = 10, 62, and 96 µM,...
Schlagworte: | LTG-d3, 6-(5,6-dichlorophenyl-2,3,4-d3)-1,2,4-triazine-3,5-diamine |
Anwendung: | GC-MS, LC-MS internal standard, quantification, oltage-gated sodium channel inhibitor |
CAS | 1132746-94-1 |
MW: | 259.1 D |
ab 225,00 €
Artikelnummer: Cay18467-25
10,11-dihydro-10-hydroxy Carbamazepine is an antiepileptic agent and active metabolite of the prodrug oxcarbazepine (Cay-17340). It is a racemic mixture of (R)- and (S)-10,11-dihydro-10-hydroxy carbamazepine. (S)-10,11-dihydro-10-hydroxy Carbamazepine protects against seizures induced by maximal electroshock (MES)...
Schlagworte: | 10,11-hydroxy-10,11 Dihydrocarbamezer, BIA 2-005, GP 47779, Licarbazepine,... |
Anwendung: | Anticonvulsant, voltage-gated sodium channel SCN1A, SCN2A, SCN3A, SCN4A, SCN5A, SCN8A, SCN9A blocker |
CAS | 29331-92-8 |
MW: | 254.3 D |
ab 68,00 €
Artikelnummer: Cay18870-100
Lennox-Gastaut syndrome (LGS) is a severe pediatric epilepsy syndrome characterized by multiple seizure types. Rufinamide is an anticonvulsant. It inhibits the activation of voltage-gated sodium channel 1.1 (Nav1.1) when used at a concentration of 100 µM. Rufinamide inhibits Nav1.1, but not Nav1.2, Nav1.3, and...
Schlagworte: | CGP 33101, RUF 331, 1-[(2,6-difluorophenyl)methyl]-1H-1,2,3-triazole-4-carboxamide |
Anwendung: | Antiepileptic |
CAS | 106308-44-5 |
MW: | 238.2 D |
ab 43,00 €